AIM： To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS： A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched co...AIM： To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS： A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. RESULTS： The frequencies of the wild and variant genotypes in cases were significantly different from those of controls （P = 0.019）. Compared with individuals with the wild genotype CC, subjects with the variant genotypes （CT ＋ IT） had a significantly higher risk of gastric cancer （adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007）. In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged 〉 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. CONCLUSION： The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.展开更多
This study explored HIV risk perception of university students. A descriptive study design amongst a convenience sample of registered students at the Nelson Mandela Metropolitan University （NMMU）, who gave voluntary...This study explored HIV risk perception of university students. A descriptive study design amongst a convenience sample of registered students at the Nelson Mandela Metropolitan University （NMMU）, who gave voluntary informed consent to participate, and with access to the student portal was employed. Frequencies and percentages were used to describe categorical data. The Pearson correlation co-efficient （r） and Spearman＇s rank co-efficient were used to measure the strength or degree of the relationship between variables and identify the significance of the correlation between two variables respectively. Results indicate that males in the sample （n = 619） are more likely to acknowledge self-perceived risk than females. This paper concludes that management strategies should be put in place in all universities in order to help the students stay HIV negative. Unless HIV and AIDS are institutionalised, the management of risk behaviour will prove difficult.展开更多
基金Supported by The National Natural Science Foundation of Chi-na,No. 30873099Nanjing Medical University start-up research fund for Wang XRthe Natural Science Foundation of education Department,Jiangsu Province,No. 08KJB320004
文摘AIM： To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS： A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. RESULTS： The frequencies of the wild and variant genotypes in cases were significantly different from those of controls （P = 0.019）. Compared with individuals with the wild genotype CC, subjects with the variant genotypes （CT ＋ IT） had a significantly higher risk of gastric cancer （adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007）. In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged 〉 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. CONCLUSION： The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
文摘This study explored HIV risk perception of university students. A descriptive study design amongst a convenience sample of registered students at the Nelson Mandela Metropolitan University （NMMU）, who gave voluntary informed consent to participate, and with access to the student portal was employed. Frequencies and percentages were used to describe categorical data. The Pearson correlation co-efficient （r） and Spearman＇s rank co-efficient were used to measure the strength or degree of the relationship between variables and identify the significance of the correlation between two variables respectively. Results indicate that males in the sample （n = 619） are more likely to acknowledge self-perceived risk than females. This paper concludes that management strategies should be put in place in all universities in order to help the students stay HIV negative. Unless HIV and AIDS are institutionalised, the management of risk behaviour will prove difficult.
