To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer. Methods Maspin and kai1 expressions were detected in normal gastric mucosa (n = 182), gastric dysplasia (n = 6...To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer. Methods Maspin and kai1 expressions were detected in normal gastric mucosa (n = 182), gastric dysplasia (n = 69), and gastric cancer (n = 113) by immunohisto-chemistry. Their expressions were compared with clinicopathological parameters of tumors. Relationship between maspin and kai1 expression was also concerned in gastric cancer. Results The positive rates of maspin expression were 79.8% (145/182), 75.4% (52/69), and 50.4% (57/113) in normal gastric mucosa, gastric dysplasia, and gastric cancer, while those of kai1 expression were 81.9% (149/182), 65.2% (49/69), and 58.4% (66/113) in corresponding tissues respectively. Gastric cancer less frequently expressed maspin than the normal gastric mucosa and gastric dysplasia (P < 0.05), while dysplasia and cancer showed less frequent expression of kai1 than normal mucosa (P < 0.05). Maspin expression showed negative association with invasive depth, metastasis, Lauren’s and histological classifications (P < 0.05), but not with tumor size, Borrmann’s classification, growth pattern or TNM staging (P > 0.05). Kai1 expression was negatively correlated with invasive depth, metastasis, growth pattern, Lauren’s and histo-logical classifications (P < 0.05), but not with tumor size, Borrmann’s classification or TNM staging (P > 0.05). Maspin and kai1 were collaboratively expressed in gastric cancer (P < 0.05). Conclusions Down-regulated expressions of maspin and kai1 play an important role in gastric carcinogenesis. Abnormal expression of maspin and kai1 might have inhibitory effects on invasion and metastasis of gastric cancer and act as an effe-ctive and objective marker to indicate the pathobiological behaviors of gastric cancer.展开更多
AIM: To determine the most cost-effective hemofiltration modality for early management of severe acute pancreatitis (SAP) in China. METHODS: We carried out a search of Pub-Medline and Chinese Biomedical Disk datab...AIM: To determine the most cost-effective hemofiltration modality for early management of severe acute pancreatitis (SAP) in China. METHODS: We carried out a search of Pub-Medline and Chinese Biomedical Disk database. Controlled clinical trials on Chinese population were included in the analysis. The four decision branches that were analyzed were: continuous or long-term veno-venous hemofiltration (CVVH/LVVH), short-term veno-venous hemofiltration (SVVH), SVVH plus peritoneal dialysis (PD), and non-hemofiltration control group. The effectiveness of the technique was determined by survival rate, complications prevention and surgery preservation. The total cost of hospitalization was also assessed. RESULTS: The SVVH only technique was the least costly modality, $5809 (44449 RMB), and was selected as the baseline treatment modality. SVVH only arm achieved the lowest C/E ratio in terms of overall survival, complications prevention and surgery preservation. In incremental cost-effectiveness analysis, the CWH/ LVVH only and the control arms were inferior to other techniques. Sensitivity analysis showed SVVH only and SVVH plus PD arms overlapped in C/survival ratio. CONCLUSION: The role of early veno-venous hemofiltration as an alternative therapy for SAP remains controversial. However, we propose that early use of short-term high-volume veno-venous hemofiltration would have a beneficial impact on the management of SAP.展开更多
Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning...Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning curves is increasing, due to increasing complexity of innovative surgical procedures, the rapid rate at which new interventions are implemented and a decrease in relative effectiveness of new interventions compared to old interventions. For minimally invasive esophagectomy(MIE), there is now robust evidence that implementation can lead to significant learning associated morbidity(morbidity during a learning curve, that could have been avoided if patients were operated by surgeons that have completed the learning curve). This article provides an overview of the evidence of the impact of learning curves after implementation of MIE. In addition, caveats for implementation and available evidence regarding factors that are important for safe implementation and safe pioneering of MIE are discussed.展开更多
AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated wi...AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease. However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type VI collagen 7S domain and hyaluronic acid. METHODS: One hundred and twelve patients with histologically proven NAFLD were studied. RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type VI collagen 75 domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type VI collagen 7S domain, 86% and hyaluronic acid, 92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type VI collagen 7S domain (≥5.0 ng/mL), 84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis. CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis.展开更多
