With the progress of aging,the incidence of vascular calcification(VC)gradually increases,which is correlated with cardiovascular events and all-cause death,aggravating global clinical burden.Over the past several dec...With the progress of aging,the incidence of vascular calcification(VC)gradually increases,which is correlated with cardiovascular events and all-cause death,aggravating global clinical burden.Over the past several decades,accumulating approaches targeting the underlying pathogenesis of VC have provided some possibilities for the treatment of VC.Unfortunately,none of the current interventions have achieved clinical effectiveness on reversing or curing VC.The purpose of this review is to make a summary of novel perspectives on the interventions of VC and provide reference for clinical decision-making.展开更多
As the most important type or component in the terrestrial ecosystems, forest ecosystem makes its role obviously prominent and important on environment and human being. It possesses non-substitutable functions in the ...As the most important type or component in the terrestrial ecosystems, forest ecosystem makes its role obviously prominent and important on environment and human being. It possesses non-substitutable functions in the process of sustainable development. However, due to the complexity of the forest ecosystem and the relatively delay or lack of the related research technology, the science is still in the case of immature and questions. This paper summarized and reviewed briefly the development and the present case of the forest ecology, then pointed out the existing problems in the forest ecosystem researches. In the end, we discussed several fields that need to pay more attention to in future researches.展开更多
The Blue-eared Pheasant (Crossoptilon auritum) is an important bird species,endemic to China and is ranked as a second grade key protected wildlife species in China.These birds are only found in the mountainous region...The Blue-eared Pheasant (Crossoptilon auritum) is an important bird species,endemic to China and is ranked as a second grade key protected wildlife species in China.These birds are only found in the mountainous regions of Qinghai,Gansu and Sichuan provinces and the Ningxia Hui Autonomous Region.In order to understand systematically the existing information on the biology of the Blue-eared Pheasant,we provide updated information on its habitat,activity,nest-site features,breeding biology,feeding habits,population status and conservation of this pheasant by integrating published data with the information from our field surveys,conducted from 2006 to 2008 in the Gaihai-zecha National Nature Reserve,Gansu.展开更多
AIM: To study the patients with low gradient ascites in hospitals of Guilan Province (northern Iran).METHODS: Patients admitted in hospitals of Guilan Province with low gradient ascites from 1993 to 2000 were enrolled...AIM: To study the patients with low gradient ascites in hospitals of Guilan Province (northern Iran).METHODS: Patients admitted in hospitals of Guilan Province with low gradient ascites from 1993 to 2000 were enrolled in the study. Serum and ascitic fluid albumin levels were determined by biochemical reactions. The serum-ascitic albumin gradient (SAAG) less than 1.1 g/dL was considered low. Statistical analysis was performed with SPSS 9.0software and P<0.05 was considered statistically significant.RESULTS: Of the 148 patients enrolled in the study, 72(48.6%) were males and 76 (51.4%) were females with a mean age of 59.03±13.54 years. Tuberculous peritonitis was the most frequent cause of low gradient ascites in 68 (45.9%). Other most frequent causes were cancer in 62 (41.9%), nephrotic syndrome in 9 (6%), pancreatitis in 6 (4%). Peritoneal cancer was found in 22 (35%),ovarian and gastric cancers were found in 14 (22.5%)and 12 (19.3%), respectively. All of which were the causes of ascites. The mean SAAG was 0.68±0.19 g/dL. The mean serum and ascitic fluid albumin concentrations were higher in tuberculous patients (P<0.006), but lactate dehydrogenase (LDH) level was higher in cancer patients (P<0.0001). In peritoneal tuberculosis, mean ascitic glucose concentration was significantly lower than other patients (P<0.0001).CONCLUSION: Tuberculosis should be considered in all patients with low gradient ascites especially in developing countries (like Iran), as the first cause of ascites. In the approach to patients with low gradient ascites, ascitic fluid glucose, and LDH level are useful indicators for decision making.展开更多
