AIM： To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS： A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched co...AIM： To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS： A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. RESULTS： The frequencies of the wild and variant genotypes in cases were significantly different from those of controls （P = 0.019）. Compared with individuals with the wild genotype CC, subjects with the variant genotypes （CT ＋ IT） had a significantly higher risk of gastric cancer （adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007）. In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged 〉 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. CONCLUSION： The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.展开更多
Spatial data uncertainty can directly affect the quality of digital products and GIS-based decision making. On the basis of the characteristics of randomicity of positional data and fuzziness of attribute data, taking...Spatial data uncertainty can directly affect the quality of digital products and GIS-based decision making. On the basis of the characteristics of randomicity of positional data and fuzziness of attribute data, taking entropy as a measure, the stochastic entropy model of positional data uncertainty and fuzzy entropy model of attribute data uncertainty are proposed. As both randomic-ity and fuzziness usually simultaneously exist in linear segments, their omnibus effects are also investigated and quantified. A novel uncertainty measure, general entropy, is presented. The general entropy can be used as a uniform measure to quantify the total un-certainty caused by stochastic uncertainty and fuzzy uncertainty in GIS.展开更多
Based on the Brinson constitutive model of SMA, a piecewise linear model for the hysteresis loop of pseudo-elasticity is proposed and applied in the analysis of responses of an SMA-spring-mass system under initial vel...Based on the Brinson constitutive model of SMA, a piecewise linear model for the hysteresis loop of pseudo-elasticity is proposed and applied in the analysis of responses of an SMA-spring-mass system under initial velocity activation. The histories of displacement and velocity of the mass, and the response of stress of SMA are calculated with Brinson’s model and the piecewise linear model. The difference of results of the two models is not significant. The calculation with piecewise-linear model needs no iteration and is highly efficient.展开更多
the establishment of multi-element airfoil in steady and unsteady ground effect N-S equation turbulence model, the S-A model of multi element airfoils during takeoff and landing high attack angle change numerical simu...the establishment of multi-element airfoil in steady and unsteady ground effect N-S equation turbulence model, the S-A model of multi element airfoils during takeoff and landing high attack angle change numerical simulation analysis, the calculation results show that the lower altitude, lift and drag wing angle decreased; the greater the ground the effect is more obvious, the greater the loss of lift. The simulation results show that the lift coefficient is slightly less than that of unsteady numerical simulation, and the drag coefficient is slightly less than that of unsteady numerical simulation. The ground disturbance to the wing not only affects the steady state flow field, but also is closely related to the unsteady aerodynamic performance. The results of this study can provide a reference for the design and flight control of large aircraft wings.展开更多
A mathematical model is presented in order to describe the dynamics of polygamous populations, bearing in mind single individuals of both sexes and the development of reproductive groups. In this context, the descript...A mathematical model is presented in order to describe the dynamics of polygamous populations, bearing in mind single individuals of both sexes and the development of reproductive groups. In this context, the description leads us to consider positive homogeneous dynamical systems, establishing conditions for the stationary state existence and its local stability. A fourth pre-reproductive stage was considered, i.e. males and females spend part of their lives before being in condition to reproduce, as a first step to consider more general models. Finally, we parametrized the proposed model using southern elephant seal data, to analyze the direct applicability to a real population.展开更多
基金Supported by The National Natural Science Foundation of Chi-na,No. 30873099Nanjing Medical University start-up research fund for Wang XRthe Natural Science Foundation of education Department,Jiangsu Province,No. 08KJB320004
文摘AIM： To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS： A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. RESULTS： The frequencies of the wild and variant genotypes in cases were significantly different from those of controls （P = 0.019）. Compared with individuals with the wild genotype CC, subjects with the variant genotypes （CT ＋ IT） had a significantly higher risk of gastric cancer （adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007）. In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged 〉 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. CONCLUSION： The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
基金Supported by the Open Research Fund Program of Geomatics and Application Laboratory, Liaoning Technical University (No.2005004).
文摘Spatial data uncertainty can directly affect the quality of digital products and GIS-based decision making. On the basis of the characteristics of randomicity of positional data and fuzziness of attribute data, taking entropy as a measure, the stochastic entropy model of positional data uncertainty and fuzzy entropy model of attribute data uncertainty are proposed. As both randomic-ity and fuzziness usually simultaneously exist in linear segments, their omnibus effects are also investigated and quantified. A novel uncertainty measure, general entropy, is presented. The general entropy can be used as a uniform measure to quantify the total un-certainty caused by stochastic uncertainty and fuzzy uncertainty in GIS.
基金National Natural Science Foundation ofChina(No.5 973 10 3 0 )
文摘Based on the Brinson constitutive model of SMA, a piecewise linear model for the hysteresis loop of pseudo-elasticity is proposed and applied in the analysis of responses of an SMA-spring-mass system under initial velocity activation. The histories of displacement and velocity of the mass, and the response of stress of SMA are calculated with Brinson’s model and the piecewise linear model. The difference of results of the two models is not significant. The calculation with piecewise-linear model needs no iteration and is highly efficient.
文摘the establishment of multi-element airfoil in steady and unsteady ground effect N-S equation turbulence model, the S-A model of multi element airfoils during takeoff and landing high attack angle change numerical simulation analysis, the calculation results show that the lower altitude, lift and drag wing angle decreased; the greater the ground the effect is more obvious, the greater the loss of lift. The simulation results show that the lift coefficient is slightly less than that of unsteady numerical simulation, and the drag coefficient is slightly less than that of unsteady numerical simulation. The ground disturbance to the wing not only affects the steady state flow field, but also is closely related to the unsteady aerodynamic performance. The results of this study can provide a reference for the design and flight control of large aircraft wings.
文摘A mathematical model is presented in order to describe the dynamics of polygamous populations, bearing in mind single individuals of both sexes and the development of reproductive groups. In this context, the description leads us to consider positive homogeneous dynamical systems, establishing conditions for the stationary state existence and its local stability. A fourth pre-reproductive stage was considered, i.e. males and females spend part of their lives before being in condition to reproduce, as a first step to consider more general models. Finally, we parametrized the proposed model using southern elephant seal data, to analyze the direct applicability to a real population.
