An improved safety analysis based on the causality diagram for the complex system of micro aero-engines is presented.The study is examined by using the causality diagram in analytical failure cases due to rupture or p...An improved safety analysis based on the causality diagram for the complex system of micro aero-engines is presented.The study is examined by using the causality diagram in analytical failure cases due to rupture or pentration in the receiver of micro turbojet engine casing,and the comparisons are also made with the results from the traditional fault tree analysis.Experimental results show two main advantages：（1）Quantitative analysis which is more reliable for the failure analysis in jet engines can be produced by the causality diagram analysis;（2）Graphical representation of causality diagram is easier to apply in real test cases and more effective for the safety assessment.展开更多
[Objective] The aim was to test the controlling effect of cleaning steriliza- tion system, material conveying system, and fermentation jar cooling system with equip- ments of fruit wine production line introduced in t...[Objective] The aim was to test the controlling effect of cleaning steriliza- tion system, material conveying system, and fermentation jar cooling system with equip- ments of fruit wine production line introduced in this study and its auto-control sys- tem field assembled and debugged. [Method] Based on controlling equipment and setting parameters on the configuration interface, the operation state of the control equipments could be real-time monitored and controlled with the help of configura- tion software. [Result] The result showed that the equipment system could reduce the temperature into 12 ℃ with the error of ＋0.5 ℃within 110 minutes when the fermentation temperature is set at 12 ℃ in real production. [Conclusion] The auto- control system of fruit wine production line was easy to be assembled and de- bugged to meet demands of different fruit wine productions.展开更多
[Objective] The efficacy of difenoconazole-azoxystrobin 32.5% SC for rice sheath blight and its application technology were discussed in this research. [Method] Three surveys were carried out. There were 5 fixed test ...[Objective] The efficacy of difenoconazole-azoxystrobin 32.5% SC for rice sheath blight and its application technology were discussed in this research. [Method] Three surveys were carried out. There were 5 fixed test clumps in each plot. The number of total plants and disease plants and disease progression in each fixed clump were recorded. The correlation effectiveness was calculated based on the growth rate of disease index. Significance analysis was performed with Dun- can＇s new multiple range method （DMRT）. [Result] The difenoconazole-azoxystrobin 32.5% SC had a good efficacy for rice sheath blight, and its efficacy increased with the increase of dose. If sprayed according to the dose of 450 ml/hm2 5 days before the beginning of heading stage of rice, difenoconazole-azoxystrobin 32.5% SC would have better effects on controlling rice sheath blight with correlation effectiveness reaching up to 95.14%, which was 2.06% higher than that of control drug （trifloxys- trobin-tebuconazole 75% WG, 225 g/hm2）. [Conclusion] Treated with difenoconazole- azoxystrobin 32.5% SC with dose of 450 ml/hm2, rice would have green upper leaves and less yellow middle and lower leaves. Moreover, the yield was in- creased significantly. The difenoconazole-azoxystrobin 32.5% SC had good safety. Therefore, difenoconazole-azoxystrobin 32.5% SC had a good application prospect in production.展开更多
AIM： To evaluate the efficacy and safety of tegaserod, 6 mg twice daily （b.i.d.）, in men and women with chronic constipation （CC） from China. METHODS： This was a multicenter, double-blind, placebo-controlled stu...AIM： To evaluate the efficacy and safety of tegaserod, 6 mg twice daily （b.i.d.）, in men and women with chronic constipation （CC） from China. METHODS： This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatmentfree baseline period, patients were randomized to receive either tegaserod （6 mg b.i.d.） or placebo （b.i.d.） for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements （CSBMs） during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients＇ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events （AEs）. RESULTS： A total of 607 patients were randomized to receive either tegaserod （n = 304） or placebo （n = 303）. Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo （1.39 vs 0.91, P = 0.0002）. A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 （47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018） and for the absolute number of≥ 3 CSBMs/wk over wk 1-4 （25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021）. Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod （3.6%） compared with placebo （1.7%）. CONCLUSION： Tecjaserod treatment improved multiple symptoms of CC and was associated with a favorable safety profile.展开更多
