AIM: To evaluate the oncologic outcomes of primary and post-irradiated early stage rectal cancer and the effectiveness of adjuvant chemotherapy for rectal cancer patients. METHODS: Eighty-four patients with stage Ⅰ r...AIM: To evaluate the oncologic outcomes of primary and post-irradiated early stage rectal cancer and the effectiveness of adjuvant chemotherapy for rectal cancer patients. METHODS: Eighty-four patients with stage Ⅰ rectal cancer after radical surgery were studied retrospectively and divided into ypstage Ⅰ group (n = 45) and pstage Ⅰ group (n = 39), according to their preoperative radiation, and compared by univariate and multivariate analysis. RESULTS: The median follow-up time of patients was 70 mo. No significant difference was observed in diseaseprogression between the two groups. The 5-year disease-free survival rate was 84.4% and 92.3%, respectively (P = 0.327) and the 5-year overall survival rate was 88.9% and 92.3%, respectively, for the two groups (P = 0.692). The disease progression was not significantly associated with the pretreatment clinical stage in ypstage Ⅰ group. The 5-year disease progression rate was 10.5% and 19.2%, respectively, for the patients who received adjuvant chemotherapy and for those who rejected chemotherapy in the ypstage Ⅰ group (P = 0.681). CONCLUSION: The oncologic outcomes of primary and post-irradiated early stage rectal cancer are similar. Patients with ypstage Ⅰ rectal cancer may slightly benefit from adjuvant chemotherapy.展开更多
Aldo-keto reductase 1D1(AKR1D1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in China.Here,we describe the first two primary 4-3-oxosteroid 5β-reductase defici...Aldo-keto reductase 1D1(AKR1D1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in China.Here,we describe the first two primary 4-3-oxosteroid 5β-reductase deficiency patients in China's Mainland diagnosed by fast atom bombardment-mass spectroscopy of urinary bile acids and confirmed by genetic analysis.A high proportion of atypical 3-oxo-4-bile acids in the urine indicated a deficiency in 4-3-oxosteroid 5β-reductase.All of the coding exons and adjacent intronic sequence of the AKR1D1 gene were sequenced using peripheral lymphocyte genomic DNA of two patients and one of the patient's parents.One patient exhibited compound heterozygous mutations:c.396C>A and c.722A>T,while the other was heterozygous for the mutation c.797G>A.Based on these mutations,a diagnosis of primary 4-3-oxosteroid 5β-reductase deficiency could be confirmed.With ursodeoxycholic acid treatment and fat-soluble vitamin supplements,liver function tests normalized rapidly,and the degree of hepatomegaly was markedly reduced in both patients.展开更多
Background：Improving motor skill competency and enhancing health-related physical fitnes are desired learning outcomes for school-aged children.Achieving motor skill competency and a healthy level of physical fitnes ...Background：Improving motor skill competency and enhancing health-related physical fitnes are desired learning outcomes for school-aged children.Achieving motor skill competency and a healthy level of physical fitnes lay a foundation for being a physically active person across a lifetime.The purpose of this study was to investigate relationships between levels of manipulative skill competency and physical fitnes for elementary school boys and girls.Methods：In this study,565 fourth-grade students and their 9 physical education teachers were voluntary participants.The students were assessed in 4 basic specialized manipulative skills and 4 fitnes components during regular physical education lessons.Data were analyzed with descriptive statistics,univariate analyses,and multiple R2 liner regression methods.Results：Boys were more proficien at the manipulative skills than girls,while girls had significan higher percentages for meeting the healthy fitnes zone for the fitnes tests than boys.Four manipulative skills significant y predicted progressive aerobic cardiovascular endurance run（PACER）,push-up,and trunk lifts tests at p〈0.05 level,but not curl-up test for both boys and girls.Boys and girls in the skill-competent group significant y outperformed their counterparts in the skill-incompetent group on PACER,push-up,and trunk lifts tests at p〈0.05 level,with an exception of curl-up test.Conclusion：The more competent in manipulative skills,the higher healthy level in cardiovascular endurance,upper-body muscular strength and endurance,and fl xibility the students demonstrated.Demonstrating manipulative skill competence and maintaining a healthy level of physical fitnes are 2 major desired learning outcomes for elementary school students to be able to achieve.展开更多
Network lending as a financial innovation mode arises at the historic moment under the wave of the Interact, is an efficient and convenient way of borrowing, largely changed the small and medium-sized enterprise finan...Network lending as a financial innovation mode arises at the historic moment under the wave of the Interact, is an efficient and convenient way of borrowing, largely changed the small and medium-sized enterprise financing difficult problem, also convenient for ordinary people to borrow in time. Network credit enterprise group the avant-garde consumption ideas and values for college students in the campus lending business, in recent years, campus loan malignant events often appear, network borrowing brought convenience for college students, to make it better to enjoy the material life, but because of inadequate supervision and lack of law related, the existence of the big risk of college loans, this article USES SPSS17.0 weight analysis method, this paper analyzes the factors which influence on the risk of lending to college students＇ network research, affecting variables to the sorting, data descriptive statistical analysis, compare the mean and standard deviation of the variable size, risk prevention Suggestions finally.展开更多
