AIM: To compare the gadolinium-enhanced multiphase dynamic magnetic resonance imaging (MRI) and multiphase multirow-detector helical CT (MDCT) scanning for detection of small hepatocellular carcinoma (HCC). METHODS: M...AIM: To compare the gadolinium-enhanced multiphase dynamic magnetic resonance imaging (MRI) and multiphase multirow-detector helical CT (MDCT) scanning for detection of small hepatocellular carcinoma (HCC). METHODS: MDCT scanning and baseline MRI with SE T1-WI and T2-WI sequence combined with FMPSPGR sequence were performed in 37 patients with 43 small HCCs. Receiver operating characteristic (ROC) curves were plotted to analyze the results for modality. RESULTS: The areas below ROC curve (Az) were calculated. There was no statistical difference in dynamic enhancement MDCT and MRI. The detection rate of small HCC was 97.5%-97.6% on multiphase MDCT scanning and 90.7%-94.7% on MRI, respectively. The sensitivity of detection for small HCC on MDCT scanning was higher than that on dynamic enhancement MRI. The sensitivity of detection for minute HCC (tumor diameter ≤ 1 cm) was 90.0%-95.0% on MDCT scanning and 70.0%-85.0% on MRI, respectively. CONCLUSION: MDCT scanning should be performed for early detection and effective treatment of small HCC in patients with chronic hepatitis and cirrhosis during follow-up.展开更多
Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the...Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by immunohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxOl is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.展开更多
Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure...Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure,mechanical characteristics and transmission routes of deck loads.The simplified calculation models were brought out for the stud design of the longitudinal girders and transverse girders in the composite floor system of Nanjing Dashengguan Yangtze River Bridge (NDB).Studs were designed and arranged by taking the middle panel of 336 m main span for example.The results show that under deck loads,the longitudinal girders in the composite floor system of through steel bridges are in tension-bending state,longitudinal shear force on the interface is caused by both longitudinal force of "The first mechanical system" and vertical bending of "The second mechanical system",and studs can be arranged with equal space in terms of the shear force in range of 0.2d (where d is the panel length) on the top ends.Transverse girders in steel longitudinal and transverse girders-concrete slab composite deck are in compound-bending state,and out-of-plane bending has to be taken into account in the stud design.In orthotropic integral steel deck-concrete slab composite deck,out-of-plane bending of transverse girders is very small so that it can be neglected,and studs on the orthotropic integral steel deck can be arranged according to the structural requirements.The above design methods and simplified calculation models have been applied in the stud design of NDB.展开更多
According to the characters of poly-ether-ether-ketone (PEEK) plastic, the spinnerets with three kinds of different structure were designed. The effects of spinneret structure on the melt spinning conditions, melt flo...According to the characters of poly-ether-ether-ketone (PEEK) plastic, the spinnerets with three kinds of different structure were designed. The effects of spinneret structure on the melt spinning conditions, melt flow instability of the screw extrusion, and the performance of PEEK fibers were studied. The results show that the appropriate screw extrusion temperature is 370 385℃. The PEEK fibers extruded using the spinnerets with L/D=6, 8holes and 0.5mm in diameter have better performances. The performances of PEEK fibers are related to the dia- meter of the spinneret hole. Increasing the L/D value of the spinnerets can not always improve the surface quality and the performances of PEEK fibers. The extrusion pressure is about 50% of that of the spinneret with 12holes and 0.3mm in diameter.展开更多
In order to evaluate the seismic behavior of confined RC column-composite beam joints, five interior joints were tested under low cyclic reversed load. The weakening extent of flanges, the number of studs, and whether...In order to evaluate the seismic behavior of confined RC column-composite beam joints, five interior joints were tested under low cyclic reversed load. The weakening extent of flanges, the number of studs, and whether to reinforce weakened flanges were used as parameters in designing these five joints. Failure characteristics, hysteretic curves, skeleton curves, ductility, energy dissipation, strength degradation, and stiffness degradation were analyzed. The test results revealed that the steel beam flanges in the joints were equivalent to the tie rod. Weakened flanges resulted in poor seismic behavior; however, the seismic behavior could be improved by increasing studs and reinforcing weakened flanges. The joint steel plate hoops, equivalent to stirrups, did not yield when the maximum load was reached, but yielded when the failure load was reached for the joints with shear failure. Increasing stud-type joints and reinforcing flange-type joints ensured good seismic behavior and met project requirements. Based on the experimental results, the failure mechanism of the joints was discussed, and the shear capacity equations of the joints was presented.展开更多
