叶芝的作品充满了多种宗教信义,"大记忆"就是其中之一。"大记忆"是叶芝在对东西方种种秘术亲身实践的基础上创立的与宗教息息相关的术语。叶芝的神秘宗教信义与《易经》的辩证哲学有着相通之处,二者均体现了人在社...叶芝的作品充满了多种宗教信义,"大记忆"就是其中之一。"大记忆"是叶芝在对东西方种种秘术亲身实践的基础上创立的与宗教息息相关的术语。叶芝的神秘宗教信义与《易经》的辩证哲学有着相通之处,二者均体现了人在社会变迁中思想精神的发展。从《易经》阴阳辩证哲学观点视角对叶芝《基督重临》(The Second Coming)的"大记忆"进行分析,探讨"大记忆"的成因及其蕴含的普世精神,并论证二者所蕴涵世界精神的互补与共存。展开更多
To reduce the number of digital predistortion coefficients, a step memory polynomial (SMP)predistorter is presented. The number of predistortion coefficients is decreased by adjusting the maximum nonlinear order for...To reduce the number of digital predistortion coefficients, a step memory polynomial (SMP)predistorter is presented. The number of predistortion coefficients is decreased by adjusting the maximum nonlinear order for different memory orders in the traditional memory polynomial (MP)predistorter. The proposed SNIP predistorter is identified by an offline learning structure on which the coefficients can be extracted directly from the sampled input and output of a PA. Simulation results show that the SMP predistorter is not tied to a particular PA model and is, therefore, robust. The effectiveness of the SMP predistorter is demonstrated by simulations and experiments on an MP model, a parallel Wiener model, a Wiener-Hammerstein model, a sparsedelay memory polynomial model and a real PA which is fabricated based on the Freescale LDMOSFET MRF21030. Compared with the traditional MP predistorter, the SMP predistorter can reduce the number of coefficients by 60%.展开更多
Based on the local canning compression,severe plastic deformation(SPD) is able to lead to the almost complete amorphous nickel-titanium shape memory alloy(NiTi SMA),in which a small amount of retained nanocrystall...Based on the local canning compression,severe plastic deformation(SPD) is able to lead to the almost complete amorphous nickel-titanium shape memory alloy(NiTi SMA),in which a small amount of retained nanocrystalline phase is embedded in the amorphous matrix.Crystallization of amorphous NiTi alloy annealed at 573,723 and 873 K was investigated,respectively.The crystallization kinetics of the amorphous NiTi alloy can be mathematically described by the Johnson-MehlAvrami-Kolmogorov(JMAK) equation.NiTi SMA with a complete nanocrystalline phase is obtained in the case of annealing at 573 K and 723 K,where martensite phase transformation is suppressed due to the constraint of the grain boundaries.Crystallization of amorphous NiTi alloy at 873 K leads to the coarse-grained NiTi sample,where(001) martensite compound twin is observed at room temperature.It can be found that the martensitic twins preferentially nucleate at the grain boundary and they grow up towards the two different grains.SPD based on the local canning compression and subsequent annealing provides a new approach to obtain the nanocrystalline NiTi SMA.展开更多
The effects of zinc deficiency on the serum cortisol and adrenocorticotrophic hormone (ACTH) concentration,and the cerebrum nitric oxide synthase (NOS) activity in rats were studied.Growing rats were allotted to three...The effects of zinc deficiency on the serum cortisol and adrenocorticotrophic hormone (ACTH) concentration,and the cerebrum nitric oxide synthase (NOS) activity in rats were studied.Growing rats were allotted to three groups,which were zinc deficiency (ZD),paired fed (PF) and zinc supplementation after feeding zinc deficient food for 21 days (ZS).The duration of feed test was 35 days.Compared with PF rats,serum cortisol concentration in ZD ones was significantly increased,whereas serum ACTH concentration and cerebrum NOS activity were significantly decreased.The results suggested that zinc might influence the metabolism of hypothalamic hypophysial adrenocortical axis and NOS.展开更多
Dependence and impairment of learning and memory are two well-established features caused by abused drugs such as opioids. The hippocampus is an important region associated with both drug dependence and learning and m...Dependence and impairment of learning and memory are two well-established features caused by abused drugs such as opioids. The hippocampus is an important region associated with both drug dependence and learning and memory. However, the molecular events in hippocampus following exposure to abused drugs such as opioids are not well understood. Here we examined the effect of chronic morphine treatment on hippocampal protein expression by proteomic analyses. We found that chronic exposure of mice to morphine for 10 days produced robust morphine withdrawal jumping and memory impairment, and also resulted in a significant downregulation of hippocampal protein levels of three metabolic enzymes, including Fe-S protein 1 ofNADH dehydrogenase, dihydrolipoamide acetyltransferase or E2 component of the pyruvate dehydrogenase complex and lactate dehydrogenase 2. Further real-time quantitative PCR analyses confirmed that the levels of the corresponding mRNAs were also remarkably