AIM: To evaluate if the guidelines for the appro-priateness of performing colonoscopy by American Society for Gastrointestinal Endoscopy (AGSE) and Italian Society of Digestive Endoscopy (SIED) yield a good diagnostic...AIM: To evaluate if the guidelines for the appro-priateness of performing colonoscopy by American Society for Gastrointestinal Endoscopy (AGSE) and Italian Society of Digestive Endoscopy (SIED) yield a good diagnostic efficacy and do not present risks of missing important colonic pathologies in an Italian population sample.METHODS: A total of 1017 consecutive patients (560 men and 457 women; mean age 64.4 ± 16 years) referred to an open-access endoscopy unit for colonoscopy from July 2004 to May 2006 were evaluated according to ASGE and SIED guidelines for appropriateness of performing the procedure. Diagnostic yield was defined as the percentage of relevant colonic pathologies of the total number of colonoscopies performed.RESULTS: About 85.2% patients underwent colono-scopy that was considered appropriate based on at least one ASGE or SIED criterion, while it was considered inappropriate for 14.8% of patients. The diagnostic yield of colonoscopy was significantly higher for appropriate colonoscopies (26.94% vs 10.6%, P < 0.001) than for inappropriate colonoscopies (5.3%). There was no missed colorectal cancer following the ASGE/SIED criteria.CONCLUSION: ASGE/SIED guidelines have shown a good diagnostic yield and the rate of missing relevant colonic pathologies seems very low. Unfortunately, the percentage of inappropriate referrals for colonoscopy in an open-access endoscopy system is still high, despite the number of papers published on the issue and the definition of international guidelines. Further steps are required to update and standardize the guidelines to increase their diffusion and to promote educational programs for general practitioners.展开更多
Before-after study with the empirical Bayes(EB)method is the state-of-the-art approach for estimating crash modification factors(CMFs).The EB method not only addresses the regression-to-the-mean bias,but also improves...Before-after study with the empirical Bayes(EB)method is the state-of-the-art approach for estimating crash modification factors(CMFs).The EB method not only addresses the regression-to-the-mean bias,but also improves accuracy.However,the performance of the CMFs derived from the EB method has never been fully investigated.This study aims to examine the accuracy of CMFs estimated with the EB method.Artificial realistic data(ARD)and real crash data are used to evaluate the CMFs.The results indicate that:1)The CMFs derived from the EB before-after method are nearly the same as the true values.2)The estimated CMF standard errors do not reflect the true values.The estimation remains at the same level regardless of the pre-assumed CMF standard error.The EB before-after study is not sensitive to the variation of CMF among sites.3)The analyses with real-world traffic and crash data with a dummy treatment indicate that the EB method tends to underestimate the standard error of the CMF.Safety researchers should recognize that the CMF variance may be biased when evaluating safety effectiveness by the EB method.It is necessary to revisit the algorithm for estimating CMF variance with the EB method.展开更多
Causality Diagram (CD) is a new graphical knowledge representation based on probability theory. The application of this methodology in the safety analysis of the gas explosion in collieries was discussed in this paper...Causality Diagram (CD) is a new graphical knowledge representation based on probability theory. The application of this methodology in the safety analysis of the gas explosion in collieries was discussed in this paper, and the Minimal Cut Set, the Minimal Path Set and the Importance were introduced to develop the methodology. These concepts are employed to analyze the influence each event has on the top event ? the gas explosion, so as to find out about the defects of the system and accordingly help to work out the emphasis of the precautionary work and some preventive measures as well. The results of the safety analysis are in accordance with the practical requirements; therefore the preventive measures are certain to work effectively. In brief, according to the research CD is so effective in the safety analysis and the safety assessment that it can be a qualitative and quantitative method to predict the accident as well as offer some effective measures for the investigation, the prevention and the control of the accident.展开更多
Consumption of functional foods with health promoting benefits and/or disease prevention has been on the increase globally. The study aimed at evaluating the potential of utilizing Kenyan orange fleshed sweet potato ...Consumption of functional foods with health promoting benefits and/or disease prevention has been on the increase globally. The study aimed at evaluating the potential of utilizing Kenyan orange fleshed sweet potato （Ipomoea batatas Lam.） for functional food production with aesthetics benefits. Purees from three different varieties of orange fleshed sweet potato （OFSP） were analyzed for nutritional, physicochemical and microbial quality, The findings of the study show that the three purees were all microbiologically safe and of near neutral pH, but differed significantly （P 〈 0.05） in nutrient content （dry matter content, 12.76-28.23%; crude fiber, 1.37-2.90% fresh weight basis （FWB）; 13-carotene, 0.94-9.27 mg/100g dry weight basis （DWB）; starch, 10.20-18.30% FWB ＆ total sugar 27.08-31.76% DWB）. The purees had attractive appearance （ranging from yellow to dark orange）, with varying significantly different spectrophotometer hunters color scale （P 〈 0.05）, and flow ability. Conclusions from the findings show great potential of utilizing the varying properties of OFSP puree to produce enriched functional food products such as probiotic/prebiotic dairy, beverages, bakery and baby foods.展开更多
文摘An improved safety analysis based on the causality diagram for the complex system of micro aero-engines is presented.The study is examined by using the causality diagram in analytical failure cases due to rupture or pentration in the receiver of micro turbojet engine casing,and the comparisons are also made with the results from the traditional fault tree analysis.Experimental results show two main advantages：（1）Quantitative analysis which is more reliable for the failure analysis in jet engines can be produced by the causality diagram analysis;（2）Graphical representation of causality diagram is easier to apply in real test cases and more effective for the safety assessment.