Ice cores contain an abundance of information about the Earth's climate in the past, and recovered from shallow drilling down to 300-350 m give sufficient information for reconstructing of the last climatic changes a...Ice cores contain an abundance of information about the Earth's climate in the past, and recovered from shallow drilling down to 300-350 m give sufficient information for reconstructing of the last climatic changes and for monitoring of pollution from human being. Cable-suspended core auger drills use an armored cable with a winch to provide power to the down-hole motor system and to retrieve the down-hole unit. Because of their lightweight, convenient transportation and installation, high penetration rates and low power consumption, core auger drills are widely used for shallow drilling in ice. Nowadays at least 14 types of auger electromechani- cal drills were designed and tested in different foreign and national glaciological laboratories. However, auger options were usually determined by experience, and the main parameters ( helix angle of the fights and rotational speed) are varied in a wide range from drill to drill. If parameters of auger are not chosen properly, poorly en- gineered drills had troubles with low efficiency of cuttings transportation, jam of ice cuttings, repeated fragmen- tation, cutters icing and stop penetration, abnormal power consumption, high rotation torques, and so on. Thus, this paper presents the method of optimization of iee cuttings transportation of cable-suspended core auger drill on the base of the theory of rotary auger. As the result, the optimal helix angle was determined correspond- ing to the rotational speed from the transportation efficiency point of view.展开更多
The evolution of leakage is studied using detailed contact finite element analysis. The distribution of stress at the gasket is analyzed using a contact condition based on slide-line elements using ABAQUS, a commercia...The evolution of leakage is studied using detailed contact finite element analysis. The distribution of stress at the gasket is analyzed using a contact condition based on slide-line elements using ABAQUS, a commercial finite element code, Slide-line elements also take into account pressure penetration as contact that is lost between flange and gasket. Results are presented for a particular flange, a raised face flange sealed by a mild steel gasket. A comparison of the results from the gasket contact analysis and the contact conditions specified by the ASME Boiler and Pressure Vessel Code, Sections VIII, Division 1 shows that the conditions specified in the ASME Code predict leakage relatively accurately.展开更多
The Fox genes encode a group of transcription factors that contain a forkhead domain, which forms a structure known as a winged helix. These transcription factors play a crucial role in several key biological processe...The Fox genes encode a group of transcription factors that contain a forkhead domain, which forms a structure known as a winged helix. These transcription factors play a crucial role in several key biological processes, including development. High-degree identity in the canonical forkhead domain has been used to divide Fox proteins into 23 families (FoxA to FoxS). We surveyed the genome of three spiralians, the oyster Crassostrea gigas, the limpet Lottia gigantea, and the annelid Capitella teleta. We identified 25 C. gigas fox genes, 21 L. gigantea fox genes, and 25 C. teleta fox genes. The C. gigas fox and L. giganteafox genes represented 19 of the 23 families, whereas FoxI, QI, R, and S were missing. The majority of the Fox families were observed within the C. teletafox genes, with the exception of FoxR and S. In addition, thefoxAB-like gene,foxY-like gene, andfoxH gene were also present in the three genomes. The conserved FoxC-FoxL 1 cluster, observed in mammals, was also found in C. gigas. The diversity of temporal expression patterns observed across the developmental process implies the C. gigasfox genes exert a wide range of functions. Further functional studies are required to gain insight into the evolution of Fox genes in bilaterians.展开更多