reduced. Consistent with these findings, lower ATP levels and an impaired ability to convert glucose into ATP were also observed in the hippocampus of chronically treated mice. Opioid antagonist naltrexone administrated concomitantly with morphine significantly suppressed morphine withdrawal jumping and reversed the downregulation of these proteins. Acute exposure to morphine also produced robust morphine withdrawal jumping and significant memory impairment, but failed to decrease the expression of these three proteins. Intrahippocampal injection of D-glucose before morphine administration significantly enhanced ATP levels and suppressed morphine withdrawal jumping and memory impairment in acute morphine-treated but not in chronic morphine-treated mice. Intraperitoneal injection of high dose of D-glucose shows a similar effect on morphine-induced withdrawal jumping as the central treatment. Taken together, our results suggest that reduced expression of the three metabolic enzymes in the hippocampus as a result of chronic morphine treatment contributes to the development of drug-induced symptoms such as morphine withdrawal jumping and memory impairment.展开更多
Metropolises in the globalization call nowadays Towns' of jazzmen, jazzwomen and jazz lovers, in a way from which we citizens. Christian Sallenave, sociologist with musical academic and Cities' into question. Jazz a...Metropolises in the globalization call nowadays Towns' of jazzmen, jazzwomen and jazz lovers, in a way from which we citizens. Christian Sallenave, sociologist with musical academic and Cities' into question. Jazz answers with stories and memories can learn a lesson for the future of towns, metropolises and their background, shows through examples of stories of jazz in New Orleans, New York, Paris, Bordeaux and Rome, how this nomad, notable and crossbreeding music contributes to the history of jazz, and world music, and listeners' memories, in "their own way" as towns, cities and their memories can contribute to the prosperity of the metropolises in globalization, through original melting pot works.展开更多
This article aims to present Beloved, a ghost-in-the-flesh protagonist of Toni Morrison's Pulitzer Prize-winning novel Beloved (1987), as an incarnation of memory of slavery. Interpreted as personal and shared expe...This article aims to present Beloved, a ghost-in-the-flesh protagonist of Toni Morrison's Pulitzer Prize-winning novel Beloved (1987), as an incarnation of memory of slavery. Interpreted as personal and shared experience, Beloved will be analyzed on the basis of memory's dynamic nature as an active mnemonic agent operating in and between the individual and collective zones. It will be also argued that on the one hand, Beloved embodies memories of past slaved lives of the novel's central characters, Sethe and Paul D, while on the other hand she plays the role of an allegoric reminder of all Black slaves who lived and died in bondage on the American continent. Finally, Beloved will be symbolically seen as a historical, cultural and psychological link between contemporary African Americans and their African ancestors of the Middle Passage. The theoretical framework for this study of Morrison's most memorable ghost figure will follow from a discussion of memory's individual and shared qualities, as well as from the concepts of a collective consciousness, the collective unconscious, and collective memory.展开更多
To simulate the brain functions,a quantum associative memory combined with information preprocessing by a sparse coding model is presented. The sparse coding scheme is used to simulate the information transformation f...To simulate the brain functions,a quantum associative memory combined with information preprocessing by a sparse coding model is presented. The sparse coding scheme is used to simulate the information transformation from retina up to primary visual cortex (V1) along the visual path and the quantum associative memory is used to simulate the pattern processing functions of the brain such as the pattern storing,forgetting and retrieving. Experimental results show that the model exhibits good associative ability on face recognition. Considering the huge storage capacity,mass parallel-distributed processing ability and oscillatory phenomena of the quantum system,this model might be a biological plausible implementation.展开更多
