崑山與安期:謝靈運《登江中孤嶼》詩新解——兼及謝靈運與早期上清傳記《馬君傳》之關係

在謝靈運的《登江中孤嶼》一詩中,最後的四句常被詬病爲不和諧的"玄言的尾巴"。由此提出的問題是,本詩的敘事寫景和説理抒情之間有什麽邏輯關係?另外,"崑山"和"安期",從表面上看分别代表不同的神話(神仙)系統,那麽,"想像崑山姿"二句與"始信安期術"二句之間又有什麽樣的聯繫?要解決上述問題,關鍵在於對"崑山"和"安期"的理解。這裏的崑山,指向的不是西王母,而是《馬君傳》中的太真夫人,安期也不是《史記》和《列仙傳》中的安期,而是《馬君傳》中的安期先生。謝靈運《山居賦》中有"安期先生是馬明生之師"的表述,這一情節當來自《馬君傳》。故本文試圖從該傳的知識背景出發,對此詩作一全新的解讀,並對謝靈運和《馬君傳》之間的關係作一考證。

Research on Optimization of Component Stock

A set of model is established to optimize BSW Company’s component stock. By analyzing the company’s current part stock condition in terms of the occupation of capitals in the precondition of continuous production, it describes how to control the purchase parameters of import parts. The model describes how to adjust slightly product output sequence and how to control the components’ purchase parameters: purchasing risk time and purchase order quantity. Then simulation is developed to illustrate the model.

NEW METHOD FOR SAFETY ASSESSMENT OF PARALLEL ROUTES

A new safety assessment method for parallel routes is presented. From the aspects of safety guard system of air traffic control（ATC） and considering the flight conflict as causing event of air collision accidents, this paper fosters a four-layer safety guard of controller command, short-term conflict alerts （STCAs）, pilot visual avoidance, and traffic alert collision avoidance system（TCAS）. Then, the problem of parallel routes collision risk is divided into two parts：the calculation of potential flight conflict and the analysis of failure probability of the four-layer safety guard. A calculation model for controller interference times is induced. By using cognitive reliability and error analysis method（CREAM）,the calculation problem to failure probability of controller sequencing flight conflicts is solved and a fault tree model of guard failure of STCA and TCAS is established. Finally, the Beijing-Shanghai parallel routes are taken as an example to be calculated and the collision risk of the parallel routes is obtained under the condition of radar control. Results show that the parallel routes can satisfy the safety demands.

Safety and Tolerance of Adefovir Dipivoxil in Chinese Healthy Volunteers: A PhaseⅠRandomized and Open-Label Trial

Aim To assess the safety and tolerance of adefovir dipivoxil （ADV） in Chinese healthy volunteers. Methods A total of 52 healthy volunteers, 26 males and 26 females, aged from 19 to 26 were enrolled in the study. Forty-two subjects were randomized into 5, 10, 20, 40, and 60 mg dose groups （6 - 10 subjects in each） matched by sex and weight for single-dose trial. Ten subjects were orally given 10 mg of ADV tablets once daily for 7 d for multiple-dose trial. Physical examination, vital signs examination, electrocardiography, type-B ultrasonography, chest fluoroscopy, routine blood test, routine urine test, coagulation tests, and blood biochemical test were conducted on schedule and statistically evaluated. Results Asthenia frequently occurred in multiple-dose trial, nausea, abdominal pain, and diarrhea occurred in both single- and multiple-dose trials. ALT, bilirubin, CK, and LDH were slightly elevated. All adverse reactions and laboratory abnormalities were mild, and the frequency and severity were not related to doses. Conclusion ADV is safe and well tolerated in Chinese healthy volunteers at dose of 5 - 60 mg oncedaily or 10 nag once daily for 7 d. The recommended oral dosage regimen is 10 mg once daily. Attention should be paid to renal and liver functions, CK, AMY and LDH, if we take ADV for a long period of time.