Objective: Dynamic hip screw (DHS) is recommended for the fixation of stable intertrochanteric fractures. Its postoperative cut-out rate ranges from I% to 6%. In osteoporotic bone, normal screws in DHS blade provid...Objective: Dynamic hip screw (DHS) is recommended for the fixation of stable intertrochanteric fractures. Its postoperative cut-out rate ranges from I% to 6%. In osteoporotic bone, normal screws in DHS blade provide less anchorage compared to locking screws. This study aims to compare DHS with locking side plate and conventional side plate. Methods: Fifty consecutive patients with intertrochanteric fractures were randomly allocated for fixation with a standard DHS (group A) and locking DHS (Combi plate, group B). We compared the clinical and radiological outcomes for the conventional DHS and locking DHS in intertrochanteric fractures. Functional outcome was evaluated using the Parker mobility score. Results: Coxa valga was found more frequently in group A than in group B (12% vs. 0%, P=0.42). Coxa vara showed the same trend (12% vs. 8%, P=0.81). Rate of restoration of postoperative neck-shaft angle within 20° of sound side was higher in group B (8% cases) than in group A (4% cases, P=0.98). The rate of anteversion angle restoration within 10° of sound side was also higher in group B (100% vs. 88%, P=0.85). The average lag screw slippage in group A and group B was 3.2 mm and 4.2 mm, the average fracture union duration was 17.1 weeks and 16.4 weeks, and the mean Parker score was 5.6 and 5.8 respectively. Screw cut-out was seen in one patient in group A. No cut-out was seen in any of the patient in group B. No patient developed deep infection, avascular necrosis, deep vein thrombosis or any other significant complications. Conclusion: The present study demonstrated that treating intertrochanteric fracture with a locking DHS allows sound bone healing and is not associated with any major complications. Although this report is promising, it should be interpreted with caution because only a prospective study with a large sample size would allow definitive conclusion.展开更多
While difficult to prevent introductions, scientific research can help guide control efforts of exotic, invasive species. South American island apple snails Pomacea insularum have quickly spread across the United Stat...While difficult to prevent introductions, scientific research can help guide control efforts of exotic, invasive species. South American island apple snails Pomacea insularum have quickly spread across the United States Gulf Coast and few control measures exist to delay their spread. Usually occupying cryptic benthic habitats, female apple snails crawl out of the water to de-posit large, bright pink egg clutches on emergent objects. To help identify the most likely place to find and remove clutches, we conducted four lab experiments to investigate what specific object qualifies (i.e. material; shape and height; plant species; natural and artificial) attracted P. insularum females to lay clutches. In our fourth experiment, we specifically examined the relationship between female size and reproductive output. To further understand reproductive output, we quantified experimental clutch chara-cteristics (height above water, dimensions, mass, approximate volume, number of eggs, hatching efficiency). Pomacea insu-larum females laid more clutches on plant material, chose round over flat surfaces and failed to differentiate between tall and short structures. In comparison to a common native plant in the eastern US, Pontederia cordata, snails clearly preferred to lay clutches on a widely distributed exotic, invasive plant (wild taro, Colocasia esculenta). Unexpectedly, smaller snails showed higher overall total fecundity as well as more eggs per clutch than larger snails. Therefore, hand removal efforts of large fe-males may not be enough to slow down clutch production. Collectively, our results indicate that conservationists and managers should search emergent plants for P. insularum clutches carefully to guard against established populations [Current Zoology 57 (5): 630-641, 2011].展开更多
基金a financial assistance from Zhuhai Technology Bureau, No. PC20052025
文摘AIM: To compare the gadolinium-enhanced multiphase dynamic magnetic resonance imaging (MRI) and multiphase multirow-detector helical CT (MDCT) scanning for detection of small hepatocellular carcinoma (HCC). METHODS: MDCT scanning and baseline MRI with SE T1-WI and T2-WI sequence combined with FMPSPGR sequence were performed in 37 patients with 43 small HCCs. Receiver operating characteristic (ROC) curves were plotted to analyze the results for modality. RESULTS: The areas below ROC curve (Az) were calculated. There was no statistical difference in dynamic enhancement MDCT and MRI. The detection rate of small HCC was 97.5%-97.6% on multiphase MDCT scanning and 90.7%-94.7% on MRI, respectively. The sensitivity of detection for small HCC on MDCT scanning was higher than that on dynamic enhancement MRI. The sensitivity of detection for minute HCC (tumor diameter ≤ 1 cm) was 90.0%-95.0% on MDCT scanning and 70.0%-85.0% on MRI, respectively. CONCLUSION: MDCT scanning should be performed for early detection and effective treatment of small HCC in patients with chronic hepatitis and cirrhosis during follow-up.
基金Project supported by the National Basic Research Program (973) of China (No. 2004CB117500) and the National Natural Science Foun-dation of China (Nos. 30571335 and 330471253)
文摘Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by immunohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxOl is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.
