Interleukin-1β（IL-1β）is one of the first cytokines ever described.It has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that...Interleukin-1β（IL-1β）is one of the first cytokines ever described.It has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness. Recently,accumulating evidence has indicated that IL-1β also adversely affects cognitive function.Nevertheless,there are also some reports showing no effects or even beneficial effects of IL-1β on learning and memory.The relationship between IL-1β and cognitive impairment has not been clearly elucidated.Here we reviewed the evidence of both negative and positive effects of IL-1β on learning and memory,and the key factors that may affect the effects of IL-1β on learning and memory were discussed.展开更多
基金supported by the grants from National Natural Science Foundation of China(No.30700213)National Basic Research Development Program of China(No.2007CB947804)
文摘Interleukin-1β（IL-1β）is one of the first cytokines ever described.It has long been recognized to play an important role in mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness. Recently,accumulating evidence has indicated that IL-1β also adversely affects cognitive function.Nevertheless,there are also some reports showing no effects or even beneficial effects of IL-1β on learning and memory.The relationship between IL-1β and cognitive impairment has not been clearly elucidated.Here we reviewed the evidence of both negative and positive effects of IL-1β on learning and memory,and the key factors that may affect the effects of IL-1β on learning and memory were discussed.