In the past decades, a lot of advances in understanding the biochemistry and physiology of the pineal gland have been made. There is evidence that it interacts with many endocrine as well as non-endocrine tissues to i...In the past decades, a lot of advances in understanding the biochemistry and physiology of the pineal gland have been made. There is evidence that it interacts with many endocrine as well as non-endocrine tissues to influence their metabolic activity modulating many organs and functions. Melatonin is secreted by the pineal gland in the brain and plays an important role in regulating the neuroendocrine system. This hormone is one of the major role players in the regulation of the circadian sleep-wake cycle. It is normally released from the pineal gland during the night in response to environmental changes in light. Studies have shown that melatonin plays a role in the regulation of many reproductive processes such as puberty, gonadal function, and pregnancy. Beside these, melatonin has been shown to be able to directly neutralize a number of free radicals and reactive oxygen and nitrogen species. The main objective of this review is to provide comprehensive information about the new developments in melatonin research regarding its role in reproduction. A review of international scientific literature was done and a question-and-answer format was used in an attempt to convey comprehensive information in a simple manner. This review discusses evidence currently available relating to the effect of melatonin on reproductive processes. It deliberates the mechanism of action of melatonin, its effect on puberty, testicular and ovafunction, pregnancy, and oxidative stress. A growing body of scientific evidence is suggesting that melatonin plays an important role in reproductive function. It is therefore imperative to highlight the beneficial effects of this hormone in improving the reproductive processes.展开更多
MicroRNAs(miRNAs) are a group of small, endogenous, single-stranded non-coding RNAs that post-transcriptionally regulate gene expression levels. Previous studies have revealed that miRNAs play key roles in multiple bi...MicroRNAs(miRNAs) are a group of small, endogenous, single-stranded non-coding RNAs that post-transcriptionally regulate gene expression levels. Previous studies have revealed that miRNAs play key roles in multiple biological processes, such as growth and development in both animals and plants. Computational identification is an efficient method for miRNA prediction in organisms with a reference genome before high-throughput miRNA sequencing experiments. In this study, we employed an integrated strategy combining the homology-based and ab initio approaches to predict miRNAs from the genome and transcriptome of large yellow croaker, one of the most commercially important marine fish in China and East Asia. A total of 418 miRNA molecules, including 287 miRNAs by the homology-based method and 131 miRNAs by the ab initio approach, were identified for large yellow croaker. Additionally, 16 053 target genes were predicted and annotated for Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) databases. Meanwhile, we analysed single nucleotide polymorphisms(SNPs) around large yellow croaker miRNA and found that the miRNA seed regions were significantly less prone to mutations, indicating that the miRNA sequences were under strict natural selection based on their essential regulation functions in living cells. Twenty-two SNPs were identified in large yellow croaker miRNA seed regions, which dramatically influenced the miRNA-gene regulation networks. This is the first reported miRNA detection from both the genome and transcriptome using the integrated strategy for large yellow croaker species, and the miRNA and SNP analyses in this work provide important resources and a reference for subsequent miRNA functional investigations in large yellow croaker.展开更多
Pudgalastikaya is one of the six constituent dravyas of loka in Jainism and is the only substance that is sense perceptible. The sense attributes ofpudgala are colour, taste, smell, and touch properties which become t...Pudgalastikaya is one of the six constituent dravyas of loka in Jainism and is the only substance that is sense perceptible. The sense attributes ofpudgala are colour, taste, smell, and touch properties which become the basis of its diversity of forms and structures. The smallest constituent of pudgala is paramanu; the other forms are its combinations. The combination ofparmanus forms various states of the matter. The paper describes different types of combinations and modes, rules for combinations and properties of aggregates known as vargana. Some varganas associate with the soul and form various types of bodies of organisms and others exist as forms of matter in loka (universe). The paramanu defines the smallest units of energy, space, time, and sense quality ofpudgala. Pudgala exists in visible and invisible forms but anything that is visible is definitely pudgala. Pudgala is classified in various ways; one of them is on the basis of touch property and there are pudgalas having two touches, four touches, and eight touches, each class having some specific character that differentiates them in respect of stability and motion. Pudgala is also classified as living, prayoga-parinat, and non-living, visrasa-parinat. The living matter existing as bodies of