脆性x智力低下1(fragile X mental retardation 1,FMRl)基因最初受到重视缘于其可导致一种常见的遗传性疾病,即脆性x综合征(fragile X syndrome,FXS),对于女性而言,除FXS外,FMRl基因还容易导致卵巢功能受损,即脆性x相关的原发性卵巢功...脆性x智力低下1(fragile X mental retardation 1,FMRl)基因最初受到重视缘于其可导致一种常见的遗传性疾病,即脆性x综合征(fragile X syndrome,FXS),对于女性而言,除FXS外,FMRl基因还容易导致卵巢功能受损,即脆性x相关的原发性卵巢功能不全,包括卵巢功能受损严重所导致的卵巢早衰及卵巢功能受损较轻所导致的卵巢储备功能下降等。本文就这一方面的进展做一综述,展开更多
Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage,characterized by progressive loss of functions until death.Different cells/tissues age differently depen...Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage,characterized by progressive loss of functions until death.Different cells/tissues age differently depending on epigenetics and cell-cell interactions.While males maintain fertility for the most part of their life females only maintain reproductive ability for a short time compared with their lifespan.The interesting question is why and how the females lose fertility so quickly.There have been many hypotheses proposed from different perspectives and recent research has revealed unusual interactions between germ cells and somatic cells which may determine the lifespan of reproduction in the females.This review briefly discusses recent progress in reproductive aging in the well studied model,C.elegans,and focuses on the molecular mechanisms which may be conserved across all animals including humans.展开更多
文摘脆性x智力低下1(fragile X mental retardation 1,FMRl)基因最初受到重视缘于其可导致一种常见的遗传性疾病,即脆性x综合征(fragile X syndrome,FXS),对于女性而言,除FXS外,FMRl基因还容易导致卵巢功能受损,即脆性x相关的原发性卵巢功能不全,包括卵巢功能受损严重所导致的卵巢早衰及卵巢功能受损较轻所导致的卵巢储备功能下降等。本文就这一方面的进展做一综述,
文摘Aging is a developmental process occurring in all living organisms after reaching a critical developmental stage,characterized by progressive loss of functions until death.Different cells/tissues age differently depending on epigenetics and cell-cell interactions.While males maintain fertility for the most part of their life females only maintain reproductive ability for a short time compared with their lifespan.The interesting question is why and how the females lose fertility so quickly.There have been many hypotheses proposed from different perspectives and recent research has revealed unusual interactions between germ cells and somatic cells which may determine the lifespan of reproduction in the females.This review briefly discusses recent progress in reproductive aging in the well studied model,C.elegans,and focuses on the molecular mechanisms which may be conserved across all animals including humans.