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基于领域知识图谱的生命医学学科知识发现探析 被引量:30
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作者 胡正银 刘蕾蕾 +1 位作者 代冰 覃筱楚 《数据分析与知识发现》 CSSCI CSCD 北大核心 2020年第11期1-14,共14页
【目的】探讨融合多源数据,开展深层次学科知识发现研究与服务的方法。【方法】通过构建科技文献SPO语义网络形成领域知识图谱的核心;通过"实体对齐、概念层次融合与关系融合"实现多源异构数据融合,生成完整领域知识图谱;基... 【目的】探讨融合多源数据,开展深层次学科知识发现研究与服务的方法。【方法】通过构建科技文献SPO语义网络形成领域知识图谱的核心;通过"实体对齐、概念层次融合与关系融合"实现多源异构数据融合,生成完整领域知识图谱;基于领域知识图谱开展深层次学科知识发现;选择造血干细胞癌症治疗进行实证研究。【结果】提出一套基于知识图谱的学科知识发现方法框架KGSKD,可多维度、细粒度融合多源异构数据,定义数据间复杂语义关系,原生支持知识推理、路径发现、链路预测等知识发现应用。【局限】KGSKD存在容易出现数据过饱和、知识发现过程可解释性较差、与领域专家沟通难度较高等局限。【结论】KGSKD具有数据类型更丰富、知识关联更全面、挖掘方法更先进、发现结果更深入等优势,可更有效地支持生命医学学科深层次知识发现研究与服务。 展开更多
关键词 学科知识发现 知识图谱 SPO三元组 数据融合 实体对齐
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融合跨物种科学数据的性状调控基因本体模型构建及应用
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作者 张丹丹 赵瑞雪 +1 位作者 鲜国建 熊赫 《生物技术通报》 CAS CSCD 北大核心 2024年第2期313-324,共12页
【目的】在新技术带来的育种数据激增与计算育种对知识服务的新需求下,为解决作物育种知识服务中跨物种学科知识获取效率低且优异多效基因发现困难的问题。【方法】本研究构建了性状调控基因本体模型框架,并定义了本体模型中的实体层次... 【目的】在新技术带来的育种数据激增与计算育种对知识服务的新需求下,为解决作物育种知识服务中跨物种学科知识获取效率低且优异多效基因发现困难的问题。【方法】本研究构建了性状调控基因本体模型框架,并定义了本体模型中的实体层次结构和实体属性。以主粮作物水稻、玉米、小麦和模式植物拟南芥为数据采集对象,构建了以性状调控基因本体模型为模式层的知识图谱并进行实验。【结果】最终形成了涵盖13种实体、16种数据属性和14个对象属性的性状调控基因本体模型,以此模型为本体层的知识图谱实现了跨物种间学科知识关联检索、优异多效基因挖掘和跨物种基因功能预测。【结论】本研究所提出的性状调控基因本体模型构建方法,能够实现跨物种间性状调控基因的关联发现,可提高跨物种学科知识的获取效率,可支撑多维度科学数据寻证分析的功能基因发现结果。本研究为多效基因的挖掘和基因功能预测提供了一条可实现的方法路径,为作物育种科学研究提供了有效的数据支撑服务。 展开更多
关键词 本体模型 学科知识发现 知识图谱 跨物种 调控基因
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Beyond Logic of Discovery and Paradigmatic Consensus: A Reanalysis of the Popper-Kuhn Debate in the Philosophy of Science
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作者 Douglas I. O. Anele 《Journal of Philosophy Study》 2011年第1期52-66,共15页
There is no patina of doubt that the central philosophical theories of Karl Popper and Thomas Kuhn concerning the nature, substance and method for acquiring scientific knowledge constitute milestones in 20th century p... There is no patina of doubt that the central philosophical theories of Karl Popper and Thomas Kuhn concerning the nature, substance and method for acquiring scientific knowledge constitute milestones in 20th century philosophy of science. Just as Popper's fundamental work on the subject, The Logic of Scientific Discovery, marked a decisive break with inductivist epistemologies, Kuhn's magnum opus, The Structure of Scientific Revolutions (1962, enlarged ed. 1970), inaugurated the coming of age of the historical turn in the philosophy of science. Some scholars seem to consider the main doctrines of both philosophers as irreconcilables or contradictories. This explains why, for example Popper and Popperians such as Imre Lakatos and John Watkins describe themselves as "critical rationalists", whereas they refer to Kuhn as an "irrationalist" or "relativist"-appellations that the latter has consistently rejected. The debate between Popper and Kuhn, especially as contained in an important work, Criticism and the Growth of Knowledge (1970), highlights some of the knotty problems connected with philosophical appraisals of science. It also demonstrates the strengths and weaknesses of logistic approaches in the philosophy of science, on the one hand, and of historically informed socio-psychological analysis of science, on the other. In this paper, we reexamine the Popper-Kuhn controversy from an experimentalist perspective. In other words, we argue that the ideas of testing and normal science can be systematically accommodated by fine-structure dissection of empirical research through which scientists learn about the world, based on the assumption that the progress of science is the growth of experimental knowledge-a fact often neglected in theory-dominated philosophies of science. Taking discovery of the cosmic background radiation by Arno Penzias and Robert Wilson as example, the paper argues that important scientific discoveries have been accomplished even in the absence of theory in any obvious sense, a situation that conflicts with the theory-dominated models of Popper and Kuhn. Thus, it offers an account of how practicing scientists learn from research to control errors and avoid blind alleys. The paper affirms, in conclusion, that going beyond the theories of Popper and Kuhn requires that philosophers of science should take what scientists learn from experiments seriously when theorising about science, by taking into account normal testing or error detection and control strategies through which scientific knowledge is acquired and extended 展开更多
关键词 logic of discovery psychology of research FALSIFICATION CORROBORATION normal science paradigm extraordinary science experimental knowledge
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