Objective To investigate the relationship between geranylgeranyl pyrophosphate synthase （GGPPS） gene polymorphisms and bone response to alendronate in Chinese osteoporotic women. Methods A total of 639 postmenopaus...Objective To investigate the relationship between geranylgeranyl pyrophosphate synthase （GGPPS） gene polymorphisms and bone response to alendronate in Chinese osteoporotic women. Methods A total of 639 postmenopausal women with osteoporosis or osteopenia were included and randomly received treatment of low dose （70 mg per two weeks） or standard dose （70 mg weekly） of alendronate for one year. The six tag single nucleotide polymorphisms of GGPPS gene were identified. Bone mineral density （BMD）, serum cross-linked C-telopeptide of type I collagen （β-CTX）, and total alkaline phosphatase （ALP） were measured before and after treatment. GGPPS gene polymorphisms and the changes of BMD and bone turnover markers after treatment were analyzed. Results rs10925503 polymorphism of GGPPS gene was correlated to serumβ-CTX levels at baseline, and patients with TT genotype had significantly higher serum β-CTX level than those with TC or CC genotype （all P〈0.05）. No correlation was found between polymorphisms of GGPPS gene and serum total ALP levels, as well as BMD at baseline. After 12 months of treatment, lumbar spine and hip BMD increased and serum bone turnover markers decreased significantly （P〈0.01）, and without obvious differences between the low dose and standard dose groups （all P〉0.05）. However, GGPPS gene polymorphisms were uncorrelated to percentage changes of BMD, serum total ALP, and β-CTX levels （all P〉0.05）. Conclusion GGPPS gene polymorphisms are correlated to osteoclasts activity, but all tag single nucleotide polymorphisms of GGPPS gene have no influence on the skeletal response to alendronate treatment.展开更多
Adichie＇s Purple Hibiscus is a feminist work that challenges the dehumanizing tendencies of the menfolk as evident in the character of Mama （Beatrice Achike） who eventually exposed the African conception of an idea...Adichie＇s Purple Hibiscus is a feminist work that challenges the dehumanizing tendencies of the menfolk as evident in the character of Mama （Beatrice Achike） who eventually exposed the African conception of an ideal woman who keeps dumb even in the face of humiliation, victimization, and brutality so as to be perceived as a good woman. We will make a resounding case to portray that Achike belongs to the category of liberal feminism. However, as events unfolds, she was forced by situations beyond her control to respond and go radical in order to crush anything that stands in her way to happiness. Efforts will be made to show how African women are rated based on the real and good women as represented by Ifeoma and Beatrice Achike respectively. This essay in exploring the different tenets of feminism will acknowledge that radical feminism is an off shoot of violence. We shall argue that radical feminism is a radical reaction to dehumanization, humiliation, and violence. This study seeks to address the issue of feminism and how characters subject to series of humiliation that leads to a radical approach to gain their freedom.展开更多
Over the past decades, there were questions often asked： What is education？ What is it purpose in the world whether it helps an individual or not to understand himself and connect his views with existing beliefs and...Over the past decades, there were questions often asked： What is education？ What is it purpose in the world whether it helps an individual or not to understand himself and connect his views with existing beliefs and critical thinking about education to deal with daily practical challenges enable in a new way. The founder of instrumentalism philosophical school, John Dewey remarks that knowledge is practical instrument that purpose must be to solve all problems that a person encounters during his/her lifetime. According to instrumentalism theoretical concepts, theories are instruments by means of that relationship with surrounding world is established （communication becomes possibleS. Representatives of traditional epistemology make distinct difference between ＂world＂ and ＂mind＂. In accordance with Dewey＇s genetic epistemology mind, constitutes the result of living being-environment relationship as the universe is defined by our mind and the development of a human＇s knowledge is adaptive response to the environment.展开更多
Male prairie voles become more responsive to infants following cohabitation with a female. Exposure to female sen- sory cues prior to offspring birth may influence male paternal tendencies by modifying his response to...Male prairie voles become more responsive to infants following cohabitation with a female. Exposure to female sen- sory cues prior to offspring birth may influence male paternal tendencies by modifying his response to infant odors in particular or to odors in general. To test these hypotheses, males were housed with an unfamiliar female or a same-sex sibling for 13 days then examined for their response towards either live infants or infant-like inanimate objects covered with one of three odors： wa- ter, infant, sub-adult. We recorded the number of males that retrieved and manipulated the infants or odor-covered objects and measured the frequency and duration of time males spent attending to them or engaged in other non-social activities. Fe- male-Cohabited males approached the container holding infant-odor covered objects faster than Male-Cohabited males, but showed no differences in time spent manipulating those objects. Males in both groups spent more time manipulating live infants than odor-covered objects. However, Female-Cohabited subjects were more likely to manipulate odor-covered objects as well as live infants than Male-Cohabited subjects. Additionally, the frequency of self-grooming in Female-Cohabited males was higher for water-covered objects compared to Male-Cohabited males. In presence of water and live infants, Female-Cohabited males groomed themselves with greater frequency than in presence of infant odor or sub-adult odor. The data suggest that female cues increase the male＇s sensitivity to infant odors and enhance the salience of non-social odors.展开更多
