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中医之“靶向治疗” 被引量:4
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作者 刘磊 李薇薇 张国海 《中医研究》 2021年第7期9-13,共5页
“靶向治疗”是在细胞分子水平上针对患癌部位进行的定位治疗,使药物能够与致癌位点进行有效结合,肿瘤细胞特异性死亡不会波及肿瘤周围的正常组织细胞,是目前一种新型的治疗方法。“靶向治疗”在西医治疗中强调其精准性,又被称为“生物... “靶向治疗”是在细胞分子水平上针对患癌部位进行的定位治疗,使药物能够与致癌位点进行有效结合,肿瘤细胞特异性死亡不会波及肿瘤周围的正常组织细胞,是目前一种新型的治疗方法。“靶向治疗”在西医治疗中强调其精准性,又被称为“生物导弹”;“靶向治疗”在中医治疗中可以称为“精准医学”。中医的“靶向治疗”也是一种新型的医学理念和医学模式,这种理念与中医学整体观念并不向违背,而是对中医学的一种推进和发展,是中医学与西医学的有效结合。结合张国海的治疗理念和临床经验,强调中医治疗的“靶向性”,在此理念的基础上辨证论治、遣方用药,取得较好的临床效果。通过对常见疾病的辨证分析、定位归经,引出了中医的“靶向治疗”。在辨证治疗中分别就定脏腑、定上下、定内外、定经络等在临床中的运用进行论述,在研究中发现“靶向治疗”在临床诊疗中的重要性。通过研究,得出在中医辨证中重视其脏腑的属性、上下内外的走向、中药的归经、经络的归行等能够有效地提高中医临床疗效,拓宽辨证思路和诊疗的精准性。 展开更多
关键词 靶向治疗 脏腑 表里 上下 定经络
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Gated Neural Network-Based Unsteady Aerodynamic Modeling for Large Angles of Attack
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作者 DENG Yongtao CHENG Shixin MI Baigang 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2024年第4期432-443,共12页
Modeling of unsteady aerodynamic loads at high angles of attack using a small amount of experimental or simulation data to construct predictive models for unknown states can greatly improve the efficiency of aircraft ... Modeling of unsteady aerodynamic loads at high angles of attack using a small amount of experimental or simulation data to construct predictive models for unknown states can greatly improve the efficiency of aircraft unsteady aerodynamic design and flight dynamics analysis.In this paper,aiming at the problems of poor generalization of traditional aerodynamic models and intelligent models,an intelligent aerodynamic modeling method based on gated neural units is proposed.The time memory characteristics of the gated neural unit is fully utilized,thus the nonlinear flow field characterization ability of the learning and training process is enhanced,and the generalization ability of the whole prediction model is improved.The prediction and verification of the model are carried out under the maneuvering flight condition of NACA0015 airfoil.The results show that the model has good adaptability.In the interpolation prediction,the maximum prediction error of the lift and drag coefficients and the moment coefficient does not exceed 10%,which can basically represent the variation characteristics of the entire flow field.In the construction of extrapolation models,the training model based on the strong nonlinear data has good accuracy for weak nonlinear prediction.Furthermore,the error is larger,even exceeding 20%,which indicates that the extrapolation and generalization capabilities need to be further optimized by integrating physical models.Compared with the conventional state space equation model,the proposed method can improve the extrapolation accuracy and efficiency by 78%and 60%,respectively,which demonstrates the applied potential of this method in aerodynamic modeling. 展开更多
关键词 large angle of attack unsteady aerodynamic modeling gated neural networks generalization ability
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