Objective:To explore the mechanism of the degradation of human hair keratin (HHK) scaffold material implanted in damaged skeletal muscle tissues. Methods: Six New Zealand rabbits with HHK scaffold material implants (c...Objective:To explore the mechanism of the degradation of human hair keratin (HHK) scaffold material implanted in damaged skeletal muscle tissues. Methods: Six New Zealand rabbits with HHK scaffold material implants (composed of 3 different types of HHK material with varied degradation speed) after musclectomy were divided into 3 groups (2 in each group) to observe the degradation of the material at 1, 3, 6weeks after operation. Another rabbit without operation was used as the control group. The degradation of HHK was observed with light microscopy, histochemistry of ubiquitin and electron microscopy. Results:Light microscopy showed that human hair cuticles fell off from the HHK material and emerged, and the macrophagocytes and multinucleate giant cells were attached onto the surface of the material, which became homogeneous at the first postoperative week. The HHK scaffold material was degraded into particles that was phagocytosed by macrophagocytes and multinucleate giant cells at the third week. Ubiquitin enzymatic histochemistry showed that the macrophagocytes and the multinucleate giant cells were positive at the first week. Under electron microscope, HHK scaffold material was degraded into particles, and at the sixth week,part of HHK scaffold material was further degraded. Conclusion: Large mass of the HHK scaffold material is degraded via ubiquitin system, and the resultant particles are phagocytosed and degraded with the cooperation of lysosome and ubiquitin.展开更多
We study the property of matter in equilibrium with a static, spherically symmetric black hole in D- dimensional spacetime. It requires that this kind of matter has an equation of state ω≡pr/ρ = -n/（n ＋ 2k）, k,...We study the property of matter in equilibrium with a static, spherically symmetric black hole in D- dimensional spacetime. It requires that this kind of matter has an equation of state ω≡pr/ρ = -n/（n ＋ 2k）, k, n ∈ N （where n 〉 1 corresponds to a mixture of vacuum matter and ＂hair＂ matter）, which seems to be independent of D. However, when we associate this result with specific models, we find that these hairy black holes can live only in some special dimensional spacetime： （i） D = 2 ＋ 2k/n while the black hole is surrounded by cosmic strings, which requires D is even or D ∈ N, depending on the value of n, this is consistent with some important results in superstring theory, it might reveal the relation between cosmic string and superstring in another aspect; （ii） the black hole can be surrounded by linear dilaton field only in 4-dimensional spacetime. In both cases, D = 4 is special. We also present some examples of such hairy black holes in higher dimensions, including a toy model with negative energy density.展开更多
文摘Objective:To explore the mechanism of the degradation of human hair keratin (HHK) scaffold material implanted in damaged skeletal muscle tissues. Methods: Six New Zealand rabbits with HHK scaffold material implants (composed of 3 different types of HHK material with varied degradation speed) after musclectomy were divided into 3 groups (2 in each group) to observe the degradation of the material at 1, 3, 6weeks after operation. Another rabbit without operation was used as the control group. The degradation of HHK was observed with light microscopy, histochemistry of ubiquitin and electron microscopy. Results:Light microscopy showed that human hair cuticles fell off from the HHK material and emerged, and the macrophagocytes and multinucleate giant cells were attached onto the surface of the material, which became homogeneous at the first postoperative week. The HHK scaffold material was degraded into particles that was phagocytosed by macrophagocytes and multinucleate giant cells at the third week. Ubiquitin enzymatic histochemistry showed that the macrophagocytes and the multinucleate giant cells were positive at the first week. Under electron microscope, HHK scaffold material was degraded into particles, and at the sixth week,part of HHK scaffold material was further degraded. Conclusion: Large mass of the HHK scaffold material is degraded via ubiquitin system, and the resultant particles are phagocytosed and degraded with the cooperation of lysosome and ubiquitin.
基金Supported in part by the National Natural Science Foundation of China under Grant Nos. 90503009 and 10775116973 Program under Grant No. 2005CB724508
文摘We study the property of matter in equilibrium with a static, spherically symmetric black hole in D- dimensional spacetime. It requires that this kind of matter has an equation of state ω≡pr/ρ = -n/（n ＋ 2k）, k, n ∈ N （where n 〉 1 corresponds to a mixture of vacuum matter and ＂hair＂ matter）, which seems to be independent of D. However, when we associate this result with specific models, we find that these hairy black holes can live only in some special dimensional spacetime： （i） D = 2 ＋ 2k/n while the black hole is surrounded by cosmic strings, which requires D is even or D ∈ N, depending on the value of n, this is consistent with some important results in superstring theory, it might reveal the relation between cosmic string and superstring in another aspect; （ii） the black hole can be surrounded by linear dilaton field only in 4-dimensional spacetime. In both cases, D = 4 is special. We also present some examples of such hairy black holes in higher dimensions, including a toy model with negative energy density.
