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FMR1基因突变与女性生殖能力相关性的研究进展 被引量:4
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作者 黄丽萨 周义文 《中国妇幼健康研究》 2016年第S1期133-134,共2页
脆性x智力低下1(fragile X mental retardation 1,FMRl)基因最初受到重视缘于其可导致一种常见的遗传性疾病,即脆性x综合征(fragile X syndrome,FXS),对于女性而言,除FXS外,FMRl基因还容易导致卵巢功能受损,即脆性x相关的原发性卵巢功... 脆性x智力低下1(fragile X mental retardation 1,FMRl)基因最初受到重视缘于其可导致一种常见的遗传性疾病,即脆性x综合征(fragile X syndrome,FXS),对于女性而言,除FXS外,FMRl基因还容易导致卵巢功能受损,即脆性x相关的原发性卵巢功能不全,包括卵巢功能受损严重所导致的卵巢早衰及卵巢功能受损较轻所导致的卵巢储备功能下降等。本文就这一方面的进展做一综述, 展开更多
关键词 FMR1基因突变 女性生殖能力
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Mechanisms of reproductive aging in the females 被引量:1
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作者 DENG ManQi 《Science China(Life Sciences)》 SCIE CAS 2012年第8期653-658,共6页
Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage,characterized by progressive loss of functions until death.Different cells/tissues age differently depen... Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage,characterized by progressive loss of functions until death.Different cells/tissues age differently depending on epigenetics and cell-cell interactions.While males maintain fertility for the most part of their life females only maintain reproductive ability for a short time compared with their lifespan.The interesting question is why and how the females lose fertility so quickly.There have been many hypotheses proposed from different perspectives and recent research has revealed unusual interactions between germ cells and somatic cells which may determine the lifespan of reproduction in the females.This review briefly discusses recent progress in reproductive aging in the well studied model,C.elegans,and focuses on the molecular mechanisms which may be conserved across all animals including humans. 展开更多
关键词 AGING females OOCYTES LIFESPAN growth factors MTOR
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