基金Supported by Fundamental Research Foundation of GXAAS(GNK2013YM02)~~
文摘[Objective] The aim was to test the controlling effect of cleaning steriliza- tion system, material conveying system, and fermentation jar cooling system with equip- ments of fruit wine production line introduced in this study and its auto-control sys- tem field assembled and debugged. [Method] Based on controlling equipment and setting parameters on the configuration interface, the operation state of the control equipments could be real-time monitored and controlled with the help of configura- tion software. [Result] The result showed that the equipment system could reduce the temperature into 12 ℃ with the error of ＋0.5 ℃within 110 minutes when the fermentation temperature is set at 12 ℃ in real production. [Conclusion] The auto- control system of fruit wine production line was easy to be assembled and de- bugged to meet demands of different fruit wine productions.
文摘[Objective] The efficacy of difenoconazole-azoxystrobin 32.5% SC for rice sheath blight and its application technology were discussed in this research. [Method] Three surveys were carried out. There were 5 fixed test clumps in each plot. The number of total plants and disease plants and disease progression in each fixed clump were recorded. The correlation effectiveness was calculated based on the growth rate of disease index. Significance analysis was performed with Dun- can＇s new multiple range method （DMRT）. [Result] The difenoconazole-azoxystrobin 32.5% SC had a good efficacy for rice sheath blight, and its efficacy increased with the increase of dose. If sprayed according to the dose of 450 ml/hm2 5 days before the beginning of heading stage of rice, difenoconazole-azoxystrobin 32.5% SC would have better effects on controlling rice sheath blight with correlation effectiveness reaching up to 95.14%, which was 2.06% higher than that of control drug （trifloxys- trobin-tebuconazole 75% WG, 225 g/hm2）. [Conclusion] Treated with difenoconazole- azoxystrobin 32.5% SC with dose of 450 ml/hm2, rice would have green upper leaves and less yellow middle and lower leaves. Moreover, the yield was in- creased significantly. The difenoconazole-azoxystrobin 32.5% SC had good safety. Therefore, difenoconazole-azoxystrobin 32.5% SC had a good application prospect in production.
文摘AIM： To evaluate the efficacy and safety of tegaserod, 6 mg twice daily （b.i.d.）, in men and women with chronic constipation （CC） from China. METHODS： This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatmentfree baseline period, patients were randomized to receive either tegaserod （6 mg b.i.d.） or placebo （b.i.d.） for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements （CSBMs） during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients＇ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events （AEs）. RESULTS： A total of 607 patients were randomized to receive either tegaserod （n = 304） or placebo （n = 303）. Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo （1.39 vs 0.91, P = 0.0002）. A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 （47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018） and for the absolute number of≥ 3 CSBMs/wk over wk 1-4 （25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021）. Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod （3.6%） compared with placebo （1.7%）. CONCLUSION： Tecjaserod treatment improved multiple symptoms of CC and was associated with a favorable safety profile.
