Adequate energy storage is essential for sustaining healthy life. Lipid droplet （LD） is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient cond...Adequate energy storage is essential for sustaining healthy life. Lipid droplet （LD） is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways： neutral lipid synthesis and atypical LD fusion. Shrinkage of LDs is mediated by the degradation of neutral lipids under energy demanding conditions and is controlled by neutral cytosolic lipases and lysosomal acidic lipases. In this review, we summarize recent progress regarding the regulatory pathways and molecular mechanisms that control the sizes and the energy storage capacity of LDs.展开更多
基金supported by the National Natural Science Foundation of China(31420040,31321003 to Peng Li,31501089 to Jinhai Yu)the National Basic Research Program(2013CB530602 to Peng Li)the China Postdoctoral Science Foundation(2015M581079 to Jinhai Yu)
文摘Adequate energy storage is essential for sustaining healthy life. Lipid droplet （LD） is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways： neutral lipid synthesis and atypical LD fusion. Shrinkage of LDs is mediated by the degradation of neutral lipids under energy demanding conditions and is controlled by neutral cytosolic lipases and lysosomal acidic lipases. In this review, we summarize recent progress regarding the regulatory pathways and molecular mechanisms that control the sizes and the energy storage capacity of LDs.