organisms exhibits some properties that are not found in non-living matter. Modem science has no such distinction which has become a cause of confusion in recognizing the existence of soul. The description of body remains incomplete without considering the presence of soul in the body. In modem terms, aparamanu is a vibrating and moving charge that is bosonic in character. The two-touch and four-touch pudgala do not appear to follow the speed limits prescribed by Special Theory of Relativity. Jain canonical works describe two types of motions sparshad type and asparshad type and these determine the motions of different class ofpudgala and soul. Jain philosophy describes the dynamics and motion ofparmanu in detail. The paper describes the Jain concepts of matter in detail and compares with the modem concepts to highlight the strength of Jain views. Modem science has explored the properties and behavior of matter in great detail but still there are many concepts that Jain philosophy has to offer.展开更多
Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteo...Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds' processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.展开更多
The presence of feacal-derived pathogens in water is responsible for several infectious diseases and deaths worldwide. As a solution, sources of fecal pollution in waters must be accurately assessed, properly determin...The presence of feacal-derived pathogens in water is responsible for several infectious diseases and deaths worldwide. As a solution, sources of fecal pollution in waters must be accurately assessed, properly determined and strictly controlled. However, the exercise has remained challenging due to the existing overlapping characteristics by different members of faecal coliform bacteria and the inadequacy of information pertaining to the contribution of seasonality and weather condition on tracking the possible sources of pollution. There are continued ef forts to improve the Faecal Contamination Source Tracking(FCST) techniques such as Microbial Source Tracking(MST). This study aimed to make contribution to MST by evaluating the efficacy of combining site specific quantification of faecal contamination indicator bacteria and detection of DNA markers while accounting for seasonality and weather conditions' eff ects in tracking the major sources of faecal contamination in a freshwater system(Donghu Lake, China). The results showed that the use of cyd gene in addition to lacZ and uidA genes differentiates E. coli from other closely related faecal bacteria. The use of selective media increases the pollution source tracking accuracy. BSA addition boosts PCR detection and increases FCST efficiency. Seasonality and weather variability also influence the detection limit for DNA markers.展开更多
The paper aims to explore Pound's early discovery of Confucianism and his conversion to Confucianism. Pound's interest in Confucianism coincided with the time when Christianity, already "contaminated" by "histori...The paper aims to explore Pound's early discovery of Confucianism and his conversion to Confucianism. Pound's interest in Confucianism coincided with the time when Christianity, already "contaminated" by "historical diseases" in Pound's view, could not offer a valid vision by which to guide the spiritual life, resulting in losing self in a modem society. Pound discovers three main deficiencies of Christianity: lack of respect for individuality, the decline of ethics, and open attack upon nature, which could not provide solutions to Western problems. Pound turned to Confucianism to search the existence of modem man in the face of society, and nature, which results in Pound's Confucian medicine to cure Western moral obtuseness.展开更多
Network media has become more and more involved in our daily life. It has become a part of modern life that cannot be stopped or rejected. Then, how to correctly face the changes in the Internet era is placed in fron...Network media has become more and more involved in our daily life. It has become a part of modern life that cannot be stopped or rejected. Then, how to correctly face the changes in the Internet era is placed in front of everyone. Students need to “learn how to use the media to get their all-round development, effectively prevent the foreign information pollution, and actively guide students to a truly rational attitude for WeChat, blog and micro-blog”. It is a kind of media literacy being confronted with the network’s ability to consciously resist the harmful information, but also to benefit their own development and firmly grasp the information, so as to make full use of the convenience of network self promotion. “Screen reading” network plays an important role in college students’ life, and the fragmentation, the text features of the writing ability of college students also have a strong impact; this paper focuses on the influence of college students in the network reading and writing patterns on their writing ability and influence. From the perspective of media literacy education for college students, writing ability and reading ability provide a feasible way.展开更多
