Objective: To investigate a previously hypothesized relation between natural hair color and endometriosis.Design: Prospective cohort study.Setting: Nurses’Health Study II with 10 years of follow- up.Participant(s): A...Objective: To investigate a previously hypothesized relation between natural hair color and endometriosis.Design: Prospective cohort study.Setting: Nurses’Health Study II with 10 years of follow- up.Participant(s): A total of 90, 065 women, 25- 42 years old, who had never been diagnosed with endometriosis, infertility, or cancer at baseline in 1989.Main Outcome Measure(s): Incidence of laparoscopically confirmed endometriosis according to natural hair color.Result(s): During 379, 422 person- years of follow- up, 1, 130 cases of laparoscopically confirmed endometriosiswere reported among women with no past infertility.After adjusting for age, calendar time, parity, race, and body mass index at age 18, we observed no association overall.However, compared with women with any other hair color, we observed an increased rate of endometriosis among women with naturally red hair who had never been infertile (incidence rate = 1.3, 95% confidence interval [CI] = 1.0- 1.7)- , but a decreased rate among women with naturally red hair among women who were infertile (incidence rate = 0.4, 95% CI = 0.2- 1.2); P value, test for heterogeneity = .03.Conclusion(s): Overall, we did not observe a significant relation between red hair color and the rate of endometriosis, however this prospective cohort study suggests that the relation may differ by infertility status.展开更多
目的验证HIrisPlex眼睛及头发颜色推断系统在中国亚欧混合人群中的准确性及适用性。方法本研究采用人工读取照片的方式,对新疆兵团公安局提供的200例亚欧混合个体样本的眼睛及头发颜色进行表型分类;对上述样本的血卡应用实验室构建的包...目的验证HIrisPlex眼睛及头发颜色推断系统在中国亚欧混合人群中的准确性及适用性。方法本研究采用人工读取照片的方式,对新疆兵团公安局提供的200例亚欧混合个体样本的眼睛及头发颜色进行表型分类;对上述样本的血卡应用实验室构建的包含24个眼睛及头发颜色相关位点的HIrisPlex复合扩增体系进行基因型检验。将分型数据上传至在线推断模型(https://HIrisPlex.erasmusmc.nl/)来推断样本的眼睛及头发颜色,并通过受试者工作特征曲线下面积(Area under the receiver characteristic operating curve,AUC)来计算模型对样本表型的推断准确性。结果人工读取后,样本被分类为2种眼睛颜色和2种头发颜色。在线模型对样本蓝色和棕色眼睛进行推断得到的AUC值分别为0.876和0.874,对棕色、黑色头发进行推断的AUC值分别为0.575和0.635。结论HIrisPlex系统对亚欧混合人群眼睛颜色推断具有较高的准确性,对头发颜色的推断具有一定的参考价值,可以尝试应用于相关案件并为之提供外貌特征线索。展开更多
文摘Objective: To investigate a previously hypothesized relation between natural hair color and endometriosis.Design: Prospective cohort study.Setting: Nurses’Health Study II with 10 years of follow- up.Participant(s): A total of 90, 065 women, 25- 42 years old, who had never been diagnosed with endometriosis, infertility, or cancer at baseline in 1989.Main Outcome Measure(s): Incidence of laparoscopically confirmed endometriosis according to natural hair color.Result(s): During 379, 422 person- years of follow- up, 1, 130 cases of laparoscopically confirmed endometriosiswere reported among women with no past infertility.After adjusting for age, calendar time, parity, race, and body mass index at age 18, we observed no association overall.However, compared with women with any other hair color, we observed an increased rate of endometriosis among women with naturally red hair who had never been infertile (incidence rate = 1.3, 95% confidence interval [CI] = 1.0- 1.7)- , but a decreased rate among women with naturally red hair among women who were infertile (incidence rate = 0.4, 95% CI = 0.2- 1.2); P value, test for heterogeneity = .03.Conclusion(s): Overall, we did not observe a significant relation between red hair color and the rate of endometriosis, however this prospective cohort study suggests that the relation may differ by infertility status.
文摘目的验证HIrisPlex眼睛及头发颜色推断系统在中国亚欧混合人群中的准确性及适用性。方法本研究采用人工读取照片的方式,对新疆兵团公安局提供的200例亚欧混合个体样本的眼睛及头发颜色进行表型分类;对上述样本的血卡应用实验室构建的包含24个眼睛及头发颜色相关位点的HIrisPlex复合扩增体系进行基因型检验。将分型数据上传至在线推断模型(https://HIrisPlex.erasmusmc.nl/)来推断样本的眼睛及头发颜色,并通过受试者工作特征曲线下面积(Area under the receiver characteristic operating curve,AUC)来计算模型对样本表型的推断准确性。结果人工读取后,样本被分类为2种眼睛颜色和2种头发颜色。在线模型对样本蓝色和棕色眼睛进行推断得到的AUC值分别为0.876和0.874,对棕色、黑色头发进行推断的AUC值分别为0.575和0.635。结论HIrisPlex系统对亚欧混合人群眼睛颜色推断具有较高的准确性,对头发颜色的推断具有一定的参考价值,可以尝试应用于相关案件并为之提供外貌特征线索。
