目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果...目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果进行统计分析。采用异质性检验和发表偏倚的评估来验证研究的可信性。用Meta分析探讨研究间潜在的异质性来源。结果共有11篇文献符合纳入标准，包括3936例肥胖者和4156例对照。敏感性分析后，Meta分析结果显示，45I／D多态性与肥胖关系的共显性模型合并OR为1．025（95％CI=0．879～1．195）、显性模型为0．998（95％CI=0．845～1．179）、隐性模型为1．169（95％CI=0．867～1．578），A55V则分别为0．976（95％CI=0．871～1．093）、0．964（95％CI=0．807～1．151）、0．972（95％CI=0．799～1．183）。结论UCP2基因45I／D和A55V多态性与高加索人肥胖可能不存在关联。展开更多
OBJECTIVE: To observe the significant differences in the frequencies of the cytochrome P450 2D6 (CYP2D6) alleles in Chinese popoulations. METHODS: Tetra-primer polymerase chain reaction (PCR), allele specific amplific...OBJECTIVE: To observe the significant differences in the frequencies of the cytochrome P450 2D6 (CYP2D6) alleles in Chinese popoulations. METHODS: Tetra-primer polymerase chain reaction (PCR), allele specific amplification (ASA) PCR and multiplex long PCR were developed to detect the CYP2D6 alleles * 2, * 3, * 4, * 5, * 6, * 8, * 10 and * 14 in 223 subjects from Chinese mainland. RESULTS: The CYP2D6 * 5 allele was the most frequent poor metabolizer (PM) allele in Chinese (7.2%), followed by CYP2D6 * 14 (2.0%) which was only detected in orientals. There was only 0.2% CYP2D6 * 4, and no CYP2D6 * 3, * 6 and * 8 were detected. In contrast to the Caucasians, the most frequent allele in Chinese was the * 10 allele with a frequency of 51.6%. CONCLUSION: The frequencies of PM alleles, CYP2D6 * 5 and CYP2D6 * 14, were higher; but the frequency of CYP2D6 * 10 was lower in mainland Chinese population than that in other orientals.展开更多
文摘目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果进行统计分析。采用异质性检验和发表偏倚的评估来验证研究的可信性。用Meta分析探讨研究间潜在的异质性来源。结果共有11篇文献符合纳入标准，包括3936例肥胖者和4156例对照。敏感性分析后，Meta分析结果显示，45I／D多态性与肥胖关系的共显性模型合并OR为1．025（95％CI=0．879～1．195）、显性模型为0．998（95％CI=0．845～1．179）、隐性模型为1．169（95％CI=0．867～1．578），A55V则分别为0．976（95％CI=0．871～1．093）、0．964（95％CI=0．807～1．151）、0．972（95％CI=0．799～1．183）。结论UCP2基因45I／D和A55V多态性与高加索人肥胖可能不存在关联。
文摘OBJECTIVE: To observe the significant differences in the frequencies of the cytochrome P450 2D6 (CYP2D6) alleles in Chinese popoulations. METHODS: Tetra-primer polymerase chain reaction (PCR), allele specific amplification (ASA) PCR and multiplex long PCR were developed to detect the CYP2D6 alleles * 2, * 3, * 4, * 5, * 6, * 8, * 10 and * 14 in 223 subjects from Chinese mainland. RESULTS: The CYP2D6 * 5 allele was the most frequent poor metabolizer (PM) allele in Chinese (7.2%), followed by CYP2D6 * 14 (2.0%) which was only detected in orientals. There was only 0.2% CYP2D6 * 4, and no CYP2D6 * 3, * 6 and * 8 were detected. In contrast to the Caucasians, the most frequent allele in Chinese was the * 10 allele with a frequency of 51.6%. CONCLUSION: The frequencies of PM alleles, CYP2D6 * 5 and CYP2D6 * 14, were higher; but the frequency of CYP2D6 * 10 was lower in mainland Chinese population than that in other orientals.
