Aim To prepare triamcinolone-acetonide-acetate (TAA)-loaded solid lipidnanoparticles (SLN) carbomer gel with tripalmitin glyceride (TPG), and investigate theircharacteristics and transdermal drug delivery. Methods SLN...Aim To prepare triamcinolone-acetonide-acetate (TAA)-loaded solid lipidnanoparticles (SLN) carbomer gel with tripalmitin glyceride (TPG), and investigate theircharacteristics and transdermal drug delivery. Methods SLN suspension was prepared by high-pressurehomogenization technique, and then mixed with carbomer gel matrix to get SLN gel. The morphology,particle size with polydispersi-ty index (PI) and zeta potential were examined by atomic forcemicroscopy (AFM) and photon correlation spectroscopy (PCS). The entrapment efficiency, stability andin vitro drug release were also studied. The transdermal drug delivery through porcine ear skin wasevaluated using modified Franz diffusion cells. Results The SLN had a spherical shape with theaverage size of (95.5 - 186.2) nm, the zeta potential of (-26.3- -15.7) mV and the entrapmentefficiency of 67.4%-90.3% for different TAA encapsulated compounds. TAA-SLN carbomer gel had goodstability, the release profile in vitro fitted Higuchi equation. In comparison with conventionalhydrogels, TAA-SLN carbomer gel resulted in higher drug permeation amount and drug deposition withinporcine ear skin after 24 h penetration experiment. Conclusion TAA-SLN carbomer gel is preparedwith stable physicochemical properties. The release profile and improved drug permeation into skinmake it be a promising vehicle for transdermal drug delivery.展开更多
A two-step method is proposed for detection and identification of invisible impact damage in composite structure under temperature changes using Lamb waves.First,a statistical outlier analysis is employed to distingui...A two-step method is proposed for detection and identification of invisible impact damage in composite structure under temperature changes using Lamb waves.First,a statistical outlier analysis is employed to distinguish whether the changes of Lamb wave signals are induced by damage within a monitoring area or are only affected by temperature changes.Damage indices are defined after the Lamb wave signals are processed by Fourier transform,and a Monte Carlo procedure is used to obtain the damage threshold value for the damage indices at the undamaged state.If the damage indices in the operation state exceed the threshold value,the presence of damage is determined.Then,a probabilistic damage imaging algorithm displaying probabilities of the presence of damage within the monitoring area is adopted to fuse information collected from multiple actuator-sensor paths to identify the location of damage.Damage indices under damaged state are used to generate the diagnostic image.Experimental study on a stiffened composite panel with random temperature changes is performed to demonstrate the effectiveness of the proposed method.展开更多
Wave velocities in haloanhydrites are difficult to determine and significantly depend on the mineralogy. We used petrophysical parameters to study the wave velocity in haloanhydrites in the Amur Darya Basin and constr...Wave velocities in haloanhydrites are difficult to determine and significantly depend on the mineralogy. We used petrophysical parameters to study the wave velocity in haloanhydrites in the Amur Darya Basin and constructed a template of the relation between haloanhydrite mineralogy （anhydrite, salt, mudstone, and pore water） and wave velocities. We used the relation between the P-wave rnoduli ratio and porosity as constraint and constructed a graphical model （petrophysical template） for the relation between wave velocity, mineral content and porosity. We tested the graphical model using rock core and well logging data.展开更多
This work aimed the incorporation of the enzyme bromelain from pineapple peel into dermatological bases for potential therapeutic application. The enzyme was incorporated into Lanette cream and lotion, as well as Carb...This work aimed the incorporation of the enzyme bromelain from pineapple peel into dermatological bases for potential therapeutic application. The enzyme was incorporated into Lanette cream and lotion, as well as Carbopol gel and Chemyunion cream and lotion, at a concentration of 0.5% （w/w）. These bases were subjected to centrifugation test and accelerated stability test during 90 days at 25 ℃（with and without sunlight）, 37 ℃ and 4 ℃, in order to evaluate bromelain stability in dermatological bases. Total protein content and enzymatic activity were measured. The bases were stable as its organoleptic characteristics （appearance, color, smell and sensitivity to touch） only when kept at 4 ℃ with activity remaining 95.5%, 84,9%. 77.7%, 73.8% and 72.3%, alter 90 days of testing in Carbopol gel, Lanette and Chemyunion cream, and Lanette and Chemyunion lotion, respectively. Based on the results, it was possible to incorporate bromelain into dermatological bases, and the activity was well preserved when these bases were kept in refrigerator at 4 ℃.展开更多
