区域国别学与国际传播“学用相生”

区域国别学与国际传播都是中国走近世界舞台中央、构建人类命运共同体的“必修课”。从近年来的文献与实践来看,研究者愈来愈体察到区域国别学与国际传播之间存在交集和并集,且着手论述二者之间的关系。当前的国际传播研究聚焦全球文化新秩序、国际传播新秩序,呈现出新的发展趋向和知识需求。区域国别学与国际传播研究在思想史渊源和实践基础上都有许多共通之处,特别是区域国别学知识生产的自主意识、问题导向、在地经验等属性,为国际传播与区域国别学之间的交叉互鉴提供了理论发展与实践探索的双重空间。区域国别学是把握“作为个体的对象国”与“作为整体的世界”之间关系的智力活动,与国家战略存在“学以致用、用以强学”的关系。国际传播作为当代中国深化对外开放的战略性工作,为区域国别学带来新的研究问题和应用场景,而区域国别学也为国际传播提供精准化、战略化的知识基础。二者互鉴共生,为构建中国对外话语体系提供了知识、实践、伦理方面的支撑。

A New Model on Origin and Evolution of Biology

Modified classical Boltzmann entropy as generalized entropy, then proposed Maximum Generalized Entropy Principle fusing physics and biology, and established a new model for biological origin and evolutions based on this principle, finally took protein evolution for an example to analyze. The model provided some reference for biological complexity research.

Pharmacokinetics and Relative Bioavailability ofsustained-release Tablets of Diclofenac Sodiumin Male Volunteers

The pharmacokinetics of a sustained- release formulation and an enteric- coated tablet of diclofenac sodium were studied on 8 healthy male volunteers in an open,randomized crossover study.Drug level in serum was assayed by HPLC method.The changes in serum concentration were conformed to a l-compartment open model.The t_1/2 (Ke)averaged 2.15±0.17 and ll.60 ± l.95 h,and the areas under the drug concentration curves were 5.87 ± 0.67 and 5.55 ± 0.57μgh/ml for enteric-coated and sustained-release tablet of diclofenac sodium,respectively. The mean relative bioavailability of sustained-release tablet was 0.95 to that of enteric-coated tablet.

Management of hypertensive crises in the elderly

Hypertensive crises are elevations of blood pressure higher than 180/120 mmHg. These can be urgent or emergent, depending on the presence of end organ damage. The clinical presentation of hypertensive crises is quite variable in elderly patients, and clinicians must be suspicious of non-specific symptoms. Managing hypertensive crises in elderly patients needs meticulous knowledge of the pathophysiological changes in them, pharmacological options, pharmacokinetics of the medications used, their side effects, and their interactions with other medications. Clevidipine, nicardipine, labetalol, esmolol, and fenoldopam are among the preferred choices in the elderly due to their efficacy and tolerability. Nitroprusside, hydralazine, and nifedipine should be avoided, unless there are no other options available, due to the high risk of complications and unpredictable responses.

Interspecific competition and allelopathic interaction between Karenia mikimotoi and Dunaliella salina in laboratory culture

Algal allelopathy is a manifold ecological/physiological phenomenon that is focused on chemical interactions and autotoxicity. We investigated the allelopathic interactions between Karenia mikimotoi and Dunaliella salina in laboratory cultures based on different temperature （15℃, 20℃, and 25℃） and lighting （40,80, and 160 umol/（m2·s）） conditions. The growth of D. salina in bi-algae culture （1：1 size/density） was significantly restrained. The results of cell-free filtrate culture indicate that direct cell-to- cell contact was not necessary in interspecific competition. Further experimental results demonstrated that allelochemicals released from K. miMmotoi were markedly influenced by both temperature （P=0.013） and irradiance （P=0.003）, resulting in different growth characteristics olD. salina in filtrate mediums. Compared with the plateau period, K. mikimotoi exudates in the exponential phase had a stronger short-term inhibition effect on D. salina in normal conditions. A clear concentration-dependent relationship was observed in the effect of allelochemicals released from K. mikimotoi with low-promoting and high-repressing effects on D. Salina in a short time-scale. In addition, allelopathic substances remain stable and effective under high temperature and pressure stress. Many flocculent sediments adhering with D. salina cells were observed in all filtrate mediums, while the quantity and color depended on the original culture conditions.