基金Project(2004G016-B) supported by the Science and Technology Development Program of Railways Department,China
文摘Aimed at two typical composite floor systems of through steel bridges in high speed railway,design methods of headed studs were put forward for different composite members through comparing and analyzing the structure,mechanical characteristics and transmission routes of deck loads.The simplified calculation models were brought out for the stud design of the longitudinal girders and transverse girders in the composite floor system of Nanjing Dashengguan Yangtze River Bridge (NDB).Studs were designed and arranged by taking the middle panel of 336 m main span for example.The results show that under deck loads,the longitudinal girders in the composite floor system of through steel bridges are in tension-bending state,longitudinal shear force on the interface is caused by both longitudinal force of "The first mechanical system" and vertical bending of "The second mechanical system",and studs can be arranged with equal space in terms of the shear force in range of 0.2d (where d is the panel length) on the top ends.Transverse girders in steel longitudinal and transverse girders-concrete slab composite deck are in compound-bending state,and out-of-plane bending has to be taken into account in the stud design.In orthotropic integral steel deck-concrete slab composite deck,out-of-plane bending of transverse girders is very small so that it can be neglected,and studs on the orthotropic integral steel deck can be arranged according to the structural requirements.The above design methods and simplified calculation models have been applied in the stud design of NDB.
文摘According to the characters of poly-ether-ether-ketone (PEEK) plastic, the spinnerets with three kinds of different structure were designed. The effects of spinneret structure on the melt spinning conditions, melt flow instability of the screw extrusion, and the performance of PEEK fibers were studied. The results show that the appropriate screw extrusion temperature is 370 385℃. The PEEK fibers extruded using the spinnerets with L/D=6, 8holes and 0.5mm in diameter have better performances. The performances of PEEK fibers are related to the dia- meter of the spinneret hole. Increasing the L/D value of the spinnerets can not always improve the surface quality and the performances of PEEK fibers. The extrusion pressure is about 50% of that of the spinneret with 12holes and 0.3mm in diameter.
基金Supported by the National Natural Science Foundation of China(No.51209094)
文摘In order to evaluate the seismic behavior of confined RC column-composite beam joints, five interior joints were tested under low cyclic reversed load. The weakening extent of flanges, the number of studs, and whether to reinforce weakened flanges were used as parameters in designing these five joints. Failure characteristics, hysteretic curves, skeleton curves, ductility, energy dissipation, strength degradation, and stiffness degradation were analyzed. The test results revealed that the steel beam flanges in the joints were equivalent to the tie rod. Weakened flanges resulted in poor seismic behavior; however, the seismic behavior could be improved by increasing studs and reinforcing weakened flanges. The joint steel plate hoops, equivalent to stirrups, did not yield when the maximum load was reached, but yielded when the failure load was reached for the joints with shear failure. Increasing stud-type joints and reinforcing flange-type joints ensured good seismic behavior and met project requirements. Based on the experimental results, the failure mechanism of the joints was discussed, and the shear capacity equations of the joints was presented.
基金Supported by Project of the National Science Foundation of China(No.41327804)
文摘Ice cores contain an abundance of information about the Earth's climate in the past, and recovered from shallow drilling down to 300-350 m give sufficient information for reconstructing of the last climatic changes and for monitoring of pollution from human being. Cable-suspended core auger drills use an armored cable with a winch to provide power to the down-hole motor system and to retrieve the down-hole unit. Because of their lightweight, convenient transportation and installation, high penetration rates and low power consumption, core auger drills are widely used for shallow drilling in ice. Nowadays at least 14 types of auger electromechani- cal drills were designed and tested in different foreign and national glaciological laboratories. However, auger options were usually determined by experience, and the main parameters ( helix angle of the fights and rotational speed) are varied in a wide range from drill to drill. If parameters of auger are not chosen properly, poorly en- gineered drills had troubles with low efficiency of cuttings transportation, jam of ice cuttings, repeated fragmen- tation, cutters icing and stop penetration, abnormal power consumption, high rotation torques, and so on. Thus, this paper presents the method of optimization of iee cuttings transportation of cable-suspended core auger drill on the base of the theory of rotary auger. As the result, the optimal helix angle was determined correspond- ing to the rotational speed from the transportation efficiency point of view.
文摘The evolution of leakage is studied using detailed contact finite element analysis. The distribution of stress at the gasket is analyzed using a contact condition based on slide-line elements using ABAQUS, a commercial finite element code, Slide-line elements also take into account pressure penetration as contact that is lost between flange and gasket. Results are presented for a particular flange, a raised face flange sealed by a mild steel gasket. A comparison of the results from the gasket contact analysis and the contact conditions specified by the ASME Boiler and Pressure Vessel Code, Sections VIII, Division 1 shows that the conditions specified in the ASME Code predict leakage relatively accurately.
