Based on the samples collected from the Chukchi Sea during the FCNARE cruise from July to August in 1999 with the ＂Xuelong＂, the research vessel of SOA, China, the relationship between the distribution characterizat...Based on the samples collected from the Chukchi Sea during the FCNARE cruise from July to August in 1999 with the ＂Xuelong＂, the research vessel of SOA, China, the relationship between the distribution characterization of phytoplankton and environmental factors was analyzed with Primer 5.2 software. The result showed that the assemblages of phytoplankton in Chukchi Sea can be divided into three ecological groups： Arctic-boreal group, distributed mostly in northeastern ice-edge where the depth is more than 2 000 m and affected directly by Arctic Ocean; Boreal group, distributed in shelf-break ice in the center water where the depth is less 100 m; Eurythermal group, mainly distributed in the south which exchanged with North Pacific water through Bering Strait. The species diversity, cell density and distribution variability of phytoplankton among stations were great different. The range of phytoplankton density among stations was 1.6 × 10^3- 90 680.2 × 10^4 cells/m^3, and the ranges of diversity index and evenness index among stations were 0.07 - 0.87 and 0.33 - 3.82, respectively. Principal components analysis （PCA） showed that temperature and salinity had made important roles in the distribution of phytoplankton in the Chukchi Sea. Furthermore, the different influences of the variant water regimes, and the extremely dynamic physical nature of the drifting pack ice （e.g. packing, breaking up and melting ） introduce short-term variability into the water conditions that no doubt affect the phytoplankton distrubition.展开更多
In this paper we consider the Cauchy problem for the singular semilinear parabolic equation u t-Δu+V 1(x)u=V 2(x)u p,x∈R n\{0},t>0, where V 1(x),V 2(x) may have singularities at the origin. Using functions...In this paper we consider the Cauchy problem for the singular semilinear parabolic equation u t-Δu+V 1(x)u=V 2(x)u p,x∈R n\{0},t>0, where V 1(x),V 2(x) may have singularities at the origin. Using functions of the Kato class and the Green tight functions we got the existence of the positive solution being singular at the origin.展开更多
A two-dimensional Brans-Dicke star model with exotic matter and dark energy is studied in this paper,the field equation and balance equation are derived at finite temperature,the analytic solutions of these equations ...A two-dimensional Brans-Dicke star model with exotic matter and dark energy is studied in this paper,the field equation and balance equation are derived at finite temperature,the analytic solutions of these equations canbe used to calculate the mass of star.In addition,we find that star's mass has a minimum when matter state parameterγ→0.展开更多
The strange hadronic matter with nucleons, -hyperons and -hyperons is studied by using an effective nuclear model in a mean-field approximation. The density and strangeness fraction dependence of the effective baryon ...The strange hadronic matter with nucleons, -hyperons and -hyperons is studied by using an effective nuclear model in a mean-field approximation. The density and strangeness fraction dependence of the effective baryon masses as well as the saturation properties and stabilities of the strange hadronic matter are discussed.展开更多
Aim In order to improve the solubility of azithromycin, the objectives of the present study were to screen an appropriate salt for azithromycin by comparing acute hepatic and renal toxicities in animals, and study the...Aim In order to improve the solubility of azithromycin, the objectives of the present study were to screen an appropriate salt for azithromycin by comparing acute hepatic and renal toxicities in animals, and study the pharmacokinetics of final chosen azithromycin salt. Methods Various salts of azithromycin, such as glutamate, citrate, hydrochloride, sulphate, dihydrogen phosphate, lactobionate, tartrate, and aspartate were given intravenously to Sprague Dawley rats at a dose of 10 mg once daily for 14 consecutive days via tail vein. The acute hepatic and renal indicators were measured before and after administration. A pharmacokinetic study was performed on 12 healthy human volunteers. The subjects were equally divided into two groups by a randomized crossover design. Azithromycin glutamate injection was administered by intravenous infusion or intramuscular injection at a single dose of 500 mg, respectively. Azithromycin concentrations in plasma were determined by microbial inhibition zone assay, and the pharmacokinetic parameters were calculated using a practical pharmacokinetic software 3P87 program. Results Azithromycin glutamate was least toxic to the liver and kidney of the rats, thus being selected as a final salt for parenteral preparation of azithromycin. Pharmacokinetic results showed that the area under the plasma concentration-time curves （AUC0-120h） were 21.47 ± 1.57 h·μg·mL^-1 for intravenous infusion, and 19.36 ± 2.44 h·μg·mL^-1 for intramuscular injection. The absolute bioavailability of intramuscular injection was 92.59%. Conclusion Azithromycin glutamate is suitable for the future clinical application, and its pharmacokinetics is characterized in human volunteers in the present study.展开更多
