药物动力学定域模型的建立和应用

目的 建立药物动力学定域模型并初步应用。方法 在房室模型基础上推导药物动力学定域模型,并由此得到药物动力学方程和若干重要参数。结果 该模型能正确描述药物在各种脏器和组织中的动力学行为,从而变房室模型的含混解释为本模型的直观解释。根据所推导的公式编制了计算机程序,计算结果表明,该模型理想地解释了实验结果。

受体显像剂^(99m)Tc-NCAM在小鼠脑组织中的药物代谢动力学研究

对N-甲基-D-天冬氨酸(NMDA)受体拮抗剂锝标记N-[2-(N-(2-巯基乙基))氨基乙酰基]-N-(2-巯基乙基)-3,5-二甲基金刚烷胺基乙酰胺(99mTc-NCAM)进行小鼠脑组织中药物动力学研究。KM小鼠尾静脉注射0.2mL(7.4MBq)99mTc-NCAM,分别于注射后5、10、30、60、120、180min处死,取大脑皮层、纹状体、海马、小脑和丘脑,称重和测计数。以相同的时间点,小鼠断尾取血20μL,测计数。用药物动力学定域模型进行脑组织和血药动力学研究。结果表明,99mTc-NCAM静脉注射给药后迅速进脑,在大脑皮层和海马有较高的摄取,最高摄取分别为1.51±0.13%ID/g和0.74±0.002%ID/g。理论计算表明,99mTc-NCAM在小鼠体内符合二室模型,并获得各种脑组织和血液的药物动力学方程和参数。99mTc-NCAM能透过血脑屏障进入小鼠脑内特定区域,以NMDA受体分布最多的大脑皮层和海马摄取较多,可望成为一种新的NMDA受体显像剂,用于一些神经退行性疾病的诊断预后等。

Comparison of Several Statistical Analysis Models for Genotypic Stability of Saccharum officinarum

[Objective] The study aimed to compare several statistical analysis models for estimating the sugarcane （Saccharum spp.） genotypic stability. [Method] The data of sugarcane regional trials in Guangdong, in 2009 was analyzed by three models respectively： Finlay and Wilkinson model： the additive main effects and multiplicative interaction （AMMI） model and linear regression-principal components analysis （LR- PCA） model, so as to compare the models. [Result] The Finlay and Wilkinson model was easier, but the analysis of the other two models was more comprehensive, and there was a bit difference between the additive main effects and multiplicative inter- action （AMMI） model and linear regression-principal components analysis （LR-PCA） model. [Conclusion] In practice, while the proper statistical method was usually con- sidered according to the different data, it should be also considered that the same data should be analyzed with different statistical methods in order to get a more reasonable result by comparison.

Application of pharmacokinetics local model to evaluaterenal function

The pharmacokinetics local model was used to evaluate renal function. Some typical kinds of renal function cases, normal or disorder, were selected to be imaged with SPECT and those data measured were treated by the pharmacokinetics local model computer program (PLM). The results indicated that parameters, including peak value, peak time, inflexion time, half-excretion time, and kinetic equation played and important role in judging renal function. The fact confirms that local model is very useful in evaluating renal function.

QUANTITATIVE ANALYSIS AND FRACTAL MODELING ON THE MOSAIC STRUCTURE OF LANDSCAPE IN THE CENTRAL AREA OF SHANGHAI METROPOLIS

The mosaic structure of landscape of the central area of Shanghai Metropolis is studied by quantitative methods of landscape ecology based on Remote Sensing (RS) and Geographic Information System (GIS) in this paper. Firstly, landscapes are classified into eight categories: residential quarter, industrial quarter, road, other urban landscape, farmland, village and small town, on-building area, river and other water bodies (such as lake, etc.). Secondly, a GIS is designed and set up based on the remote sensing data and field investigation, and a digital map of landscape mosaic is made. Then the indexes of diversity, dominance, fragmentation and isolation, and fractal dimension of each type of landscape in different periods are calculated by using spatial analysis method of GIS. With reference to the calculated results, a series of relative issues are discussed.

Development and Validation of National Cotton Cultivar Registration Index Model in Yangtze River Valley

[Objective] Based on the cotton variety high yielding potential, fiber quality traits, disease resistance, and early maturity characters, a cultivar registration index model was developed to simplify the tedious calculation process in national cotton registration procedure, and thus to enhance the practical application of cultivar regis- tration index in cotton breeding ancl cotton recommending. [Method] By means of correlation analysis, partial correlation analysis and path analysis methods, the cor- relation of cotton main properties and their effects on cultivar registration index were explored using the dataset of national cotton regional trials in Yangtze River Valley during 1996-2013. The cultivar registration index model was constructed with step- wise regression statistical technique to ascertain the quantitative relationship of main characters with cultivar registration index, and the regional cotton trial dataset in 2013 was used to validate the model. [Result] Several characters with larger deter- minants to cultivar registration index were screened out,ie. lint yield increase ratio, pro-frost yield ratio, verticillium wilt index, fiber strength, fusarium wilt index and mi- cronaire value. The cultivar registration index model defined the functional relation- ship of cultivar registration index with the selected main characters, among which lint yield increase ratio, fiber strength and micronaire value contributed most to culti- var registration index. The model validation with regional cotton trials in 2013 indi- cated the root mean square error, RMSE was only 2.77, and the variation coeffi- cient was 6.77%, which confirmed the model prediction effect was quite perfect. [Conclusion] The developed cultivar registration index model was reliable enough to simulate the complicated scoring system in cultivar registration procedure, also sim- plified cotton registration process, and enhanced the practicability of the cultivar reg- istration index.

