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“ARE”教育理念在全面培养动画专业学生素质中的必要性
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作者 刘桂华 《美术教育研究》 2013年第20期85-86,共2页
"ARE"分别是Attitude and manner(态度与习惯)、Responsibility(责任感)、Ethical value(s价值观)的首字母缩写,是当下所有大学生亟待补上的一课。动画专业连续三年被评为高失业风险型专业,改变其教育理念成为当务之急。
关键词 ARE动画专业大学生素 质教育理念
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普通高校大学生综合国防素质的量表编制 被引量:1
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作者 程春 阚阅 《应用心理学》 CSSCI 2022年第1期88-96,共9页
本研究通过初始问卷编制、项目分析、探索性因素分析和验证性因素分析等程序,编制普通高校大学生综合国防素质量表,并进行了相关实证测量。结果显示,量表有8个维度共35个题项。量表的α系数和重测信度均符合心理测量学指标要求,具有良... 本研究通过初始问卷编制、项目分析、探索性因素分析和验证性因素分析等程序,编制普通高校大学生综合国防素质量表,并进行了相关实证测量。结果显示,量表有8个维度共35个题项。量表的α系数和重测信度均符合心理测量学指标要求,具有良好的结构效度、聚敛区分效度与校标关联效度,可用于大学生综合国防素质的测量。测量结果发现,大学生综合国防素质总体处于中等偏上水平,且存在显著的性别差异与年级差异。 展开更多
关键词 学生综合国防质量表 信度 效度
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探讨小学信息技术课堂中培养学生信息素养和综合能力 被引量:1
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作者 叶懿行 《学苑教育》 2022年第8期24-26,共3页
在社会发展及进步下,信息技术于不同领域中有了极大的应用。现阶段,通过科学手段培养学生信息素养,使其成为技术型人才,是信息技术的一大教学目标,不但可以拓宽学生的学习渠道,同时对于学生学习信息技术也有着极大帮助。但是,现阶段小... 在社会发展及进步下,信息技术于不同领域中有了极大的应用。现阶段,通过科学手段培养学生信息素养,使其成为技术型人才,是信息技术的一大教学目标,不但可以拓宽学生的学习渠道,同时对于学生学习信息技术也有着极大帮助。但是,现阶段小学信息技术教学在培养学生信息素养和综合能力上存在诸多问题需要解决。 展开更多
关键词 小学信息技术 学生信息 综合能力 方法策略
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美术欣赏教学对提高学生审美素养的实践思考
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作者 高丽华 《中国科技经济新闻数据库 教育》 2021年第8期83-83,共1页
审美作为学生个人素质中重要的组成部分,美术欣赏教学能够提高学生的审美欣赏能力。因此,作为美术教师要明确自身的重大责任,精心准备美术作品,创设宽松有序的美术课堂,加强美术欣赏课的人文性和趣味性,确保学生全面发展。基于此,本文... 审美作为学生个人素质中重要的组成部分,美术欣赏教学能够提高学生的审美欣赏能力。因此,作为美术教师要明确自身的重大责任,精心准备美术作品,创设宽松有序的美术课堂,加强美术欣赏课的人文性和趣味性,确保学生全面发展。基于此,本文将主要论述美术欣赏教学对提高学生审美素养的实践思考。 展开更多
关键词 美术欣赏教学 学生审美 实践思考
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Calling and Mating Behavior of Malacosoma rectifascia Lajonquère 被引量:3
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作者 李咏玲 曹天文 +2 位作者 王瑞 韩福生 张金桐 《Agricultural Science & Technology》 CAS 2010年第1期69-72,共4页
[Objective]The research aimed to study the calling and mating behavior of Malacosoma rectifascia Lajonquère and provide theoretical basis for utilization of sex pheromone to prevent and control M.rectifascia. [Me... [Objective]The research aimed to study the calling and mating behavior of Malacosoma rectifascia Lajonquère and provide theoretical basis for utilization of sex pheromone to prevent and control M.rectifascia. [Method]Through indoor and outdoor observation,effects of M.rectifascia mating behavior occurrence process,calling period,different sex ratio and population density on mating rate were studied. [Result]The sex ratio of M.rectifascia in nature was 1∶1.2,while in lab was 1∶1.8; the calling peak took place from 19:00 to 21:00;different sex ratio and population density had significant effects on mating behavior,and mating rate would be reduced if the population density was higher; both male and female M.rectifascia mate only once throughout their life. [Conclusion]Controlling M.rectifascia with sex pheromone has good application prospects. 展开更多
关键词 Malacosoma rectifascia Lajonquère Sex pheromone BIOLOGY
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Herpetin, a New Bioactive Lignan Isolated from Herpetospermum caudigerum 被引量:5
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作者 袁海龙 刘毅 +1 位作者 赵艳玲 肖小河 《Journal of Chinese Pharmaceutical Sciences》 CAS 2005年第3期140-143,共4页
Aim To study the chemical constituents of seeds of Herpetospermum caudigerum. Methods Column chromatography was used in the isolation procedure, and the structure was elucidated by spectral data, whose pharmacologic a... Aim To study the chemical constituents of seeds of Herpetospermum caudigerum. Methods Column chromatography was used in the isolation procedure, and the structure was elucidated by spectral data, whose pharmacologic activity was assayed in vitro. Results A new compound named herpetin was isolated, whose structure was determined to be 3-benzofuran methanol-2, 3-dihydm-2-(4- hydroxy-3-methoxyphenyl )-4-methoxy-6-[ tetrahydm-2-( 3-hydroxy-4-methoxyphenyl )-3-methanol ]-2- furanmethyl, showed significant inhibitory effects on HBV-DNA and the replication and expression of HBsAg and HBeAg. Conclusion Herpetin offers wide research and development prospect. 展开更多