Polyketides have been widely used clinically due to their significant biological activities, but the needed structural and functional diversity cannot be achieved by common chemical synthetic methods. The tool of comb...Polyketides have been widely used clinically due to their significant biological activities, but the needed structural and functional diversity cannot be achieved by common chemical synthetic methods. The tool of combinatorial biosynthesis provides the possibility to produce "unnatural" natural drugs, which has achieved initial success. This paper provides an overview for the strategies of combinatorial biosynthesis in producing the structural and functional diversity of polyketides, including the redesign of metabolic flow, polyketide synthase(PKS) engineering, and PKS post-translational modification. Although encouraging progress has been made in the last decade, challenges still exist regarding the rational combinatorial biosynthesis of polyketides. In this review, the perspectives of polyketide combinatorial biosynthesis are also discussed.展开更多
The seasonal variations in biomass, abundance, and species composition of plankton in relation to hydrography were studied in the saline Bange Lake, northern Tibet, China. Sampling was carried out between one to three...The seasonal variations in biomass, abundance, and species composition of plankton in relation to hydrography were studied in the saline Bange Lake, northern Tibet, China. Sampling was carried out between one to three times per month from May 2001 to July 2002. Salinity ranged from 14 to 146. The air and water temperature exhibited a clear seasonal pattern, and mean annual temperatures were approximately 4.8℃ and 7.3℃, respectively. The lowest water temperature occurred in winter from December to March at-2℃ and the highest in June and July at 17.7℃. Forty-one phytoplankton taxa, 21 zooplankton, and 5 benthic or facultative zooplankton were identifi ed. The predominant phytoplankton species were Gloeothece linearis, Oscillatoria tenuis, Gloeocapsa punctata, Ctenocladus circinnatus, Dunaliella salina, and Spirulina major. The predominant zooplankton species included H olophrya actra, Brachionus plicatilis, Daphniopsis tibetana, Cletocamptus dertersi, and A rctodiaptomus salinus. The mean annual total phytoplankton density and biomass for the entire lake were 4.52×10^7 cells/L and 1.60 mg/L, respectively. The annual mean zooplankton abundance was 52, 162, 322, and 57, 144 ind./L, in the three sublakes. The annual mean total zooplankton biomass in Lakes 1–3 was 1.23, 9.98, and 2.13 mg/L, respectively. The annual mean tychoplankton abundances in Bg1, 2, and 3 were 47, 67, and 654 ind./L. The annual mean tychoplankton biomass was 2.36, 0.16, and 2.03 mg/L, respectively. The zooplankton biomass（including tychoplankton） in the lake was 9.11 mg/L. The total number of plankton species in the salt lake was signifi cantly negatively correlated with salinity.展开更多
The nonlinear predator-prey reaction diffusion systems for singularly perturbed Robin Problems are considered. Under suitable conditions, the theory of differential inequalities can be used to study the asymptotic beh...The nonlinear predator-prey reaction diffusion systems for singularly perturbed Robin Problems are considered. Under suitable conditions, the theory of differential inequalities can be used to study the asymptotic behavior of the solution for initial boundary value problems.展开更多
The littlest Higgs model with T-parity, which is called LHT model, predicts the existence of the new particles, such as heavy top quarks, heavy gauge bosons, and mirror fermions. We calculate the one-loop contribution...The littlest Higgs model with T-parity, which is called LHT model, predicts the existence of the new particles, such as heavy top quarks, heavy gauge bosons, and mirror fermions. We calculate the one-loop contributions of these new particles to the top quark ehromomagnetic dipole moment （CMDM） AK. We find that the contribution of the LHT model is one order of magnitude smaller than the standard model prediction value.展开更多
In this paper, firstly, we investigate the neutrino emissivity from quark Urca process in strong magnetic field. Then, we discuss the heat capacity of strange stars in strong magnetic field. Finally, we give the cooli...In this paper, firstly, we investigate the neutrino emissivity from quark Urca process in strong magnetic field. Then, we discuss the heat capacity of strange stars in strong magnetic field. Finally, we give the cooling curve in strong magnetic field. In order to make a comparison, we also give the corresponding cooling curve in the case of null magnetic field. It turns out that strange stars cool faster in strong magnetic field than that without magnetic field.展开更多