Tal fescue (Festuca arundinacea Schreb.) is an important cool-season forage grasses and turfgrasses at home and abroad. In order to provide a reference for tal fescue breeding, we reviewed the genetic constitution a...Tal fescue (Festuca arundinacea Schreb.) is an important cool-season forage grasses and turfgrasses at home and abroad. In order to provide a reference for tal fescue breeding, we reviewed the genetic constitution and heritability, endo-phytic fungi and new tal fescue variety breeding, application of modern biological technology (expressed sequence tag, genetic linkage map construction and trans-genic breeding) in breeding new varieties of tal fescue and the breeding status of tal fescue in Guizhou region.展开更多
Previous studies have suggested that the transforming growth factor-β receptor ALK5 is crucial for articular chondrogenesis by bone marrow mesenchymal stem cells. Here, the wild-type ALK5 plasmids were mutated by ove...Previous studies have suggested that the transforming growth factor-β receptor ALK5 is crucial for articular chondrogenesis by bone marrow mesenchymal stem cells. Here, the wild-type ALK5 plasmids were mutated by overlapping extended PCR and transfected into bone marrow mesenchymal stem cells. The knee joint osteoarthritis mouse model was constructed by cutting oft" the anterior cruciate ligament and divided into three groups: saline group, bone marrow mesenchymal stem cells and ALK5-transfected bone marrow mesenchymal stem cells group. HE staining showed that the articular cartilage lesions were more serious of saline group compared with that of mesenchymal stem cell group, and this trend was more pronounced as time goes on. Immunohistochemical staining showed that although the expression level of type II collagen in all three groups down-regulated gradually upon time, its expression in ALK5-transfected bone marrow mesenchymal stem cells group was significantly enhanced compared with the other two groups. Micro-CT also suggested that ALK5 transfection of mouse bone marrow mesenchymal stem cells would promote repairing the knee cartilage lesions with arthritis of the mice. Although the osteoarthritis mechanism underlying a variety of factors work together, and the appropriate proportion of ALKS/ALK1 was also emphasized for the treatment of osteoarthritis. This work therefore demonstrated that ALK5 transfection of bone marrow mesenchymal stem cells could be a promising stem cell therapy for repair of cartilage lesions.展开更多
文摘With the progress of aging,the incidence of vascular calcification(VC)gradually increases,which is correlated with cardiovascular events and all-cause death,aggravating global clinical burden.Over the past several decades,accumulating approaches targeting the underlying pathogenesis of VC have provided some possibilities for the treatment of VC.Unfortunately,none of the current interventions have achieved clinical effectiveness on reversing or curing VC.The purpose of this review is to make a summary of novel perspectives on the interventions of VC and provide reference for clinical decision-making.
基金This study was supported by the National Natural Science Foundation of China (NSFC39970123 30170744)+1 种基金 Chinese Academy of Sciences (A grant KZCX2-406) and Changbai Mountain Open Research Station.
文摘As the most important type or component in the terrestrial ecosystems, forest ecosystem makes its role obviously prominent and important on environment and human being. It possesses non-substitutable functions in the process of sustainable development. However, due to the complexity of the forest ecosystem and the relatively delay or lack of the related research technology, the science is still in the case of immature and questions. This paper summarized and reviewed briefly the development and the present case of the forest ecology, then pointed out the existing problems in the forest ecosystem researches. In the end, we discussed several fields that need to pay more attention to in future researches.
基金supported by the National Natural Science Foundation of China (30530130,31101650)
文摘The Blue-eared Pheasant (Crossoptilon auritum) is an important bird species,endemic to China and is ranked as a second grade key protected wildlife species in China.These birds are only found in the mountainous regions of Qinghai,Gansu and Sichuan provinces and the Ningxia Hui Autonomous Region.In order to understand systematically the existing information on the biology of the Blue-eared Pheasant,we provide updated information on its habitat,activity,nest-site features,breeding biology,feeding habits,population status and conservation of this pheasant by integrating published data with the information from our field surveys,conducted from 2006 to 2008 in the Gaihai-zecha National Nature Reserve,Gansu.
