学据:引领课堂灵动的一汪活水

循证教学倡导"经验+证据"共同引领教师的教学决策,学据是循证教学的重要内容。教师可以从课前预学单、课堂研学单以及课后反馈单三种途径获取学据,并在展示学据时灵活运用、有序展示,循序进阶;突破困惑,引智启思;思证辨析,厘清认知等教学策略。

Evidence-based Clinical Chinese Medicine:What Has Changed Over the Past 20 Years

Chinese medicine has been used for centuries to treat a range of health conditions.This history has produced a wealth of classical literature,case studies and clinical research data detailing its use and effectiveness.However,high-quality and conclusive evidence that meets modern requirements for clinical decision support is lacking.This evidence gap limits the integration of Chinese medicine with contemporary medicine,which in turn limits global access and acceptance of Chinese medicine as a form of safe and effective health care.Over the past 20 years,researchers and organisations around the world,including the World Health Organization(WHO)and United Nations,have worked to support the integration of traditional medicines,such as Chinese medicine,with conventional medicines to improve global health care.This paper provides an overview of Chinese medicine studies published in the top four general medical journals(BMJ,JAMA,Lancet and New England Journal of Medicine)from February 2005 to February 2024 in the past 20 years to highlight the progress in the development of this evidence base.It also highlights key actions taken to promote evidence-based clinical Chinese medicine,including product and practitioner regulation,formalising education standards,and international collaborations.Research conducted at the China-Australia International Research Centre for Chinese Medicine demonstrates the benefits of such a collaboration.Through development of its unique and inclusive‘whole-evidence’approach,plus clinical studies and systematic reviews,the Centre has significantly contributed to the evidence base for clinical Chinese medicine.In addition,its high-impact papers and groundbreaking monographs have been cited in international conventional medicine guidelines.While progress has certainly been made during the past 20 years to build a stronger evidence base for clinical Chinese medicine,there is still a considerable gap that limits its integration with conventional medicine.Future funding and research are needed to continue this work and achieve to safe,effective and accessible traditional medicine as part of the WHO’s Universal Health Coverage strategy.

Thermal decomposition of ammonium hexafluoroaluminate and preparation of aluminum fluoride

The thermal decomposition process of （NH4）3AlF6 was studied by DTA-TGA method and the related thermodynamic data were obtained. The results show that AlF3 is obtained after three-step decomposition reaction of （NH4）3AlF6, and the solid products of the first two decomposition reactions are NH4AlF4 and AlF3（NH4F）0.69, respectively. The three reactions occur at 194.9, 222.5 and 258.4 ℃, respectively. Gibbs free energy changes of pertinent materials at the reaction temperatures were calculated. Enthalpy and entropy changes of the three reactions were analyzed by DSC method. Anhydrous aluminum fluoride was prepared. The XRD analysis and mass loss calculation show that AlF3 with high purity can be obtained by heating （NH4）3AlF6 at 400 ℃ for 3 h.

Mechanical model for failure modes of rock and soil under compression

The failure modes of rock and soil under compression are complex phenomena that have not been explained in a mechanical perspective. However, large amounts of studies indicate that the failure modes of rock and soil samples can be categorized into eight types. In this work, the inner tensile stress and the dissipation and conversion of energy of rock and soil under compression are analyzed, then the effective conversion coefficient of energy is deduced, thus the tensile failure criterion of rock and soil under compression is established. Combined with the shear strength criterion of Mohr–Coulomb, a tensile joint shear strength criterion for rock and soil under compression is built. Therefore, a mechanical criterion model concerning the failure modes of rock and soil under compression is established and verified by tests. This model easily explains the test results in the existing literature and many natural phenomena, such as collapse.

Hardware-in-loop Simulation(HLS) of Homing Anti-tank Missile

The simulation techniques of hardware-in-loop simulation(HLS) of homing antitank missile based on the personal computer (PC) are discussed. The PC and MCS-96 chip controller employ A/D and D/A boards (with photoelectricity isolation) to transfer measur ment and control information about homing head, gyro and rudder and utilize the digital hand shaking board to build correct communication communication protocol. In order to satisfy the real-time requirement of HLS, this paper first simplifies the aerodynamic data file reasonably, then builds a PC software with C language. The program of the controller part is made with PL/M language. The simulation of HLS based on PC is done with the same sampling period of 10ms as that of YH-F1 and the experiment results are identical to those of digital simulation of the homing anti-tank guided missile.

