AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Coliti...AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.展开更多
Objective： Assess clinical efficacy and safety analysis of laparoscopic-assisted vaginal surgery and laparoscopic-alone surgery in treatment of endometrial cancer. Methods： select 76 cases of endometrial cancer pati...Objective： Assess clinical efficacy and safety analysis of laparoscopic-assisted vaginal surgery and laparoscopic-alone surgery in treatment of endometrial cancer. Methods： select 76 cases of endometrial cancer patients, divided into two groups, 40 in laparoscopic-alone group and 36 in laparoscopic-assisted group, and compare operation time, intraoperative blood loss, intraoperative complications, postoperative complications, lymph node number, anal exhaust time, indwelling catheter days and hospitalization days by group. Result： compared with laparoscopic-alone surgery, laparoscopic-assisted vaginal surgery has certain advantages in reducing intraoperative blood loss, intraoperative and postoperative complications, anal exhaust time, indwelling catheter days and hospitalization days. Discussion： laparoscopic-assisted vaginal surgery is a relatively safe, effective and good economic benefit surgical method in treatment of endometrial cancer.展开更多
基金Supported by Danish Innovation Law Grant,J.nr.3414-06-01530from the Danish Food Industry Agency under the Ministry of Food,Agriculture and FisheriesNordisk Rebalance,who developed and manufactured Profermin,and partly financed the study
文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.
文摘Objective： Assess clinical efficacy and safety analysis of laparoscopic-assisted vaginal surgery and laparoscopic-alone surgery in treatment of endometrial cancer. Methods： select 76 cases of endometrial cancer patients, divided into two groups, 40 in laparoscopic-alone group and 36 in laparoscopic-assisted group, and compare operation time, intraoperative blood loss, intraoperative complications, postoperative complications, lymph node number, anal exhaust time, indwelling catheter days and hospitalization days by group. Result： compared with laparoscopic-alone surgery, laparoscopic-assisted vaginal surgery has certain advantages in reducing intraoperative blood loss, intraoperative and postoperative complications, anal exhaust time, indwelling catheter days and hospitalization days. Discussion： laparoscopic-assisted vaginal surgery is a relatively safe, effective and good economic benefit surgical method in treatment of endometrial cancer.