文摘AIM: To study the patients with low gradient ascites in hospitals of Guilan Province (northern Iran).METHODS: Patients admitted in hospitals of Guilan Province with low gradient ascites from 1993 to 2000 were enrolled in the study. Serum and ascitic fluid albumin levels were determined by biochemical reactions. The serum-ascitic albumin gradient (SAAG) less than 1.1 g/dL was considered low. Statistical analysis was performed with SPSS 9.0software and P<0.05 was considered statistically significant.RESULTS: Of the 148 patients enrolled in the study, 72(48.6%) were males and 76 (51.4%) were females with a mean age of 59.03±13.54 years. Tuberculous peritonitis was the most frequent cause of low gradient ascites in 68 (45.9%). Other most frequent causes were cancer in 62 (41.9%), nephrotic syndrome in 9 (6%), pancreatitis in 6 (4%). Peritoneal cancer was found in 22 (35%),ovarian and gastric cancers were found in 14 (22.5%)and 12 (19.3%), respectively. All of which were the causes of ascites. The mean SAAG was 0.68±0.19 g/dL. The mean serum and ascitic fluid albumin concentrations were higher in tuberculous patients (P<0.006), but lactate dehydrogenase (LDH) level was higher in cancer patients (P<0.0001). In peritoneal tuberculosis, mean ascitic glucose concentration was significantly lower than other patients (P<0.0001).CONCLUSION: Tuberculosis should be considered in all patients with low gradient ascites especially in developing countries (like Iran), as the first cause of ascites. In the approach to patients with low gradient ascites, ascitic fluid glucose, and LDH level are useful indicators for decision making.
文摘In the past decades, a lot of advances in understanding the biochemistry and physiology of the pineal gland have been made. There is evidence that it interacts with many endocrine as well as non-endocrine tissues to influence their metabolic activity modulating many organs and functions. Melatonin is secreted by the pineal gland in the brain and plays an important role in regulating the neuroendocrine system. This hormone is one of the major role players in the regulation of the circadian sleep-wake cycle. It is normally released from the pineal gland during the night in response to environmental changes in light. Studies have shown that melatonin plays a role in the regulation of many reproductive processes such as puberty, gonadal function, and pregnancy. Beside these, melatonin has been shown to be able to directly neutralize a number of free radicals and reactive oxygen and nitrogen species. The main objective of this review is to provide comprehensive information about the new developments in melatonin research regarding its role in reproduction. A review of international scientific literature was done and a question-and-answer format was used in an attempt to convey comprehensive information in a simple manner. This review discusses evidence currently available relating to the effect of melatonin on reproductive processes. It deliberates the mechanism of action of melatonin, its effect on puberty, testicular and ovafunction, pregnancy, and oxidative stress. A growing body of scientific evidence is suggesting that melatonin plays an important role in reproductive function. It is therefore imperative to highlight the beneficial effects of this hormone in improving the reproductive processes.