Literature Views on Second Language Acquisition The Ways of Incorporating Interaction and Participation

Most current theories of second language acquisition and current views on methods and approaches to teaching English as a second language place a high value on student participation and interaction in the language classroom. This interaction may be between teacher and student and/or student and student. Despite this, in many English classrooms around the world, students have very few opportunities to interact in the second language. In this paper, using the literature on second language acquisition research and methodology to prepare a case which highlights why teachers and course designers should find ways to incorporate second language interaction and student participation in their language classes despite the practical difficulties they may face.

The Interpretation of Mathematical Difficulties in Primary School： Which Perspective to Choose？

Research on learning difficulties in mathematics adopts one of two distinct perspectives. According to the first, learning difficulties are due to the intrinsic characteristics of the student. For supporters of the second perspective, those difficulties result from the interaction between the student and the school system. The objective of this study is to test the validity of these two perspectives in interpreting learning difficulties in mathematics among at-risk students. To this end, we collaborated with normally achieving （undiagnosed） and at-risk students. Results show that the second perspective is better suited to the interpretation of learning difficulties in mathematics students

The Effect of Background Knowledge on EFL Learners＇ Reading Comprehension

Schema is known to play an important role in reading comprehension. The schema embodying the learners background knowledge of cultural familiar materials facilitates the understanding of the text （Pritchard, 1990）. Also Steffensen, Joag-Dev, and Anderson （1979） and Nelson （1987） proposed that the schemata embodying background knowledge influenced how well the text would be comprehended. However, Hudson （1982） and Carrell （1984） found there was no significant background effect in advanced level learners. From those studies, it seems that background effect is different at different language proficiency levels. Thus, the present study examines the interaction between background knowledge and language proficiency in reading comprehension. The participants were freshmen of National Chiayi University. They were divided into three language proficiency levels based on the General English Proficiency Test. Four reading comprehension tests were constructed to assess their reading comprehension： cultural familiar/unfamiliar text and topic familiar/unfamiliar text. The results of this study showed that participants had better performance on the culture/topic familiar text than the culture/topic unfamiliar text. Thus the findings suggest that the teacher can use teaching activities, such as pre-reading activities or vocabulary teaching to increase the background knowledge when teaching readings to EFL （English as a foreign language） learners

The recent disciplinal progresses of agricultural entomology in China

In this paper, four recent advances and achievements of China in agricultural insect research, namely, on the genome of silkworm (Bombyx mori Linnaeus), on the geographical differentiation and regional migration of cotton bollworm (Helicoverpa armigera (Hübner)), on the standardized monitoring techniques for safety of honey bee (Apis mellifera Linnaeus) products, and on the virus transmission property of small brown planthopper (Laodelphax striatellus (Fallén)) as well as the interactions between vector and rice stripe virus (RSV), were reported. All of these researches are very important for controlling agricultural insect pests and the diseases they transmit, accelerating the molecular biological research of silkworm, and promoting the international trade of honey bee products. Most of these achievements mentioned above have got the national, provincial, ministerial or municipal awards on science and technology.

Ecological Study on Bacteria-Zooplankton Interaction in Domat AI-Gandal Lake, AL-Jouf Area, Kingdom of Saudi Arabia

A year-long survey of some physical parameters （water temperature, dissolved oxygen, pH, turbidity）, chemical parameters （Biological Oxygen Demand ＂BOD＂, Chemical Oxygen Demand ＂COD＂, nitrate, ammonia, orthophosphate） and some biological （zooplankton） and microbiological （total bacteria, indicator bacteria, pathogenic bacteria） components in Domat AI-Gandal Lake was conducted. Water samples were collected seasonally from spring 2004 to winter 2005. Four locations on the Lake were sampled in order to evaluate the condition of the Lake. To investigate the possible effect of zooplankton in controlling the presence of faecal indicator bacteria, a 24 hour experiment was carried out to examine this hypothesis as well as the grazing pressure of zooplankton on the bacterial community of the Lake. The results showed that variations in season temperature affected the zooplankton and density of bacteria in the Lake. Zooplankton was composed by Protozoa 75%, Rotifera 20.6%, Cladocera 3% and Copepoda 2%. The reduction rates for the tested faecal pollution indicators in presence of zooplankton predators were remarkable （up to 99%）. In conclusion zooplankton, especially protozoa, was found to play an important role as biological control against bacterial indicators of faecal pollution.

