The last ten years have seen remarkable progress in cancer research. However, despite significant breakthroughs in the understanding, prevention, and treatment of cancer, the disease continues to affect millions of pe...The last ten years have seen remarkable progress in cancer research. However, despite significant breakthroughs in the understanding, prevention, and treatment of cancer, the disease continues to affect millions of people worldwide. Cancer＇s complexity compounded with financial, policy and regulatory roadblocks has slowed the rate of progress being made against cancer. In this paper, we review a few of the most recent breakthroughs that are fueling medical advances and bringing new hope for patients affected by this devastating disease. We also address the challenges facing us and the opportunities to accelerate future progress against cancer. The efforts of the American Association for Cancer Research （AACK） to address the cancer burden already extend beyond the borders of the United States of America. The AACR is committed to increasing its efforts to stem the tide of cancer worldwide by promoting innovative programs, strategies, and initiatives for cancer researchers and all those engaged in cancer-related biomedical sciences around the world.展开更多
Density functional theory is applied to predicting the structures and electrostatic potentials of planar electrochemical surfaces within the framework of the restricted primitive model where small ions are represented...Density functional theory is applied to predicting the structures and electrostatic potentials of planar electrochemical surfaces within the framework of the restricted primitive model where small ions are represented by charged hard spheres of equal diameter and the solvent is assumed to be a continuous dielectric medium. The hard-sphere contribution to the excess Helmholtz energy functional is evaluated using the modified fundamentalmeasure theory and the electrostatic contribution is obtained from the quadratic functional Taylor expansion using the second-order direct correlation function from the mean-spherical approximation. Numerical results for the ionic density profiles and the mean electrostatic potentials near a planar surface of various charge densities are in excellent agreement with molecular simulations. In contrast to the modified Gouy-Chapman theory, the present density functional theory correctly predicts the second layer formation and charge inversion of charged surfaces as observed in simulations and in experiments. The theory has also been tested with the zeta potentials of positively charged polystyrene particles in aqueous solutions of KBr. Good agreement is achieved between the calculated and experimental results.展开更多
This study focuses on the role of researcher/academia in making low carbon policy in the UK. UK researchers and universities enjoy relatively high degree of independence of their research from the government due to it...This study focuses on the role of researcher/academia in making low carbon policy in the UK. UK researchers and universities enjoy relatively high degree of independence of their research from the government due to its statute that guarantees its independence （＂The Haldene Principle＂）. In addition, there was a recent movement for evidence-based policy in the UK, which requires more economic and scientific robustness, therefore role of engineers and social scientists are increasingly important. In particular, social science will have a greater role in changing people＇s behavior with high level of uncertainty. UK businesses have played a leading role to move forward the climate policy such as UKETS （United Kingdom Emissions Trading Scheme） as well as low carbon policy. The regular communication and consultation is a crucial basis for making integrated policy, which involves wide range of stakeholders. The legally binding targets set out by Climate Change Act 2008 required structural change of the government to implement the necessary policies and measures especially by integrating climate and energy policy.展开更多
In October 2010, the American Institute of Certified Public Accountants [AICPA] announced that the CPA （Certified Public Accountant） examination would be changed to include International Financial Reporting Standar...In October 2010, the American Institute of Certified Public Accountants [AICPA] announced that the CPA （Certified Public Accountant） examination would be changed to include International Financial Reporting Standards （IFRS）. A reason given for this change was the supposed importance given to IFRS knowledge in the latest practice analysis. This paper examines this practice analysis as well as a review by graduate students of some accounting textbooks. The conclusion given by the students, other academic research and the practice analysis is that US is not prepared to immediately make this change.展开更多
In the process of transition from the planned economy to the socialist market economy, college students＇ interest views are uneven. The shown diversified characteristics have carousedthe academic circle＇s attention ...In the process of transition from the planned economy to the socialist market economy, college students＇ interest views are uneven. The shown diversified characteristics have carousedthe academic circle＇s attention about college students＇ interest views. The academic circle has conducted comprehensive researches on the characteristics and causes, status and the necessity, the basic principles, the main content and the implementation strategies of college students＇ interest view education. However, since researchingtime is limited, the construction of theoretical system, research and development and effectiveness of college students＇ interest views education still has a long way to go.展开更多
This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving aca...This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving academic basic research and clinical research are discussed and the Singapore model for pursuit of open R&D described. The importance of well-characterized, validated drug targets for the search for novel targeted anti-cancer agents is emphasized, as well as a structured, high quality translational R&D. Furthermore, the characteristics of an attractive preclinical development drug candidate are discussed laying the foundation of a successful preclinical development. The most frequent sources of failures are described and risk management at every stage is highly recommended. Organizational factors are also considered to play an important role. The factors to consider before starting a new drug discovery & development project are described, and an example is given of a successful clinical project that has had its roots in local universities and was carried through preclinical development into phase I clinical trials.展开更多