The scattering of oblique incident surface waves by the edge of a small cylindrical deformation on a porous bed in an ocean of finite depth, is investigated here within the framework of linearized water wave theory. U...The scattering of oblique incident surface waves by the edge of a small cylindrical deformation on a porous bed in an ocean of finite depth, is investigated here within the framework of linearized water wave theory. Using perturbation analysis, the corresponding problem governed by modified Helmholtz equation is reduced to a boundary value problem for the first-order correction of the potential function. The first-order potential and, hence, the reflection and transmission coefficients are obtained by a method based on Green＇s integral theorem with the introduction of appropriate Green＇s function. Consideration of a patch of sinusoidal ripples shows that when the quotient of twice the component of the incident field wave number along x-direction and the ripple wave number approaches one, the theory predicts a resonant interaction between the bed and the free-surface, and the reflection coefficient becomes a multiple of the number of ripples. Again, for small angles of incidence, the reflected energy is more as compared to the other angles of incidence. It is also observed that the reflected energy is somewhat sensitive to the changes in the porosity of the ocean bed. From the derived results, the solutions for problems with impermeable ocean bed can be obtained as particular cases.展开更多
In this paper, a method to construct oblique wave-free potentials in the linearised theory of water waves for water with uniform finite depth is presented in a systematic manner. The water has either a free surface or...In this paper, a method to construct oblique wave-free potentials in the linearised theory of water waves for water with uniform finite depth is presented in a systematic manner. The water has either a free surface or an ice-cover modelled as a thin elastic plate. For the case of free surface, the effect of surface tension may be neglected or taken into account. Here, the wave-free potentials are singular solutions of the modified Helmholtz equation, having singularity at a point in the fluid region and they satisfy the conditions at the upper surface and the bottom of water region and decay rapidly away from the point of singularity. These are useful in obtaining solutions to oblique water wave problems involving bodies with circular cross-sections such as long horizontal cylinders submerged or half-immersed in water of uniform fmite depth with a free surface or an ice-cover modelled as a floating elastic plate. Finally, the forms of the upper surface related to the wave-free potentials constructed here are depicted graphically in a number of figures to visualize the wave motion. The results for non-oblique wave-free potentials and the upper surface wave-free potentials are obtained. The wave-free potentials constructed here will be useful in the mathematical study of water wave problems involving infinitely long horizontal cylinders, either half-immersed or completely immersed in water.展开更多
文摘Aim To prepare triamcinolone-acetonide-acetate (TAA)-loaded solid lipidnanoparticles (SLN) carbomer gel with tripalmitin glyceride (TPG), and investigate theircharacteristics and transdermal drug delivery. Methods SLN suspension was prepared by high-pressurehomogenization technique, and then mixed with carbomer gel matrix to get SLN gel. The morphology,particle size with polydispersi-ty index (PI) and zeta potential were examined by atomic forcemicroscopy (AFM) and photon correlation spectroscopy (PCS). The entrapment efficiency, stability andin vitro drug release were also studied. The transdermal drug delivery through porcine ear skin wasevaluated using modified Franz diffusion cells. Results The SLN had a spherical shape with theaverage size of (95.5 - 186.2) nm, the zeta potential of (-26.3- -15.7) mV and the entrapmentefficiency of 67.4%-90.3% for different TAA encapsulated compounds. TAA-SLN carbomer gel had goodstability, the release profile in vitro fitted Higuchi equation. In comparison with conventionalhydrogels, TAA-SLN carbomer gel resulted in higher drug permeation amount and drug deposition withinporcine ear skin after 24 h penetration experiment. Conclusion TAA-SLN carbomer gel is preparedwith stable physicochemical properties. The release profile and improved drug permeation into skinmake it be a promising vehicle for transdermal drug delivery.
基金Supported by the Aeronautical Science Foundation of China(2008ZA52012)the Six Kinds of Excellent Talent Project in Jiangsu Province of China(2010JZ004)the Research Foundation of Nanjing University of Aeronautics and Astronautics(NS2010027)~~
文摘A two-step method is proposed for detection and identification of invisible impact damage in composite structure under temperature changes using Lamb waves.First,a statistical outlier analysis is employed to distinguish whether the changes of Lamb wave signals are induced by damage within a monitoring area or are only affected by temperature changes.Damage indices are defined after the Lamb wave signals are processed by Fourier transform,and a Monte Carlo procedure is used to obtain the damage threshold value for the damage indices at the undamaged state.If the damage indices in the operation state exceed the threshold value,the presence of damage is determined.Then,a probabilistic damage imaging algorithm displaying probabilities of the presence of damage within the monitoring area is adopted to fuse information collected from multiple actuator-sensor paths to identify the location of damage.Damage indices under damaged state are used to generate the diagnostic image.Experimental study on a stiffened composite panel with random temperature changes is performed to demonstrate the effectiveness of the proposed method.