关键词 Herpetospermum caudigerum Lignan Herpetin HBV 2.2.15 cell line
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Anemia in Rural China’s Elementary Schools: Prevalence and Correlates in Northwest Area 被引量:1
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作者 蔡颖萍 《Agricultural Science & Technology》 CAS 2013年第3期546-548,共3页
[Objective] The goal of this paper was to measure anemia prevalence and identify factors that correlate with anemia among school-aged children in rural areas, provide a scientific basis for effective prevention and tr... [Objective] The goal of this paper was to measure anemia prevalence and identify factors that correlate with anemia among school-aged children in rural areas, provide a scientific basis for effective prevention and treatment. [Method] The data set covered three provinces in northwest area. We detected hemoglobin of the sample pupils randomly chosen from the 3rd-6th grade of 305 rural elementary schools in 26 poor counties, and carried out questionnaires among them. [Result] 25.24% of the pupils had anemia, most of them were girl and the lower grade stu- dents. The multiple-regression revealed that the eating habits and family condition had certain impact on their anemia. [Conclusion] Anemia is still a serious problem of rural pupils. Improving diet conditions, providing balanced meals, enhancing the knowledge of the principals, teachers and parents about anemia and the importance of students' nutritional status and health contribute to the prevention and treatment of anemia of rural pupils. 展开更多
关键词 Rural pupils ANEMIA Influencing factors
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Determination of the Trace Element Contents in Plants Using Atomic Absorption Spectrophotometer 被引量:37
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作者 高淑云 《Agricultural Science & Technology》 CAS 2008年第2期6-9,共4页
The aim of the study is to investigate the contents of trace element Se, Cd, Pb in three plants including burdock, ginkgol and garlic via graphite furnace atomic absorption and standard addition method. The results sh... The aim of the study is to investigate the contents of trace element Se, Cd, Pb in three plants including burdock, ginkgol and garlic via graphite furnace atomic absorption and standard addition method. The results show that Se in burdock stem, skin and leaf are 32.40, 48.63, 38.10 μg/g, respectively; Cd in burdock stem, skin and leaf are 0. 160 0, 0. 300 0, 0. 140 0 μg/g, respectively; Cd in burdock stem, skin and leaf are 2. 020, 3. 960, 2. 410 μg/g, respectively. In the ginkgo and ginko leaf, Se contents are 17.63 and 16.91 μg/g, respectively ; for Cd are 0. 181 0 and 0.2020μg/g, respectively ; for Pb are 3. 572 and 4. 021 μg/g, respectively. In garlic, Se, Cd and Pb are 73. 900 0, 6. 900 0 and 0. 390 0, respectively. All the standard deviations of measured results are below 2.3%, recovery rate are from 99% to 101%. 展开更多
关键词 Trace elements GFT AAS BURDOCK GINKGO GARLIC
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Adjustment to affective factors in English learning by using Internet English Curriculum Resource
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作者 马云霞 任重远 《Sino-US English Teaching》 2008年第1期25-27,共3页
The new curriculum standard points out that affection is one of the most important goals of fundamental education. The non-target language environment is easier to cause the affective change of middle school students ... The new curriculum standard points out that affection is one of the most important goals of fundamental education. The non-target language environment is easier to cause the affective change of middle school students who are changeable in their affective state. Based on the affective filter hypothesis, this paper deals with the adjustment to affective factors in English learning by using Internet English Curriculum Resource, such as attitude and motivation, anxiety and inhibition, self-esteem and self-confidence. At last, some suggestions are offered to judge Internet English Curriculum Resource. 展开更多
