The internal modes of the North Pacific can lead to climatic oscillations through ocean-atmosphere interactions and induce global climate responses.The best example is the Pacific Decadal Oscillation, but this fails t...The internal modes of the North Pacific can lead to climatic oscillations through ocean-atmosphere interactions and induce global climate responses.The best example is the Pacific Decadal Oscillation, but this fails to explain many climate phenomena. Here, another multidecadal variability over the North Pacific is described, found by analyzing reconstructed data covering the past 140 years. It is named the Pacific Multidecadal Oscillation （PMO）, with anomalously high/low SSTs over the northeastern Pacific, and a quasi-60-year cycle. Related to this low-frequency variability of SST, the global mean temperature and precipitation present significant interdecadal differences. More importantly, the PMO index leads the global mean surface air temperature and SST by one to three years. The Arctic Oscillation pattern and atmospheric circulations are shown to change substantially with the transition of the PMO mode from positive to negative phases. This multidecadal oscillation improves the prospect for a long-term forecast of the global warming trend, since the PMO bears a remarkable relationship with global temperature.展开更多
More than 10% of the population in Salta is regarded as rural. Many rural areas suffer a shortage of energy, and consequently, possibilities of social and economic development of the inhabitants become reduced. The ac...More than 10% of the population in Salta is regarded as rural. Many rural areas suffer a shortage of energy, and consequently, possibilities of social and economic development of the inhabitants become reduced. The activation of renewable energy sources in these areas presents inhabitants the advantages to generate their own energy. Dispersed rural communities create small electricity demands that are not considered by suppliers, because they are not profitable. Although thus far, feasibility analyses to install photovoltaic or thermal solar collectors are based on technical reasons, it seems more convenient that, in the future, projects for the installation of technology based on renewable energy should consider social indicators. As a preliminary step to field work is proposed in this paper using an equation that allows us to obtain a value of＂social index＂. With this analysis and the current survey accompanied by the local people, knowledge will be obtained of the real needs of these rural communities. The results show that there is a variation that would allow a classification or ordering of localities. To validate the results obtained is proposed as the next step to perform field work in each of the localities.展开更多
Depression is a psychological disease with no particularly effective therapy currently available.In the present study,we aimed to examine the antidepressive activity of a pharmaceutical Chinese medicine called TaiZi(T...Depression is a psychological disease with no particularly effective therapy currently available.In the present study,we aimed to examine the antidepressive activity of a pharmaceutical Chinese medicine called TaiZi(TZ)capsule,consisting of total polysaccharides of Radix Pseudostellariae and total flavonoids of both Radix Pueraria and Herba Epimedii.A tail suspension test and forced swimming test were performed to assess the effect of TZ in vivo.A plasmid of TPH2(tryptophan hydroxylase-2)was constructed to determine the exact target of TZ in vitro.In addition,mRNA expression was detected using a real-time PCR assay,and the protein expression was investigated using a Western blotting analysis.The results showed that TZ had an anti-depression effect in mouse and rat models with increased serotonin in the brain,and in the upregulation of mRNA and protein expression of TPH2 in the brain simultaneously by inhibition of NRSF(neuron restrictive silencer factor)expression because NRSF could bind to NRSE(neuron restrictive silencer element)to repress TPH2 transcription during the depression conditions.Icariin could bind to NRSE directly and block NRSF protein toward to NRSE for TPH2 inhibition.Therefore,we concluded that TZ had potential antidepressive effects because it could ameliorat the depression-like behavior in the animals,and the underlying mechanism of the effect was involved in NRSF/NRSE-TPH2 signaling.Icariin was identified as the active component of TZ.This study provided a new perspective for the development of antidepression drugs(Chinese medicines)based on NRSF/NRSE-TPH2 signaling.展开更多
基金supported by the National Natural Science Foundation of China[grant number 41421004],[grant number41130103]
文摘The internal modes of the North Pacific can lead to climatic oscillations through ocean-atmosphere interactions and induce global climate responses.The best example is the Pacific Decadal Oscillation, but this fails to explain many climate phenomena. Here, another multidecadal variability over the North Pacific is described, found by analyzing reconstructed data covering the past 140 years. It is named the Pacific Multidecadal Oscillation （PMO）, with anomalously high/low SSTs over the northeastern Pacific, and a quasi-60-year cycle. Related to this low-frequency variability of SST, the global mean temperature and precipitation present significant interdecadal differences. More importantly, the PMO index leads the global mean surface air temperature and SST by one to three years. The Arctic Oscillation pattern and atmospheric circulations are shown to change substantially with the transition of the PMO mode from positive to negative phases. This multidecadal oscillation improves the prospect for a long-term forecast of the global warming trend, since the PMO bears a remarkable relationship with global temperature.
文摘More than 10% of the population in Salta is regarded as rural. Many rural areas suffer a shortage of energy, and consequently, possibilities of social and economic development of the inhabitants become reduced. The activation of renewable energy sources in these areas presents inhabitants the advantages to generate their own energy. Dispersed rural communities create small electricity demands that are not considered by suppliers, because they are not profitable. Although thus far, feasibility analyses to install photovoltaic or thermal solar collectors are based on technical reasons, it seems more convenient that, in the future, projects for the installation of technology based on renewable energy should consider social indicators. As a preliminary step to field work is proposed in this paper using an equation that allows us to obtain a value of＂social index＂. With this analysis and the current survey accompanied by the local people, knowledge will be obtained of the real needs of these rural communities. The results show that there is a variation that would allow a classification or ordering of localities. To validate the results obtained is proposed as the next step to perform field work in each of the localities.
基金The Student Research Training(SRT)Program of Tsinghua University(Grant No.1522T0221)the National Natural Science Foundation of China(Grant No.81374006 and 81073092)。
文摘Depression is a psychological disease with no particularly effective therapy currently available.In the present study,we aimed to examine the antidepressive activity of a pharmaceutical Chinese medicine called TaiZi(TZ)capsule,consisting of total polysaccharides of Radix Pseudostellariae and total flavonoids of both Radix Pueraria and Herba Epimedii.A tail suspension test and forced swimming test were performed to assess the effect of TZ in vivo.A plasmid of TPH2(tryptophan hydroxylase-2)was constructed to determine the exact target of TZ in vitro.In addition,mRNA expression was detected using a real-time PCR assay,and the protein expression was investigated using a Western blotting analysis.The results showed that TZ had an anti-depression effect in mouse and rat models with increased serotonin in the brain,and in the upregulation of mRNA and protein expression of TPH2 in the brain simultaneously by inhibition of NRSF(neuron restrictive silencer factor)expression because NRSF could bind to NRSE(neuron restrictive silencer element)to repress TPH2 transcription during the depression conditions.Icariin could bind to NRSE directly and block NRSF protein toward to NRSE for TPH2 inhibition.Therefore,we concluded that TZ had potential antidepressive effects because it could ameliorat the depression-like behavior in the animals,and the underlying mechanism of the effect was involved in NRSF/NRSE-TPH2 signaling.Icariin was identified as the active component of TZ.This study provided a new perspective for the development of antidepression drugs(Chinese medicines)based on NRSF/NRSE-TPH2 signaling.