Aiming at the relation linking task for question answering over knowledge base,especially the multi relation linking task for complex questions,a relation linking approach based on the multi-attention recurrent neural...Aiming at the relation linking task for question answering over knowledge base,especially the multi relation linking task for complex questions,a relation linking approach based on the multi-attention recurrent neural network(RNN)model is proposed,which works for both simple and complex questions.First,the vector representations of questions are learned by the bidirectional long short-term memory(Bi-LSTM)model at the word and character levels,and named entities in questions are labeled by the conditional random field(CRF)model.Candidate entities are generated based on a dictionary,the disambiguation of candidate entities is realized based on predefined rules,and named entities mentioned in questions are linked to entities in knowledge base.Next,questions are classified into simple or complex questions by the machine learning method.Starting from the identified entities,for simple questions,one-hop relations are collected in the knowledge base as candidate relations;for complex questions,two-hop relations are collected as candidates.Finally,the multi-attention Bi-LSTM model is used to encode questions and candidate relations,compare their similarity,and return the candidate relation with the highest similarity as the result of relation linking.It is worth noting that the Bi-LSTM model with one attentions is adopted for simple questions,and the Bi-LSTM model with two attentions is adopted for complex questions.The experimental results show that,based on the effective entity linking method,the Bi-LSTM model with the attention mechanism improves the relation linking effectiveness of both simple and complex questions,which outperforms the existing relation linking methods based on graph algorithm or linguistics understanding.展开更多
The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that...The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time c-Jun expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of c-Jun immune reactive cells of Batroxobin-treated rats was also less than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of c-Jun is probably related to the neuroprotective mechanism.展开更多
Objective To investigate whether estrogen modulates learning and memory and long-term potentiation (LTP) in the hippocampus of rats with Alzheimer's disease (AD). Methods The rats were divided into ovariectomy (...Objective To investigate whether estrogen modulates learning and memory and long-term potentiation (LTP) in the hippocampus of rats with Alzheimer's disease (AD). Methods The rats were divided into ovariectomy (OVX) and estrogen replacement therapy (ERT) groups. Rats in the ERT group received OVX, followed by ERT, while rats in the OVX group received only OVX. The rat model of AD was established by injection of 1 μL (10 μg/μL) amyloid-beta peptide 1-40(Aβ1-40) into the hippocampus. The learning and memory ability and LTP were determined by Morris water maze and electrophysiological method, respectively. Results The escape latency in Morris water maze significantly decreased in ERT group compared with that in OVX group (P 〈 0.05). Besides, rats in ERT group exhibited a significant enhancement of the magnitude of LTP at 30 min after high-frequency stimulation (HFS), compared with that in OVX group (P 〈 0.01). Conclusion ERT can attenuate the cognitive deficits in the rat model of AD, and estrogen can regulate LTP and synaptic remodeling in AD rats.展开更多
Objective To investigate the effect of acupuncture on the addiction memory of rats. Methods A model for heroin re-addicted rats was made by coupling heroin injection in increasing doses on the platform of a Morris wat...Objective To investigate the effect of acupuncture on the addiction memory of rats. Methods A model for heroin re-addicted rats was made by coupling heroin injection in increasing doses on the platform of a Morris water maze with high-frequency sounds cues. The animals were randomly divided into control group, relapse group, acupuncture group, and drug group, with 10 individuals in each group. For the acupuncture group, Baihui (百会 GV 20) and "Dazhui" (大椎 GV 24) were selected. Morris water maze was used to assess the time elapsed and the distance traveled before a rat reached the platform. The expression levels of A FosB and cAMP response element binding protein (CREB) in hippocampal CA 1 area were assessed with immunohistochemical staining. Results Upon completion of three treatments, the acupuncture group had significantly longer lengths of latency and swimming distance compared to the relapse group (P〈0.05). Furthermore, the acupuncture group had significantly lowered expression levels of A FosB and CREB compared to the relapse group (P〈0.05). Conclusion Acupuncture can downregulate A FosB and CREB expression in rats' hippocampal area and inhibit the addiction memory.展开更多