关键词 middle school students affective factors English learning English Curriculum Resource
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Bioinformatics Analysis of Cytochrome P450 Monooxygenase Family from Artemisia
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作者 郭书巧 束红梅 +3 位作者 巩元勇 蒋璐 朱静雯 倪万潮 《Agricultural Science & Technology》 CAS 2016年第8期1813-1819,1827,共8页
Artemisinin, a sesquiterpene lactone endoperoxide derived from Artemisia annua L, forms the basis of the most important medicines for treating malaria in use today. In the study, a total of 41 full genes coded cytochr... Artemisinin, a sesquiterpene lactone endoperoxide derived from Artemisia annua L, forms the basis of the most important medicines for treating malaria in use today. In the study, a total of 41 full genes coded cytochrome P450 monooxygenases were identified from NCBI. These genes were classified into 11 families in 3 gene clans according to sequence similarity. One of the first interesting features in sequence alignment was that the CYP82, CYP83 and CYP716 families specific in Arabidopsis genome were present in Artemisia, and the CYP92 specific in rice was also present in Artemisia. The physical and chemical properties and structure characteristics of the identified P450s were studied. The results showed their secondary structures were very similar and their senior structures mainly contained α-helix. 展开更多
关键词 Artemisinim Cytochrome P450 BIOINFORMATICS
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Preparation and Pharmacokinetic Characterization of Sustained Release Melatonin Tablet 被引量:1
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作者 何仲贵 张天虹 +1 位作者 唐星 张汝华 《Journal of Chinese Pharmaceutical Sciences》 CAS 2003年第2期82-86,共5页
Aim To prepare the sustained release melatonin tablet with HPMC matrix and study its pharmacokinetics and bioavailatility. Methods HPMC was used as matrix to formulate the sustained release tablet. The influences of t... Aim To prepare the sustained release melatonin tablet with HPMC matrix and study its pharmacokinetics and bioavailatility. Methods HPMC was used as matrix to formulate the sustained release tablet. The influences of the size of melatonin, type and amount of HPMC, drug loading, type and amount of additives, and compressing pressure were investigated. Plasma concentration of melatonin in dogs after intravenous injection of two doses and oral administration of sustained release tablets and unmodified release capsules was detected by HPLC using fluorescence detector. Results The drug release from sustained release tablets was influenced by the size of melatonin, type and amount of HPMC, drug loading, and type and amount of additives. Melatonin was found to fit two compartment model after intravenous injection, AUC was proportional to doses, and t(1/2β) of two doses has no significant difference. Relative bioavailability of melatonin sustained release tablet to normal capsule was 83.8%, and absolute bioavailability was 3.75% for sustained release tablet and 4.49% for capsule. Conclusion The melatonin sustained release tablet was well formulated. The absolute bioavilability for oral administration of either sustained release tablet or unmodified release capsule of melatonin was less than 5%. The bioavailability of melatonin sustained release tablet was lower than that of unmodified release capsule, but MRT of sustained release tablet was significantly longer than that of capsule. 展开更多
关键词 MELATONIN HPMC sustained release tablet BIOAVAILABILITY pharmacokinetics
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Studies on a Traditional Chinese Medical Prescription Ma Xing Shi Gan Tang by Bio-coordination Chemistry 被引量:2
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作者 陈求浩 吴炳辅 崔万钧 《Journal of Chinese Pharmaceutical Sciences》 CAS 1993年第1期85-87,共3页
本文报道 pH 电位滴定法测出麻黄碱与生石膏中的 Cu^(2+)、Fe^(2+)、Zn^(2+)、Mn^(2+)离子形成的 ML 及 ML_2型络合物的稳定常数。滴定曲线显示甘草酸与上述四种金属离子也能分别形成不同稳定程度的络合物。用麻黄碱加甘草酸和上述四种... 本文报道 pH 电位滴定法测出麻黄碱与生石膏中的 Cu^(2+)、Fe^(2+)、Zn^(2+)、Mn^(2+)离子形成的 ML 及 ML_2型络合物的稳定常数。滴定曲线显示甘草酸与上述四种金属离子也能分别形成不同稳定程度的络合物。用麻黄碱加甘草酸和上述四种金属离子配制成的模拟麻杏石甘汤和单纯生石膏煎剂与麻性石甘汤一样均有使家兔退热的效果,与对照组比较均有显著性差异(P<0.05);而用麻黄碱加甘草酸配制成的溶液无退热效果。作者认为应从生物—配位无机化学的多金属—多配体体系的观点去研究某些传统中医药方剂。 展开更多