Currently for the steel tube reinforced concrete composite pile research, although predecessors make a comprehensive research on the composite pile beating performance, design technology, but there are still many prob...Currently for the steel tube reinforced concrete composite pile research, although predecessors make a comprehensive research on the composite pile beating performance, design technology, but there are still many problems have not been solved, such as the steel tube reinforced concrete pile composite interracial force learn performance research is still in the initial stage. In this paper, we mainly discuss the research methods of several interface mechanical properties and propose the possibility of studying the mechanical properties of the steel tube reinforced concrete composite pile by using the principle of ultrasonic speckle.展开更多
In view of the important prestige of Zhang Heng’s seismoscope in world culture,scholars in different countries have performed restoration research,however,so far all restored models have only reached the drawing desi...In view of the important prestige of Zhang Heng’s seismoscope in world culture,scholars in different countries have performed restoration research,however,so far all restored models have only reached the drawing design and exhibition stage. In recent decades,new research achievements on historical materials,archaeology and historical seismology have been made in Chinese academic society,which lay a good foundation for the establishment of a new restored model. Not only does the new model more accord with historical materials,but it can be used to detect earthquakes for the first time. This paper will introduce the restoration in four aspects: scientific train of thought,structural restoration,formation restoration and scientific testing.展开更多
Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD b...Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.展开更多
Modem Chinese study of world history began in the middle of the nineteenth century and was closely related to the main theme of the times, that of saving the nation from subjugation and ensuring its survival. Its chie...Modem Chinese study of world history began in the middle of the nineteenth century and was closely related to the main theme of the times, that of saving the nation from subjugation and ensuring its survival. Its chief feature was that it was attuned to the pulse of the times; in all historical periods, the main current of its research has never deviated from the main theme of the times, showing a strong sense of responsibility to society. Under the new historical conditions of reform and opening up, this sense of social responsibility should be reflected in fundamental adherence to the direction of serving the people and socialism.展开更多
In recent years, Chinese scholars have made important progress in research on later Greek philosophy. Using current European and American work as a reference point, this article explores the differences and gaps betwe...In recent years, Chinese scholars have made important progress in research on later Greek philosophy. Using current European and American work as a reference point, this article explores the differences and gaps between foreign and Chinese scholars in this field of research. The author believes that on the question of the boundaries of later Greek philosophy, Chinese scholars have, through long years of exploration, come up with independent opinions and solutions that differ from those of their European and Ameriean counterparts, and that they have a better grasp of the distinctive features of later Greek philosophy. Their work, however, clearly falls short with regard to historical source material. As far as methodology is concerned, there is a clear tendency towards convergence between Chinese scholars and their foreign colleagues.展开更多
文摘The last ten years have seen remarkable progress in cancer research. However, despite significant breakthroughs in the understanding, prevention, and treatment of cancer, the disease continues to affect millions of people worldwide. Cancer＇s complexity compounded with financial, policy and regulatory roadblocks has slowed the rate of progress being made against cancer. In this paper, we review a few of the most recent breakthroughs that are fueling medical advances and bringing new hope for patients affected by this devastating disease. We also address the challenges facing us and the opportunities to accelerate future progress against cancer. The efforts of the American Association for Cancer Research （AACK） to address the cancer burden already extend beyond the borders of the United States of America. The AACR is committed to increasing its efforts to stem the tide of cancer worldwide by promoting innovative programs, strategies, and initiatives for cancer researchers and all those engaged in cancer-related biomedical sciences around the world.
文摘Density functional theory is applied to predicting the structures and electrostatic potentials of planar electrochemical surfaces within the framework of the restricted primitive model where small ions are represented by charged hard spheres of equal diameter and the solvent is assumed to be a continuous dielectric medium. The hard-sphere contribution to the excess Helmholtz energy functional is evaluated using the modified fundamentalmeasure theory and the electrostatic contribution is obtained from the quadratic functional Taylor expansion using the second-order direct correlation function from the mean-spherical approximation. Numerical results for the ionic density profiles and the mean electrostatic potentials near a planar surface of various charge densities are in excellent agreement with molecular simulations. In contrast to the modified Gouy-Chapman theory, the present density functional theory correctly predicts the second layer formation and charge inversion of charged surfaces as observed in simulations and in experiments. The theory has also been tested with the zeta potentials of positively charged polystyrene particles in aqueous solutions of KBr. Good agreement is achieved between the calculated and experimental results.
