依达拉奉治疗急性期脑梗死的疗效及安全性评价

目的评价依达拉奉治疗急性脑梗死的疗效和安全性。方法 80例急性脑梗死患者随机分为观察组和对照组,每组各40例。对照组给予脱水剂,控制血糖、血压,应用活血化瘀、抗血小板药物及对症支持等常规治疗;观察组在常规治疗基础上加用依达拉奉治疗,2组治疗前后进行神经功能缺损评分并比较。结果观察组总有效率明显高于对照组(P<0.01);观察组神经功能缺损评分下降更明显(P<0.01)。治疗期间,未见明显不良反应。结论依达拉奉具有自由基清除及神经功能保护作用,应用依达拉奉治疗急性脑梗死能有效改善神经功能缺损评分,提高临床疗效且副反应小,值得临床推广应用。

浅析地铁区间隔断门对运营安全的影响因素

成都轨道交通工程中现行的人防门涂装颜色为灰色。在成都轨道交通第三轮线路初期运营前安全评估过程中,有专家提出“区间人防隔断门涂装建议调整为显眼的颜色”。针对此条意见,梳理了现行规范中的相关规定,发现并无对人防门涂装颜色的相关规定。根据调研梳理,全国范围内多个省份城市地铁人防门涂装颜色各地均有不同,总结起来主要有三种:米黄色、白色、灰色。因此,梳理了人防门影响运营安全的潜在因素,并提出相应的解决建议以及区间人防隔断门安全性量化评分体系。

基于fuzzing测试的网络协议安全评估方法研究

安全漏洞是网络和信息安全的核心问题。安全漏洞导致的信息泄露等问题越来越严重,如何发现漏洞、修复漏洞、加强防御等成为安全研究的热点话题。文章利用fuzzing测试技术对网络设备支持的协议进行漏洞扫描,然后对扫描到的异常case进行逆向分析从而发现漏洞,并针对漏洞扫描和逆向分析的结果提出一种安全评估机制,对网络协议进行安全性评估,最终得到协议安全性评分。通过文章的研究,可以将存在安全隐患的安全要素通过总安全系数体现出来,实现了对网络设备的真实安全性能的准确评估。使用者根据网络设备的总安全系数将设备安全分为高、中、低3个等级。通过设备安全性的等级将设备使用在不同的网络环境当中,从而在很大程度上降低了网络安全事件发生的概率,对保障网络安全具有重大的意义。

Integrated Assessment of Environmental and Economic Performance of Chemical Products Using Analytic Hierarchy Process Approach

With the increasing public consciousness on environmental issues, chemical products and process designs require simultaneous satisfaction and compromise of environmental and economical requirements. To fulfill the two conflicting while complementary objectives, a systematic approach for life cycle design of a chemical product is proposed in this article. Multiattribute decision-making is adopted in a trade-off consideration of both technical economical evaluation and environmental impacts assessment using the analytic hierarchy process （AHP） approach. On the basis of an evaluation of the relative importance of the criteria multicriteria decision making is performed. In this study, an AHP model is used to derive single a criteria score by analyzing the environmental impact and life cycle cost of a product, respectively. And a fluctuant weight analysis is put forth to calculate the integrated index of the product to enable products to be ranked or selected intuitionally and conveniently. The proposed AHP model has been applied to a case study, a comparative study on chamber cleaning with NF3 and C2F6. The resuits show that the protposed AHP model is Capable of providing a rational and relevant evaluation.

Three-dimensional analysis of slopes reinforced with piles

Based on the upper bound of limit analysis, the plane-strain analysis of the slopes reinforced with a row of piles to the 3D case was extended. A 3D rotational failure mechanism was adopted to yield the upper bound of the factor of safety. Parametric studies were carried out to explore the end effects of the slope failures and the effects of the pile location and diameter on the safety of the reinforced slopes. The results demonstrate that the end effects nearly have no effects on the most suitable location of the installed piles but have significant influence on the safety of the slopes. For a slope constrained to a narrow width, the slope becomes more stable owing to the contribution of the end effects. When the slope is reinforced with a row of piles in small space between piles, the effects of group piles are significant for evaluating the safety of slopes. The presented method is more appropriate for assessing the stability of slopes reinforced with piles and can be also utilized in the design of plies stabilizing the unstable slopes.

Theoretical study on safety assessment indexes system of coal mines

The safety status of the coal mines is closely correlated with the operating status and its changes of the whole working system in the coal mines, and the safety system is the sub system of the whole production system. In this paper, based on the analysis of the complicacy of the safety sub system and its affecting factors, the theory basis of the indexes system of the safety assessment was studied, including the establishing principles of the indexes system , the structure of the indexes system, the determining methods of the assessment indexes. The complete indexes system was established for the safety assessment of the coal mines in the paper.