关键词 Traditional Chinese Medical Prescription Trace Elements Bio-coordination Chemistry Decoction of Chinese Ephedra Apricot Kernel Gypsum and Licorice
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Isolation and analysis of pepper ACC oxidase gene partial sequence
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作者 陈银华 张广平 +3 位作者 王海 蔡铭 袁平该 陈宪成 《Agricultural Science & Technology》 CAS 2006年第1期2-7,共6页
Ethylene plays an extensive role in plant growth and development.. 1-aminocyclopropane-1-carboxylate (ACC) oxidase (ACO) is the key enzyme in ethylene biosynthesis. In this study, a 354 g DNA and a 213 bp cDNA bas... Ethylene plays an extensive role in plant growth and development.. 1-aminocyclopropane-1-carboxylate (ACC) oxidase (ACO) is the key enzyme in ethylene biosynthesis. In this study, a 354 g DNA and a 213 bp cDNA base pair (bp) candidate fragment was amplified from pepper with primers derived from the ACO sequence (AJ011109) reported by Ernesto. The putative new gene was analyzed by bioinformatics tools. 展开更多
关键词 ACC oxidase CLONING PCR BIOINFORMATICS
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优秀传统文化融入思政教学的意义与途径——试述传统文化在职业院校语文教学中的应用
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作者 张静 《好日子》 2021年第34期242-242,共1页
将优秀传统文化融入思政教学中,主张“仁爱”,有助于人际和谐;明辨“义理”,有助于确立正确的价值取向;追求“内圣外王”,有助于塑造理想人格。本文以优秀传统文化融入思政教学为目标,从传统文化教育在中高职语文教学中的应用出发,探讨... 将优秀传统文化融入思政教学中,主张“仁爱”,有助于人际和谐;明辨“义理”,有助于确立正确的价值取向;追求“内圣外王”,有助于塑造理想人格。本文以优秀传统文化融入思政教学为目标,从传统文化教育在中高职语文教学中的应用出发,探讨了通过加强职业院校语文教育的文化性、综合性,从而更好地培养职业人才文化素养和国学基础的教育策略。希望能通过本文的研究,为职业院校教育更好的贯彻实施素质教育思想,提升学生的文化水平与综合素质做出有益的推动。 展开更多
关键词 思政教学 职业院校 传统文化 学生素
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Research on Stoichiometry of Early-spring Herbs Functional Group in the Subtropical Artificial Wetland
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作者 牛晓音 常杰 +1 位作者 葛滢 郑家文 《Agricultural Science & Technology》 CAS 2011年第8期1182-1185,1190,共5页
[Objective]The aim was to carry out stoichiometry on the early-spring herbs functional group in subtropical artificial wetland.[Method]UV-Vis spectrophotometer was used for the determination of nitrate-nitrogen,ammoni... [Objective]The aim was to carry out stoichiometry on the early-spring herbs functional group in subtropical artificial wetland.[Method]UV-Vis spectrophotometer was used for the determination of nitrate-nitrogen,ammonium nitrogen and phosphorus concentrations.Potassium persulfate absorptiometry was used for the measurement of total N content,while the flame photometer was used to detect the potassium and sodium concentration in plants.All the nutrient determination of plant samples were repeated for four times.[Result]The four nutrient concentrations in almost all samples were in the normal range of natural plant nutrition concentrations;in early-spring herbs functional groups,different species showed diversity on the nutrient concentrations;plant height had no significant effect on the nutrient concentrations in plants;the nutrient concentrations of non-grass group plants were higher than that of grass group plants;the nutrient concentrations of the annual herb were higher than that of perennial herbs.[Conclusion]The study had provided basis for the understanding of the effects of changes in nutritional conditions on species diversity,community structure and succession of the system. 展开更多
关键词 Early-spring herbs Functional group BIODIVERSITY Element STOICHIOMETRY
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Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature 被引量:16
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作者 Natasha A Koloski Laurel Bret Graham Radford-Smith 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第2期165-173,共9页
The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hyp... The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended. 展开更多
关键词 Inflammatory bowel disease Hygiene hypothesis Microbial exposure Cold chain hypothesis H pylori HELMINTHS MEASLES Antibiotic BREASTFEEDING Child care