Analysis of distance headway

By means of the relationship between speed and distance headway, this paperattempts to directly determine the road capacity based on a new concept. At first it makes acomprehensive analysis of distance headway, including safe distance headway and desired one. Theformer is decided by the demand for the degree of safety, and the latter depends on the motorists'behavior, i.e. the model of traffic flow. Both of them are functions of speed. According to thecharacteristics of their curves, we can find a crossing point that is the capacity of a roadsegment. This capacity represents the maximum flow rate meeting the minimum safety requirement.

Effects of metoclopramide on gastric motility measured by short-term bio-impedance

AIM:To analyze the accuracy of short-term bio-impedance as a means of measuring gastric motility.METHODS: We evaluated differences in the short-term electrical bio-impedance signal from the gastric region in the following conditions: (1) fasting state, (2) after the administration of metoclopramide (a drug that induces an increase in gastric motility) and (3) after food ingestion in 23 healthy volunteers. We record-ed the real component of the electrical impedance signal from the gastric region for 1000 s. We performed a Fast Fourier Transform (FFT) on this data and then compared the signal among the fasting, medicated, and postprandial conditions using the median of the area under the curve, the relative area under the curve and the main peak activity.RESULTS: The median of the area under the curve of the frequency range in the region between 2-8 cycles per minute (cpm) decreased from 4.7 cpm in the fasting condition to 4.0 cpm in the medicated state (t=3.32, P=0.004). This concurred with the decrease seen in the relative area under the FFT curve in the region from 4 to 8 cpm from 38.3% to 26.6% (t=2.81, P=0.012) and the increase in area in the region from 2 to 4 cpm from 22.4% to 27.7%, respectively (t=-2.5, P=0.022). Finally the main peak position also decreased in the region from 2 to 8 cpm. Main peak activity in the fasting state was 4.72 cpm and declined to 3.45 cpm in the medicated state (t=2.47, P=0.025). There was a decrease from the fasting state to the postprandial state at 3.02 cpm (t=4.0, P=0.0013). CONCLUSION: Short-term electrical bio-impedance can assess gastric motility changes in individuals experiencing gastric stress by analyzing the area medians and relative areas under the FFT curve.

Could quantitative liver function tests gain wide acceptance among hepatologists?

It has been emphasized that the assessment of residual liver function is of paramount importance to determine the following： severity of acute or chronic liver diseases independent of etiology; long-term prognosis; step-bystep disease progression; surgical risk; and efficacy of antiviral treatment. The most frequently used tools are the galactose elimination capacity to asses hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, and antipyrine clearance to estimate microsomal activity. However, a widely accepted liver test （not necessarily a laboratory one） to assess quantitative functional hepatic reserve still needs to be established, although there have been various proposals. Furthermore, who are the operators that should order these tests？ Advances in analytic methods are expected to allow quantitative liver function tests to be used in clinical practice.

Antibiotic susceptibility of strains in Chinese medical probiotic products

Objective： To investigate the susceptibility of strains separated from probiotic products for medical purpose to 14 antimicrobial agents. Methods：The single aerobic strains were isolated from these products respectively and disc agar diffusion assay was proceeded to determine the susceptibility. Results： Probiotics tested in the study mostly showed multiresistant to the agents. Lactobacillus acidophilus LAP, LAB, Lactobacillus bulgaricus LBJ and Streptococcus therrnophilus STJ were resistant to vancomycin. Conclusion： Drug resistance exists in most of commercial probiotics. The evaluation and monitoring of safety of probiotic products for medical purpose should be paid great attention.

A CENTRAL-STAGE BUFFERED THREE-STAGE CLOS SWITCHING FABRIC AND THE SCHEDULING ALGORITHM

Current MSM switching fabric has poor performance under unbalanced traffic. This paper presents an alternative, novel Central-stage Buffered Three-stage Clos switching (CB-3Clos) fabric and proves that this fabric can emulate output queuing switch without any speedup. By analyzing the condition to satisfy the central-stage load-balance, this paper also proposes a Central-stage Load-balanced-based Distributed Scheduling algorithm (CLDS) for CB-3Clos. The results show that, compared with Concurrent Round-Robin based Dispatching (CRRD) algorithm based on MSM, CLDS algorithm has high throughput irrespective with the traffic model and better performance in mean packet delay.

