Sustainable waterfront development is about creating a vision for an area and then deploying the skills and resources to realize it after involving a dialogue with the customer within an area. Also, it draws together ...Sustainable waterfront development is about creating a vision for an area and then deploying the skills and resources to realize it after involving a dialogue with the customer within an area. Also, it draws together many strands of place making such as environmental responsibility, social equity and economic viability, planning and transportation policy, architectural design into the creation of places of beauty and distinct identity. The development of waterfronts shapes communities around the water bodies and reflects the ability of cities to adapt to altered economic and social circumstances. The aim of this paper is to identify some approaches for applying sustainable waterfront development. By respecting the quality of life and defining sustainability in a broader context, a case will he made for enhancing the waterfront development, through the place making criteria, analyzing the Bahary waterfront in Alexandria, Egypt. The paper concludes some recommendations to develop Bahary waterfront based on the principles that are collected from the theoretical study in order to well design a waterfront responded to the wishes of the community.展开更多
This paper presents a model to simulate the safe behavior of Dagangshan arch dam with a rate-dependency anisotropic damage model. This model considers the damage of asymmetry and anisotropy under cyclic loading of ten...This paper presents a model to simulate the safe behavior of Dagangshan arch dam with a rate-dependency anisotropic damage model. This model considers the damage of asymmetry and anisotropy under cyclic loading of tension and compression, and it is used in the compiled finite element code. The material parameters used in the model can be identified from uniaxial static and dynamic experiments. Thereafter, it is used for analyzing damage and failure patterns of the dam subjected to water pressure and strong earthquakes. The numerical results show that it is necessary to consider both asymmetry between tension and compression and anisotropy of damage. Severe damage regions of the dam reveal brittle and risky positions clearly. Meanwhile damage patterns show the failure trend and safety behaviors of the dam. These results match well with that of the experiments carried out in DUT. The proposed model may be used to predict the damage patterns and potential failure modes of concrete structures like the dam. And the aseismic performance of the dam can be figured out.展开更多
In this study, differentially expressed genes in peripheral blood from patients with Kashin-Beck disease and Keshan disease were compared to further investigate the etiology and pathogenesis of both diseases, which oc...In this study, differentially expressed genes in peripheral blood from patients with Kashin-Beck disease and Keshan disease were compared to further investigate the etiology and pathogenesis of both diseases, which occur in a common endemic area of China. Twenty Kashin-Beck disease patients and 12 healthy controls, and 16 Keshan disease patients and 16 healthy controls, were grouped into four pairs. Patients and controls were selected from common endemic areas for the two diseases. Total RNA was isolated from peripheral blood mononuclear cells from all patients and controls, and gene expression profiles analyzed by oligonucleotide microarrays. Sixteen genes differentially expressed in both Kashin-Beck disease and Keshan disease (versus controls) were identified, and comprised nine genes showing synchronous and seven asynchronous expression. The Comparative Toxicogenomics Database shows that expression and biological function of these genes can be affected by multiple environmental factors, including mycotoxin and selenium content, potential environmental risk factors for the two diseases. Thus, these shared differentially expressed genes may contribute to the distinct organ lesions, caused by common environmental risk factors of Kashin-Beck disease and Keshan disease.展开更多
文摘Sustainable waterfront development is about creating a vision for an area and then deploying the skills and resources to realize it after involving a dialogue with the customer within an area. Also, it draws together many strands of place making such as environmental responsibility, social equity and economic viability, planning and transportation policy, architectural design into the creation of places of beauty and distinct identity. The development of waterfronts shapes communities around the water bodies and reflects the ability of cities to adapt to altered economic and social circumstances. The aim of this paper is to identify some approaches for applying sustainable waterfront development. By respecting the quality of life and defining sustainability in a broader context, a case will he made for enhancing the waterfront development, through the place making criteria, analyzing the Bahary waterfront in Alexandria, Egypt. The paper concludes some recommendations to develop Bahary waterfront based on the principles that are collected from the theoretical study in order to well design a waterfront responded to the wishes of the community.
基金supported by the National Natural Science Foundation of China (Grant Nos. 90510017 and 50878123)the National Basic Research Program of China (Grant No. 2007CB714104 )+1 种基金the Innovative Project for Postdoctor of Shandong Province (Grant No. 200803037)the Research Project of SUST Spring Bud (Grant No. 2008AZZ107)
文摘This paper presents a model to simulate the safe behavior of Dagangshan arch dam with a rate-dependency anisotropic damage model. This model considers the damage of asymmetry and anisotropy under cyclic loading of tension and compression, and it is used in the compiled finite element code. The material parameters used in the model can be identified from uniaxial static and dynamic experiments. Thereafter, it is used for analyzing damage and failure patterns of the dam subjected to water pressure and strong earthquakes. The numerical results show that it is necessary to consider both asymmetry between tension and compression and anisotropy of damage. Severe damage regions of the dam reveal brittle and risky positions clearly. Meanwhile damage patterns show the failure trend and safety behaviors of the dam. These results match well with that of the experiments carried out in DUT. The proposed model may be used to predict the damage patterns and potential failure modes of concrete structures like the dam. And the aseismic performance of the dam can be figured out.
基金supported in part by the Key Scientific and Technological Innovation Special Projects of Shaanxi "13115" of China (2009ZDKG-79)the National Natural Science Foundation of China (30872192, 81273008)
文摘In this study, differentially expressed genes in peripheral blood from patients with Kashin-Beck disease and Keshan disease were compared to further investigate the etiology and pathogenesis of both diseases, which occur in a common endemic area of China. Twenty Kashin-Beck disease patients and 12 healthy controls, and 16 Keshan disease patients and 16 healthy controls, were grouped into four pairs. Patients and controls were selected from common endemic areas for the two diseases. Total RNA was isolated from peripheral blood mononuclear cells from all patients and controls, and gene expression profiles analyzed by oligonucleotide microarrays. Sixteen genes differentially expressed in both Kashin-Beck disease and Keshan disease (versus controls) were identified, and comprised nine genes showing synchronous and seven asynchronous expression. The Comparative Toxicogenomics Database shows that expression and biological function of these genes can be affected by multiple environmental factors, including mycotoxin and selenium content, potential environmental risk factors for the two diseases. Thus, these shared differentially expressed genes may contribute to the distinct organ lesions, caused by common environmental risk factors of Kashin-Beck disease and Keshan disease.