This study investigates differential effects of etymological elaboration and rote memorization on idiom acquisition and retention in Chinese college EFL learners. The sample (N = 70) involved two intact groups of coll...This study investigates differential effects of etymological elaboration and rote memorization on idiom acquisition and retention in Chinese college EFL learners. The sample (N = 70) involved two intact groups of college students. Subjects in one group exposed to instruction in the form of etymological familiarity while subjects in the comparison group were asked to memorize idioms on the basis of their given meaning. Subjects were then administered two post-tests: one to assess initial idiom acquisition, and another four weeks later to assess idiom retention. Statistical analyses produced sufficient support for both the first hypothesis (that the etymological elaboration condition would acquire more idioms than the rote memorization condition), and the second hypothesis—that the etymological familiarity would exhibit superior retention rates. The finding of this study suggests that for the purpose of encouraging long-term retention, elaborating on the original usage of idioms is preferable to requiring students to learn idioms by rote.展开更多
The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the...The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research.展开更多
文摘叶芝的作品充满了多种宗教信义,"大记忆"就是其中之一。"大记忆"是叶芝在对东西方种种秘术亲身实践的基础上创立的与宗教息息相关的术语。叶芝的神秘宗教信义与《易经》的辩证哲学有着相通之处,二者均体现了人在社会变迁中思想精神的发展。从《易经》阴阳辩证哲学观点视角对叶芝《基督重临》(The Second Coming)的"大记忆"进行分析,探讨"大记忆"的成因及其蕴含的普世精神,并论证二者所蕴涵世界精神的互补与共存。
基金The National High Technology Research and Development Program of China (863 Program) (No.2008AA01Z211)the Project of Industry-Academia-Research Demonstration Base of Education Ministry of Guangdong Province (No.2007B090200012)
文摘To reduce the number of digital predistortion coefficients, a step memory polynomial (SMP)predistorter is presented. The number of predistortion coefficients is decreased by adjusting the maximum nonlinear order for different memory orders in the traditional memory polynomial (MP)predistorter. The proposed SNIP predistorter is identified by an offline learning structure on which the coefficients can be extracted directly from the sampled input and output of a PA. Simulation results show that the SMP predistorter is not tied to a particular PA model and is, therefore, robust. The effectiveness of the SMP predistorter is demonstrated by simulations and experiments on an MP model, a parallel Wiener model, a Wiener-Hammerstein model, a sparsedelay memory polynomial model and a real PA which is fabricated based on the Freescale LDMOSFET MRF21030. Compared with the traditional MP predistorter, the SMP predistorter can reduce the number of coefficients by 60%.
基金Project (51071056) supported by the National Natural Science Foundation of ChinaProject (HEUCF201317002) supported by the Fundamental Research Funds for the Central Universities of China
文摘Based on the local canning compression,severe plastic deformation(SPD) is able to lead to the almost complete amorphous nickel-titanium shape memory alloy(NiTi SMA),in which a small amount of retained nanocrystalline phase is embedded in the amorphous matrix.Crystallization of amorphous NiTi alloy annealed at 573,723 and 873 K was investigated,respectively.The crystallization kinetics of the amorphous NiTi alloy can be mathematically described by the Johnson-MehlAvrami-Kolmogorov(JMAK) equation.NiTi SMA with a complete nanocrystalline phase is obtained in the case of annealing at 573 K and 723 K,where martensite phase transformation is suppressed due to the constraint of the grain boundaries.Crystallization of amorphous NiTi alloy at 873 K leads to the coarse-grained NiTi sample,where(001) martensite compound twin is observed at room temperature.It can be found that the martensitic twins preferentially nucleate at the grain boundary and they grow up towards the two different grains.SPD based on the local canning compression and subsequent annealing provides a new approach to obtain the nanocrystalline NiTi SMA.
基金SupportedbyNationalNaturalScienceFoundationofChina (No 3970 0 12 0 )andbyNationalEducationMinistrygrants (No A9410 7)
文摘The effects of zinc deficiency on the serum cortisol and adrenocorticotrophic hormone (ACTH) concentration,and the cerebrum nitric oxide synthase (NOS) activity in rats were studied.Growing rats were allotted to three groups,which were zinc deficiency (ZD),paired fed (PF) and zinc supplementation after feeding zinc deficient food for 21 days (ZS).The duration of feed test was 35 days.Compared with PF rats,serum cortisol concentration in ZD ones was significantly increased,whereas serum ACTH concentration and cerebrum NOS activity were significantly decreased.The results suggested that zinc might influence the metabolism of hypothalamic hypophysial adrenocortical axis and NOS.
基金Acknowledgments We thank Dr Boja Emily S (NHLBI, NIH, USA) for expert technical assistance in mass spectrometry analyses, and our colleagues Drs Bin Lu, Zhao-Qiu Wu for helpful comments. This work was supported by a National Basic Research Program grant from the Ministry of Science and Technology of China (G2003CB515401), National Science Fund for Distinguished Young Scholar from the National Natural Science Foundation of China (30425002) and a fund supported by the "100 Talents Project" of Chinese Academy of Sciences (J-G Liu).