Determination of fractional energy loss of waves in nearshore waters using an improved high-order Boussinesq-type model

Fractional energy losses of waves due to wave breaking when passing over a submerged bar are studied systematically using a modified numerical code that is based on the high-order Boussinesq-type equations.The model is first tested by the additional experimental data,and the model's capability of simulating the wave transformation over both gentle slope and steep slope is demonstrated.Then,the model's breaking index is replaced and tested.The new breaking index,which is optimized from the several breaking indices,is not sensitive to the spatial grid length and includes the bottom slopes.Numerical tests show that the modified model with the new breaking index is more stable and efficient for the shallow-water wave breaking.Finally,the modified model is used to study the fractional energy losses for the regular waves propagating and breaking over a submerged bar.Our results have revealed that how the nonlinearity and the dispersion of the incident waves as well as the dimensionless bar height(normalized by water depth) dominate the fractional energy losses.It is also found that the bar slope(limited to gentle slopes that less than 1:10) and the dimensionless bar length(normalized by incident wave length) have negligible effects on the fractional energy losses.

Lateral stability region conservativeness estimation and torque distribution for FWIA electric vehicle steering

Estimation of the lateral stability region and torque distribution on steering is very important to improve stability in lateral handling for all wheel drive electric vehicles.Based on the built-nonlinear vehicle dynamic model,the lateral stability region of the vehicle related to steering is estimated using Lyapunov function.We obtained stable equilibrium points of non-straight driving according to the estimated lateral stability region and also reconstructed the Lyapunov function matrix,which proved that the closed-loop system composed of yaw rate and lateral velocity is satisfied with negative definite property.In addition,the designed controller dynamically allocates the drive torque in terms of the vertical load and slip rate of the four wheels.The simulation results show that the estimated lateral stability region and the designed controller are satisfactory in handling stability performance against different roads and vehicle parameters.

Indecomposable Calabi-Yau Objects in Stable Module Categories of Finite Type

The authors give a discription of the finite representation type over an algebraically stable categories of selfinjective algebras of closed field, which admits indecomposable Calabi-Yau obdjects. For selfinjective algebras with such properties, the ones whose stable categories are not Calabi-Yau are determined. For the remaining ones, i.e., those selfinjective algebras whose stable categories are actually Calabi-Yau, the difference between the Calabi-Yau dimensions of the indecomposable Calabi-Yau objects and the Calabi-Yau dimensions of the stable categories is described.

Probabilistic total transfer capability analysis based on static voltage stability region integrated with a modified distributed-level nodal-loading model

In this paper, a new evaluation method of probabilistic TTC based on SVSR calculation is developed through a hierarchical simulation. A smooth technology based on the non-parametric kernel estimator is adapted to obtain the time-dependent probabilistic density function of the feeder-head load data. In order to describe possible operating change directions of the operating point, the original hyper-cone-like(HCL) model is constructed to consider the probabilistic distribution function(PDF) extracted from feeder-head load data to replace the simple Normal Distribution model and the uncertain generator outputs. To realize the fast TTC calculation of the current operating point in random conditions, a sub-hyper-cone-like(SHCL) model in full power injections space is proposed, which is a similarity transformation of the original one.

Dynamic analysis on pressure fluctuation in vaneless region of a pump turbine

As the pump turbine tends to be operated with high head and high rotational speed, the study of stability problems becomes more important. The pump turbine usually works at operating conditions where the guide vanes experience strong vibrations. However, most traditional studies were carried out based on constant GVO(guide vane opening) simulations. In this work, dynamic analysis on pressure fluctuation in the vaneless region of a pump turbine model was conducted using a dynamic mesh method in turbine mode. 3D unsteady simulations were conducted where GVO was closed and opened by 1° from the initial 18°. Detailed time domain and frequency domain characteristics on pressure fluctuation in the vaneless region under different guide vane rotational states compared with constant GVO simulations were investigated. Results show that, during the guide vanes oscillating process, the low and intermediate frequency components in the vaneless region are significantly different. The amplitudes of pressure fluctuation are higher than those with constant GVO simulations, which agree better with the experimental data. In addition, the pressure fluctuation increases when GVO is opened, and vice versa. It can be concluded that pressure fluctuation in the vaneless region is strongly influenced by the oscillating of the guide vanes.

A spatial echinococcosis transmission model with time delays： Stability and traveling waves

In this paper, we derive a time-delayed and diffusive echinococcosis transmission model. We first address the well-posedness to the initial-value problem for the model and give the basic reproduction number TO0. In the case of a bounded spatial domain, we establish the local stability as well as the global stability of the disease-free and disease equilibria of the model. The methods to prove the local and the global stability are to analyze the corresponding characteristic equations and construct Lyapunov functionals, respectively. In the case of an unbounded spatial domain, by applying Schauder＇s fixed point theorem and the limiting arguments, we show that when R0 〉 1, there exists a constant c＊ 〉 0 such that the model admits positive traveling wave solutions connecting the disease-free and endemic equilibrium for c 〉 c＊, and when R0 〉 1 and c 〈 c＊, the model has no positive traveling wave solutions connecting them.