We often see different time and space scenes, different stories and different viewpoints change organically through one lens converge to form a complete film in the movie, and one of a series of the shearing lens elem...We often see different time and space scenes, different stories and different viewpoints change organically through one lens converge to form a complete film in the movie, and one of a series of the shearing lens elements and convergence is the montage technique. Such a method actually also often exists in different scenes in our ancient literature and different scenes and jumping thinking thoughts form a series of montage in the mind, and then it can be expressed through poetry. This case is the same as it in art, different time and spaces, the characters appear in a scene in a picture, and we distinguish them with a series of symbols to convergence in each scene. Therefore, we can say that if the montage was born after his birth of firms in the twentieth century, then it has existed since ancient time, and it has always existed in the fine arts, however, such thinking played an important role in the development of Chinese art, especially in the convergence and performance practices screen scene.展开更多
In this paper, a singularly perturbed Robin type boundary value problem for second-order ordinary differential equation with discontinuous convection coefficient and source term is considered. A robust-layer-resolving...In this paper, a singularly perturbed Robin type boundary value problem for second-order ordinary differential equation with discontinuous convection coefficient and source term is considered. A robust-layer-resolving numerical method is proposed. An e-uniform global error estimate for the numerical solution and also to the numerical derivative are established. Numerical results are presented, which are in agreement with the theoretical predictions.展开更多
In recent years, peculiar physical phenomena enabled by non-Hermitian systems, especially the parity-time(PT)-symmetric systems, have drawn tremendous research interests. Particularly, special spectral degeneracies kn...In recent years, peculiar physical phenomena enabled by non-Hermitian systems, especially the parity-time(PT)-symmetric systems, have drawn tremendous research interests. Particularly, special spectral degeneracies known as exceptional points(EPs) and coherent perfect absorber-laser(CPAL) points where zero and infinite large eigenvalues coexist are the most popular topics to be studied. To date, the discussions of EPs that serve as transition boundaries between broken PT-symmetry phase and exact PT-symmetry phase have been intensively presented. However, the theoretical analysis and experimental validations of CPAL points are inadequate. Different from EPs, CPAL points, as a special solution of broken PT-symmetry phase, may exhibit even further counterintuitive physical features, which may have significant implications to study non-Hermitian physics. Here, we review some recent advances of CPAL phenomena in different sub-disciplines of physics, including optics, electronics and electromagnetics, and acoustics.Additionally, we also provide an envision of future directions and applications of CPAL systems.展开更多
基金supported by the Ministy of Science and Technology survey project under contract No.2006FY220700
文摘Based on the samples collected from the Chukchi Sea during the FCNARE cruise from July to August in 1999 with the ＂Xuelong＂, the research vessel of SOA, China, the relationship between the distribution characterization of phytoplankton and environmental factors was analyzed with Primer 5.2 software. The result showed that the assemblages of phytoplankton in Chukchi Sea can be divided into three ecological groups： Arctic-boreal group, distributed mostly in northeastern ice-edge where the depth is more than 2 000 m and affected directly by Arctic Ocean; Boreal group, distributed in shelf-break ice in the center water where the depth is less 100 m; Eurythermal group, mainly distributed in the south which exchanged with North Pacific water through Bering Strait. The species diversity, cell density and distribution variability of phytoplankton among stations were great different. The range of phytoplankton density among stations was 1.6 × 10^3- 90 680.2 × 10^4 cells/m^3, and the ranges of diversity index and evenness index among stations were 0.07 - 0.87 and 0.33 - 3.82, respectively. Principal components analysis （PCA） showed that temperature and salinity had made important roles in the distribution of phytoplankton in the Chukchi Sea. Furthermore, the different influences of the variant water regimes, and the extremely dynamic physical nature of the drifting pack ice （e.g. packing, breaking up and melting ） introduce short-term variability into the water conditions that no doubt affect the phytoplankton distrubition.