基金Supported by the National Natural Science Foundation of China(Nos.U1205122,31602207)the Key Project of the Xiamen Southern Ocean Research Center(No.14GZY70NF34)+2 种基金the Fujian Provincial Natural Science Foundation(No.2016J05081)the National High Technology Research and Development Program of China(863 Program)(No.2012AA10A403)the Foundation for Innovation Research Team of Jimei University(No.2010A02)
文摘MicroRNAs(miRNAs) are a group of small, endogenous, single-stranded non-coding RNAs that post-transcriptionally regulate gene expression levels. Previous studies have revealed that miRNAs play key roles in multiple biological processes, such as growth and development in both animals and plants. Computational identification is an efficient method for miRNA prediction in organisms with a reference genome before high-throughput miRNA sequencing experiments. In this study, we employed an integrated strategy combining the homology-based and ab initio approaches to predict miRNAs from the genome and transcriptome of large yellow croaker, one of the most commercially important marine fish in China and East Asia. A total of 418 miRNA molecules, including 287 miRNAs by the homology-based method and 131 miRNAs by the ab initio approach, were identified for large yellow croaker. Additionally, 16 053 target genes were predicted and annotated for Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) databases. Meanwhile, we analysed single nucleotide polymorphisms(SNPs) around large yellow croaker miRNA and found that the miRNA seed regions were significantly less prone to mutations, indicating that the miRNA sequences were under strict natural selection based on their essential regulation functions in living cells. Twenty-two SNPs were identified in large yellow croaker miRNA seed regions, which dramatically influenced the miRNA-gene regulation networks. This is the first reported miRNA detection from both the genome and transcriptome using the integrated strategy for large yellow croaker species, and the miRNA and SNP analyses in this work provide important resources and a reference for subsequent miRNA functional investigations in large yellow croaker.
文摘Pudgalastikaya is one of the six constituent dravyas of loka in Jainism and is the only substance that is sense perceptible. The sense attributes ofpudgala are colour, taste, smell, and touch properties which become the basis of its diversity of forms and structures. The smallest constituent of pudgala is paramanu; the other forms are its combinations. The combination ofparmanus forms various states of the matter. The paper describes different types of combinations and modes, rules for combinations and properties of aggregates known as vargana. Some varganas associate with the soul and form various types of bodies of organisms and others exist as forms of matter in loka (universe). The paramanu defines the smallest units of energy, space, time, and sense quality ofpudgala. Pudgala exists in visible and invisible forms but anything that is visible is definitely pudgala. Pudgala is classified in various ways; one of them is on the basis of touch property and there are pudgalas having two touches, four touches, and eight touches, each class having some specific character that differentiates them in respect of stability and motion. Pudgala is also classified as living, prayoga-parinat, and non-living, visrasa-parinat. The living matter existing as bodies of organisms exhibits some properties that are not found in non-living matter. Modem science has no such distinction which has become a cause of confusion in recognizing the existence of soul. The description of body remains incomplete without considering the presence of soul in the body. In modem terms, aparamanu is a vibrating and moving charge that is bosonic in character. The two-touch and four-touch pudgala do not appear to follow the speed limits prescribed by Special Theory of Relativity. Jain canonical works describe two types of motions sparshad type and asparshad type and these determine the motions of different class ofpudgala and soul. Jain philosophy describes the dynamics and motion ofparmanu in detail. The paper describes the Jain concepts of matter in detail and compares with the modem concepts to highlight the strength of Jain views. Modem science has explored the properties and behavior of matter in great detail but still there are many concepts that Jain philosophy has to offer.
文摘Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds' processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.
基金Supported by the National Natural Science Foundation of China(Nos.31670465,31370504)
文摘The presence of feacal-derived pathogens in water is responsible for several infectious diseases and deaths worldwide. As a solution, sources of fecal pollution in waters must be accurately assessed, properly determined and strictly controlled. However, the exercise has remained challenging due to the existing overlapping characteristics by different members of faecal coliform bacteria and the inadequacy of information pertaining to the contribution of seasonality and weather condition on tracking the possible sources of pollution. There are continued ef forts to improve the Faecal Contamination Source Tracking(FCST) techniques such as Microbial Source Tracking(MST). This study aimed to make contribution to MST by evaluating the efficacy of combining site specific quantification of faecal contamination indicator bacteria and detection of DNA markers while accounting for seasonality and weather conditions' eff ects in tracking the major sources of faecal contamination in a freshwater system(Donghu Lake, China). The results showed that the use of cyd gene in addition to lacZ and uidA genes differentiates E. coli from other closely related faecal bacteria. The use of selective media increases the pollution source tracking accuracy. BSA addition boosts PCR detection and increases FCST efficiency. Seasonality and weather variability also influence the detection limit for DNA markers.
