The Republic of Uzbekistan differs amongst other countries of the Central Asia by its peculiar medical-geographical conditions. Uzbekistan has dry, roast summer and cool winter which is uncharacteristic to subtropical...The Republic of Uzbekistan differs amongst other countries of the Central Asia by its peculiar medical-geographical conditions. Uzbekistan has dry, roast summer and cool winter which is uncharacteristic to subtropical climate. These factors have certain influence on health of the population. The meteorological conditions of each season promote the activations or decrease of various diseases in the Republic. The growth of the diseases of digestive organs, respiratory apparatus and cardiovascular diseases cause the special anxiety in the country. The analysis shows that from 1999 to 2009 nosogeographical situation is mostly worsened in Navaiy region. On the contrary, in the regions of Dzhizak, Samarkand and Khorezm common sickness rate of the population is decreased slightly.展开更多
Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tiss...Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development.展开更多
文摘The Republic of Uzbekistan differs amongst other countries of the Central Asia by its peculiar medical-geographical conditions. Uzbekistan has dry, roast summer and cool winter which is uncharacteristic to subtropical climate. These factors have certain influence on health of the population. The meteorological conditions of each season promote the activations or decrease of various diseases in the Republic. The growth of the diseases of digestive organs, respiratory apparatus and cardiovascular diseases cause the special anxiety in the country. The analysis shows that from 1999 to 2009 nosogeographical situation is mostly worsened in Navaiy region. On the contrary, in the regions of Dzhizak, Samarkand and Khorezm common sickness rate of the population is decreased slightly.
基金supported by the National Natural Science Foundation of China (81301802,81230051,30830048,81321003,31170711)Ministry of Science and Technology of China (2013CB910501,2010CB912203,2010CB529402)+3 种基金Program of Introducing Talents of Discipline to Universities of Ministry of EducationBeijing Natural Science Foundation (7120002)Peking University (BMU20120314,BMU20130364)a Leading Academic Discipline Project of Beijing Education Bureau
文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development.
