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失血对凝血纤溶系统中PAI-1含量的影响 被引量:3
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作者 李平 李平(2) 《中国医药导报》 CAS 2011年第1期6-8,共3页
目的:观察失血对大鼠凝血纤溶系统中纤溶酶原激活物抑制物-1(plasminogen activator inhibitor-1,PAI-1)的影响。方法:将大鼠随机分为急性失血组(A组)、慢性失血组(B组)和对照组(C组),每组10只。制备动物贫血模型,采血后先检测血红蛋白(... 目的:观察失血对大鼠凝血纤溶系统中纤溶酶原激活物抑制物-1(plasminogen activator inhibitor-1,PAI-1)的影响。方法:将大鼠随机分为急性失血组(A组)、慢性失血组(B组)和对照组(C组),每组10只。制备动物贫血模型,采血后先检测血红蛋白(HB)并记录,血标本离心后分离血浆,ELISA法检测血浆中PAI-1的含量,共观察8 d,期间不采取任何干预措施。结果:大鼠失血、HB降低后血浆中PAI-1含量增加,其中,A组和B组PAI-1的含量较对照组差异明显,B组中随失血量的增加和HB的降低,血浆中PAI-1的含量显著增加后维持在这一高水平。A组急性大量失血后PAI-1含量先达高峰后迅速下降,随后缓慢增加,但增加的幅度不及B组。结论:大鼠血浆中PAI-1的含量随失血量的增加和HB降低而增高。 展开更多
关键词 失血:血红蛋白 PAI-1
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Outcome ofJudet's quadricepsplasty for knee contractures and the effect of local infiltration of epinephrine on reducing blood loss
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作者 Akbar Jaleel Zubairi Haroon Rashid +2 位作者 Rizwan Haroon Rashid Moiz Ali Pervaiz Mehmood Hashmi 《Chinese Journal of Traumatology》 CAS CSCD 2017年第3期147-150,共4页
Objective: To evaluate the effectiveness ofJudet's quadricepsplasty for treatment of knee contractures and to identify the effect of local infiltration of epinephrine on blood loss associated with this procedure. Me... Objective: To evaluate the effectiveness ofJudet's quadricepsplasty for treatment of knee contractures and to identify the effect of local infiltration of epinephrine on blood loss associated with this procedure. Methods: A retrospective cohort study was conducted in which all cases of knee contractures managed with Judet's quadricepsplasty from 1st January 2009 to 31st December 2013 were included and were divided into two groups. The epinephrine group included patients who were infiltrated with diluted epinephrine (1:400,000) along with xylocaine, around the operative field 15 min prior to the incision time, while the control group did not receive any infiltration. Judet's outcome, blood loss, drop in he- moglobin and required blood transfusion were noted for all patients and compared between both groups. Results: Most common preceding pathology identified for the development of knee contractures was periarticular fracture while ilizarov application was the most common etiology. Both groups were found similar in all preoperative characteristics except preoperative flexion contracture (p = 0.02). All func- tional outcome measures including Judet's outcome were similar in both groups. In contrast, duration of surgery (p = 0.01), blood loss (p = 0.02), drop in hemoglobin (p = 0.01) and number of transfusions (p = 0.03) were significantly reduced in epinephrine group. Conclusion: Judet's quadricepsplasty is a useful procedure to increase the range of motion of rigid knees and local infiltration of epinephrine is effective in decreasing the amount of subsequent blood loss and transfusion requirements. 展开更多
关键词 Knee contracture Blood transfusion EPINEPHRINE Knee range of motion Operative time
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