We present a controlled secure quantum dialogue protocol using a non-maximally （pure） entangled Greenberger-Horne-Zeibinger （GHZ） states at first, and then discuss the requirements for a real quantum dialogue. We ...We present a controlled secure quantum dialogue protocol using a non-maximally （pure） entangled Greenberger-Horne-Zeibinger （GHZ） states at first, and then discuss the requirements for a real quantum dialogue. We show that the authorized two users can exchange their secret messages after purifying the non-maximally entangled GHZ states quantum channel unconditionally securely and simultaneously under the control of a third party.展开更多
Because of ground clutter wave interf e rence,it is difficult to measure smoke screen disturbance in the field.In this pape r,a kind of indoor measurement method of smoke screen disturbance efficiency ba sed on Gaussi...Because of ground clutter wave interf e rence,it is difficult to measure smoke screen disturbance in the field.In this pape r,a kind of indoor measurement method of smoke screen disturbance efficiency ba sed on Gaussian diffusion model is put forward.As a characteristic,the measur ement result of smoke screen area density proves that the indoor measurement met hod of smoke screen disturbance efficiency based on Gaussian diffusion model is fea sible.展开更多
Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were...Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were obtained from the Traditional Chinese Medicine Systems and Pharmacology Database and Analysis Platform(TCMSP),Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-TCM)database,and the literature.The component-target regulatory network and protein-protein interaction(PPI)network were constructed by Cytoscape 3.7.2,and a bioinformatics analysis was performed to identify the significant pathways and their relevant targets.Molecular docking of the core active components and relevant targets was performed.Results A total of 98 active components of SAD and the corresponding 113 drug targets were identified.The component-target regulatory network and PPI network were successfully established.Results of the bioinformatics analysis indicated that 2281 Gene Ontology(GO)terms were enriched in chronic cough,including 2062 terms were in biological processes,77 in cellular components,and 142 in molecular functions,and top 20 significant pathways in Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis.Molecular docking study demonstrated that quercetin,luteolin,kaempferol,and naringenin were in good agreement with the corresponding targets.Conclusion The active compounds of SAD,such as quercetin,luteolin,kaempferol,and naringenin,may act on AKT1,MAPK1,RELA,EGFR,and Bcl-2 and regulate the PI3 K-Akt signaling pathway,AGE-RAGE signaling pathway,and fluid shear stress and atherosclerosis pathway to exert the effects of anti-inflammatory,anti-airway remodeling,anti-oxidant stress effects,and repair airway damage,thus treating chronic cough.展开更多
The study analysed the behaviour of titanium dioxide （TiO2） in polyethylene teraphthalate （PET） polymer coatings on ECCS steel plates. The work determined the thermal source affecting rutile distribution in the PE...The study analysed the behaviour of titanium dioxide （TiO2） in polyethylene teraphthalate （PET） polymer coatings on ECCS steel plates. The work determined the thermal source affecting rutile distribution in the PET coating： It originated in the manufacturing processes and thermomechanical treatments of the composite, and affected PET adherence on the steel. These results were contrasted with the behaviour of a non-heated coating to determine the conditions under which the ruffle exhibits changes on the PET coating. Measurements at cross-section and parallel intervals from the surface to the metal interface were made by FTIR-ATR and Raman vibrational spectroscopy techniques to characterise the rutile distribution in the PET thickness.展开更多
Objective The study aimed to synthesize and characterize pyrimidine-linked benzimidazole hybrids,define their antimicrobial and antifungal activities in vitro,and determine their ability to inhibit the main protease a...Objective The study aimed to synthesize and characterize pyrimidine-linked benzimidazole hybrids,define their antimicrobial and antifungal activities in vitro,and determine their ability to inhibit the main protease and spike glycoprotein of SARS-CoV-2.Methods The ability of the synthesized compounds to inhibit the main protease and spike glycoprotein inhibitory of SARS-CoV-2 was investigated by assessing their mode of binding to the allosteric site of the enzyme using molecular docking.The structures of pyrimidine-linked benzimidazole derivatives synthesized with microwave assistance were confirmed by spectral analysis.Antibacterial and antifungal activities were determined by broth dilution.Results Gram-negative bateria(Escherichia coli and Pseudomonas aeruginosa)were more sensitive than gram-positive bateria(Staphylococcus aureus and Streptococcus pyogenes)to the derivatives.Candida albicans was sensitive to the derivatives at a minimal inhibitory concentration(MIC)of 250μg/mL.The novel derivatives had better binding affinity(kcal/mol)than nelfinavir,lopinavir,ivermectin,remdesivir,and favipiravir,which are under investigation as treatment for SARS-CoV-2 infection.Compounds 2c,2e,and 2g formed four hydrogen bonds with the active cavity of the main protease.Many derivatives had good binding affinity for the RBD of the of SARS-CoV-2 spike glycoprotein with the formation of up to four hydrogen bonds.Conclusion We synthesized novel pyrimidine-linked benzi-midazole derivatives that were potent antimicrobial agents with ability to inhibit the SARS-CoV-2 spike glycoprotein.Understanding the pharmacophore features of the main protease and spike glycoprotein offers much scope for the development of more potent agents.We plan to optimize the properties of the derivatives using models in vivo and in vitro so that they will serve as more effective therapeutic options against bacterial and SARS-CoV-2 infections.展开更多