文摘AIM: To evaluate if the guidelines for the appro-priateness of performing colonoscopy by American Society for Gastrointestinal Endoscopy (AGSE) and Italian Society of Digestive Endoscopy (SIED) yield a good diagnostic efficacy and do not present risks of missing important colonic pathologies in an Italian population sample.METHODS: A total of 1017 consecutive patients (560 men and 457 women; mean age 64.4 ± 16 years) referred to an open-access endoscopy unit for colonoscopy from July 2004 to May 2006 were evaluated according to ASGE and SIED guidelines for appropriateness of performing the procedure. Diagnostic yield was defined as the percentage of relevant colonic pathologies of the total number of colonoscopies performed.RESULTS: About 85.2% patients underwent colono-scopy that was considered appropriate based on at least one ASGE or SIED criterion, while it was considered inappropriate for 14.8% of patients. The diagnostic yield of colonoscopy was significantly higher for appropriate colonoscopies (26.94% vs 10.6%, P < 0.001) than for inappropriate colonoscopies (5.3%). There was no missed colorectal cancer following the ASGE/SIED criteria.CONCLUSION: ASGE/SIED guidelines have shown a good diagnostic yield and the rate of missing relevant colonic pathologies seems very low. Unfortunately, the percentage of inappropriate referrals for colonoscopy in an open-access endoscopy system is still high, despite the number of papers published on the issue and the definition of international guidelines. Further steps are required to update and standardize the guidelines to increase their diffusion and to promote educational programs for general practitioners.
基金Project(51978082)supported by the National Natural Science Foundation of ChinaProject(19B022)supported by the Outstanding Youth Foundation of Hunan Education Department,ChinaProject(2019QJCZ056)supported by the Young Teacher Development Foundation of Changsha University of Science&Technology,China。
文摘Before-after study with the empirical Bayes(EB)method is the state-of-the-art approach for estimating crash modification factors(CMFs).The EB method not only addresses the regression-to-the-mean bias,but also improves accuracy.However,the performance of the CMFs derived from the EB method has never been fully investigated.This study aims to examine the accuracy of CMFs estimated with the EB method.Artificial realistic data(ARD)and real crash data are used to evaluate the CMFs.The results indicate that:1)The CMFs derived from the EB before-after method are nearly the same as the true values.2)The estimated CMF standard errors do not reflect the true values.The estimation remains at the same level regardless of the pre-assumed CMF standard error.The EB before-after study is not sensitive to the variation of CMF among sites.3)The analyses with real-world traffic and crash data with a dummy treatment indicate that the EB method tends to underestimate the standard error of the CMF.Safety researchers should recognize that the CMF variance may be biased when evaluating safety effectiveness by the EB method.It is necessary to revisit the algorithm for estimating CMF variance with the EB method.
基金Supported by the Natural Science Foundation of China (No. 59677009) the National Research Foundation for the Doctoral Program of Higher Education of China (No.99061116)
文摘Causality Diagram (CD) is a new graphical knowledge representation based on probability theory. The application of this methodology in the safety analysis of the gas explosion in collieries was discussed in this paper, and the Minimal Cut Set, the Minimal Path Set and the Importance were introduced to develop the methodology. These concepts are employed to analyze the influence each event has on the top event ? the gas explosion, so as to find out about the defects of the system and accordingly help to work out the emphasis of the precautionary work and some preventive measures as well. The results of the safety analysis are in accordance with the practical requirements; therefore the preventive measures are certain to work effectively. In brief, according to the research CD is so effective in the safety analysis and the safety assessment that it can be a qualitative and quantitative method to predict the accident as well as offer some effective measures for the investigation, the prevention and the control of the accident.
文摘Consumption of functional foods with health promoting benefits and/or disease prevention has been on the increase globally. The study aimed at evaluating the potential of utilizing Kenyan orange fleshed sweet potato （Ipomoea batatas Lam.） for functional food production with aesthetics benefits. Purees from three different varieties of orange fleshed sweet potato （OFSP） were analyzed for nutritional, physicochemical and microbial quality, The findings of the study show that the three purees were all microbiologically safe and of near neutral pH, but differed significantly （P 〈 0.05） in nutrient content （dry matter content, 12.76-28.23%; crude fiber, 1.37-2.90% fresh weight basis （FWB）; 13-carotene, 0.94-9.27 mg/100g dry weight basis （DWB）; starch, 10.20-18.30% FWB ＆ total sugar 27.08-31.76% DWB）. The purees had attractive appearance （ranging from yellow to dark orange）, with varying significantly different spectrophotometer hunters color scale （P 〈 0.05）, and flow ability. Conclusions from the findings show great potential of utilizing the varying properties of OFSP puree to produce enriched functional food products such as probiotic/prebiotic dairy, beverages, bakery and baby foods.