Analysis of the Secondary Structure of the Transmembrane Domain of SARS CoV E Protein Using FTIR Spectroscopy

One of the major obstacles facing the field of structural biology in the post genomic era is the inherent difficulty of analyzing the structure of membrane proteins under native conditions. The method of choice for studying such proteins is FTIR spectroscopy. Following the outbreaking of the severe acute respiratory syndrome （SARS） virus, in 2003, extensive work has been directed at elucidating the structure of the E transmembrane proteins of the SARS coronavirus. In this study, the secondary structure of the transmembrane a-helical bundles was analysised using the biophysical method site specific infrared dichroism （SSID）. Sixteen amino acids were isotopically labeled with （~3C=180） at different positions of the primary structure of the synthesized E protein CoV. The secondary structure was studied using Attenuated Total Internal Reflection （ATR） FTIR spectroscopy. Based on our findings, the presence of two possible H-bonding interactions between the carbonyl oxygen of two residues 26 and 31 （Phe and Leu） respectively with water molecules which may be trapped within the helix structure were postulatesed. These interactions may cause a change in this structure.

Tectonomicrobiology:A new paradigm for geobiological research

Geomicrobiology is a sub-discipline of geobiology and emphasizes the interaction between microorganisms and their environment on Earth. There is a need to explicitly emphasize the biogeochemical processes performed by microorganisms associated with Earth's tectonic activities, especially under the framework of the modern theory of plate tectonics. Tectonomicrobiology aims to create a better synergy between microbial and active tectonic processes. This explicit synergy should also foster better communications between solid Earth scientists and life scientists in terms of holistic Earth system dynamics at both tectonic and micro-scales.

The deubiquitinase UCHLS/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened

The Hedgehog （Hh） signaling pathway plays important roles in developmental processes including pattern formation and tissue homeostasis. The seven-pass transmembrane receptor Smoothened （Smo） is the pivotal transducer in the pathway; it, and thus the pathway overall, is regulated by ubiquitin-mediated degradation, which occurs in the absence of Hh. In the presence of Hh, the ubiquitination levels of Smo are decreased, but the molecular basis for this outcome is not well understood. Here, we identify the deubiquitinase UCHL5 as a positive regulator of the Hh pathway. We provide both genetic and biochemical evidence that UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane. Strikingly, we find that Hh enhances the interaction between UCHL5 and Smo, thereby stabilizing Smo. We also find that proteasome subunit RPN13, an activator of UCHL5, could enhance the effect of UCHL5 on Smo protein level. More importantly, we find that the mammalian counterpart of UCHL5, UCH37, plays the same role in the regulation of Hh signaling by modulating hSmo ubiquitination and stability. Our findings thus identify UCHL5/UCH37 as a critical regulator of Hh signaling and potential therapeutic target for cancers.

Membrane protein reconstitution for functional and structural studies

Membrane proteins are involved in various critical biological processes,and studying membrane proteins represents a major challenge in protein biochemistry.As shown by both structural and functional studies,the membrane environment plays an essential role for membrane proteins.In vitro studies are reliant on the successful reconstitution of membrane proteins.This review describes the interaction between detergents and lipids that aids the understanding of the reconstitution processes.Then the techniques of detergent removal and a few useful techniques to refine the formed proteoliposomes are reviewed.Finally the applications of reconstitution techniques to study membrane proteins involved in Ca2+ signaling are summarized.

