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定制设计法在盐酸丁咯地尔缓释片处方设计中的应用 被引量:1
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作者 杨伯阳 王淑君 +3 位作者 叶田田 张强 孙完 刘程宇 《沈阳药科大学学报》 CAS CSCD 北大核心 2011年第4期253-257,共5页
目的应用定制设计法优化盐酸丁咯地尔缓释片的处方。方法以片芯中乙基纤维素和氯化钠比例的变化、包衣增重为考察因素,以不同时间点的累积释放量为优化指标,应用定制设计法筛选最佳处方,并对优化处方进行验证。结果最优处方组成为,盐酸... 目的应用定制设计法优化盐酸丁咯地尔缓释片的处方。方法以片芯中乙基纤维素和氯化钠比例的变化、包衣增重为考察因素,以不同时间点的累积释放量为优化指标,应用定制设计法筛选最佳处方,并对优化处方进行验证。结果最优处方组成为,盐酸丁咯地尔600 mg、乙基纤维素90 mg、氯化钠10 mg、包衣增量为3%,12 h累积释放量为80%以上,体外释放曲线平稳。结论采用定制设计法得到了盐酸丁咯地尔缓释片的处方优化模型,应用优化处方制备缓释片所得的实测值与预测值无明显差异,实现了处方优化。 展开更多
关键词 定制设计法 盐酸丁咯地尔 包衣缓释片
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采用定制设计法设计中药外用乳剂处方 被引量:1
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作者 王宇 陈伟 +3 位作者 盛明宇 张寒 田爱平 李国辉 《中国药师》 CAS 2021年第11期2107-2110,共4页
目的:筛选中药亚微乳制剂的最佳处方。方法:通过单因素试验筛选,确定油相为大豆油,乳化剂为卵磷脂,助乳化剂为吐温80和丙二醇。以乳剂中大豆油的用量(X_(1))、卵磷脂的用量(X_(2))、吐温80的用量(X_(3))、丙二醇的用量(X_(4))为因素。... 目的:筛选中药亚微乳制剂的最佳处方。方法:通过单因素试验筛选,确定油相为大豆油,乳化剂为卵磷脂,助乳化剂为吐温80和丙二醇。以乳剂中大豆油的用量(X_(1))、卵磷脂的用量(X_(2))、吐温80的用量(X_(3))、丙二醇的用量(X_(4))为因素。以粒径(Y)为效应。采用JMP软件进行定制试验设计,确定各因素试验水平,生成试验表,依次试验取得结果输入表格,计算各回归方程和影响因素的P值,通过预测刻画器预测关键因素最佳数值,确定最佳处方。结果:选用定制试验设计法安排试验,筛选出用于治疗靶向药物皮疹的最佳处方:大豆油为15 ml,卵磷脂为3.75 g,吐温80为3 ml,丙二醇为8 ml时,预测最小粒径为103.72 nm。结论:采用定制试验设计的方法进行中药亚微乳制剂处方筛选,试验效率高,结果可靠。 展开更多
关键词 定制设计法 中药 亚微乳剂 处方
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CMOS工艺复接器模块中选择器的设计
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作者 窦建华 陈守府 许良凤 《现代电子技术》 2006年第4期21-22,29,共3页
在光纤传输系统中,为了提高信道的利用率,需要用复接器将多路低速信号合成一路高速信号。选择器就是高速复接器模块中的关键部分,选择器的逻辑功能和性能直接影响复接器的工作。由于源极耦合场效应管逻辑(SCFL)电路工作速率高,因此选择... 在光纤传输系统中,为了提高信道的利用率,需要用复接器将多路低速信号合成一路高速信号。选择器就是高速复接器模块中的关键部分,选择器的逻辑功能和性能直接影响复接器的工作。由于源极耦合场效应管逻辑(SCFL)电路工作速率高,因此选择器的设计就采用了SCFL电路结构。设计采用全定制的设计方法,在参数调整过程中,采用一种观察分组的新方法,并用SmartSpice进行了仿真,其结果达到了预期的目标。 展开更多
关键词 CMOS工艺 选择器 定制设计法 复接器
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Settling Time Design and Parameter Tuning Methods for Finite-Time P-PI Control 被引量:1
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作者 Keigo Hiruma Hisakazu Nakamura Yasuyuki Satoh 《Journal of Control Science and Engineering》 2016年第1期1-10,共10页
High precision position control and high speed control of the robot manipulators are fundamental and important control problems. The effectiveness of finite-time P-PI control was confirmed by end-effector position con... High precision position control and high speed control of the robot manipulators are fundamental and important control problems. The effectiveness of finite-time P-PI control was confirmed by end-effector position control of robot manipulators. However, parameter tuning method has not been proposed to finite-time P-PI control. In this paper, we propose a settling time design method and a parameter tuning method for the finite-time P-PI control. The effectiveness of the proposed parameter tuning method is confirmed by experiments of end-effcctor position control of a robot manipulator. 展开更多
关键词 Nonlinear control finite-time control P-PI control settling time design robot manipulator.
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Integrated Open Source Design for Architecture in High-Density Housing Practice
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作者 Yan Gao Xin Guo +1 位作者 Tiantian Lo Qiang Chang 《Journal of Civil Engineering and Architecture》 2015年第9期1085-1098,共14页
High-density housing can be interpreted as collections of individual units, which inevitably results in the dilemma between the global standardization designed by architects and local customization implemented by user... High-density housing can be interpreted as collections of individual units, which inevitably results in the dilemma between the global standardization designed by architects and local customization implemented by users. However, it is impossible to reflect the users' various needs in the conceptual design stage for high-density housing because of the economic, industrial and time constrains. In response to this challenge, this research paper outlines a different high-density housing design approach that can adopt users' individual customization in the conceptual design stage during the housing design practice. Hence, the design process would be an open-ended evolutionary and transparent process rather than deterministic executions as we have now in most high-density cities, such as Hong Kong. In order to overcome the deficiency in addressing future uncertainties of different users and address the issues of one-off developments without iterating users' feedback in the housing practice, this essay proposes IOSDA (integrated open source design for architecture) for the design practice of high-density housing, through collective data and parametric connectivity between users and architects. IOSDA reflects a different design attitude towards the future, i.e., to shift from architects' heroic prediction of the future to collective engagement of the present with more robust capacities for new possibilities. 展开更多
关键词 Open source architecture high density urban transformation plug-in infrastructure smart BIM iterative design parametric crowd network thinking.
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A product module mining method for PLM database 被引量:2
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作者 雷佻钰 彭卫平 +3 位作者 雷金 钟院华 张秋华 窦俊豪 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第7期1754-1766,共13页
Modular technology can effectively support the rapid design of products, and it is one of the key technologies to realize mass customization design. With the application of product lifecycle management(PLM) system in ... Modular technology can effectively support the rapid design of products, and it is one of the key technologies to realize mass customization design. With the application of product lifecycle management(PLM) system in enterprises, the product lifecycle data have been effectively managed. However, these data have not been fully utilized in module division, especially for complex machinery products. To solve this problem, a product module mining method for the PLM database is proposed to improve the effect of module division. Firstly, product data are extracted from the PLM database by data extraction algorithm. Then, data normalization and structure logical inspection are used to preprocess the extracted defective data. The preprocessed product data are analyzed and expressed in a matrix for module mining. Finally, the fuzzy c-means clustering(FCM) algorithm is used to generate product modules, which are stored in product module library after module marking and post-processing. The feasibility and effectiveness of the proposed method are verified by a case study of high pressure valve. 展开更多
关键词 product design module division product module mining product lifecycle management (PLM) database
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