细读《文心雕龙·铭箴》篇

《文心雕龙》首《原道》篇、终《程器》篇,此仿《周易》道器形上形下之理,故《文心雕龙》当本源于易学易理。《文心雕龙》《序志》篇不曰"自序",必用"志"字,即"入道见志"、"述道言治"之书也,故《文心雕龙》必内涵子家胸怀,亦必据"子学"为评人论文之说。以上二者,汇为文术文论,皆印证于"选文"与"选例"之品评,必经由"细读"始得其本义,爰述此文。

Partial Physiologic Differences between High-fat Diet Induced Obesity-prone and Obesity-resistant Rats

Objective: To observe the differences of partial physiologic indexes including weight, food intake, Lee's index, the wet weight of fat pad, plasma lipids and the genetic expression of LPL mRNA in adipose tissue between obesity-prone rats (OP) and obesity-resistant rats (OR) on a high-fat diet. Methods: After 1 week of free access to a high-fat diet (HFD), 48 rats were separated on the basis of 1 week body weight percentage gained in OP (OP≥P75) or OR (OR≤P25) groups. Rats were continuously fed on the HFD for another 4 weeks. The body weight and food intake were recorded in the course of model-making. And the Lee's index, the plasma lipid and lipoproteins, the wet weight of both epididymal and retroperitoneal fat pad were measured after the rat was killed. And the level of LPL mRNA expression in adipose tissue was detected by Northern Blot technique. Results: ① In OP rats, the speed of body weight gain, the cumulative energy intake, the Lee's index, and the wet weight of fat pad at both epididymal and retroperitoneal sites were significantly higher than those in OR rats, but there was no significant difference in the level of plasma lipid and lipoproteins between these two groups. ② After 1 week and 5 weeks on the high-fat diet, the gain of body weight in OP rats were about 6.45 and 4.25 times of those in OR rats. Meanwhile, the cumulative energy intake in OP rats was only about 1.13 and 1.15 times of those in OR rats. ③ Despite the depressive effect of the high-fat diet on the level of LPL mRNA expression in adipose tissue, there was a significant level of LPL mRNA in adipose tissue of OP rats compared with that in OR rats. Conclusion: The physiologic differences exist between OP and OR rats. Besides a higher level of energy intake, the higher energy efficiency associated with LPL mRNA expression in adipose tissue may also contribute to the enhancement of susceptibility to obesity in OP rats.

CARPAL TUNNEL SYNDROME：ETIOLOGICAL，CLINICAL AND ELECTROPHYSIOLOGICAL ASPECTS OF 262 CASES

Two hundred and sixty-two patients with carpal tunnel syndrome (CTS) were analyzed retrospectively. Results showed that middle-and older-age women were more apt to have CTS than men, and that the dominant hand was more frequently affected. Hormonal changes , repetitive and forceful movements, awkward positions of hand and wrist, and other factors may be associated with CTS. Typical clinical manifestations include pain and paresthesia in the median nerve territory, worsening at night or in the early morning , and being relieved by shaking the hand. Although the patients may localize the discomfort beyond the territory, sensory changes are variable and not entirely reliable. Conduction abnormalities often appeared selectively in the median nerve distal to the wrist in CTS. If the patient who is clinically suggestive of CTS shows normal conduction with conventional methods, palmar stimulation and inching technique is recommended. The diagnosis of CTS requires confirmation of illness history, symptoms and signs with objective electrodiagnostic tests.

Physico-mechanical performance of debris-flow deposits with particular reference to characterization and recognition of debris flow-related sediments

To characterize and recognize the debris flow-related deposits,the physico-mechanical performance of four deposits from the Dongyuege(DYG),Shawa(SW),Jiangjia Gully(JJG),and Gengdi(GD)debris flows in southwest China is investigated through laboratory analyses and tests.The four debris-flow materials can all be remolded into coherent,homogeneous cylinders with high densification and strength–porosity of 25%-36%,mean pore-throat radius of 0.46-5.89μm,median pore-throat radius of 0.43-4.28μm,P-wave velocity of 800-1200 m/s,modulus of elasticity of 28-103 MPa,unconfined compressive strength(UCS)of 220-760 kPa,and cohesion of 65-281 kPa.Based on the comparison in slurryability and formability among debris-flow deposits,granular flow deposits,fluvial deposits,residual lateritic clay and loess,whether a sediment can be cast into competent cylinders for physico-mechanical tests can be regarded as a diagnostic evidence of old debris-flow deposits.The discrepancy in physico-mechanical properties among the four debris-flow deposits suggests that the combination of foregoing physico-mechanical parameters can characterize assembling characteristics of debris flow-related sediments including grain size distribution,mineralogy,and accidental detritus.Four deposited sediments above can be surprisingly classified as hard soil-soft rocks according to UCS,and the hard soil-soft rock behaviors can advance the further understanding of debris flows.