Preliminary studies on the basic factors of bionics

The bionic consciousness,idea,and practice opened a unique path for the progress of mankind,the development of the society,and the innovation of science and technology from the subconscious bionic activities of the ancient humans to the significant bionic designs in modern engineering.Nowadays,driven by the practical demand of human beings,bionics becomes an important factor for the sustainable development of technology.A lot of new and outstanding innovations have been produced through the effective interactions between bionics,technology,and demand.The stronger the interactions,the greater the innovation success would be.In this article,the basic factors such as the connotation,characteristics,and interactions of bionic demands,bionic models,bionic simulations,and bionic products were explained,which are the indispensable basic knowledge for improving the ability of innovation especially for the original one,realizing the design and innovation of new technology and manufacturing for better bionic products.

A survey on fabrication,control,and hydrodynamic function of biomimetic robotic fish

Understanding and replicating the locomotion principles offish are fundamental in the development of artificial fishlike robotic systems,termed robotic fish.This paper has two objectives:(1) to review biological clues on biomechanics and hydrodynamic flow control offish swimming and(2) to summarize design and control methods for efficient and stable swimming in robotic fishes.Our review of state-of-the-art research and future-oriented new directions indicates that fish-inspired biology and engineering interact in mutually beneficial ways.This strong interaction offers an important insight into the design and control of novel fish-inspired robots that addresses the challenge of environmental uncertainty and competing objectives;in addition,it also facilitates refinement of biological knowledge and robotic strategies for effective and efficient swimming.

Design,synthesis,and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs

A series of new benzimidazole derivatives was synthesized and characterized by IR,1H NMR,13C NMR,MS,and HRMS spectra.All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique.The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin,Norfloxacin,and Fluconazole.The combination of2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin,Norfloxacin,and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A.flavus.In addition,the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity.

Mathematical model of the effects of government intervention and rehabilitation of prostitution

In the United States, prostitution is considered illegal in all but one state; Nevada allows some legal activities in exchange for substantial guidelines. In 2010, approxi- mately 43,600 females were arrested for prostitution. Numerous intervention programs were established in order to obstruct the lifestyle of a prostitute （PRP~ Project ROSE, etc.）. There are many documentations and programs that share their forethought on prostitution; however, few target prostitution directly. To determine the dynamics of prostitution, this paper constructs a four-class compartmental model that focuses on the effectiveness of government intervention and rehabilitation of prostitutes mathematically. The basic reproductive number, R0, helps to discover the threshold values for the dynamics of prostitution to become both prevalent or absent in society. This paper predominately observes government intervention to curtail a prostitution prevalent society. Various parameters and variables help to define and indicate the dynamics of pros- titution to construct viable simulations. Successful prostitution interaction prevention deemed essential in prostitution prevention; however, government intervention corresponding with successful rehabilitation competitively challenges prostitution interaction prevention in reducing basic reproductive values.

Creating a Community of Learners in the Language Classroom

This paper reports a study designed to observe how a learning community arose when a group of learners of English focused on a common project. The students＇ task was to participate as speakers in an international conference. Undergraduate students in a course of Business English at a small private university in western Mexico worked in teams to research and develop a topic to be sent as a proposal to the conference.The study used Interaction Analysis with a qualitative focus to observe participant interactions. Video and audio recordings were supplemented with participant interviews and questionnaires. Analysis shows that in the course of the project, the students learned not only business terminology, but also how to work together.

A molecular dynamics and computational study of human KAT3 involved in KYN pathway

Kynurenine aminotransferases （KATs） catalyze the transamination of kynurenine （KYN） pathway and endogenous KYNs have been suggested to highly correlate to abnormal brain diseases. HKAT3 is a key member of KAT family, while the binding mechanism of KYN and cofactor with HKAT3 has not been determined yet. In this study, we focus on the structure-function relationship among KYN, cofactor and HKAT3. The binding models of KYN complex and KYN＆cofactor complex were ob- tained and were studied by molecular dynamics （MD） simulations. We identified several critical residues and influence of conformational changes in human kynurenine aminotransferase 3 （HKAT3） complexes. The cofactor may contribute largely not only to the catalysis, but also to the binding. In addition, a hypothesis is proposed that a strong hydrophobic interaction between Tyr159 and Lys280 may influence the binding mode and the binding region of the substrate and the cofactor. Our re- suits will be a good starting point for further determination of the biological role.