健康与教育是社会发展的重要主题,也是联合国开发署＂人类发展指数（human development index,HDI）＂的重要组成部分。教育水平是健康的重要影响因素,健康是获得良好教育的前提[1],健康与教育有着密不可分的关系。教育的改善可以促进...健康与教育是社会发展的重要主题,也是联合国开发署＂人类发展指数（human development index,HDI）＂的重要组成部分。教育水平是健康的重要影响因素,健康是获得良好教育的前提[1],健康与教育有着密不可分的关系。教育的改善可以促进健康水平的提高。展开更多
文摘AIM: To evaluate the oncologic outcomes of primary and post-irradiated early stage rectal cancer and the effectiveness of adjuvant chemotherapy for rectal cancer patients. METHODS: Eighty-four patients with stage Ⅰ rectal cancer after radical surgery were studied retrospectively and divided into ypstage Ⅰ group (n = 45) and pstage Ⅰ group (n = 39), according to their preoperative radiation, and compared by univariate and multivariate analysis. RESULTS: The median follow-up time of patients was 70 mo. No significant difference was observed in diseaseprogression between the two groups. The 5-year disease-free survival rate was 84.4% and 92.3%, respectively (P = 0.327) and the 5-year overall survival rate was 88.9% and 92.3%, respectively, for the two groups (P = 0.692). The disease progression was not significantly associated with the pretreatment clinical stage in ypstage Ⅰ group. The 5-year disease progression rate was 10.5% and 19.2%, respectively, for the patients who received adjuvant chemotherapy and for those who rejected chemotherapy in the ypstage Ⅰ group (P = 0.681). CONCLUSION: The oncologic outcomes of primary and post-irradiated early stage rectal cancer are similar. Patients with ypstage Ⅰ rectal cancer may slightly benefit from adjuvant chemotherapy.
基金Supported by National Natural Science Foundation of China, No.81070281
文摘Aldo-keto reductase 1D1(AKR1D1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in China.Here,we describe the first two primary 4-3-oxosteroid 5β-reductase deficiency patients in China's Mainland diagnosed by fast atom bombardment-mass spectroscopy of urinary bile acids and confirmed by genetic analysis.A high proportion of atypical 3-oxo-4-bile acids in the urine indicated a deficiency in 4-3-oxosteroid 5β-reductase.All of the coding exons and adjacent intronic sequence of the AKR1D1 gene were sequenced using peripheral lymphocyte genomic DNA of two patients and one of the patient's parents.One patient exhibited compound heterozygous mutations:c.396C>A and c.722A>T,while the other was heterozygous for the mutation c.797G>A.Based on these mutations,a diagnosis of primary 4-3-oxosteroid 5β-reductase deficiency could be confirmed.With ursodeoxycholic acid treatment and fat-soluble vitamin supplements,liver function tests normalized rapidly,and the degree of hepatomegaly was markedly reduced in both patients.
基金funded by U.S.Department of Education,Carol White Physical Education Program grant(CFDA 84.215F)
文摘Background：Improving motor skill competency and enhancing health-related physical fitnes are desired learning outcomes for school-aged children.Achieving motor skill competency and a healthy level of physical fitnes lay a foundation for being a physically active person across a lifetime.The purpose of this study was to investigate relationships between levels of manipulative skill competency and physical fitnes for elementary school boys and girls.Methods：In this study,565 fourth-grade students and their 9 physical education teachers were voluntary participants.The students were assessed in 4 basic specialized manipulative skills and 4 fitnes components during regular physical education lessons.Data were analyzed with descriptive statistics,univariate analyses,and multiple R2 liner regression methods.Results：Boys were more proficien at the manipulative skills than girls,while girls had significan higher percentages for meeting the healthy fitnes zone for the fitnes tests than boys.Four manipulative skills significant y predicted progressive aerobic cardiovascular endurance run（PACER）,push-up,and trunk lifts tests at p〈0.05 level,but not curl-up test for both boys and girls.Boys and girls in the skill-competent group significant y outperformed their counterparts in the skill-incompetent group on PACER,push-up,and trunk lifts tests at p〈0.05 level,with an exception of curl-up test.Conclusion：The more competent in manipulative skills,the higher healthy level in cardiovascular endurance,upper-body muscular strength and endurance,and fl xibility the students demonstrated.Demonstrating manipulative skill competence and maintaining a healthy level of physical fitnes are 2 major desired learning outcomes for elementary school students to be able to achieve.
文摘Network lending as a financial innovation mode arises at the historic moment under the wave of the Interact, is an efficient and convenient way of borrowing, largely changed the small and medium-sized enterprise financing difficult problem, also convenient for ordinary people to borrow in time. Network credit enterprise group the avant-garde consumption ideas and values for college students in the campus lending business, in recent years, campus loan malignant events often appear, network borrowing brought convenience for college students, to make it better to enjoy the material life, but because of inadequate supervision and lack of law related, the existence of the big risk of college loans, this article USES SPSS17.0 weight analysis method, this paper analyzes the factors which influence on the risk of lending to college students＇ network research, affecting variables to the sorting, data descriptive statistical analysis, compare the mean and standard deviation of the variable size, risk prevention Suggestions finally.