文摘This study focuses on the role of researcher/academia in making low carbon policy in the UK. UK researchers and universities enjoy relatively high degree of independence of their research from the government due to its statute that guarantees its independence （＂The Haldene Principle＂）. In addition, there was a recent movement for evidence-based policy in the UK, which requires more economic and scientific robustness, therefore role of engineers and social scientists are increasingly important. In particular, social science will have a greater role in changing people＇s behavior with high level of uncertainty. UK businesses have played a leading role to move forward the climate policy such as UKETS （United Kingdom Emissions Trading Scheme） as well as low carbon policy. The regular communication and consultation is a crucial basis for making integrated policy, which involves wide range of stakeholders. The legally binding targets set out by Climate Change Act 2008 required structural change of the government to implement the necessary policies and measures especially by integrating climate and energy policy.
文摘In October 2010, the American Institute of Certified Public Accountants [AICPA] announced that the CPA （Certified Public Accountant） examination would be changed to include International Financial Reporting Standards （IFRS）. A reason given for this change was the supposed importance given to IFRS knowledge in the latest practice analysis. This paper examines this practice analysis as well as a review by graduate students of some accounting textbooks. The conclusion given by the students, other academic research and the practice analysis is that US is not prepared to immediately make this change.
文摘In the process of transition from the planned economy to the socialist market economy, college students＇ interest views are uneven. The shown diversified characteristics have carousedthe academic circle＇s attention about college students＇ interest views. The academic circle has conducted comprehensive researches on the characteristics and causes, status and the necessity, the basic principles, the main content and the implementation strategies of college students＇ interest view education. However, since researchingtime is limited, the construction of theoretical system, research and development and effectiveness of college students＇ interest views education still has a long way to go.
文摘This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving academic basic research and clinical research are discussed and the Singapore model for pursuit of open R&D described. The importance of well-characterized, validated drug targets for the search for novel targeted anti-cancer agents is emphasized, as well as a structured, high quality translational R&D. Furthermore, the characteristics of an attractive preclinical development drug candidate are discussed laying the foundation of a successful preclinical development. The most frequent sources of failures are described and risk management at every stage is highly recommended. Organizational factors are also considered to play an important role. The factors to consider before starting a new drug discovery & development project are described, and an example is given of a successful clinical project that has had its roots in local universities and was carried through preclinical development into phase I clinical trials.
文摘Currently for the steel tube reinforced concrete composite pile research, although predecessors make a comprehensive research on the composite pile beating performance, design technology, but there are still many problems have not been solved, such as the steel tube reinforced concrete pile composite interracial force learn performance research is still in the initial stage. In this paper, we mainly discuss the research methods of several interface mechanical properties and propose the possibility of studying the mechanical properties of the steel tube reinforced concrete composite pile by using the principle of ultrasonic speckle.
基金sponsored by the National Natural Science Foundation of China(40644019)the Special Found of Scientific Research Program for "The Optimization and Design for Reconstruction Models of Seismoscope",China Earthquake Administration
文摘In view of the important prestige of Zhang Heng’s seismoscope in world culture,scholars in different countries have performed restoration research,however,so far all restored models have only reached the drawing design and exhibition stage. In recent decades,new research achievements on historical materials,archaeology and historical seismology have been made in Chinese academic society,which lay a good foundation for the establishment of a new restored model. Not only does the new model more accord with historical materials,but it can be used to detect earthquakes for the first time. This paper will introduce the restoration in four aspects: scientific train of thought,structural restoration,formation restoration and scientific testing.
基金supported by the National Key Research Project(2020YFE0201800)Henan Province Science and Technology Program for Tackling Key Problems(21210230347)2021 Postgraduate Scientifc Re-search Innovation Progrpm of Henan Universityof Chinese Medicine(2021KYCX008).
文摘Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.
文摘Modem Chinese study of world history began in the middle of the nineteenth century and was closely related to the main theme of the times, that of saving the nation from subjugation and ensuring its survival. Its chief feature was that it was attuned to the pulse of the times; in all historical periods, the main current of its research has never deviated from the main theme of the times, showing a strong sense of responsibility to society. Under the new historical conditions of reform and opening up, this sense of social responsibility should be reflected in fundamental adherence to the direction of serving the people and socialism.
基金financed by the Distinguished Professor Project of Zhejiang University
文摘In recent years, Chinese scholars have made important progress in research on later Greek philosophy. Using current European and American work as a reference point, this article explores the differences and gaps between foreign and Chinese scholars in this field of research. The author believes that on the question of the boundaries of later Greek philosophy, Chinese scholars have, through long years of exploration, come up with independent opinions and solutions that differ from those of their European and Ameriean counterparts, and that they have a better grasp of the distinctive features of later Greek philosophy. Their work, however, clearly falls short with regard to historical source material. As far as methodology is concerned, there is a clear tendency towards convergence between Chinese scholars and their foreign colleagues.