基金Supported by National Natural Science Foundation of China(81570802)National Key Program of Clinical Science(WBYZ2011-873)
文摘Objective To investigate the relationship between geranylgeranyl pyrophosphate synthase （GGPPS） gene polymorphisms and bone response to alendronate in Chinese osteoporotic women. Methods A total of 639 postmenopausal women with osteoporosis or osteopenia were included and randomly received treatment of low dose （70 mg per two weeks） or standard dose （70 mg weekly） of alendronate for one year. The six tag single nucleotide polymorphisms of GGPPS gene were identified. Bone mineral density （BMD）, serum cross-linked C-telopeptide of type I collagen （β-CTX）, and total alkaline phosphatase （ALP） were measured before and after treatment. GGPPS gene polymorphisms and the changes of BMD and bone turnover markers after treatment were analyzed. Results rs10925503 polymorphism of GGPPS gene was correlated to serumβ-CTX levels at baseline, and patients with TT genotype had significantly higher serum β-CTX level than those with TC or CC genotype （all P〈0.05）. No correlation was found between polymorphisms of GGPPS gene and serum total ALP levels, as well as BMD at baseline. After 12 months of treatment, lumbar spine and hip BMD increased and serum bone turnover markers decreased significantly （P〈0.01）, and without obvious differences between the low dose and standard dose groups （all P〉0.05）. However, GGPPS gene polymorphisms were uncorrelated to percentage changes of BMD, serum total ALP, and β-CTX levels （all P〉0.05）. Conclusion GGPPS gene polymorphisms are correlated to osteoclasts activity, but all tag single nucleotide polymorphisms of GGPPS gene have no influence on the skeletal response to alendronate treatment.
文摘Adichie＇s Purple Hibiscus is a feminist work that challenges the dehumanizing tendencies of the menfolk as evident in the character of Mama （Beatrice Achike） who eventually exposed the African conception of an ideal woman who keeps dumb even in the face of humiliation, victimization, and brutality so as to be perceived as a good woman. We will make a resounding case to portray that Achike belongs to the category of liberal feminism. However, as events unfolds, she was forced by situations beyond her control to respond and go radical in order to crush anything that stands in her way to happiness. Efforts will be made to show how African women are rated based on the real and good women as represented by Ifeoma and Beatrice Achike respectively. This essay in exploring the different tenets of feminism will acknowledge that radical feminism is an off shoot of violence. We shall argue that radical feminism is a radical reaction to dehumanization, humiliation, and violence. This study seeks to address the issue of feminism and how characters subject to series of humiliation that leads to a radical approach to gain their freedom.
文摘Over the past decades, there were questions often asked： What is education？ What is it purpose in the world whether it helps an individual or not to understand himself and connect his views with existing beliefs and critical thinking about education to deal with daily practical challenges enable in a new way. The founder of instrumentalism philosophical school, John Dewey remarks that knowledge is practical instrument that purpose must be to solve all problems that a person encounters during his/her lifetime. According to instrumentalism theoretical concepts, theories are instruments by means of that relationship with surrounding world is established （communication becomes possibleS. Representatives of traditional epistemology make distinct difference between ＂world＂ and ＂mind＂. In accordance with Dewey＇s genetic epistemology mind, constitutes the result of living being-environment relationship as the universe is defined by our mind and the development of a human＇s knowledge is adaptive response to the environment.
文摘Male prairie voles become more responsive to infants following cohabitation with a female. Exposure to female sen- sory cues prior to offspring birth may influence male paternal tendencies by modifying his response to infant odors in particular or to odors in general. To test these hypotheses, males were housed with an unfamiliar female or a same-sex sibling for 13 days then examined for their response towards either live infants or infant-like inanimate objects covered with one of three odors： wa- ter, infant, sub-adult. We recorded the number of males that retrieved and manipulated the infants or odor-covered objects and measured the frequency and duration of time males spent attending to them or engaged in other non-social activities. Fe- male-Cohabited males approached the container holding infant-odor covered objects faster than Male-Cohabited males, but showed no differences in time spent manipulating those objects. Males in both groups spent more time manipulating live infants than odor-covered objects. However, Female-Cohabited subjects were more likely to manipulate odor-covered objects as well as live infants than Male-Cohabited subjects. Additionally, the frequency of self-grooming in Female-Cohabited males was higher for water-covered objects compared to Male-Cohabited males. In presence of water and live infants, Female-Cohabited males groomed themselves with greater frequency than in presence of infant odor or sub-adult odor. The data suggest that female cues increase the male＇s sensitivity to infant odors and enhance the salience of non-social odors.