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Alterations of biliary biochemical constituents and cytokines in infantile hepatitis syndrome 被引量:19
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作者 Yan Ding Lei Zhao +2 位作者 Hong Mei Zhi-Hua Huang Shu-Ling Zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第43期7038-7041,共4页
AIM: To investigate the biliary biochemical constituents and cytokines in infantile hepatitis syndrome (IHS). METHODS: From 42 IHS subjects and 21 controls, serum and biliary biochemical constituents, including total ... AIM: To investigate the biliary biochemical constituents and cytokines in infantile hepatitis syndrome (IHS). METHODS: From 42 IHS subjects and 21 controls, serum and biliary biochemical constituents, including total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GT), total bile acid (TBA), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) both in bile and serum, were assayed. The subjects with IHS were divided into a cholestasis group (n = 21) and a hepatitis group (n = 21). RESULTS: In the cholestasis group, serum TBIL, DBIL, ALT, γ-GT, TBA, IL-6 and TNF-α levels were higher than those in the control (P < 0.01); and also the biliary TBIL, DBIL, γ-GT and TBA levels were lower than those in the control, whereas biliary IL-6 and TNF-α levels were higher than those in the control (P < 0.01). In the cholestasis group, serum IL-6 and TNF-α levels were lower than those in bile (P < 0.01). In the hepatitis group, serum DBIL, ALT, γ-GT, TBA, IL-6 and TNF-α levels were higher than those in the control (P < 0.01 or 140.57 ± 70.32 vs 79.06 ± 35.25, P < 0.05), while biliary TBIL, DBIL, γ-GT and TBA levels were lower than those in the control (P < 0.01), and biliary IL-6 and TNF-α levels were higher than those in the control (P < 0.01). In the hepatitis group, serum IL-6 and TNF-α levels were also lower than those in bile (P < 0.01). Serum TBIL, DBIL, γ-GT, IL-6 and TNF-α levels in the cholestasis group were higher than those in the hepatitis group, while biliary IL-6 and TNF-α levels in the cholestasis group were higher than those in the hepatitisgroup. Biliary IL-6 and TNF-α were found to be more significantly increased than serum IL-6 and TNF-α in IHS (P < 0.01). The biliary IL-6 and TNF-α levels were positively correlated with serum DBIL, TBA and γ-GT levels in IHS subjects. CONCLUSION: Biliary biochemical constituents alter in coincidence with pathological changes in hepatocellular injury. Cholestasis is more serious in IHS patients of cholestasis subtype. Assay of biliary IL-6 and TNF-α levels can be specific and sensitive to determine the inflammatory status of impaired liver in IHS. 展开更多
关键词 Infantile hepatitis syndrome Biliarybiochemical constituents Biliary cytokines INTERLEUKIN-6 Tumor necrosis factor-α
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Organic Phosphorus in Shallow Lake Sediments in Middle and Lower Reaches of the Yangtze River Area in China 被引量:24
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作者 JIN Xiang-Can WANG Sheng-Rui +1 位作者 CHU Jian-Zhou WU Feng-Chang 《Pedosphere》 SCIE CAS CSCD 2008年第3期394-400,共7页
Thirteen sediment core samples(0-10 cm) were taken from the seven lakes in the middle and lower reaches of the Yangtze River to determine the contents and distributions of organic phosphorus(P) fractions in the sedime... Thirteen sediment core samples(0-10 cm) were taken from the seven lakes in the middle and lower reaches of the Yangtze River to determine the contents and distributions of organic phosphorus(P) fractions in the sediments of the shallow lakes in the area.The organic P fractions in the sediments were in the order of moderately labile organic P(MLOP) > moderately resistant organic P(MROP) > highly resistant organic P(HROP) > labile organic P(LOP),with average proportional ratios of 13.2:2.8:1.3:1.0.LOP,MLOP,and MROP were significantly related to the contents of total organic carbon(TOC),water-soluble P(WSP),algal-available P(AAP),NaHCO3-extractable P(Olsen-P),total P(TP),organic P(OP),and inorganic P(IP).However,HROP was significantly related to OP and weakly correlated with TOC,WSP,AAP,Olsen-P,TP or IP.This suggested that organic P,especially LOP and MLOP in sediments,deserved even greater attention than IP in regards to lake eutrophication.In terms of organic P,sediments were more hazardous than soils in lake eutrophication.Although OP concentrations were higher in moderately polluted sediment than those in heavily polluted sediment,LOP and MLOP were higher in the heavily polluted sediment,which indicated that heavily polluted sediment was more hazardous than moderately polluted sediment in lake eutrophication. 展开更多