Temporal-Spatial Variances of Holocene Precipitation at the Marginal Area of the East Asian Monsoon Influences from Pollen Evidence

The woodland-steppe ecotone in the. southern Nei Mongol Plateau is located at the northern edge of the east Asian monsoon influences. A marked southeastern - northwestern (SE - NW) precipitation gradient exists in this region. Quantitative reconstruction of palaeo-precipitation of this region is helpful to reveal the development of monsoon climate and to predict die future desertification. Based on modern vegetation and surface pollen studies, a pollen-precipitation transfer function in the study region was established. Pollen data from three sediment sequences within the ecotone were used to reconstruct palaeo-precipitation during the Holocene. The processes of precipitation changes in the three sequences were quite different. There was a tendency of precipitation declined from the onset of the Holocene to 1 100 a BP in Haoluku. But, in Liuzhouwan and Xiaoniuchang, both located south of Haoluku, the annual precipitation reached highest values during 7 800 - 6 200 a BP and 7 200 - 5 000 a BP, respectively. The influences of southwestern (SW) monsoon and the variances of topographical conditions have possibly caused these temporal-spatial variances.

IMPROVED ALGORITHM FOR CFD/CSD COUPLED SYSTEM DESIGN AND CALCULATION

The data information transfer and time marching strategies between computational fluid dynamics （CFD） and computational structural dynamics （CSD） play crucial roles on the aeroelastic analysis in a time domain. An improved CFD/CSD coupled system is designed, including an interpolation method and an improved loosely coupled algorithm. The interpolation method based on boundary element method （BEM） is developed to transfer aerodynamic loads and structural displacements between CFD and CSD grid systems, it can be universally used in fluid structural interaction solution by keeping energy conservation. The improved loosely coupled algo-rithm is designed, thus it improves the computational accuracy and efficiency. The new interface is performed on the two-dimensional （2-D） extrapolation and the aeroelastie response of AGARD445.6 wing. Results show that the improved interface has a superior accuracy.

Ontology and metadata for online learning resource repository management based on semantic web

An ontology and metadata for online learning resource repository management is constructed. First, based on the analysis of the use-case diagram, the upper ontology is illustrated which includes resource library ontology and user ontology, and evaluated from its function and implementation; then the corresponding class diagram, resource description framework （RDF） schema and extensible markup language （XML） schema are given. Secondly, the metadata for online learning resource repository management is proposed based on the Dublin Core Metadata Initiative and the IEEE Learning Technologies Standards Committee Learning Object Metadata Working Group. Finally, the inference instance is shown, which proves the validity of ontology and metadata in online learning resource repository management.

FORMAL PROOF OF RELATIVE STRENGTH OF SECURITY AMONG ECK2007 MODEL AND OTHER PROOF MODELS FOR KEY AGREEMENT PROTOCOLS

The differences among the extended Canetti ＆ Krawezyk 2007 model （ECK2007） and other four models, i.e., the Bellare ＆ Rogaway （1993, 1995）models （BR93,BR95）, the Bellare, Pointcheval ＆ Rogaway （2000） model （BPR2000） and the Canetti ＆ Krawczyk （2001） model （CK2001） are given. The relative strength of security among these models is analyzed. To support the implication or non-implication relation among these models, the formal proof or the counter-example is provided.

The Calculation of Parameters for DNA Kinetic Structure Based on Monte-Carlo Multiple Integrals

Based on protein-DNA complex crystal structural data in up-to-date Nucleic Acid Database,the related parameters of DNA Kinetic Structure were investigated by Monte-Carlo Multiple Integrals on the base of modified DNA structure statistical mechanical model,and time complexity and precision were analyzed on the calculated results.

