Rotavirus is an acute enteric pathogen in infants and children. We reported a rare case of a 6-mo-old infant with protein-loosing enteropathy (PLE) caused by rotavirus gastroenteritis, and evaluated the immunological ...Rotavirus is an acute enteric pathogen in infants and children. We reported a rare case of a 6-mo-old infant with protein-loosing enteropathy (PLE) caused by rotavirus gastroenteritis, and evaluated the immunological profile in peripheral blood lymphocytes. Laboratory examinations showed lymphopenia, hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and elevation of alpha-1-antitrypsin (α1-AT) clearance. Lymphocytes subpopulation study revealed the reversal of CD4+/CD8+ ratio with the selective decrease of CD4- positive lymphocytes. Moreover, the excessive increase of T cells producing IFN-gamma (IFN-γ) was found, which plays an important role in the protection against viral infection. The primary or secondary activation of immune system by rotavirus may influence structural integrity and vascular permeability, which may play a triggering role in protein-loosing enteropathy.展开更多
Objective： To observe the clinical effect of tuina plus medications on infantile diarrhea induced by rotavirus infection. Methods： After 55 cases of confirmed sick infants were divided into two groups by the order o...Objective： To observe the clinical effect of tuina plus medications on infantile diarrhea induced by rotavirus infection. Methods： After 55 cases of confirmed sick infants were divided into two groups by the order of their visits, 30 cases in the medication group were treated by intravenous infusion of Ribavirin and oral administration of Smecta; 25 cases in the tuina plus medication group were treated by the manual techniques of tonifying Pijing（脾经） and clarifying Dachangjing （大肠经）, rubbing the abdomen and kneading the navel clockwise, pushing Shangqijiegu （上七节骨）, kneading Guiwei （龟尾）, and pinching the skin of the spine, in combination with same medications used as in the medication group. Results： The total effective rate was 96% in the tuina plus medication group, P 〈 0.01, in comparison with the medication group. Conclusion： tuina has a good therapeutic effect in the treatment of infantile diarrhea induced by rotavirus infection and is importantly significant for shortening the course, enhancing the therapeutic effect and lowering down the medical cost.展开更多
文摘Rotavirus is an acute enteric pathogen in infants and children. We reported a rare case of a 6-mo-old infant with protein-loosing enteropathy (PLE) caused by rotavirus gastroenteritis, and evaluated the immunological profile in peripheral blood lymphocytes. Laboratory examinations showed lymphopenia, hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and elevation of alpha-1-antitrypsin (α1-AT) clearance. Lymphocytes subpopulation study revealed the reversal of CD4+/CD8+ ratio with the selective decrease of CD4- positive lymphocytes. Moreover, the excessive increase of T cells producing IFN-gamma (IFN-γ) was found, which plays an important role in the protection against viral infection. The primary or secondary activation of immune system by rotavirus may influence structural integrity and vascular permeability, which may play a triggering role in protein-loosing enteropathy.
文摘Objective： To observe the clinical effect of tuina plus medications on infantile diarrhea induced by rotavirus infection. Methods： After 55 cases of confirmed sick infants were divided into two groups by the order of their visits, 30 cases in the medication group were treated by intravenous infusion of Ribavirin and oral administration of Smecta; 25 cases in the tuina plus medication group were treated by the manual techniques of tonifying Pijing（脾经） and clarifying Dachangjing （大肠经）, rubbing the abdomen and kneading the navel clockwise, pushing Shangqijiegu （上七节骨）, kneading Guiwei （龟尾）, and pinching the skin of the spine, in combination with same medications used as in the medication group. Results： The total effective rate was 96% in the tuina plus medication group, P 〈 0.01, in comparison with the medication group. Conclusion： tuina has a good therapeutic effect in the treatment of infantile diarrhea induced by rotavirus infection and is importantly significant for shortening the course, enhancing the therapeutic effect and lowering down the medical cost.