文摘In this paper we consider the Cauchy problem for the singular semilinear parabolic equation u t-Δu+V 1(x)u=V 2(x)u p,x∈R n\{0},t>0, where V 1(x),V 2(x) may have singularities at the origin. Using functions of the Kato class and the Green tight functions we got the existence of the positive solution being singular at the origin.
基金Supported by the Natural Science Foundation of Sichuan Education Committee under Grant No.08ZA038
文摘A two-dimensional Brans-Dicke star model with exotic matter and dark energy is studied in this paper,the field equation and balance equation are derived at finite temperature,the analytic solutions of these equations canbe used to calculate the mass of star.In addition,we find that star's mass has a minimum when matter state parameterγ→0.
文摘The strange hadronic matter with nucleons, -hyperons and -hyperons is studied by using an effective nuclear model in a mean-field approximation. The density and strangeness fraction dependence of the effective baryon masses as well as the saturation properties and stabilities of the strange hadronic matter are discussed.
文摘Aim In order to improve the solubility of azithromycin, the objectives of the present study were to screen an appropriate salt for azithromycin by comparing acute hepatic and renal toxicities in animals, and study the pharmacokinetics of final chosen azithromycin salt. Methods Various salts of azithromycin, such as glutamate, citrate, hydrochloride, sulphate, dihydrogen phosphate, lactobionate, tartrate, and aspartate were given intravenously to Sprague Dawley rats at a dose of 10 mg once daily for 14 consecutive days via tail vein. The acute hepatic and renal indicators were measured before and after administration. A pharmacokinetic study was performed on 12 healthy human volunteers. The subjects were equally divided into two groups by a randomized crossover design. Azithromycin glutamate injection was administered by intravenous infusion or intramuscular injection at a single dose of 500 mg, respectively. Azithromycin concentrations in plasma were determined by microbial inhibition zone assay, and the pharmacokinetic parameters were calculated using a practical pharmacokinetic software 3P87 program. Results Azithromycin glutamate was least toxic to the liver and kidney of the rats, thus being selected as a final salt for parenteral preparation of azithromycin. Pharmacokinetic results showed that the area under the plasma concentration-time curves （AUC0-120h） were 21.47 ± 1.57 h·μg·mL^-1 for intravenous infusion, and 19.36 ± 2.44 h·μg·mL^-1 for intramuscular injection. The absolute bioavailability of intramuscular injection was 92.59%. Conclusion Azithromycin glutamate is suitable for the future clinical application, and its pharmacokinetics is characterized in human volunteers in the present study.
基金supported by the Major Research Plan of Tianjin(No.16YFXTSF00460)
文摘Polyketides have been widely used clinically due to their significant biological activities, but the needed structural and functional diversity cannot be achieved by common chemical synthetic methods. The tool of combinatorial biosynthesis provides the possibility to produce "unnatural" natural drugs, which has achieved initial success. This paper provides an overview for the strategies of combinatorial biosynthesis in producing the structural and functional diversity of polyketides, including the redesign of metabolic flow, polyketide synthase(PKS) engineering, and PKS post-translational modification. Although encouraging progress has been made in the last decade, challenges still exist regarding the rational combinatorial biosynthesis of polyketides. In this review, the perspectives of polyketide combinatorial biosynthesis are also discussed.