An Efficient Approach to Rules-Based Optical Proximity Correction

A new approach for rules-based optical proximity correction is presented.The discussion addresses on how to select and construct more concise and practical rules-base as well as how to apply that rules-base.Based on those ideas,several primary rules are suggested.The v-support vector regression method is used to generate a mathematical expression according to rule data.It enables to make correction according to any given rules parameters.Experimental results demonstrate applying rules calculated from the expression match well with that from the rule table.

Design of research platform on telerobot system based on virtual reality technology

A design strategy for a research platform of a telepresence telerobot system based on virtual reality technology is put forward. The design frame of the system is described, and its important core techniques are described. An octrees data structure is utilized to build kinematic and dynamic modeling of the virtual simulation environment, Delphi+OpenGL+3DS MAX are adopted to carry through the virtual modeling and visible simulation exploitation of the slave-robot and its environment. Photo-correction is adopted to correct positioning deviation of the virtual geometric model and modeling errors. The cost of software and hardware equipment for the research platform realized is low. The master/slave robot (manipulator) system and all software in the system were designed and manufactured by our research group. The performance of the system has reached the level required for research. An indispensable experiment base is provided for the research of a telepresence telerobot system based on virtual reality technology.

Equilibrium and kinetic data of adsorption and separation for zirconium and hafnium onto MIBK extraction resin

The equilibrium and kinetics of methyl isobutyl ketone(MIBK) extraction resin for adsorption and separation of zirconium and hafnium were studied under the different conditions of acidity,initial total concentrations of zirconium and hafnium and temperature.The equilibrium data of both zirconium and hafnium are found to follow the Freundlich adsorption isotherm,and the Freundlich isotherm constants(KF) are 3.53 and 0.64 mg/g,respectively.The equilibrium data of zirconium also fit the Langmuir adsorption isotherm,and the saturation adsorption capacity(Qmax) and the Langmuir isotherm constant(KL)are 75.93 mg/g and-0.012 7 L/g,respectively.The obtained kinetic data of both zirconium and hafnium are found to fit the HO pseudo-second-order kinetic model,and the rate constants of pseudo-second-order equation(k2) are-0.019 and 0.41 g/(mg·min),respectively.Column tests show that the MIBK extraction resin could be used as efficient adsorbent material for separating hafnium from zirconium.

Review of salt consumption and stomach cancer risk:Epidemiological and biological evidence

Stomach cancer is still the fourth most common cancer;thus,it remains an important public health burden worldwide,especially in developing countries.The remarkable geographic variations in the rates of stomach cancer indicate that dietary factors,including a range of food groups to which salt and/or nitrates have been added,may affect stomach cancer risk.In this paper,we review the results from ecologic,case-control and cohort studies on the relationship between salt or salted foods and stomach cancer risk.The majority of ecological studies indicated that the average salt intake in each population was closely correlated with gastric cancer mortality.Most case-control studies showed similar results,indicating a moderate to high increase in risk for the highest level of salt or salted food consumption.The overall results from cohort studies are not totally consistent,but are suggestive of a moderate direct association.Since salt intake has been correlated with Helicobacter pylori(H pylori) infection,it is possible that these two factors may synergize to promote the development of stomach cancer.Additionally,salt may also cause stomach cancer through directly damaging gastric mucus,improving temporary epithelial proliferation and the incidence of endogenous mutations,and inducing hypergastrinemia that leads to eventual parietal cell loss and progression to gastric cancer.Based on the considerable evidence from ecological,case-control and cohort studies worldwide and the mechanistic plausibility,limitation on salt and salted food consumption is a practical strategy for preventing gastric cancer.

Covariation between personalities and individual differences in coping with stress:Converging evidence and hypotheses

In the past decade there has been a profusion of studies highlighting covariation between individual differences in stress physiology and behavioural profiles, here called personalities. Such individual differences in ways of coping with stress are relevant both in biomedicine, since different personalities may experience a different stress and disease vulnerability, and in behavioural ecology, since their adaptive value and evolutionary maintenance are the subject of debate. However, the precise way in which individual stress differences and personalities are linked is unclear. Here we provide an updated overview of this covariation across different species and taxa, consider its functional significance and present working hypotheses for how behavioural and physiological responses to stress might be causally linked, affecting life-history traits such as dispersal and life-span [Current Zoology 56 （6）： 728-740, 2010].