The validity measurement of fuzzy clustering is a key problem. If clustering is formed, it needs a kind of machine to verify its validity. To make mining more accountable, comprehensible and with a usable spatial patt...The validity measurement of fuzzy clustering is a key problem. If clustering is formed, it needs a kind of machine to verify its validity. To make mining more accountable, comprehensible and with a usable spatial pattern, it is necessary to first detect whether the data set has a clustered structure or not before clustering. This paper discusses a detection method for clustered patterns and a fuzzy clustering algorithm, and studies the validity function of the result produced by fuzzy clustering based on two aspects, which reflect the un-certainty of classification during fuzzy partition and spatial location features of spatial data, and proposes a new validity function of fuzzy clustering for spatial data. The experimental result indicates that the new validity function can accurately measure the validity of the results of fuzzy clustering. Especially, for the result of fuzzy clustering of spatial data, it is robust and its classification result is better when compared to other indices.展开更多
We revisit the protocols to create maximally entangled states between two Josephson junction (33) charge phase qubits coupled to a microwave field in a cavity as a quantum data bus. We analyze a novel mechanism of q...We revisit the protocols to create maximally entangled states between two Josephson junction (33) charge phase qubits coupled to a microwave field in a cavity as a quantum data bus. We analyze a novel mechanism of quantum decoherence due to the adiabatic entanglement between qubits and the data bus, the off-resonance microwave field. We show that even if the variable of the data bus can be adiabatically eliminated, the entanglement between the qubits and data bus remains and can decohere the superposition of two-particle state. Fortunately we can construct a decoherencefree subspace of two-dimension to against this adiabatic decoherence. To carry out the analytic study for this decoherence problem, we develop Frohlich transformation to re-derive the effective Hamiltonian of these systems, which is equivalent to that obtained from the adiabatic elimination approach.展开更多
The interview is an important segment and a usual means of choosing staffs, and the interview's quality directly influences the result of recruitment. This composition has posed and analyzed eight psychology errors, ...The interview is an important segment and a usual means of choosing staffs, and the interview's quality directly influences the result of recruitment. This composition has posed and analyzed eight psychology errors, including first-sight effect, halo effect, casting effect, order effect, contrast effect, convergence effect, induce effect and fatigue effect. The interviewers should try their best to avoid them and ensure the interview's quality,展开更多
Hail is one of the important weather disasters that affects the Beijing-Tianjin(BT) region.To better understand and to improve the forecasting of hail events over the BT region,the precursor weather conditions for hai...Hail is one of the important weather disasters that affects the Beijing-Tianjin(BT) region.To better understand and to improve the forecasting of hail events over the BT region,the precursor weather conditions for hail based on 30 previous hail events were derived.It was found that the high-level trough and low-level cold front over the Mongolian region,the accumulated convective available potential energy,the decrease of the height of the 0℃-isotherm in the morning,and the persistence and intensification of these factors from morning to afternoon are valuable clues for forecasting the occurrence of hail events over the BT region.展开更多
Task-based teaching approach is a new teaching method which absorbs the achievements of modem language teaching theories. It is supposed to be an effective method in promoting learners' language competence. However, ...Task-based teaching approach is a new teaching method which absorbs the achievements of modem language teaching theories. It is supposed to be an effective method in promoting learners' language competence. However, empirical studies of its application are rarely found in the field of grammar teaching. This paper tries to integrate task-based teaching approach into grammar teaching in order to probe into its validity and feasibility in grammar teaching.展开更多
Using the effective-field theory we studied the magnetic properties of a spin-1/2 Ising supedattice, which consist of three different ferromagnet materials. The magnetic behavior of this superlattice is examined. The ...Using the effective-field theory we studied the magnetic properties of a spin-1/2 Ising supedattice, which consist of three different ferromagnet materials. The magnetic behavior of this superlattice is examined. The critical temperature and the compensation temprature of the system are studied as a function of the exchange interactions between the nearest-neiboring spins across the interface and in the intraface. Temperature dependence of magenetizations is also given.展开更多