Development of a Genetic Algorithm for Evaluating the Performance of Overhead Power Distribution Lines and Proposing Solutions to Improve Distribution Line Safety

This paper aims to present and discuss the use of a power flow methodology based on Gauss elimination method to evaluate the performance of distribution network taking into account the neutral conductor absence at specific sections, and a development of a methodology based on GA （genetic algorithm） capable of evaluating alternative solutions in different bars of the feeder, in order to propose appropriate solutions to improve the distribution network safety. Besides the technical aspects, the proposed GA methodology takes into account the economic feasibility analysis. The results of power flow simulations have shown that the presence of single-phase transformers along with the absence of the neutral conductor at specific sections of the MV （medium voltage） network may increase the Vng （neutral-to-ground voltage） levels of the feeders involved, jeopardizing the system＇s safety. On the other hand, the solutions proposed by the GA methodology may reduce the network Vng levels and improve the safety conditions, providing values close to the ones found before the neutral conductor theft.

Fatigue reliability for LNG carrier

The procedure of reliability-based fatigue analysis of liquefied natural gas(LNG) carrier of membrane type under wave loads is presented. The stress responses of the hotspots in regular waves with different wave heading angles and wave lengths are evaluated by global ship finite element method(FEM) . Based on the probabilistic distribution function of hotspots' short-term stress-range using spectral-based analysis,Weibull distribution is adopted and discussed for fitting the long-term probabilistic distribution of stress-range. Based on linear cumulative damage theory,fatigue damage is characterized by an S-N relationship,and limit state function is established. Structural fatigue damage behavior of several typical hotspots of LNG middle ship section is clarified and reliability analysis is performed. It is believed that the presented results and conclusions can be of use in calibration for practical design and initial fatigue safety evaluation for membrane type LNG carrier.

Statistical Analysis of the Dynamic Parameters of Silty Clay in the Beijing Area

Soil dynamic parameters,including dynamic shear modulus ratio and damping ratio,have important effects on the results of layered soil earthquake response. In this paper,the mean parameter values of silty clay in different depths are obtained after statistical analysis of the experimental soil dynamic data from 20 recent site seismic safety evaluation reports in the Beijing area. Furthermore,based on two typical engineering sites,the influence of four different soil dynamic parameters,the statistic mean values,experimental values, values recommended by Yuan Xiaoming,and the values recommended in the code for seismic safety evaluation of engineering sites( DB001-94) are analyzed. The result shows that mean statistical values are applicable to seismic safety evaluation work in the Beijing area,especially for some inter-layered silty clays whose undisturbed soil samples are hard to obtain.

Research on the Seismic Activity of the Lower Yangtze River-South Yellow Sea Seismic Zone

The Lower Yangtze River-South Yellow Sea Seismic Zone,located at the southeast of the Northern China Seismic Zone, characterized by moderate-strong earthquakes, is an intensive earthquake zone,which is controlled by a series of faults within the Lower Yangtze River-South Yellow Sea Seismic Zone. This article counts and calculates the bvalue,V 4 and energy density value of medium-small earthquakes by taking full advantage of the latest data from regional seismic stations,reviews data of historical earthquakes and seismic structure,and discusses the relationship between spatial distribution of the b-value, historical strong earthquakes and spatial distribution of energy density of medium-small earthquakes,and further investigates the seismic activity of the Lower Yangtze River- South Yellow Sea Seismic Zone. This article obtains seismic activity parameters of the Lower Yangtze River-South Yellow Sea Seismic Zone as calculation parameters for probabilistic seismic hazard analysis,and discusses the trend of this seismic zone in the next one hundred years and deduces the potential seismic hazard region within this seismic zone,which provides references and methods for long-term prediction on seismic activity. The research results are significant to seismic zoning, seismic safety evaluation of engineering sites and long-term prediction of seismic activity.

Safety of ivabradine, a heart rate lowering drug: a systematic review and meta-analysis

As a novel heart rate lowing agent, ivabradine can reduce the heart rate by inhibiting the If （pacemaker） current in the sinoatrial node without affecting blood pressure or left ventricular systolic function. However, the safety of ivabradine remains controversial. In the present work, we aimed to assess any risk of cardiovascular mortality, bradycardia, phosphenes and atrial fibrillation associated with the ivabradine administration by recta-analysis. Studies were retrieved from PubMed, EMBASE, MEDLINE, Web of Science, Cochrane, www.clinicaltrials.gov web site and related conferences. Randomized controlled trials comparing ivabradine with comparators were identified and analyzed. Two reviewers independently extracted relevant information from the eligible trials and processed the data. This recta-analysis was performed by using Review Manager （5.3） and Stata （14.1） software. Moreover, sensitivity analysis and publication bias of the included studies were evaluated. A total of 12 randomized controlled trials meeting the inclusion criteria were included. Results of the meta-analysis revealed that there was no significant difference between ivabradine group and control groups in cardiovascular mortality （RR = 0.97, 95% CI： 0.89-1.06, P = 0.49）. While the administration of ivabradine was associated with a significant increase in the incidence of bradycardia （RR = 3.90, 95% CI： 2.47-6.17, P〈0.00001） and phosphenes （RR = 4.95, 95% CI： 3.24-7.55, P〈0.00001） as well as atrial fibrillation （RR = 1.24, 95% CI： 1.07-1.43, P = 0.003）. High quality of the included studies was confirmed by quality assessment. No publication bias was observed, and sensitivity analysis confirmed that the obtained results were stable. In conclusion, the meta-analysis proved that the use of ivabradine was associated with a significant increase in the risk of bradycardia, phosphenes and atrial fibrillation. Therefore, clinicians need to take these risks into account when using ivabradine in treatment.