Proposed Simplified Procedure for Safety Factor Scaling for Various Life Cycles

It is common to assume that structures are designed in view of 50 year life cycle as per Euro-Code 2 and other codes. In special cases, structures are designed in view of longer life cycle, such as bridges, important infrastructure facilities, important religious structures or in case of extended returning period of seismic event or floods. Beside issues of durability and maintenance aspects, this involves also the need to cover the probability of exceeding characteristic design live loads during the extended period, while keeping the same levels of the accepted risk that were assumed by the various codes, as good enough for the standard 50 year life cycle. Bearing in mind that design procedures, formulations, materials characteristic strengths and partial safety factors are used for these structures as per the existing codes, scaling of partial safety factors, or alternatively an additional ＂compensating＂ factor is required. A simplified approach and procedure to arrive at a reasonable calibration of the code safety factors based on 50 years to compensate for an extended life cycle, based upon structural reliability considerations, is proposed.

The Principle and Method for Delineation of Potential Seismic Sources in Northwest Yunnan

Based on the collection and analysis of achievements of other scholars, and by consulting the results of seismic safety evaluation of engineering sites and field surveys of recent years, the seismotectonic indicators are determined for northwest Yunnan and its vicinity, and then potential seismic sources are further delineated. In practice, the following principles are applied: for areas with strong historical earthquakes, the recurrence principle is used to determine the upper bound magnitude; for areas with distinct seismogenic structure but no historical strong earthquake records, the tectonic analogy principle is used in the light of the size and activity behavior of the structure; for areas where the segmentation of the active fault is well studied, the potential sources will be demarcated more precisely; and for areas with buried fault, the seismicity pattern and geophysical abnormity are used to determine the direction of the major axis of the potential seismic source.

Efficacy and safety of viscum fraxini-2 in advanced hepatocellular carcinoma:a phase Ⅱ study

Objective： New systemic therapies are needed to improve the prognosis of patients with advanced-stage hepatocellular carcinoma. The study was conducted to determine the efficacy and safety of viscum fraxini-2 in advanced Hepatocellular carcinoma. Methods： A phase II study with a two-stage design that enrolled a total of 120 patients with chemotherapy nai＇ve advanced hepatocellular carcinoma. The mistletoe preparation for the study is an aqueous injectable solution that contains one milliliter of viscum fraxini. Two ampoules of viscum fraxini were administered subcutaneously once weekly. Re- suits： Chronic hepatitis C virus infection was the predominant cause of liver disease （60%） in studied cases. According to the response evaluation criteria in solid tumors 24 patients （20%） achieved objective response （including 2 complete responses） and 40 patients （33.3%） achieved stable disease. The median progression free survival for all patients was 4 months （range 1-28 months; 95% CI 3.3：4.7 months）. The median overall survival for all patients was 8 months （range 1-28 months; 95% CI 6.3：9.7 months）. The median survival for patients who achieved responsive or stable disease was 16 months. The toxicity was generally mild and well tolerated, mainly in the form of local reaction and fever. There were no drug related discontinu- ation or toxic deaths. Conclusion： Viscum fraxini-2 is an effective, safe treatment for patients with advanced hepatocellular carcinoma. Further randomized controlled trials are recommended.

Distributed Solar PV System for Industrial Application

The paper presents the design and field test of a distributed solar PV system for industrial application （DGPVi）. DGPVi utilizes HyPV （hybrid PV） system which generates solar power for self-consumption in lighting and air conditioning in a production line of a factory when solar energy is available. It does not feed the excess PV power to the grid. HyPV will be switched to grid power supply when solar energy is not available. A 3 kWp DGPVi is installed in a factory for field demonstration. The test results show that the solar PV power generated can be utilized immediately. The solar energy generation efficiency （kWh/day per kWp PV installation） of DGPVi is close to that of grid-tied PV system without self-consumption and battery storage. The yearly return on investment of DGPVi is 2.0% at the present installation cost or 3.3% at further cost-down cost. The payback time will be 14.3 years at the present installation cost or 12.1 years at cost-down cost. The present study verifies the economic feasibility of DGPVi.