关键词 BIOAVAILABILITY chemical extracted phosphorus lake sediment middle and lower reaches of the Yangtze River area organic phosphorus fractions
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Humanity factors and more: A little heads up for medical students and future doctors 被引量:1
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作者 CHANG Yifan 《Journal of Medical Colleges of PLA(China)》 CAS 2013年第1期29-31,共3页
Exactly how can we become a successful doctor in the future? It has been widely accepted that chasing perfection in our field of expertise alone is not enough. Here in China, doctors have the liability to do more. Chi... Exactly how can we become a successful doctor in the future? It has been widely accepted that chasing perfection in our field of expertise alone is not enough. Here in China, doctors have the liability to do more. Chinese doctors are relatively more prone to confronting difficult situations in a more complex manner. Therefore, the humanity factor in medical practice is discussed, and some essential communication skills are suggested for medical practitioners, with heartfelt anticipation for a better medical environment as well as a more pleasant Doctor-Patient relationship. 展开更多
关键词 Medical humanity EMPATHY Communication skills Doctor-Patient relationship
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Role of calcium and other trace elements in the gastrointestinal physiology 被引量:2
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作者 P Kirchhoff JP Geibel 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第20期3229-3236,共8页
Calcium is an essential ion in both marine and terrestrial organisms, where it plays a crucial role in processes ranging from the formation and maintenance of the skeleton to the regulation of neuronal function. The C... Calcium is an essential ion in both marine and terrestrial organisms, where it plays a crucial role in processes ranging from the formation and maintenance of the skeleton to the regulation of neuronal function. The Ca^2+ balance is maintained by three organ systems, including the gastrointestinal tract, bone and kidney. Since first being cloned in 1993 the Ca^2+-sensing receptor has been expressed along the entire gastrointestinal tract, until now the exact function is only partly elucidated. As of this date it still remains to be determined if the Ca^2+-sensing receptor is involved in calcium handling by the gastrointestinal tract. However, there are few studies showing physiological effects of the Ca^2+-sensing receptor on gastric acid secretion and fluid transport in the colon. In addition, polyamines and amino acids have been shown to activate the Ca^2+-sensing receptor and also act as allosteric modifiers to signal nutrient availability to intestinal epithelial cells. Activation of the colonic Ca^2+-sensing receptor can abrogate cyclic nucleotide-mediated fluid secretion suggesting a role of the receptor in modifying secretory diarrheas like cholera. For many cell types changes in extracellular Ca^2+ concentration can switch the cellular behavior from proliferation to terminal differentiation or quiescence. As cancer remains predominantly a disease of disordered balance between proliferation, termination and apoptosis, disruption in the function of the Ca^2+-sensing receptor may contribute to the progression of neoplastic disease. Loss of the growth suppressing effects of elevated extracellular Ca^2+ have been demonstrated in colon carcinoma, and have been correlated with changes in the level of CaSR expression. 展开更多
关键词 CALCIUM Trace elements Gastrointestinal physiology
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