At present, the anti-noise property and the information leakage resistant property are two great concerns for quantum dialogue(QD). In this paper, two anti-noise QD protocols without information leakage are presented ...At present, the anti-noise property and the information leakage resistant property are two great concerns for quantum dialogue(QD). In this paper, two anti-noise QD protocols without information leakage are presented by using the entanglement swapping technology for two logical Bell states. One works well over a collective-dephasing noise channel, while the other takes effect over a collective-rotation noise channel. The negative influence of noise is erased by using logical Bell states as the traveling quantum states. The problem of information leakage is avoided by swapping entanglement between two logical Bell states. In addition, only Bell state measurements are used for decoding, rather than four-qubit joint measurements.展开更多
p-Nitrophenylphosphate （PNPP） is usually employed as the substrate for enzyme-linked immunosorbent assays, p-Nitrophenol （PNP）, the product of PNPP, with the catalyst alkaline phosphatase （ALP）, will passivate a...p-Nitrophenylphosphate （PNPP） is usually employed as the substrate for enzyme-linked immunosorbent assays, p-Nitrophenol （PNP）, the product of PNPP, with the catalyst alkaline phosphatase （ALP）, will passivate an electrode, which limits applications in electrochemical analysis. A novel anti-passivation ink used in the preparation of a graphene/ionic liquid/chitosan composited （rGO/IL/Ghi） electrode is proposed to solve the problem. The anti-passivation electrode was fabricated by directly writing the graphene-ionic liquid-chitosan composite on a single-side conductive gold strip. A glassy carbon electrode, a screen-printed electrode, and a graphene-chitosan composite-modified screen-printed electrode were investigated for comparison. Scanning electron microscopy was used to characterize the surface structure of the four different electrodes and cyclic voltammetry was carried out to compare their performance. The results showed that the rGO/IL/Ghi electrode had the best performance according to its low peak potential and large peak current. Amperometdc responses of the different electrodes to PNP proved that only the rGO/IL/Chi electrode was capable of anti-passivation. The detection of cardiac troponin I was used as a test example for electrochemical immunoassay. Differential pulse voltammetry was performed to detect cardiac troponin I and obtain a calibration curve. The limit of detection was 0.05 ng/ml.展开更多
基金The project supported by National Natural Science Foundation of China under Grant No. 10575017
文摘We present a controlled secure quantum dialogue protocol using a non-maximally （pure） entangled Greenberger-Horne-Zeibinger （GHZ） states at first, and then discuss the requirements for a real quantum dialogue. We show that the authorized two users can exchange their secret messages after purifying the non-maximally entangled GHZ states quantum channel unconditionally securely and simultaneously under the control of a third party.
文摘Because of ground clutter wave interf e rence,it is difficult to measure smoke screen disturbance in the field.In this pape r,a kind of indoor measurement method of smoke screen disturbance efficiency ba sed on Gaussian diffusion model is put forward.As a characteristic,the measur ement result of smoke screen area density proves that the indoor measurement met hod of smoke screen disturbance efficiency based on Gaussian diffusion model is fea sible.
基金funding support from the National Natural Science Foundation of China(No.82174093)。
文摘Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were obtained from the Traditional Chinese Medicine Systems and Pharmacology Database and Analysis Platform(TCMSP),Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-TCM)database,and the literature.The component-target regulatory network and protein-protein interaction(PPI)network were constructed by Cytoscape 3.7.2,and a bioinformatics analysis was performed to identify the significant pathways and their relevant targets.Molecular docking of the core active components and relevant targets was performed.Results A total of 98 active components of SAD and the corresponding 113 drug targets were identified.The component-target regulatory network and PPI network were successfully established.Results of the bioinformatics analysis indicated that 2281 Gene Ontology(GO)terms were enriched in chronic cough,including 2062 terms were in biological processes,77 in cellular components,and 142 in molecular functions,and top 20 significant pathways in Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis.Molecular docking study demonstrated that quercetin,luteolin,kaempferol,and naringenin were in good agreement with the corresponding targets.Conclusion The active compounds of SAD,such as quercetin,luteolin,kaempferol,and naringenin,may act on AKT1,MAPK1,RELA,EGFR,and Bcl-2 and regulate the PI3 K-Akt signaling pathway,AGE-RAGE signaling pathway,and fluid shear stress and atherosclerosis pathway to exert the effects of anti-inflammatory,anti-airway remodeling,anti-oxidant stress effects,and repair airway damage,thus treating chronic cough.
