医用压缩空气系统的质量控制方法

医用压缩空气系统作为重要的生命支持系统,需保证24 h不间断供气,且压缩空气各成分含量根据用途不同要求也不同。用于呼吸机及麻醉机的压缩空气系统是否可靠,直接影响患者的安危,而其中任一环节出现问题都有可能导致很大的安全隐患,因此临床工程人员在日常维护中对每一环节都要做好严格的质量控制。通过阐述组成压缩空气系统的空气压缩机、储气罐、干燥机、空气过滤系统、减压装置以及相应管路系统的质量控制方法,提出日常工作中应做好预防性维护的具体措施。

Combinative Approaches of Chemistry, Pharmacology and Toxicology for the Optimal Pharmaceutical Preparation of an Anti-arthritic Chinese Medicine Formulation QFJBT

Objective Qing Fu Juan Bi Tang(QFJBT)is an anti-arthritic Chinese medicine formula consisting of five herbs:Aconiti Lateralis Radix Praeparata(Fu Zi,附子),Sinomenii Caulis(Qing Feng Teng,青风藤),Astragali Radix(Huang Qi,黄芪),Paeoniae Radix Alba(Bai Shao,白芍)and Moutan Cortex(Mu Dan Pi,牡丹皮),which have well-established histories of use for treatment of rheumatic and arthritic diseases.We intended to establish the optimized and standardized pharmaceutical procedures and manufacturing processes for the pilot production of QFJBT to develop it as a novel botanical drug product for treatment of rheumatoid arthritis(RA).Methods The combinative approaches of chemical assessment,toxicological and pharmacological evaluation were explored to define the pharmaceutical preparation of QFJBT.Results The optimized and standardized pharmaceutical procedures and manufacturing processes for the pilot production of QFJBT were established in terms of greatest chemical contents of bioactive constituents,potent anti-inflammatory and antinociceptive activities,and favorable safety profile.Quality analysis of the pilot product of QFJBT by high-performance liquid chromatography(HPLC)demonstrated that the chromatographic fingerprint profiles of three batches of QFJBT were basically identical and the contents of four characteristic and bioactive markers were relatively consistent.General toxicological studies showed a favorable safety profile of QFJBT.The maximum tolerated single dose of QFJBT was determined in both sexes of rats to be 33.63 g/kg body weight which is equivalent to 346 times of clinical dose.In the chronic oral toxicity study,the results of laboratory investigation showed that QFJBT at doses of 3.89,6.80 and 9.72 g/kg body weight(equivalent to 40,70 and 100-fold clinical doses,respectively)caused no changes in all hematological parameters and blood biochemical parameters of rats.No mortality or specific toxic responses were observed in animals after three months of repeated dosing with QFJBT.Conclusion The optimized and standardized pharmaceutical and manufacturing processes for the production of QFJBT have been successfully screened and identified through established rigorous in-process controls.

Study on life-cycle risk management of high earth-rock dam project

Based on advanced computer technology, internet of things （lOT） technology, project management con- cept and professional technology and combined with the innovative theories, methods and techniques in earlier hy- dropower projects, the life-cycle risk management system of high earth-rock dam project for Nuozhadu project was developed. The system mainly includes digital dam, three-dimensional design, construction quality monito- ring, safety assessment and warning, etc, to integrally manage and analyze the dam design, constructional quality and safety monitoring information. It realized the dynamic updates of the comprehensive information and the safe- ty quality monitoring in the project life cycle, and provided the basic platform for the scientific management of the construction and operation safety of high earth-rock dam. Application in Nuozhadu earth-rock dam showed that construction safety monitoring and warning greatly helped accelerate the construction progress and improve project quality, and provided a new way for the quality safety control of high earth-rock dam.

Exploration of Factors Influencing Oolong Quality and Control Technology in Anxi County

In the research, harmful substances to oolong in Anxi were introduced and production environment, agricultural residual, heavy metal and rare earth ele-ments of oolong in Anxi were analyzed. Furthermore, the factors influencing oolong quality were explored, and the control measures for guaranteeing oolong safety were proposed.

Food Physics and Food Safety- Some Aspects in Food Processing and Food Quality Control

The article deals with special questions of some aspects of food safety and application of methods of food physics in food processing and also in food quality control and quality assurance. The role of food safety has developed significantly in the last 2 decades, so today the production and processing of safe and quality food is of primary importance. Modem food production is based on principles of GAP and GMP （including GHP） and different methods and tools for quality control and assurance （IFS, HACCP, ISO-9000, ISO-9000/2010, ISO-22000, TQM）. There are different techniques and methods to produce safe food and to control the quality of the foodstuffs. The modem, up-to-date technologies and measurement techniques involve the application of many physical methods - high pressure, pulsing electrical field, microwave, non-destructive techniques （e.g., INAA, NMR, NIR-NIT, PAS）, radiation treatments as well. Using radiation technologies （of course not only nuclear ones） it is possible to fulfil some very important expectations of modem food processing, e.g., decrease of microbial contamination, improvement of sensory properties, increase of storability of food products.

Characteristics of China's Automobile Recall Actions

For the purpose of enhancing automobile safety and the effectiveness of recalls,increasing manufacturers' quality control capabilities,and reducing defects,we investigated thestatus of recalls over the last five years.We have examined patterns and trends in motor vehiclesafety recalls using databases from China,Europe and the United States.A recall rate parameterwas developed to evaluate the level of recall enforcement based on analyzing the reasonsfor recalls and manufactures' characteristics.Moreover,there were substantial differencesin the recall rates of China compared with those in other countries,indicating that Chinese manufacturersneed to take more active action in recall.