文摘The paper aims to explore Pound's early discovery of Confucianism and his conversion to Confucianism. Pound's interest in Confucianism coincided with the time when Christianity, already "contaminated" by "historical diseases" in Pound's view, could not offer a valid vision by which to guide the spiritual life, resulting in losing self in a modem society. Pound discovers three main deficiencies of Christianity: lack of respect for individuality, the decline of ethics, and open attack upon nature, which could not provide solutions to Western problems. Pound turned to Confucianism to search the existence of modem man in the face of society, and nature, which results in Pound's Confucian medicine to cure Western moral obtuseness.
文摘Network media has become more and more involved in our daily life. It has become a part of modern life that cannot be stopped or rejected. Then, how to correctly face the changes in the Internet era is placed in front of everyone. Students need to “learn how to use the media to get their all-round development, effectively prevent the foreign information pollution, and actively guide students to a truly rational attitude for WeChat, blog and micro-blog”. It is a kind of media literacy being confronted with the network’s ability to consciously resist the harmful information, but also to benefit their own development and firmly grasp the information, so as to make full use of the convenience of network self promotion. “Screen reading” network plays an important role in college students’ life, and the fragmentation, the text features of the writing ability of college students also have a strong impact; this paper focuses on the influence of college students in the network reading and writing patterns on their writing ability and influence. From the perspective of media literacy education for college students, writing ability and reading ability provide a feasible way.
基金Supported by the Key Agricultural Technology R&D Program of Guizhou Province(Qiankehe NY(2008)3070Qiankehe NY(2010)3044)+1 种基金the Foundation for Science andTechnology of Guizhou Province(Qiankehe J(2009)2133Qiankehe J(2012)2202)~~
文摘Tal fescue (Festuca arundinacea Schreb.) is an important cool-season forage grasses and turfgrasses at home and abroad. In order to provide a reference for tal fescue breeding, we reviewed the genetic constitution and heritability, endo-phytic fungi and new tal fescue variety breeding, application of modern biological technology (expressed sequence tag, genetic linkage map construction and trans-genic breeding) in breeding new varieties of tal fescue and the breeding status of tal fescue in Guizhou region.
基金This work was financially supported by National Natural Science Foundation of China (81600838, 51502262), Key Research and Development Program of Zhejiang, China (2017C01054), Medical Technology and Education of Zhejiang Province of China (2016KYB178), Research Science and Technology Department of Zhejiang Province social welfare development projects under Grant 2013C33161, Natural Science Foundation of Zhejiang Provence of China under Grant LY 15H 160019, and Ningbo Natural Science Foundation 2016A610166.
文摘Previous studies have suggested that the transforming growth factor-β receptor ALK5 is crucial for articular chondrogenesis by bone marrow mesenchymal stem cells. Here, the wild-type ALK5 plasmids were mutated by overlapping extended PCR and transfected into bone marrow mesenchymal stem cells. The knee joint osteoarthritis mouse model was constructed by cutting oft" the anterior cruciate ligament and divided into three groups: saline group, bone marrow mesenchymal stem cells and ALK5-transfected bone marrow mesenchymal stem cells group. HE staining showed that the articular cartilage lesions were more serious of saline group compared with that of mesenchymal stem cell group, and this trend was more pronounced as time goes on. Immunohistochemical staining showed that although the expression level of type II collagen in all three groups down-regulated gradually upon time, its expression in ALK5-transfected bone marrow mesenchymal stem cells group was significantly enhanced compared with the other two groups. Micro-CT also suggested that ALK5 transfection of mouse bone marrow mesenchymal stem cells would promote repairing the knee cartilage lesions with arthritis of the mice. Although the osteoarthritis mechanism underlying a variety of factors work together, and the appropriate proportion of ALKS/ALK1 was also emphasized for the treatment of osteoarthritis. This work therefore demonstrated that ALK5 transfection of bone marrow mesenchymal stem cells could be a promising stem cell therapy for repair of cartilage lesions.