A Discussion on Dealing With Chinese Transfer in English Teaching

Native language transfer is a common phenomenon in foreign language learning and is all the time influencing the learners＇ language. As to us English teachers in China, how to use or avoid the Chinese transfer in students＇ English learning is an issue we need to further explore. The paper, based on the theory of SLA （second language acquisition） and language transfer, discusses this phenomenon, analyzes the factors that cause the transfer, and puts forward some suggestions to deal with the influence of transfer in teaching English as a foreign language Contrastive analysis, with examples, is employed to find the similarities and difficulties in students＇ learning Some of the difficulties can be predicted and positive transfer indeed plays a positive role in language acquisition.

Experimental and Theoretical Study on Pyrolysis of Isopsoralen

The pyrolysis of isopsoralen was studied by synchrotron vacuum ultraviolet photoionization mass spectrometry at low pressure. The pyrolysis products were detected at different photon energies, the ratios of products to precursor were measured at various pyrolysis temperatures. The experimental results demonstrate that the main pyrolysis products are primary CO and sequential CO elimination products （C10H602 and C9H60）. The decomposition channels of isopsoralen were also studied by the density functional theory, then rate constants for competing pathways were calculated by the transition state theory. The dominant decom- position channels of isopsoralen and the molecular structures for corresponding products were identified by combined experimental and theoretical studies.

Nerve growth factor and diarrhea-predominant irritable bowel syndrome(IBS-D):a potential therapeutic target?

Irritable bowel syndrome （IBS） is a common functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort associated with abnormal bowel habits. Diarrhea-predominant IBS （IBS-D） is a major subtype of IBS, the predominant manifestations of which are abdominal pain and diarrhea. The pathogenesis of IBS-D remained unknown until recently. The effects of psychosocial stress, central hypervigilance, neuroendocrine abnor- mality, disturbed gastrointestinal motility, mucosal immune activation, intestinal barrier dysfunction, visceral hyper- sensitivity （VH）, altered gut flora, and genetic susceptibility may be involved in its development. Recently, increased attention has been placed on the neural-immune-endocrine network mechanism in IBS-D, especially the role of var- ious neuroendocrine mediators. As a member of the neurotrophin family, nerve growth factor （NGF） has diverse bio- logical effects, and participates in the pathogenesis of many diseases. Basic studies have demonstrated that NGF is associated with inflammatory- and stress-related VH, as well as stress-related intestinal barrier dysfunction. The aim of this study is to summarize recent literature and discuss the role of NGF in the pathophysiology of IBS-D, especially in VH and intestinal barrier dysfunction, as well as its potential as a therapeutic target in IBS-D.

Industrial structure optimization in central China under the energy constraint

Optimizing industrial structure is an important research object of human-economic geography, and it is also the object of government departments to strengthen macro-control. This has become even greater problem that China has entered the "new normal" in recent years. The study uses a multi-regional input-output model, with linear programming to build an optimal model of industrial structure as well as a model of optimization degree under the energy constraint. The results of the study revealed that:(1) the degree of optimization of industrial structure in Anhui Province is optimal(0.763), while that of Shanxi Province is the lowest(0.662);(2) the degree of optimization of industrial structure is negatively related to energy consumption per unit output value and the proportion of heavy industry; and(3) overall, central China should maintain or moderately increase the proportions of resource-based industry, greatly increase the proportions of manufacturing, including transport and telecommunications equipment, computers and other electronic equipment, and moderately reduce the proportions of smelting and pressing of metals and non-metal mineral products. In terms of service industries, the region should greatly increase the proportions of the production and supply of natural gas and tap water, moderately reduce or maintain the proportions of transport and storage as well as tourism, and maintain or moderately reduce the proportions of wholesale trade, retail trade and catering services.