Research on learning difficulties in mathematics adopts one of two distinct perspectives. According to the first, learning difficulties are due to the intrinsic characteristics of the student. For supporters of the se...Research on learning difficulties in mathematics adopts one of two distinct perspectives. According to the first, learning difficulties are due to the intrinsic characteristics of the student. For supporters of the second perspective, those difficulties result from the interaction between the student and the school system. The objective of this study is to test the validity of these two perspectives in interpreting learning difficulties in mathematics among at-risk students. To this end, we collaborated with normally achieving (undiagnosed) and at-risk students. Results show that the second perspective is better suited to the interpretation of learning difficulties in mathematics students展开更多
文摘To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer. Methods Maspin and kai1 expressions were detected in normal gastric mucosa (n = 182), gastric dysplasia (n = 69), and gastric cancer (n = 113) by immunohisto-chemistry. Their expressions were compared with clinicopathological parameters of tumors. Relationship between maspin and kai1 expression was also concerned in gastric cancer. Results The positive rates of maspin expression were 79.8% (145/182), 75.4% (52/69), and 50.4% (57/113) in normal gastric mucosa, gastric dysplasia, and gastric cancer, while those of kai1 expression were 81.9% (149/182), 65.2% (49/69), and 58.4% (66/113) in corresponding tissues respectively. Gastric cancer less frequently expressed maspin than the normal gastric mucosa and gastric dysplasia (P < 0.05), while dysplasia and cancer showed less frequent expression of kai1 than normal mucosa (P < 0.05). Maspin expression showed negative association with invasive depth, metastasis, Lauren’s and histological classifications (P < 0.05), but not with tumor size, Borrmann’s classification, growth pattern or TNM staging (P > 0.05). Kai1 expression was negatively correlated with invasive depth, metastasis, growth pattern, Lauren’s and histo-logical classifications (P < 0.05), but not with tumor size, Borrmann’s classification or TNM staging (P > 0.05). Maspin and kai1 were collaboratively expressed in gastric cancer (P < 0.05). Conclusions Down-regulated expressions of maspin and kai1 play an important role in gastric carcinogenesis. Abnormal expression of maspin and kai1 might have inhibitory effects on invasion and metastasis of gastric cancer and act as an effe-ctive and objective marker to indicate the pathobiological behaviors of gastric cancer.
基金Supported by The National Natural Science Foundation of China, No.30500684 and Clinical Research Foundation for Residency Granted by the Cooperative Project of West China Hospital and Daiichi Pharmaceutical Co. Ltd., the level Ⅰ
文摘AIM: To determine the most cost-effective hemofiltration modality for early management of severe acute pancreatitis (SAP) in China. METHODS: We carried out a search of Pub-Medline and Chinese Biomedical Disk database. Controlled clinical trials on Chinese population were included in the analysis. The four decision branches that were analyzed were: continuous or long-term veno-venous hemofiltration (CVVH/LVVH), short-term veno-venous hemofiltration (SVVH), SVVH plus peritoneal dialysis (PD), and non-hemofiltration control group. The effectiveness of the technique was determined by survival rate, complications prevention and surgery preservation. The total cost of hospitalization was also assessed. RESULTS: The SVVH only technique was the least costly modality, $5809 (44449 RMB), and was selected as the baseline treatment modality. SVVH only arm achieved the lowest C/E ratio in terms of overall survival, complications prevention and surgery preservation. In incremental cost-effectiveness analysis, the CWH/ LVVH only and the control arms were inferior to other techniques. Sensitivity analysis showed SVVH only and SVVH plus PD arms overlapped in C/survival ratio. CONCLUSION: The role of early veno-venous hemofiltration as an alternative therapy for SAP remains controversial. However, we propose that early use of short-term high-volume veno-venous hemofiltration would have a beneficial impact on the management of SAP.
文摘Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning curves is increasing, due to increasing complexity of innovative surgical procedures, the rapid rate at which new interventions are implemented and a decrease in relative effectiveness of new interventions compared to old interventions. For minimally invasive esophagectomy(MIE), there is now robust evidence that implementation can lead to significant learning associated morbidity(morbidity during a learning curve, that could have been avoided if patients were operated by surgeons that have completed the learning curve). This article provides an overview of the evidence of the impact of learning curves after implementation of MIE. In addition, caveats for implementation and available evidence regarding factors that are important for safe implementation and safe pioneering of MIE are discussed.
文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease. However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type VI collagen 7S domain and hyaluronic acid. METHODS: One hundred and twelve patients with histologically proven NAFLD were studied. RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type VI collagen 75 domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type VI collagen 7S domain, 86% and hyaluronic acid, 92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type VI collagen 7S domain (≥5.0 ng/mL), 84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis. CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis.