Revealing the Invisible： A New Approach for Enhancing Industrial Safety, Reliability and Remaining Life Assessment

Today＇s industry requires more reliable information on the current status of their hard assets; prognosis for continued usability of systems and better predictability of equipment life cycle maintenance. Therefore, an innovative technique for early detection of potential failure and condition monitoring is urgently required by many engineers. This document describes a novel approach to improve industrial equipment safety, reliability and life cycle management. A new field portable instrument called the ＂IMS （indicator of mechanical stresses）＂ utilizes magneto-anisotropic （＂cross＂） transducers to measure anisotropy of magnetic properties in ferromagnetic material. Mechanical stresses including residual stresses in Ferro-magnetic parts, are ＂not visible＂ to most traditional NDT （non-destructive testing） methods; for example, radiography and ultrasonic inspection. Stress build-up can be the first indicator that something is faulty with a structure. This can be the result of a manufacturing defect; or as assets age and fatigue, stress loads can become unevenly distributed throughout the metal. We outline the evaluation of IMS as a fast screening tool to provide structural condition or deterioration feedback in novel applications for pipelines, petrochemical refinery, cranes, and municipal infrastructure.

Where do Random Rough Surfaces Fail？ Part I： Fracture Loci Safety Envelopes at Early Stages of Degradation

Damage on surfaces often compromises the efficiency of some types of energy production, the safety and reliability of components, and ultimately increases costs. The environment can degrade the structural integrity of surfaces in service by the accumulation of large numbers of small destructive events, which based on the Central Limit Theorem leads to a Gaussian distribution of pit depth. In order to develop safety envelopes relating fracture loci with topological parameters of a brittle material, scatter plots were obtained and analyzed. Starting with an engineering surface, after 6 to 9 micrometers of average degradation depth, safety envelopes could be developed using average roughness and two other proposed parameters. Interestingly, maximum pit depth showed very low correlation with the location of fracture, at the early stage of degradation studied. This is attributed to relaxation of stress concentration at a given pit location due to the assuaging effect caused by neighboring pits. Additionally, energy at fracture was obtained, and a maximum relaxation region was observed. Analytical and experimental study of this region, as well as ductility effects are currently under research.

Safety of lamivudine treatment for chronic hepatitis B in early pregnancy

AIM:To evaluate the safety of lamivudine(LAM) treatment for chronic hepatitis B in early pregnancy.METHODS:A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study.All of the pregnant women volunteered to take lamivudine during pregnancy and were not co-infected with hepatitis C virus,human immunodeficiency virus,cytomegalovirus,or other viruses.All infants received passiveactive immunoprophylaxis with 200 IU hepatitis B immunoglobulin and three doses of 10 μg hepatitis B vaccines(0-1-6 mo) according to the guidelines for the prevention and treatment of chronic hepatitis B.Adverse events were observed throughout the entire pregnancy and perinatal period,and the effectiveness of lamivudine treatment for blocking mother-to-infant transmission of hepatitis B virus(HBV) was evaluated.All adverse events in mothers and infants during pregnancy and the perinatal period and the HBV motherto-infant transmission blocking rate were compared with the literature.RESULTS:Among the 92 pregnant women,spontaneous abortions occurred in 11 cases,while 3 mothers had a second pregnancy after the initial abortion;72 mothers delivered 73 live infants,of whom 68 infants were followed up for no less than 6 mo,and 12 mothers were still pregnant.During pregnancy,the main maternal adverse events were vaginitis(12/72,16.7%),spontaneous abortion(11/95,11.6%),and gestational diabetes(6/72,8.3%);only one case had 1-2 degree elevation of the creatine kinase level(195 U/L).During the perinatal period,the main maternal adverse events were premature rupture of the membranes(8/72,11.1%),preterm delivery(5/72,6.9%),and meconium staining of the amniotic fluid(4/72,5.6%).In addition,2 infants were found to have congenital abnormalities;1 had a scalp hemangioma that did not change in size until 7 mo,and the other had early cerebral palsy,but with rehabilitation training,the infant's motor functions became totally normal at 2 years of age.The incidence of adverse events among the mothers or abnormalities in the infants was not higher than that of normal mothers or HBV-infected mothers who did not receive lamivudine treatment.In only 2 cases,mother-to-infant transmission blocking failed;the blocking rate was 97.1%(66/68),which was higher than has been previously reported.CONCLUSION:Lamivudine treatment is safe for chronic HBV-infected pregnant mothers and their fetuses with a gestational age of less than 12 wk or throughout the entire pregnancy.

