AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Coliti...AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.展开更多
Despite the tremendous effort made by industry and academia,we are still searching for metrics that can characterize Cyberspace and system security risks. In this paper,we study the class of security risks that are in...Despite the tremendous effort made by industry and academia,we are still searching for metrics that can characterize Cyberspace and system security risks. In this paper,we study the class of security risks that are inherent to the dependence structure in software with vulnerabilities and exhibit a "cascading" effect. We present a measurement framework for evaluating these metrics,and report a preliminary case study on evaluating the dependence-induced security risks in the Apache HTTP Server. The experiment results show that our framework can not only clearly analyze the root cause of the security risks but also quantitatively evaluate the attack consequence of the risks.展开更多
According to the SRAM-based FPGA's single event effect problem in space application,single event upset induced multi-block error(SEU-MBE) phenomenon and its mitigation strategy are studied in the paper.After analy...According to the SRAM-based FPGA's single event effect problem in space application,single event upset induced multi-block error(SEU-MBE) phenomenon and its mitigation strategy are studied in the paper.After analyzing the place and route result,the paper points out that the essence of SEU-MBE is that some important modules exceed the safe internal distance.Two approaches,area constraint method(ACM) and incremental route algorithm(IRA),are proposed,which can reduce the error rate by manipulating programmable switch matrix and interconnection points within FPGA route resource.Fault injection experiments indicate that error detection rate is above 98.6% for both strategies,and FPGA resources increment and performance penalty are around 10%.展开更多
基金Supported by Danish Innovation Law Grant,J.nr.3414-06-01530from the Danish Food Industry Agency under the Ministry of Food,Agriculture and FisheriesNordisk Rebalance,who developed and manufactured Profermin,and partly financed the study
文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.
基金supported by Natural Science Foundation of China under award No.61303024Natural Science Foundation of Jiangsu Province under award No.BK20130372+3 种基金National 973 Program of China under award No.2014CB340600National High Tech 863 Program of China under award No.2015AA016002supported by Natural Science Foundation of China under award No.61272452supported in part by ARO Grant # W911NF-12-1-0286 and NSF Grant #1111925
文摘Despite the tremendous effort made by industry and academia,we are still searching for metrics that can characterize Cyberspace and system security risks. In this paper,we study the class of security risks that are inherent to the dependence structure in software with vulnerabilities and exhibit a "cascading" effect. We present a measurement framework for evaluating these metrics,and report a preliminary case study on evaluating the dependence-induced security risks in the Apache HTTP Server. The experiment results show that our framework can not only clearly analyze the root cause of the security risks but also quantitatively evaluate the attack consequence of the risks.
基金supported by the National High Technology Research and Development Program of China ("863" Program) (Grant No. 2006SQ710375)the Civil Aerospace Technologies Advanced Research Pro-gram of China (Grant No. C1320061301)Ministries and Commissions’Advanced Research Found of China (Grant No. 9140A20070209KG0160)
文摘According to the SRAM-based FPGA's single event effect problem in space application,single event upset induced multi-block error(SEU-MBE) phenomenon and its mitigation strategy are studied in the paper.After analyzing the place and route result,the paper points out that the essence of SEU-MBE is that some important modules exceed the safe internal distance.Two approaches,area constraint method(ACM) and incremental route algorithm(IRA),are proposed,which can reduce the error rate by manipulating programmable switch matrix and interconnection points within FPGA route resource.Fault injection experiments indicate that error detection rate is above 98.6% for both strategies,and FPGA resources increment and performance penalty are around 10%.
