目的了解食管癌患者血清维生素E水平,为食管癌的防治及病因探索提供参考依据。方法检索中国知网数据库、万方数据库、Pub Med数据库、Web of Science数据库,并辅以手工检索和文献追溯法收集1980年1月—2015年12月公开发表的关于食管癌...目的了解食管癌患者血清维生素E水平,为食管癌的防治及病因探索提供参考依据。方法检索中国知网数据库、万方数据库、Pub Med数据库、Web of Science数据库,并辅以手工检索和文献追溯法收集1980年1月—2015年12月公开发表的关于食管癌患者血清维生素E水平的相关文献;采用Stata 12.0软件对纳入的文献进行meta分析。结果最终纳入9篇文献(中文文献7篇,英文文献2篇),累计病例组患者358例,对照组人群538例;meta分析结果显示,病例组食管癌患者血清维生素E水平较对照组人群低(SMD=-0.50,95%CI=-0.65^-0.36,P<0.001);亚组分析结果显示,国家为中国(SMD=-0.50,95%CI=-0.67^-0.33)和其他国家(SMD=-0.51,95%CI=-0.77^-0.25)、对照来源于社区(SMD=-0.54,95%CI=-0.69^-0.39)、样本量>50例(SMD=-0.56,95%CI=-0.71^-0.41)、年龄匹配(SMD=-0.57,95%CI=-0.72^-0.42)、测定方法为高效液相色谱法(SMD=-0.41,95%CI=-0.59^-0.24)和其他方法(SMD=-0.67,95%CI=-0.91^-0.43)的研究中病例组食管癌患者血清维生素E水平均低于对照组人群(均P<0.001);敏感性分析和发表偏倚检验结果显示,本研究meta分析结果稳定,且不存在发表偏倚。结论食管癌患者血清维生素E水平较低。展开更多
Context: Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this...Context: Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this malignancy. Objective: To investigate whether prediagnostic fasting glucose and insulin concentrations and insulin resistance are associated with subsequent incidence of exocrine pancreatic cancer in a cohort of male smokers. Design, Setting, and Participants: A case-cohort prospective study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-1988) cohort of 29 133 male Finnish smokers ages 50 to 69 years. The study included 400 randomly sampled subcohort control participants and 169 incident pancreatic cancer cases that occurred after the fifth year of follow-up. All participants were followed up through December 2001 (up to 16.7 years of follow-up). Main Outcome Measures: Incident exocrine pancreatic cancer identified from the Finnish Cancer Registry. Results: After adjusting for age, smoking, and body mass index, higher baseline fasting serum concentrations of glucose, insulin, and insulin resistance were positively associated with pancreatic cancer. The presence of biochemically defined diabetes mellitus (glucose, ≥ 126 mg/dL ≥ 6.99 mmol/L ) and insulin concentration in the highest vs lowest quartile both showed a significant 2-fold increased risk (hazard ratio HR , 2.13; 95% confidence interval CI , 1.04-4.35; and HR, 2.01; 95% CI, 1.03-3.93; respectively). There were significant interactions for all the biomarker exposures by follow-up time, such that the positive associations were stronger among the cases that occurred more than 10 years after baseline (highest vs lowest quartile: glucose, HR, 2.16; 95% CI, 1.05-4.42; P for trend=.02; insulin, HR, 2.90; 95% CI, 1.22-6.92; P for trend=.005; and insulin resistance, HR, 2.71; 95% CI, 1.19-6.18; P for trend=.006). Conclusions: These results support the hypothesis that exposure to higher insulin concentrations and insulin resistance predicts the risk of exocrine pancreatic cancer.展开更多
文摘目的了解食管癌患者血清维生素E水平,为食管癌的防治及病因探索提供参考依据。方法检索中国知网数据库、万方数据库、Pub Med数据库、Web of Science数据库,并辅以手工检索和文献追溯法收集1980年1月—2015年12月公开发表的关于食管癌患者血清维生素E水平的相关文献;采用Stata 12.0软件对纳入的文献进行meta分析。结果最终纳入9篇文献(中文文献7篇,英文文献2篇),累计病例组患者358例,对照组人群538例;meta分析结果显示,病例组食管癌患者血清维生素E水平较对照组人群低(SMD=-0.50,95%CI=-0.65^-0.36,P<0.001);亚组分析结果显示,国家为中国(SMD=-0.50,95%CI=-0.67^-0.33)和其他国家(SMD=-0.51,95%CI=-0.77^-0.25)、对照来源于社区(SMD=-0.54,95%CI=-0.69^-0.39)、样本量>50例(SMD=-0.56,95%CI=-0.71^-0.41)、年龄匹配(SMD=-0.57,95%CI=-0.72^-0.42)、测定方法为高效液相色谱法(SMD=-0.41,95%CI=-0.59^-0.24)和其他方法(SMD=-0.67,95%CI=-0.91^-0.43)的研究中病例组食管癌患者血清维生素E水平均低于对照组人群(均P<0.001);敏感性分析和发表偏倚检验结果显示,本研究meta分析结果稳定,且不存在发表偏倚。结论食管癌患者血清维生素E水平较低。
文摘Context: Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this malignancy. Objective: To investigate whether prediagnostic fasting glucose and insulin concentrations and insulin resistance are associated with subsequent incidence of exocrine pancreatic cancer in a cohort of male smokers. Design, Setting, and Participants: A case-cohort prospective study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-1988) cohort of 29 133 male Finnish smokers ages 50 to 69 years. The study included 400 randomly sampled subcohort control participants and 169 incident pancreatic cancer cases that occurred after the fifth year of follow-up. All participants were followed up through December 2001 (up to 16.7 years of follow-up). Main Outcome Measures: Incident exocrine pancreatic cancer identified from the Finnish Cancer Registry. Results: After adjusting for age, smoking, and body mass index, higher baseline fasting serum concentrations of glucose, insulin, and insulin resistance were positively associated with pancreatic cancer. The presence of biochemically defined diabetes mellitus (glucose, ≥ 126 mg/dL ≥ 6.99 mmol/L ) and insulin concentration in the highest vs lowest quartile both showed a significant 2-fold increased risk (hazard ratio HR , 2.13; 95% confidence interval CI , 1.04-4.35; and HR, 2.01; 95% CI, 1.03-3.93; respectively). There were significant interactions for all the biomarker exposures by follow-up time, such that the positive associations were stronger among the cases that occurred more than 10 years after baseline (highest vs lowest quartile: glucose, HR, 2.16; 95% CI, 1.05-4.42; P for trend=.02; insulin, HR, 2.90; 95% CI, 1.22-6.92; P for trend=.005; and insulin resistance, HR, 2.71; 95% CI, 1.19-6.18; P for trend=.006). Conclusions: These results support the hypothesis that exposure to higher insulin concentrations and insulin resistance predicts the risk of exocrine pancreatic cancer.
