Objective To study the pharmacokinetics of intravenous magnesium isoglycyrrhizinate injection in health volunteers with HPLC-UV. Methods Single doses of 2OOmg magnesium isoglycyrrhizinate were administrated to 10 heal...Objective To study the pharmacokinetics of intravenous magnesium isoglycyrrhizinate injection in health volunteers with HPLC-UV. Methods Single doses of 2OOmg magnesium isoglycyrrhizinate were administrated to 10 health volunteers by i. v. infusion. The concentrations of magnesium isoglycyrrhizinate in plasma were assayed by HPLC-UV method. The pharmacokinetic parameters of magnesium isoglycyrrhizinate injection were calculated by program 3P87. Results The main pharmacokinetic parameters of intravenous magnesium isoglycyrrhizinate were as follows： cmax （ 67. 58 ± 8. 84 ） mg/L, T1/2α （ 1.46 ± 0. 35 ） h, T1/2β （ 23. 95 ± 4. 72 ） h, Vd （ 2. 921 ± 0. 382） L, CL （0. 186 ±0. 048） L/h,k10（0. 064 ±0. 016） h^-1, AUC0-T（1015.29 ±225. 14） mg·h^-1·L^-1 ,respectively. Conclusion We have successfully used the analytical method for magnesium isoglycyrrhizinate to study its pharmacokinetical properties of health volunteers after i. v. infusion. The method is found to be simple, accurate, stable and sensitive for application in clinical pharmacokinetics study. The concentration-time plot was fitted to a two-compartment open model with first-order elimination.展开更多
On the basis of the findings of 227 surveys of Chinese fertility intentions over the years 1980-2011, this paper investigates the longitudinal changes in fertility intentions through cross-temporal meta-analysis. It i...On the basis of the findings of 227 surveys of Chinese fertility intentions over the years 1980-2011, this paper investigates the longitudinal changes in fertility intentions through cross-temporal meta-analysis. It is found that the ideal number of children for the Chinese trended downwards from 1980, but since 2000 the average number has remained basically stable at 1.6 to 1.8. In the 1980s, people＇s fertility levels were higher than their fertility intentions. With economic and educational progress in China, both fertility levels and fertility intentions showed a downward trend, with the former declining faster than the latter. Since 1990, people＇s fertility levels have been lower than their fertility intentions; that is, their actual number of children has been less than their ideal number. This provides an empirical basis for examining the changes in China＇s fertility intentions and fertility levels.展开更多
文摘Objective To study the pharmacokinetics of intravenous magnesium isoglycyrrhizinate injection in health volunteers with HPLC-UV. Methods Single doses of 2OOmg magnesium isoglycyrrhizinate were administrated to 10 health volunteers by i. v. infusion. The concentrations of magnesium isoglycyrrhizinate in plasma were assayed by HPLC-UV method. The pharmacokinetic parameters of magnesium isoglycyrrhizinate injection were calculated by program 3P87. Results The main pharmacokinetic parameters of intravenous magnesium isoglycyrrhizinate were as follows： cmax （ 67. 58 ± 8. 84 ） mg/L, T1/2α （ 1.46 ± 0. 35 ） h, T1/2β （ 23. 95 ± 4. 72 ） h, Vd （ 2. 921 ± 0. 382） L, CL （0. 186 ±0. 048） L/h,k10（0. 064 ±0. 016） h^-1, AUC0-T（1015.29 ±225. 14） mg·h^-1·L^-1 ,respectively. Conclusion We have successfully used the analytical method for magnesium isoglycyrrhizinate to study its pharmacokinetical properties of health volunteers after i. v. infusion. The method is found to be simple, accurate, stable and sensitive for application in clinical pharmacokinetics study. The concentration-time plot was fitted to a two-compartment open model with first-order elimination.
基金supported by the Social Research and Database Construction Project of CentralUniversity of Finance and Economicsthe National Social Sciences Fund(Project No.:14CRK011)
文摘On the basis of the findings of 227 surveys of Chinese fertility intentions over the years 1980-2011, this paper investigates the longitudinal changes in fertility intentions through cross-temporal meta-analysis. It is found that the ideal number of children for the Chinese trended downwards from 1980, but since 2000 the average number has remained basically stable at 1.6 to 1.8. In the 1980s, people＇s fertility levels were higher than their fertility intentions. With economic and educational progress in China, both fertility levels and fertility intentions showed a downward trend, with the former declining faster than the latter. Since 1990, people＇s fertility levels have been lower than their fertility intentions; that is, their actual number of children has been less than their ideal number. This provides an empirical basis for examining the changes in China＇s fertility intentions and fertility levels.