基金supported by the National Major Scientific and Technological Special Project(No.2011ZX05029-003)the project of the Research Institute of Petroleum Exploration&Development(No.2012Y-058)
文摘Wave velocities in haloanhydrites are difficult to determine and significantly depend on the mineralogy. We used petrophysical parameters to study the wave velocity in haloanhydrites in the Amur Darya Basin and constructed a template of the relation between haloanhydrite mineralogy （anhydrite, salt, mudstone, and pore water） and wave velocities. We used the relation between the P-wave rnoduli ratio and porosity as constraint and constructed a graphical model （petrophysical template） for the relation between wave velocity, mineral content and porosity. We tested the graphical model using rock core and well logging data.
文摘This work aimed the incorporation of the enzyme bromelain from pineapple peel into dermatological bases for potential therapeutic application. The enzyme was incorporated into Lanette cream and lotion, as well as Carbopol gel and Chemyunion cream and lotion, at a concentration of 0.5% （w/w）. These bases were subjected to centrifugation test and accelerated stability test during 90 days at 25 ℃（with and without sunlight）, 37 ℃ and 4 ℃, in order to evaluate bromelain stability in dermatological bases. Total protein content and enzymatic activity were measured. The bases were stable as its organoleptic characteristics （appearance, color, smell and sensitivity to touch） only when kept at 4 ℃ with activity remaining 95.5%, 84,9%. 77.7%, 73.8% and 72.3%, alter 90 days of testing in Carbopol gel, Lanette and Chemyunion cream, and Lanette and Chemyunion lotion, respectively. Based on the results, it was possible to incorporate bromelain into dermatological bases, and the activity was well preserved when these bases were kept in refrigerator at 4 ℃.
基金partially supported by a research grant from Department of Science and Technology(DST),India(No.SB/FTP/MS-003/2013)
文摘The scattering of oblique incident surface waves by the edge of a small cylindrical deformation on a porous bed in an ocean of finite depth, is investigated here within the framework of linearized water wave theory. Using perturbation analysis, the corresponding problem governed by modified Helmholtz equation is reduced to a boundary value problem for the first-order correction of the potential function. The first-order potential and, hence, the reflection and transmission coefficients are obtained by a method based on Green＇s integral theorem with the introduction of appropriate Green＇s function. Consideration of a patch of sinusoidal ripples shows that when the quotient of twice the component of the incident field wave number along x-direction and the ripple wave number approaches one, the theory predicts a resonant interaction between the bed and the free-surface, and the reflection coefficient becomes a multiple of the number of ripples. Again, for small angles of incidence, the reflected energy is more as compared to the other angles of incidence. It is also observed that the reflected energy is somewhat sensitive to the changes in the porosity of the ocean bed. From the derived results, the solutions for problems with impermeable ocean bed can be obtained as particular cases.
文摘In this paper, a method to construct oblique wave-free potentials in the linearised theory of water waves for water with uniform finite depth is presented in a systematic manner. The water has either a free surface or an ice-cover modelled as a thin elastic plate. For the case of free surface, the effect of surface tension may be neglected or taken into account. Here, the wave-free potentials are singular solutions of the modified Helmholtz equation, having singularity at a point in the fluid region and they satisfy the conditions at the upper surface and the bottom of water region and decay rapidly away from the point of singularity. These are useful in obtaining solutions to oblique water wave problems involving bodies with circular cross-sections such as long horizontal cylinders submerged or half-immersed in water of uniform fmite depth with a free surface or an ice-cover modelled as a floating elastic plate. Finally, the forms of the upper surface related to the wave-free potentials constructed here are depicted graphically in a number of figures to visualize the wave motion. The results for non-oblique wave-free potentials and the upper surface wave-free potentials are obtained. The wave-free potentials constructed here will be useful in the mathematical study of water wave problems involving infinitely long horizontal cylinders, either half-immersed or completely immersed in water.