文摘Dependence and impairment of learning and memory are two well-established features caused by abused drugs such as opioids. The hippocampus is an important region associated with both drug dependence and learning and memory. However, the molecular events in hippocampus following exposure to abused drugs such as opioids are not well understood. Here we examined the effect of chronic morphine treatment on hippocampal protein expression by proteomic analyses. We found that chronic exposure of mice to morphine for 10 days produced robust morphine withdrawal jumping and memory impairment, and also resulted in a significant downregulation of hippocampal protein levels of three metabolic enzymes, including Fe-S protein 1 ofNADH dehydrogenase, dihydrolipoamide acetyltransferase or E2 component of the pyruvate dehydrogenase complex and lactate dehydrogenase 2. Further real-time quantitative PCR analyses confirmed that the levels of the corresponding mRNAs were also remarkably reduced. Consistent with these findings, lower ATP levels and an impaired ability to convert glucose into ATP were also observed in the hippocampus of chronically treated mice. Opioid antagonist naltrexone administrated concomitantly with morphine significantly suppressed morphine withdrawal jumping and reversed the downregulation of these proteins. Acute exposure to morphine also produced robust morphine withdrawal jumping and significant memory impairment, but failed to decrease the expression of these three proteins. Intrahippocampal injection of D-glucose before morphine administration significantly enhanced ATP levels and suppressed morphine withdrawal jumping and memory impairment in acute morphine-treated but not in chronic morphine-treated mice. Intraperitoneal injection of high dose of D-glucose shows a similar effect on morphine-induced withdrawal jumping as the central treatment. Taken together, our results suggest that reduced expression of the three metabolic enzymes in the hippocampus as a result of chronic morphine treatment contributes to the development of drug-induced symptoms such as morphine withdrawal jumping and memory impairment.
文摘Metropolises in the globalization call nowadays Towns' of jazzmen, jazzwomen and jazz lovers, in a way from which we citizens. Christian Sallenave, sociologist with musical academic and Cities' into question. Jazz answers with stories and memories can learn a lesson for the future of towns, metropolises and their background, shows through examples of stories of jazz in New Orleans, New York, Paris, Bordeaux and Rome, how this nomad, notable and crossbreeding music contributes to the history of jazz, and world music, and listeners' memories, in "their own way" as towns, cities and their memories can contribute to the prosperity of the metropolises in globalization, through original melting pot works.
文摘This article aims to present Beloved, a ghost-in-the-flesh protagonist of Toni Morrison's Pulitzer Prize-winning novel Beloved (1987), as an incarnation of memory of slavery. Interpreted as personal and shared experience, Beloved will be analyzed on the basis of memory's dynamic nature as an active mnemonic agent operating in and between the individual and collective zones. It will be also argued that on the one hand, Beloved embodies memories of past slaved lives of the novel's central characters, Sethe and Paul D, while on the other hand she plays the role of an allegoric reminder of all Black slaves who lived and died in bondage on the American continent. Finally, Beloved will be symbolically seen as a historical, cultural and psychological link between contemporary African Americans and their African ancestors of the Middle Passage. The theoretical framework for this study of Morrison's most memorable ghost figure will follow from a discussion of memory's individual and shared qualities, as well as from the concepts of a collective consciousness, the collective unconscious, and collective memory.
基金Natural Science Foundation of Fujian Province of China (No.2009J01306)
文摘To simulate the brain functions,a quantum associative memory combined with information preprocessing by a sparse coding model is presented. The sparse coding scheme is used to simulate the information transformation from retina up to primary visual cortex (V1) along the visual path and the quantum associative memory is used to simulate the pattern processing functions of the brain such as the pattern storing,forgetting and retrieving. Experimental results show that the model exhibits good associative ability on face recognition. Considering the huge storage capacity,mass parallel-distributed processing ability and oscillatory phenomena of the quantum system,this model might be a biological plausible implementation.
基金The National Natural Science Foundation of China(No.61502095).
