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血小板生成素受体激动剂研发进展及安全性特征
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作者 刘明霞 韩风生 +1 位作者 刘延珍 孙运贝 《药学研究》 CAS 2024年第2期184-188,193,共6页
原发免疫性血小板减少症(ITP)是一种免疫介导的出血性疾病,其特征是血小板计数减少和出血风险增加。传统的ITP治疗策略可通过减轻免疫介导的血小板破坏发挥治疗作用,如糖皮质激素、免疫球蛋白、免疫调节剂或脾切除术等。但许多患者对这... 原发免疫性血小板减少症(ITP)是一种免疫介导的出血性疾病,其特征是血小板计数减少和出血风险增加。传统的ITP治疗策略可通过减轻免疫介导的血小板破坏发挥治疗作用,如糖皮质激素、免疫球蛋白、免疫调节剂或脾切除术等。但许多患者对这些疗法响应性差,且与治疗相关的副作用和禁忌证也限制了其使用。近年来,促血小板生成素受体激动剂(TPO-RA)成为ITP治疗新的选择。本文着重讨论TPO-RA的研发进展及安全性特征,旨在为TPO-RA的研发和临床用药提供参考。 展开更多
关键词 免疫性血小板减少症 血小板生成素受体激动剂 安全性特征 研发进展
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证券纸
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《造纸化学品》 CAS 2002年第4期54-55,共2页
关键词 证券纸 造纸 专利 安全性特征
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Research on key technologies in design of middle pylon of Taizhou Bridge 被引量:1
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作者 Ji Lin 《Engineering Sciences》 EI 2012年第3期2-7,共6页
At the middle pylon of a three-pylon two-span suspension bridge, the effect of unbalanced loads on the adjacent spans may result in a series of technical bottlenecks in design, such as stability and anti-slippage betw... At the middle pylon of a three-pylon two-span suspension bridge, the effect of unbalanced loads on the adjacent spans may result in a series of technical bottlenecks in design, such as stability and anti-slippage between saddles and main cables. This article presents the researches conducted on structure selection and behavior characteristics of middle pylon, interaction mechanism between main cables and saddles and their anti-slippage safety performance, elastic and plastic stability analysis and safety assessment of steel middle pylon, and fatigue design load and method for steel pylon of Taizhou Bridge. According to the research results, a longitudinal inverted Y shape steel middle pylon is used in design, effectively solving many technical difficulties, and this type of pylon has become a suitable middle pylon structural form for many three-ovlon two-soan susoension bridges. 展开更多
关键词 three-pylon two-span suspension bridge structural behavior and selection elastic and plastic stability main cable and saddle anti-slippage
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Effects of behavioral characteristics of taxi drivers on safety and capacity of signalized intersections 被引量:2
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作者 徐铖铖 刘攀 +2 位作者 王炜 蒋璇 陈昱光 《Journal of Central South University》 SCIE EI CAS 2014年第10期4033-4042,共10页
Comparative analyses were conducted to compare the effects of the behavioral characteristics of the drivers of taxis and private cars on the capacity and safety of signalized intersections. Data were collected at sixt... Comparative analyses were conducted to compare the effects of the behavioral characteristics of the drivers of taxis and private cars on the capacity and safety of signalized intersections. Data were collected at sixteen signalized intersections in the Nanjing area in China. The risk-taking behaviors of the drivers of taxis and private cars were compared. The results suggest that 19.9% of taxi drivers have committed at least one of the identified risky behaviors, which is 2.37 times as high as that of the drivers of private cars(8.4%). The traffic conflicts technique was used to estimate the safety effects of taxis and private cars. The overall conflict rate for taxis is 21.4% higher than that for private cars, implying that taxis are more likely to be involved in conflicts. Almost all of the identified traffic conflicts can be attributed to certain levels of risk-taking behaviors committed by either taxi drivers or the drivers of private cars, and taxi drivers are more likely to be at fault in a conflict. Failure to yield to right-of-way and improper lane change is the leading causes of the conflicts in which taxis are at-fault. The research team further studied the effects of taxis on the queue discharge characteristics at signalized intersections. The results show that the presence of taxis significantly reduces both start-up lost time and saturation headways. The effects of taxis on saturation flow rates are dependent on the proportion of taxis in the discharge flow, and the saturation flow rates increase with the increase in the proportion of taxis. The adjustment factors for various proportions of taxis for different turning movements are then calculated to quantitatively evaluate the effects of taxis on the capacity of signalized intersections. 展开更多
关键词 TAXI private car SAFETY capacity signalized intersection
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Stability assessment and feature analysis of slope in Nanfen Open Pit Iron Mine 被引量:10
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作者 Yang Jun Tao Zhigang +2 位作者 Li Baoliang Gui Yang Li Haifeng 《International Journal of Mining Science and Technology》 SCIE EI 2012年第3期329-333,共5页
Under the combined influences of special topography and the long term mining in Nanfen Open Pit Iron Mine, many large scale landslide masses appeared in heading side of stope, and tens of millions of iron mine is buri... Under the combined influences of special topography and the long term mining in Nanfen Open Pit Iron Mine, many large scale landslide masses appeared in heading side of stope, and tens of millions of iron mine is buried underside, making great economic losses. In order to guide the safety mining and increase the supply quantity, this paper through the use of MSARMA-method and the ''MSARMA evaluation and analytical system for slope stability analysis'' based on this method, which aimed at the quantitative evaluating of the slope stability before and after the actual mining below the slip mass, and the sensitivity analysis for the main influencing factor, providing scientific proof for the parameter optimization of open mine surface slope, the security and sustainable exploitation. 展开更多
关键词 Landslide disasterMSARMA methodStability assessmentSensitivity analysisSafety miningAnalysis system
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