基金Supported by the National Basic Research Program of China(973 Program)(No.2010CB126401)the National Natural Science Foundation of China(No.31402285)+3 种基金the National High Technology Research and Development Program of China(863 Program)(No.2012AA10A405)the Earmarked Fund for Modern Agro-Industry Technology Research System(No.CARS-48)the Taishan Scholars Climbing Program of Shandong Provincethe Oversea Taishan Scholars Program of Shandong Province
文摘The Fox genes encode a group of transcription factors that contain a forkhead domain, which forms a structure known as a winged helix. These transcription factors play a crucial role in several key biological processes, including development. High-degree identity in the canonical forkhead domain has been used to divide Fox proteins into 23 families (FoxA to FoxS). We surveyed the genome of three spiralians, the oyster Crassostrea gigas, the limpet Lottia gigantea, and the annelid Capitella teleta. We identified 25 C. gigas fox genes, 21 L. gigantea fox genes, and 25 C. teleta fox genes. The C. gigas fox and L. giganteafox genes represented 19 of the 23 families, whereas FoxI, QI, R, and S were missing. The majority of the Fox families were observed within the C. teletafox genes, with the exception of FoxR and S. In addition, thefoxAB-like gene,foxY-like gene, andfoxH gene were also present in the three genomes. The conserved FoxC-FoxL 1 cluster, observed in mammals, was also found in C. gigas. The diversity of temporal expression patterns observed across the developmental process implies the C. gigasfox genes exert a wide range of functions. Further functional studies are required to gain insight into the evolution of Fox genes in bilaterians.
文摘Objective: Dynamic hip screw (DHS) is recommended for the fixation of stable intertrochanteric fractures. Its postoperative cut-out rate ranges from I% to 6%. In osteoporotic bone, normal screws in DHS blade provide less anchorage compared to locking screws. This study aims to compare DHS with locking side plate and conventional side plate. Methods: Fifty consecutive patients with intertrochanteric fractures were randomly allocated for fixation with a standard DHS (group A) and locking DHS (Combi plate, group B). We compared the clinical and radiological outcomes for the conventional DHS and locking DHS in intertrochanteric fractures. Functional outcome was evaluated using the Parker mobility score. Results: Coxa valga was found more frequently in group A than in group B (12% vs. 0%, P=0.42). Coxa vara showed the same trend (12% vs. 8%, P=0.81). Rate of restoration of postoperative neck-shaft angle within 20° of sound side was higher in group B (8% cases) than in group A (4% cases, P=0.98). The rate of anteversion angle restoration within 10° of sound side was also higher in group B (100% vs. 88%, P=0.85). The average lag screw slippage in group A and group B was 3.2 mm and 4.2 mm, the average fracture union duration was 17.1 weeks and 16.4 weeks, and the mean Parker score was 5.6 and 5.8 respectively. Screw cut-out was seen in one patient in group A. No cut-out was seen in any of the patient in group B. No patient developed deep infection, avascular necrosis, deep vein thrombosis or any other significant complications. Conclusion: The present study demonstrated that treating intertrochanteric fracture with a locking DHS allows sound bone healing and is not associated with any major complications. Although this report is promising, it should be interpreted with caution because only a prospective study with a large sample size would allow definitive conclusion.
文摘While difficult to prevent introductions, scientific research can help guide control efforts of exotic, invasive species. South American island apple snails Pomacea insularum have quickly spread across the United States Gulf Coast and few control measures exist to delay their spread. Usually occupying cryptic benthic habitats, female apple snails crawl out of the water to de-posit large, bright pink egg clutches on emergent objects. To help identify the most likely place to find and remove clutches, we conducted four lab experiments to investigate what specific object qualifies (i.e. material; shape and height; plant species; natural and artificial) attracted P. insularum females to lay clutches. In our fourth experiment, we specifically examined the relationship between female size and reproductive output. To further understand reproductive output, we quantified experimental clutch chara-cteristics (height above water, dimensions, mass, approximate volume, number of eggs, hatching efficiency). Pomacea insu-larum females laid more clutches on plant material, chose round over flat surfaces and failed to differentiate between tall and short structures. In comparison to a common native plant in the eastern US, Pontederia cordata, snails clearly preferred to lay clutches on a widely distributed exotic, invasive plant (wild taro, Colocasia esculenta). Unexpectedly, smaller snails showed higher overall total fecundity as well as more eggs per clutch than larger snails. Therefore, hand removal efforts of large fe-males may not be enough to slow down clutch production. Collectively, our results indicate that conservationists and managers should search emergent plants for P. insularum clutches carefully to guard against established populations [Current Zoology 57 (5): 630-641, 2011].