Tryptamine-derived natural products have been discovered from different sources including animals, plants and bacteria,and they show various biological activities. However, they are not discovered widely compared with...Tryptamine-derived natural products have been discovered from different sources including animals, plants and bacteria,and they show various biological activities. However, they are not discovered widely compared with the large amounts of tryptamine derivatives generated by chemical synthesis. We here report the discovery of five tryptamine-derived natural products(1-5) and one known polyketide 6 from Bacillus sp. PKU-TA00001. Compounds 1 and 2 are new compounds featuring methyl-hexanamide moieties, compound 4 is first discovered as a natural product, and 3 and 4’s NMR data are first provided. All compounds showed MIC(minimum inhibitory concentration) values higher than 50 μM against several Gram-positive and negative strains, and showed no cytotoxicity at the concentration of 100 μM against the human cancer cell lines A549, HCT-8 and MCF-7. The discovery of 1-4 expands the structural diversity of tryptamine-derived natural products, and sets the stage for revealing their biosynthetic mechanisms and biological activities in the future.展开更多
基金National Natural Science Foundation of China(Grant No.81673332,81573326,81741148)
文摘Tryptamine-derived natural products have been discovered from different sources including animals, plants and bacteria,and they show various biological activities. However, they are not discovered widely compared with the large amounts of tryptamine derivatives generated by chemical synthesis. We here report the discovery of five tryptamine-derived natural products(1-5) and one known polyketide 6 from Bacillus sp. PKU-TA00001. Compounds 1 and 2 are new compounds featuring methyl-hexanamide moieties, compound 4 is first discovered as a natural product, and 3 and 4’s NMR data are first provided. All compounds showed MIC(minimum inhibitory concentration) values higher than 50 μM against several Gram-positive and negative strains, and showed no cytotoxicity at the concentration of 100 μM against the human cancer cell lines A549, HCT-8 and MCF-7. The discovery of 1-4 expands the structural diversity of tryptamine-derived natural products, and sets the stage for revealing their biosynthetic mechanisms and biological activities in the future.