The Use of Life Cycle Cost Analysis to Determine the Most Effective Cost of Installation High Voltage Undersea Cable Bali Strait

Indonesian National Electricity Company （PT.PLN （Persero）） has planned to install additional high voltage undersea cable for circuit llI and IV Java-Bali to fulfill electricity demand in Bali. This project was more prefered compared to building another power plant in Bali which could raise social and cultural resistance. Life cycle cost method was used to complete the financial feasibility study to ensure if the project has economic benefit, and the asset would be used effectively and efficiently along its benefit period. In this paper, a life cycle cost will be simulated to analyze which alternative is the most profitable： installation circuit III and IV in 2012 or installation circuit III in 2012 and circuit IV in 2017 in accordance with load forecasting demand. This study is used to help the management to make a decision about the project.

Product and Market Success

Essentially, it is the lack of these basic abilities： The ability to secure efficiently the production based on the qualitatively reasonable organization and control of the manufacturing processes, and consequently to reach production and technical standards and time and financial parameters, supporting the reasonable strategic objectives of an enterprise. This efficiency must be manifested in elimination of basic lasting shortcomings （i.e., inability to meet time schedule of products delivery, the long time of production, the insufficient survey of their course--especially at products with long-run production cycle）.

The influence of autologous cytokine-induced killer cell treatment on the objective efficacy and safety of gefitinib in advanced non-small cell lung cancer

Objective The aim of the study was to observe the influence of autologous cytokine-induced killer cell （CIK） treatment on the objective efficacy and safety of gefitinib in advanced non-small ceil lung cancer （NSCLC）. Methods Sixty-six patients with NSCLC received gefitinib as second-line treatment. They were randomly divided into 2 groups, and informed consent forms were signed before grouping. Gefitinib was administrated to the control group, and autologous CIK treatment was added to the observation group. The objective treatment and adverse reactions were evaluated in both groups. Results The objective response rate （ORR） and the disease control rate （DCR） of the observation group were slightly higher than those of the control group, although no statistical differences were found between the 2 groups （P 〉 0.05）. The incidences of diarrhea, fatigue, anorexia, oral ulcers, and myelosuppression in the observation group were much lower than those in the control group （P 〈 0.05）. However, there were no statistical differences between the incidences of skin rash, and liver and kidney toxicities （P 〉 0.05）. Conclusion Autologous CIK in combination with gefitinib is effective as second-line treatment fore ad- vanced NSCLC, and can significantly reduce adverse reactions and improve the objective efficacy.

Significance and Microscopic Analysis of Deformation in the Cultural Remains of Western Zhou Dynasty-Late Spring and Autumn Period at Daijiayuan Ruins in Huoshan,Anhui Province,China

During an excavation survey to the Daijiayuan vestige of the Western Zhou Dynasty-Late Spring and Autumn Period at Huoshan in Western Anhui,a ground crack related to tectonic movement and filled with silty fine sand was found. This phenomenon was initially confirmed to be due to seismic liquefaction. Many microscopic seismic relics,such as load structure,flow structure,cutoff plane and flotation of organic matter were found in the directional microscopic analysis of deformation. These discoveries and cognitions prove that there were two earthquake events taking place in the Western Zhou Dynasty-Late Spring and Autumn Period in this area. Above-mentioned works enrich and develop the research methods to identify prehistoric earthquake event in eastern China area to a certain extent.