文摘The validity measurement of fuzzy clustering is a key problem. If clustering is formed, it needs a kind of machine to verify its validity. To make mining more accountable, comprehensible and with a usable spatial pattern, it is necessary to first detect whether the data set has a clustered structure or not before clustering. This paper discusses a detection method for clustered patterns and a fuzzy clustering algorithm, and studies the validity function of the result produced by fuzzy clustering based on two aspects, which reflect the un-certainty of classification during fuzzy partition and spatial location features of spatial data, and proposes a new validity function of fuzzy clustering for spatial data. The experimental result indicates that the new validity function can accurately measure the validity of the results of fuzzy clustering. Especially, for the result of fuzzy clustering of spatial data, it is robust and its classification result is better when compared to other indices.
基金The project partially supported by National Natural Science Foundation of China under Grant Nos. 90203018 and 10347147, the Knowledge Innovation Program (KIP) of the Chinese Academy of Sciences, the National Fundamental Research Program of China under Grant No. 001GB309310, K.C. Wong Education Foundation, Hong Kong, and China Postdoctoral Science Foundation
文摘We revisit the protocols to create maximally entangled states between two Josephson junction (33) charge phase qubits coupled to a microwave field in a cavity as a quantum data bus. We analyze a novel mechanism of quantum decoherence due to the adiabatic entanglement between qubits and the data bus, the off-resonance microwave field. We show that even if the variable of the data bus can be adiabatically eliminated, the entanglement between the qubits and data bus remains and can decohere the superposition of two-particle state. Fortunately we can construct a decoherencefree subspace of two-dimension to against this adiabatic decoherence. To carry out the analytic study for this decoherence problem, we develop Frohlich transformation to re-derive the effective Hamiltonian of these systems, which is equivalent to that obtained from the adiabatic elimination approach.
文摘The interview is an important segment and a usual means of choosing staffs, and the interview's quality directly influences the result of recruitment. This composition has posed and analyzed eight psychology errors, including first-sight effect, halo effect, casting effect, order effect, contrast effect, convergence effect, induce effect and fatigue effect. The interviewers should try their best to avoid them and ensure the interview's quality,
基金supported by the Scientific Research Foundation for Returned Scholars of the State Personnel Ministry of China,the Research Foundation of Institute of Urban Meteorology, CMA (Grant No. UMRF 200809)the R&D Special Fund for Public Welfare Industry (Meteorology) (Grant No. GYHY200906003)the National Basic Research Program of China (Grant No. 2009CB421406)
文摘Hail is one of the important weather disasters that affects the Beijing-Tianjin(BT) region.To better understand and to improve the forecasting of hail events over the BT region,the precursor weather conditions for hail based on 30 previous hail events were derived.It was found that the high-level trough and low-level cold front over the Mongolian region,the accumulated convective available potential energy,the decrease of the height of the 0℃-isotherm in the morning,and the persistence and intensification of these factors from morning to afternoon are valuable clues for forecasting the occurrence of hail events over the BT region.
文摘Task-based teaching approach is a new teaching method which absorbs the achievements of modem language teaching theories. It is supposed to be an effective method in promoting learners' language competence. However, empirical studies of its application are rarely found in the field of grammar teaching. This paper tries to integrate task-based teaching approach into grammar teaching in order to probe into its validity and feasibility in grammar teaching.
基金The project supported by Shanghai Leading Academic Discipline Project under Grant No. T0104
文摘Using the effective-field theory we studied the magnetic properties of a spin-1/2 Ising supedattice, which consist of three different ferromagnet materials. The magnetic behavior of this superlattice is examined. The critical temperature and the compensation temprature of the system are studied as a function of the exchange interactions between the nearest-neiboring spins across the interface and in the intraface. Temperature dependence of magenetizations is also given.
文摘Research on learning difficulties in mathematics adopts one of two distinct perspectives. According to the first, learning difficulties are due to the intrinsic characteristics of the student. For supporters of the second perspective, those difficulties result from the interaction between the student and the school system. The objective of this study is to test the validity of these two perspectives in interpreting learning difficulties in mathematics among at-risk students. To this end, we collaborated with normally achieving (undiagnosed) and at-risk students. Results show that the second perspective is better suited to the interpretation of learning difficulties in mathematics students