文摘The study analysed the behaviour of titanium dioxide （TiO2） in polyethylene teraphthalate （PET） polymer coatings on ECCS steel plates. The work determined the thermal source affecting rutile distribution in the PET coating： It originated in the manufacturing processes and thermomechanical treatments of the composite, and affected PET adherence on the steel. These results were contrasted with the behaviour of a non-heated coating to determine the conditions under which the ruffle exhibits changes on the PET coating. Measurements at cross-section and parallel intervals from the surface to the metal interface were made by FTIR-ATR and Raman vibrational spectroscopy techniques to characterise the rutile distribution in the PET thickness.
文摘Objective The study aimed to synthesize and characterize pyrimidine-linked benzimidazole hybrids,define their antimicrobial and antifungal activities in vitro,and determine their ability to inhibit the main protease and spike glycoprotein of SARS-CoV-2.Methods The ability of the synthesized compounds to inhibit the main protease and spike glycoprotein inhibitory of SARS-CoV-2 was investigated by assessing their mode of binding to the allosteric site of the enzyme using molecular docking.The structures of pyrimidine-linked benzimidazole derivatives synthesized with microwave assistance were confirmed by spectral analysis.Antibacterial and antifungal activities were determined by broth dilution.Results Gram-negative bateria(Escherichia coli and Pseudomonas aeruginosa)were more sensitive than gram-positive bateria(Staphylococcus aureus and Streptococcus pyogenes)to the derivatives.Candida albicans was sensitive to the derivatives at a minimal inhibitory concentration(MIC)of 250μg/mL.The novel derivatives had better binding affinity(kcal/mol)than nelfinavir,lopinavir,ivermectin,remdesivir,and favipiravir,which are under investigation as treatment for SARS-CoV-2 infection.Compounds 2c,2e,and 2g formed four hydrogen bonds with the active cavity of the main protease.Many derivatives had good binding affinity for the RBD of the of SARS-CoV-2 spike glycoprotein with the formation of up to four hydrogen bonds.Conclusion We synthesized novel pyrimidine-linked benzi-midazole derivatives that were potent antimicrobial agents with ability to inhibit the SARS-CoV-2 spike glycoprotein.Understanding the pharmacophore features of the main protease and spike glycoprotein offers much scope for the development of more potent agents.We plan to optimize the properties of the derivatives using models in vivo and in vitro so that they will serve as more effective therapeutic options against bacterial and SARS-CoV-2 infections.
基金Supported by the National Natural Science Foundation of China under Grant Nos.61402407 and 11375152
文摘At present, the anti-noise property and the information leakage resistant property are two great concerns for quantum dialogue(QD). In this paper, two anti-noise QD protocols without information leakage are presented by using the entanglement swapping technology for two logical Bell states. One works well over a collective-dephasing noise channel, while the other takes effect over a collective-rotation noise channel. The negative influence of noise is erased by using logical Bell states as the traveling quantum states. The problem of information leakage is avoided by swapping entanglement between two logical Bell states. In addition, only Bell state measurements are used for decoding, rather than four-qubit joint measurements.
基金Project supported by the National Natural Science Foundation of China(No.31571918)
文摘p-Nitrophenylphosphate （PNPP） is usually employed as the substrate for enzyme-linked immunosorbent assays, p-Nitrophenol （PNP）, the product of PNPP, with the catalyst alkaline phosphatase （ALP）, will passivate an electrode, which limits applications in electrochemical analysis. A novel anti-passivation ink used in the preparation of a graphene/ionic liquid/chitosan composited （rGO/IL/Ghi） electrode is proposed to solve the problem. The anti-passivation electrode was fabricated by directly writing the graphene-ionic liquid-chitosan composite on a single-side conductive gold strip. A glassy carbon electrode, a screen-printed electrode, and a graphene-chitosan composite-modified screen-printed electrode were investigated for comparison. Scanning electron microscopy was used to characterize the surface structure of the four different electrodes and cyclic voltammetry was carried out to compare their performance. The results showed that the rGO/IL/Ghi electrode had the best performance according to its low peak potential and large peak current. Amperometdc responses of the different electrodes to PNP proved that only the rGO/IL/Chi electrode was capable of anti-passivation. The detection of cardiac troponin I was used as a test example for electrochemical immunoassay. Differential pulse voltammetry was performed to detect cardiac troponin I and obtain a calibration curve. The limit of detection was 0.05 ng/ml.
