Objective To investigate the expression of PTEN and Caspase-3 in malignant lymphoma of the stomach and explore their role in progression of primary gastric malignant lymphoma. Methods Formalin-fixed paraffin embedded ...Objective To investigate the expression of PTEN and Caspase-3 in malignant lymphoma of the stomach and explore their role in progression of primary gastric malignant lymphoma. Methods Formalin-fixed paraffin embedded tissues from 56 cases of primary gastric malignant lymphoma and their adjacent non-tumor mucosa were evaluated for PTEN and Caspase-3 protein ex-pression by streptavidin-biotin-complex (SABC) immunohistochemistry. Their expression was compared with clinical tumor parameters with the relationship between PTEN and Caspase-3 expression concerned as well. Results The positive rate of PTEN expression in primary gastric lymphomas(50.0%, 28/56) was significantly lower than that in adjacent non-tumor gastric mucosa(96.4%, 27/28)(P < 0.05). Meanwhile,43 of 56(76.8%)gastric lymphomas indicated Caspase-3 expression, less than that in adjacent non-tumor mucosa (93.5%, 29/31) (P < 0.05). The expression of PTEN was negatively correlated with invasion and lymph node metastasis of gastric lymphoma(P < 0.05), while the Caspase-3 expression was negatively associated with the latter one(P < 0.05). Additionally, the PTEN expression was posi-tively correlated with Caspase-3 expression in the primary gastric malignant lymphoma(P < 0.05). Conclusions The down-regulated expression of PTEN and Caspase-3 played an important role in progression of primary malignant gastric lymphoma. PTEN, as a molecular marker of pathobiological behaviors of tumor, contributes to tumor progression by increasing cell mobility and angiogenesis, as well as decreasing cell adhesion and apoptosis.展开更多
The ＂Pictorial＂ or ＂Iconic Turn＂ is a central issue in the contemporary theory of images and visual cultural studies. Should the theories concerning the ＂Iconic Turn＂ and formulated in the last 20 years by schol...The ＂Pictorial＂ or ＂Iconic Turn＂ is a central issue in the contemporary theory of images and visual cultural studies. Should the theories concerning the ＂Iconic Turn＂ and formulated in the last 20 years by scholars such as Gottfried Boehm, William Mitchell, Hans Belting be taken as critical theories of crisis？ Is the currently experienced ＂turn towards images＂ （and their progressive rehabilitation after a long standing philosophical and theological rejection） a sign and symptom of some crisis of people＇s relation with images, language and, generally speaking, with the representation forms of reality？ The main hypothesis of this essay envisages two sets of problems： first, the analysis of the relation between the possible idea of turning point and the concept of crisis; secondly, the thorough investigation of the relation connecting the iconic turn to the project of ＂critical iconology＂ or ＂critique of visual culture,＂ as outlined by Hans Belting and William Mitchell. From the interpretation of the ＂Iconic Turn＂ as situation of crisis and aesthetic, anthropological, and epistemological transformation follows the need for the sciences of image to provide a ＂critical iconology＂ in order to be able to theoretically reformulate the ideological and political presuppositions of some dominant contemporary forms of visual representation.展开更多
This paper provides an overview of positive psychology(PP),or the study of elements that make life most worth living(Peterson,2006),and demonstrates its efficacy by detailing five intervention studies.By aligning PP o...This paper provides an overview of positive psychology(PP),or the study of elements that make life most worth living(Peterson,2006),and demonstrates its efficacy by detailing five intervention studies.By aligning PP objectives and linguistic aims in second language teaching and learning,the studies show multiplied,concurrent results,heightened teacher and learner wellbeing and improved language proficiency.One important caveat is that PP interventions work best when they cater specifically to individual learners.展开更多
文摘Objective To investigate the expression of PTEN and Caspase-3 in malignant lymphoma of the stomach and explore their role in progression of primary gastric malignant lymphoma. Methods Formalin-fixed paraffin embedded tissues from 56 cases of primary gastric malignant lymphoma and their adjacent non-tumor mucosa were evaluated for PTEN and Caspase-3 protein ex-pression by streptavidin-biotin-complex (SABC) immunohistochemistry. Their expression was compared with clinical tumor parameters with the relationship between PTEN and Caspase-3 expression concerned as well. Results The positive rate of PTEN expression in primary gastric lymphomas(50.0%, 28/56) was significantly lower than that in adjacent non-tumor gastric mucosa(96.4%, 27/28)(P < 0.05). Meanwhile,43 of 56(76.8%)gastric lymphomas indicated Caspase-3 expression, less than that in adjacent non-tumor mucosa (93.5%, 29/31) (P < 0.05). The expression of PTEN was negatively correlated with invasion and lymph node metastasis of gastric lymphoma(P < 0.05), while the Caspase-3 expression was negatively associated with the latter one(P < 0.05). Additionally, the PTEN expression was posi-tively correlated with Caspase-3 expression in the primary gastric malignant lymphoma(P < 0.05). Conclusions The down-regulated expression of PTEN and Caspase-3 played an important role in progression of primary malignant gastric lymphoma. PTEN, as a molecular marker of pathobiological behaviors of tumor, contributes to tumor progression by increasing cell mobility and angiogenesis, as well as decreasing cell adhesion and apoptosis.
文摘The ＂Pictorial＂ or ＂Iconic Turn＂ is a central issue in the contemporary theory of images and visual cultural studies. Should the theories concerning the ＂Iconic Turn＂ and formulated in the last 20 years by scholars such as Gottfried Boehm, William Mitchell, Hans Belting be taken as critical theories of crisis？ Is the currently experienced ＂turn towards images＂ （and their progressive rehabilitation after a long standing philosophical and theological rejection） a sign and symptom of some crisis of people＇s relation with images, language and, generally speaking, with the representation forms of reality？ The main hypothesis of this essay envisages two sets of problems： first, the analysis of the relation between the possible idea of turning point and the concept of crisis; secondly, the thorough investigation of the relation connecting the iconic turn to the project of ＂critical iconology＂ or ＂critique of visual culture,＂ as outlined by Hans Belting and William Mitchell. From the interpretation of the ＂Iconic Turn＂ as situation of crisis and aesthetic, anthropological, and epistemological transformation follows the need for the sciences of image to provide a ＂critical iconology＂ in order to be able to theoretically reformulate the ideological and political presuppositions of some dominant contemporary forms of visual representation.
文摘This paper provides an overview of positive psychology(PP),or the study of elements that make life most worth living(Peterson,2006),and demonstrates its efficacy by detailing five intervention studies.By aligning PP objectives and linguistic aims in second language teaching and learning,the studies show multiplied,concurrent results,heightened teacher and learner wellbeing and improved language proficiency.One important caveat is that PP interventions work best when they cater specifically to individual learners.