基金Supported by the China Geological Survey(Resources No.[2002]004)the National Natural Science Foundation of China(No.30371112)+1 种基金the Liaoning Science and Technology Foundation(Nos.002119,20022100)the Special Program for Key Basic Research of Ministry of Science and Technology,China(No.2014FY210700)
文摘The seasonal variations in biomass, abundance, and species composition of plankton in relation to hydrography were studied in the saline Bange Lake, northern Tibet, China. Sampling was carried out between one to three times per month from May 2001 to July 2002. Salinity ranged from 14 to 146. The air and water temperature exhibited a clear seasonal pattern, and mean annual temperatures were approximately 4.8℃ and 7.3℃, respectively. The lowest water temperature occurred in winter from December to March at-2℃ and the highest in June and July at 17.7℃. Forty-one phytoplankton taxa, 21 zooplankton, and 5 benthic or facultative zooplankton were identifi ed. The predominant phytoplankton species were Gloeothece linearis, Oscillatoria tenuis, Gloeocapsa punctata, Ctenocladus circinnatus, Dunaliella salina, and Spirulina major. The predominant zooplankton species included H olophrya actra, Brachionus plicatilis, Daphniopsis tibetana, Cletocamptus dertersi, and A rctodiaptomus salinus. The mean annual total phytoplankton density and biomass for the entire lake were 4.52×10^7 cells/L and 1.60 mg/L, respectively. The annual mean zooplankton abundance was 52, 162, 322, and 57, 144 ind./L, in the three sublakes. The annual mean total zooplankton biomass in Lakes 1–3 was 1.23, 9.98, and 2.13 mg/L, respectively. The annual mean tychoplankton abundances in Bg1, 2, and 3 were 47, 67, and 654 ind./L. The annual mean tychoplankton biomass was 2.36, 0.16, and 2.03 mg/L, respectively. The zooplankton biomass（including tychoplankton） in the lake was 9.11 mg/L. The total number of plankton species in the salt lake was signifi cantly negatively correlated with salinity.
文摘The nonlinear predator-prey reaction diffusion systems for singularly perturbed Robin Problems are considered. Under suitable conditions, the theory of differential inequalities can be used to study the asymptotic behavior of the solution for initial boundary value problems.
基金supported in part by the Program for New Century Excellent Talents in Universities under Grant No.NCET-04-0290National Natural Science Foundation of China under Grant No.10675057
文摘The littlest Higgs model with T-parity, which is called LHT model, predicts the existence of the new particles, such as heavy top quarks, heavy gauge bosons, and mirror fermions. We calculate the one-loop contributions of these new particles to the top quark ehromomagnetic dipole moment （CMDM） AK. We find that the contribution of the LHT model is one order of magnitude smaller than the standard model prediction value.
基金supported by National Natural Science Foundation of China under Grant No.10778719
文摘In this paper, firstly, we investigate the neutrino emissivity from quark Urca process in strong magnetic field. Then, we discuss the heat capacity of strange stars in strong magnetic field. Finally, we give the cooling curve in strong magnetic field. In order to make a comparison, we also give the corresponding cooling curve in the case of null magnetic field. It turns out that strange stars cool faster in strong magnetic field than that without magnetic field.
文摘We often see different time and space scenes, different stories and different viewpoints change organically through one lens converge to form a complete film in the movie, and one of a series of the shearing lens elements and convergence is the montage technique. Such a method actually also often exists in different scenes in our ancient literature and different scenes and jumping thinking thoughts form a series of montage in the mind, and then it can be expressed through poetry. This case is the same as it in art, different time and spaces, the characters appear in a scene in a picture, and we distinguish them with a series of symbols to convergence in each scene. Therefore, we can say that if the montage was born after his birth of firms in the twentieth century, then it has existed since ancient time, and it has always existed in the fine arts, however, such thinking played an important role in the development of Chinese art, especially in the convergence and performance practices screen scene.
基金the Council of Scientific and Industrial Research,New Delhi,India for its financial support.
文摘In this paper, a singularly perturbed Robin type boundary value problem for second-order ordinary differential equation with discontinuous convection coefficient and source term is considered. A robust-layer-resolving numerical method is proposed. An e-uniform global error estimate for the numerical solution and also to the numerical derivative are established. Numerical results are presented, which are in agreement with the theoretical predictions.
文摘In recent years, peculiar physical phenomena enabled by non-Hermitian systems, especially the parity-time(PT)-symmetric systems, have drawn tremendous research interests. Particularly, special spectral degeneracies known as exceptional points(EPs) and coherent perfect absorber-laser(CPAL) points where zero and infinite large eigenvalues coexist are the most popular topics to be studied. To date, the discussions of EPs that serve as transition boundaries between broken PT-symmetry phase and exact PT-symmetry phase have been intensively presented. However, the theoretical analysis and experimental validations of CPAL points are inadequate. Different from EPs, CPAL points, as a special solution of broken PT-symmetry phase, may exhibit even further counterintuitive physical features, which may have significant implications to study non-Hermitian physics. Here, we review some recent advances of CPAL phenomena in different sub-disciplines of physics, including optics, electronics and electromagnetics, and acoustics.Additionally, we also provide an envision of future directions and applications of CPAL systems.
