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益气活血法对肾病大鼠血液流变学影响的实验研究
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作者 于杰 李文浦 《辽宁中医杂志》 CAS 1989年第7期,共4页
近年来,大量研究发现,肾小球肾炎特别是表现为肾病综合征者,存在着血液的高凝状态西药抗凝疗法。目前尚存分歧,而临床运用活血化瘀方药取得了较好的疗效
关键词 大鼠血液流变学 益气活血法 活血化瘀方药 肾小球肾炎 抗凝疗法 血液流变性 益气活血方药 高凝状态 红细胞电泳 实验动物
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心复宁5号对实验性高脂血症大鼠血液流变学的影响及其抗氧化作用
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作者 李清 王凤芝 《中国中西医结合杂志》 CAS CSCD 北大核心 2000年第S1期27-29,共3页
心复宁5号是王朝宏教授根据中医学理论及现代药理研究成果,长期潜心于高脂血症、动脉粥样硬化的临床研究而得出的调脂验方,临床和实验研究均表明该方具有显著的调脂作用,为治疗高脂血症的理想复方。本研究旨在通过观察该方对实验性高脂... 心复宁5号是王朝宏教授根据中医学理论及现代药理研究成果,长期潜心于高脂血症、动脉粥样硬化的临床研究而得出的调脂验方,临床和实验研究均表明该方具有显著的调脂作用,为治疗高脂血症的理想复方。本研究旨在通过观察该方对实验性高脂血症大鼠血液流变学及脂质过氧化作用的影响,进一步预测其对动脉粥样硬化的防治作用。 展开更多
关键词 心复宁 动脉粥样硬化 动脉硬化 实验性高脂血症大鼠血液流变学 脂质过氧化 大鼠血浆
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葛根素单磷酸酯盐衍生物的合成及其药效学的研究 被引量:4
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作者 李新宇 支钦 +1 位作者 张健存 姚志勇 《中国处方药》 2017年第2期30-33,共4页
目的将葛根素分子A环7位上的羟基进行磷酸酯化衍生,以期提高其水溶性,并对比葛根素及葛根素单磷酸酯盐衍生物对高血脂大鼠血液流变学的影响。方法葛根素在醋酐条件下生成全乙酰保护的葛根素,再在咪唑条件下选择性脱除7位上的乙酰保护基... 目的将葛根素分子A环7位上的羟基进行磷酸酯化衍生,以期提高其水溶性,并对比葛根素及葛根素单磷酸酯盐衍生物对高血脂大鼠血液流变学的影响。方法葛根素在醋酐条件下生成全乙酰保护的葛根素,再在咪唑条件下选择性脱除7位上的乙酰保护基,然后与氯代亚磷酸二苄酯反应,最后脱苄基保护,得到目标产物,产物经阳离子交换树脂处理、甲醇重结晶纯化分离,产物结构经波谱解析鉴定;分别测定葛根素及葛根素单磷酸酯盐在水中的溶解度;SD大鼠分为空白对照组:蒸馏水,20 m L/kg,ig;模型组:蒸馏水,20 m L/kg,ig;愈风宁心片阳性药物对照组:200 mg/kg,ig;葛根素组:400 mg/kg,ig;葛根素单磷酸盐衍生物组:510 mg/kg,ig。首先对各组动物连续灌胃5 d,除空白对照组外,其它组于第4天给药1 h后,再皮下注射肾上腺素0.08 m L/100 g。4 h后再注射1次,在两次注射肾上腺素期间的中间时间点,将大鼠用冷水浸湿,在4℃冰箱中放置10 min,处置后禁食,次晨给药1 h后取血检测全血高切黏度、全血低切黏度、血浆黏度等12项指标。结果得到葛根素单磷酸酯盐衍生物:葛根素-7-磷酸酯钠,葛根素单磷酸酯盐在水中的溶解度明显高于葛根素;与模型组比较,葛根素和葛根素-7-磷酸酯钠均能显著改善急性高脂血症大鼠血液流变学相关指标,其中葛根素-7-磷酸酯钠的作用较其它药物更为明显(P<0.01)。结论葛根素-7-磷酸酯钠具有较好的水溶性;能更加显著地改善急性高脂血症大鼠血液流变学相关指标。 展开更多
关键词 葛根素单磷酸酯盐衍生物 水溶性 高脂血症 大鼠血液流变学
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《昆明医学院学报》1993年第14卷文题索引
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《昆明医科大学学报》 CAS 1993年第4期81-84,共4页
关键词 昆明医学院学报 文题索引 亚克汀病 田芳镇 淋病性阴道炎 血清过氧化脂质 大鼠血液流变学 胆道镜取石 房室传导系统 血动力学
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Effects of different directions of moxibustion therapy on hemorheology in rats with blood stasis due to cold retention 被引量:3
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作者 王宽 呼雪庆 +5 位作者 黄玉萨 王清然 高春鹏 刘民 刘慧荣 杨燕萍(译) 《Journal of Acupuncture and Tuina Science》 CSCD 2016年第1期10-15,共6页
Objective: To investigate the effects of different directions of moxibustion therapy on hemorheology in rat models with blood stasis due to cold retention. Methods: A total of 32 Wistar rats were randomly divided in... Objective: To investigate the effects of different directions of moxibustion therapy on hemorheology in rat models with blood stasis due to cold retention. Methods: A total of 32 Wistar rats were randomly divided into 4 groups, based on the random digits table, including a normal group, a model group, a moxibustion along the meridian group, and a moxibustion against the meridian group, with 8 rats in each group. Except the normal group, the other 3 groups were used to make the rat models with blood stasis due to cold retention. Rats in the moxibustion along and against the meridian groups accepted moxibustion therapy in different directions on the trunk segment of the Bladder Meridian after successful modeling. Moxibustion for 10 min every day, and 7 d as a course of treatment. Two courses of treatment(a total of 14 d) were carried out. Quantitative score of signs and symptoms change was observed once a week, with a total of 7 times. Hemorheological indexes of rats were detected when the treatment finished. Results: The quantitative scores of signs and symptoms in the model, moxibustion along the meridian and against the meridian groups were significantly higher than those in the normal group after modeling(P〈0.05). When the treatment finished, the quantitative score of signs and symptoms in the model group was significantly higher than that in the normal group(P〈0.05); the quantitative scores of signs and symptoms of rats in the moxibustion along and against the meridian groups were significantly lower than that in the model group(P〈0.05); the quantitative score of signs and symptoms in the moxibustion along the meridian group was significantly lower than that in the moxibustion against the meridian group(P〈0.05); the whole blood viscosity and erythrocyte aggregation index in the model group were significantly higher than those in the normal group(P〈0.05), however the increases of erythrocyte hematocrit and erythrocyte sedimentation rate were not obvious(P〈0.05); whole blood viscosity and erythrocyte aggregation index in the moxibustion along and against the meridian groups were significantly lower than those in the model group(P〈0.05), while there were no statistically significant differences between the moxibustion along the meridian group and moxibustion against the meridian group(P〈0.05). Conclusion: Moxibustion along and against the meridian both showed different degrees of improvement for hemorrheology and symptoms of blood stasis due to cold retention. Improvement for symptoms of blood stasis due to cold retention was better in the moxibustion along the meridian group than that in the moxibustion against the meridian group. The influence on rat hemorrheology showed no significant difference between moxibustion along the meridian and moxibustion against the meridian. 展开更多
关键词 Moxibustion Therapy Bladder Meridian Blood Stasis Due to Coagulated Cold HEMORHEOLOGY RATS
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