About 20%-30% of genome products have been predicted as membrane proteins, which have sig-nificant biological functions. The prediction of the amount and position for the transmembrane protein helical segments (TMHs) ...About 20%-30% of genome products have been predicted as membrane proteins, which have sig-nificant biological functions. The prediction of the amount and position for the transmembrane protein helical segments (TMHs) is the hot spot in bioinformatics. In this paper, a new approach, maximum spectrum of continuous wavelet transform (MSCWT), is proposed to predict TMHs. The predictions for eight SARS-CoV membrane proteins indicate that MSCWT has the same capacity with software TMpred. Moreover, the test on a dataset of 131 structure-known proteins with 548 TMHs shows that the predic-tion accuracy of MSCWT for TMHs is 91.6% and that for membrane protein is 89.3%.展开更多
基金the National Natural Science Foundation of China (Grant Nos. 20775060 and 20335030), the TeachingResearch Award Program for Out-standing Young Teachers in Higher Education Institutions of Chinathe Key Lab of Polymer Material Science of Gansu Province, China
文摘About 20%-30% of genome products have been predicted as membrane proteins, which have sig-nificant biological functions. The prediction of the amount and position for the transmembrane protein helical segments (TMHs) is the hot spot in bioinformatics. In this paper, a new approach, maximum spectrum of continuous wavelet transform (MSCWT), is proposed to predict TMHs. The predictions for eight SARS-CoV membrane proteins indicate that MSCWT has the same capacity with software TMpred. Moreover, the test on a dataset of 131 structure-known proteins with 548 TMHs shows that the predic-tion accuracy of MSCWT for TMHs is 91.6% and that for membrane protein is 89.3%.