Big Data for Precision Medicine

This article focuses on the potential impact of big data analysis to improve health, prevent and detect disease at an earlier stage, and personalize interventions. The role that big data analytics may have in interrogating the patient electronic health record toward improved clinical decision support is discussed. Weexamine developments in pharmacogenetics that have increased our appreciation of the reasons why patients respond differently to chemotherapy. We also assess the expansion of online health communications and the way in which this data may be capitalized on in order to detect public health threats and control or contain epidemics. Finally, we describe how a new generation of wearable and implantable body sensors may improve wellbeing, streamline management of chronic diseases, and improve the quality of surgical implants.

Is changing footstrike pattern beneficial to runners?

Some researchers, running instructors, and coaches have suggested that the "optimal" footstrike pattern to improve performance and reduce running injuries is to land using a mid-or forefoot strike. Thus, it has been recommended that runners who use a rearfoot strike would benefit by changing their footstrike although there is little scientific evidence for suggesting such a change. The rearfoot strike is clearly more prevalent. The major reasons often given for changing to a mid-or forefoot strike are(1) it is more economical;(2) there is a reduction in the impact peak and loading rate of the vertical component of the ground reaction force; and(3) there is a reduction in the risk of a running-related injuries. In this paper,we critique these 3 suggestions and provide alternate explanations that may provide contradictory evidence for altering one's footstrike pattern.We have concluded, based on examining the research literature, that changing to a mid-or forefoot strike does not improve running economy, does not eliminate an impact at the foot-ground contact, and does not reduce the risk of running-related injuries.

Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease

Misconceptions are common in the care of patients with inflammatory bowel disease(IBD).In this paper,we state the most commonly found misconceptions in clinical practice and deal with the use of 5-aminosalicylates and thiopurines,to review the related scientificevidence,and make appropriate recommendations.Prevention of errors needs knowledge to avoid making such errors through ignorance.However,the amount of knowledge is increasing so quickly that one new danger is an overabundance of information.IBD is a model of a very complex disease and our goal with this review is to summarize the key evidence for the most common daily clinical problems.With regard to the use of 5-aminosalicylates,the best practice may to be consider abandoning the use of these drugs in patients withsmall bowel Crohn's disease.The combined approach with oral plus topical 5-aminosalicylates should be the first-line therapy in patients with active ulcerative colitis;once-daily treatment should be offered as a first choice regimen due to its better compliance and higher efficacy.With regard to thiopurines,they seem to be as effective in ulcerative colitis as in Crohn's disease.Underdosing of thiopurines is a form of undertreatment.Thiopurines should probably be continued indefinitely because their withdrawal is associated with a high risk of relapse.Mercaptopurine is a safe alternative in patients with digestive intolerance or hepatotoxicity due to azathioprine.Finally,thiopurine methyltransferase(TPMT)screening cannot substitute for regular monitoring because the majority of cases of myelotoxicity are not TPMT-related.

Improvement of Laih and Yen＇s multisignature scheme

A new attack is proposed to show that a specified group of verifiers can cooperate to forge the signature for any message by secret key substitution due to the leaked secret key or by the group public key adjustment because of the renewed members. This paper presents the improvement scheme which overcomes the security weakness of Laih and Yen's scheme.

Calculation and Verification for the Thermodynamic Data of 3CaO·3Al_2O_3·CaSO_4

Calcium sulfoaluminate,3CaO·3Al2O3·CaSO4,has been widely recognized in the realms of high-temperature combustion and cement chemistry.However,the lack of relevant thermodynamic data limits the progress of its research and development.Through comparative calculations using several different approaches,we obtain the thermochemical properties of 3CaO·3Al2O3·CaSO4 in this work,such as its standard formation enthalpy,Gibbs free en- ergy of formation,entropy,and molar heat capacity.With these fundamental data,thermodynamic calculations become possible for reactions involving this mineral.It is found that some reactions proposed in literature to generate this mineral may not proceed thermodynamically.