文摘Aiming at the relation linking task for question answering over knowledge base,especially the multi relation linking task for complex questions,a relation linking approach based on the multi-attention recurrent neural network(RNN)model is proposed,which works for both simple and complex questions.First,the vector representations of questions are learned by the bidirectional long short-term memory(Bi-LSTM)model at the word and character levels,and named entities in questions are labeled by the conditional random field(CRF)model.Candidate entities are generated based on a dictionary,the disambiguation of candidate entities is realized based on predefined rules,and named entities mentioned in questions are linked to entities in knowledge base.Next,questions are classified into simple or complex questions by the machine learning method.Starting from the identified entities,for simple questions,one-hop relations are collected in the knowledge base as candidate relations;for complex questions,two-hop relations are collected as candidates.Finally,the multi-attention Bi-LSTM model is used to encode questions and candidate relations,compare their similarity,and return the candidate relation with the highest similarity as the result of relation linking.It is worth noting that the Bi-LSTM model with one attentions is adopted for simple questions,and the Bi-LSTM model with two attentions is adopted for complex questions.The experimental results show that,based on the effective entity linking method,the Bi-LSTM model with the attention mechanism improves the relation linking effectiveness of both simple and complex questions,which outperforms the existing relation linking methods based on graph algorithm or linguistics understanding.
文摘The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time c-Jun expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of c-Jun immune reactive cells of Batroxobin-treated rats was also less than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of c-Jun is probably related to the neuroprotective mechanism.
基金supported by the National Natural Science Foundation of China (No. 30700938,30872656, 30700861, 30800451) the Natural Science Foundation of Liaoning Province, China (No. 20082078)
文摘Objective To investigate whether estrogen modulates learning and memory and long-term potentiation (LTP) in the hippocampus of rats with Alzheimer's disease (AD). Methods The rats were divided into ovariectomy (OVX) and estrogen replacement therapy (ERT) groups. Rats in the ERT group received OVX, followed by ERT, while rats in the OVX group received only OVX. The rat model of AD was established by injection of 1 μL (10 μg/μL) amyloid-beta peptide 1-40(Aβ1-40) into the hippocampus. The learning and memory ability and LTP were determined by Morris water maze and electrophysiological method, respectively. Results The escape latency in Morris water maze significantly decreased in ERT group compared with that in OVX group (P 〈 0.05). Besides, rats in ERT group exhibited a significant enhancement of the magnitude of LTP at 30 min after high-frequency stimulation (HFS), compared with that in OVX group (P 〈 0.01). Conclusion ERT can attenuate the cognitive deficits in the rat model of AD, and estrogen can regulate LTP and synaptic remodeling in AD rats.
基金Supported by National College Student Innovation Entrepreneurship Training Programs:2014038National Natural Science Foundation of China:81173325
文摘Objective To investigate the effect of acupuncture on the addiction memory of rats. Methods A model for heroin re-addicted rats was made by coupling heroin injection in increasing doses on the platform of a Morris water maze with high-frequency sounds cues. The animals were randomly divided into control group, relapse group, acupuncture group, and drug group, with 10 individuals in each group. For the acupuncture group, Baihui (百会 GV 20) and "Dazhui" (大椎 GV 24) were selected. Morris water maze was used to assess the time elapsed and the distance traveled before a rat reached the platform. The expression levels of A FosB and cAMP response element binding protein (CREB) in hippocampal CA 1 area were assessed with immunohistochemical staining. Results Upon completion of three treatments, the acupuncture group had significantly longer lengths of latency and swimming distance compared to the relapse group (P〈0.05). Furthermore, the acupuncture group had significantly lowered expression levels of A FosB and CREB compared to the relapse group (P〈0.05). Conclusion Acupuncture can downregulate A FosB and CREB expression in rats' hippocampal area and inhibit the addiction memory.
文摘This study investigates differential effects of etymological elaboration and rote memorization on idiom acquisition and retention in Chinese college EFL learners. The sample (N = 70) involved two intact groups of college students. Subjects in one group exposed to instruction in the form of etymological familiarity while subjects in the comparison group were asked to memorize idioms on the basis of their given meaning. Subjects were then administered two post-tests: one to assess initial idiom acquisition, and another four weeks later to assess idiom retention. Statistical analyses produced sufficient support for both the first hypothesis (that the etymological elaboration condition would acquire more idioms than the rote memorization condition), and the second hypothesis—that the etymological familiarity would exhibit superior retention rates. The finding of this study suggests that for the purpose of encouraging long-term retention, elaborating on the original usage of idioms is preferable to requiring students to learn idioms by rote.
基金Georgia Research Alliance for funding the Brain Decoding Initiative (2007 present)Yunnan Province Department of Science and Technology for the support of our work
文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research.