Objectives: To evaluate the influence of initial and postinitial treatment factors on cognitive, psychomotor, and psychological outcome in schoolchildren with congenital hypothyroidism (CH). Study design: We studied 4...Objectives: To evaluate the influence of initial and postinitial treatment factors on cognitive, psychomotor, and psychological outcome in schoolchildren with congenital hypothyroidism (CH). Study design: We studied 45 patients (19 with severe CH and 26 with mild CH) and 37 control children by correlating initial and postinitial treatment factors (free thyroxine and thyroid-stimulating hormone TSH concentrations, and the percentage of overtre-atment and undertreatment periods) with the results of neuropsychological tests and behavior (as reported on the Teacher Report Form TRF ). Results: The global IQ of the children with CH was comparable to that of the controls; visuomotor and verbal scores were lower, and total TRF scores were higher. Ethnic group, previous development, and overtreatment predicted IQ and verbal scores, with higher scores seen for the overtreated patients than for the control children and those patients who had not been overtreated. As initial treatment was less satisfactory, total TRF scores were higher. Conclusions: Our study suggests that initial and postinitial suboptimal treatment of CH leads to abnormalities in IQ and specific fields. Overtreatment may advance cognitive development in 5-12-to 7-year-olds. Suboptimal initial treatment may lead to behavioral problems. We recommend that TSH concentrations be maintained within the normal range in patients with CH.展开更多
由于传统淡水鱼池塘养殖存在废物过量堆积、水体污染严重等问题,以及中国对水产品需求的增加,工厂化循环水养殖、集装箱、圈养模式等高质量、高产量、集约化的新型淡水鱼养殖模式逐渐得到应用。针对新型淡水鱼养殖模式存在投饲劳动强度...由于传统淡水鱼池塘养殖存在废物过量堆积、水体污染严重等问题,以及中国对水产品需求的增加,工厂化循环水养殖、集装箱、圈养模式等高质量、高产量、集约化的新型淡水鱼养殖模式逐渐得到应用。针对新型淡水鱼养殖模式存在投饲劳动强度大、自动化程度低等问题,设计了一款气送式自动投饲系统,实现了定向、定时和定量投饲功能。设计了特定的四通装置和三通装置以保证饲料的定向输送;基于计算流体力学和离散单元法(Computational fluid dynamics-Discrete element method,CFD-DEM)耦合技术,初步确定了满足投饲要求的投饲速度并由此确定了风机型号;开发了以Arduino Mega 2560单片机为核心处理器的投饲控制系统,通过时钟模块实时获取当前时间信息,通过称量传感器实时获取料仓内物料质量信息,通过蓝牙传输预计投饲区域、投饲时间和投饲质量,从而实现定向定时定量投饲;最后试制样机并进行了性能试验,两种工况下投饲的实际投饲距离与仿真结果误差分别为5.74%和9.54%,定向、定时和定量投饲可以准确实现,控制系统响应时间小于1 s,定量投饲最大误差为5.37%。研究结果表明,自动投饲系统结构可靠、控制系统精度较高,满足自动投饲要求。展开更多
文摘Objectives: To evaluate the influence of initial and postinitial treatment factors on cognitive, psychomotor, and psychological outcome in schoolchildren with congenital hypothyroidism (CH). Study design: We studied 45 patients (19 with severe CH and 26 with mild CH) and 37 control children by correlating initial and postinitial treatment factors (free thyroxine and thyroid-stimulating hormone TSH concentrations, and the percentage of overtre-atment and undertreatment periods) with the results of neuropsychological tests and behavior (as reported on the Teacher Report Form TRF ). Results: The global IQ of the children with CH was comparable to that of the controls; visuomotor and verbal scores were lower, and total TRF scores were higher. Ethnic group, previous development, and overtreatment predicted IQ and verbal scores, with higher scores seen for the overtreated patients than for the control children and those patients who had not been overtreated. As initial treatment was less satisfactory, total TRF scores were higher. Conclusions: Our study suggests that initial and postinitial suboptimal treatment of CH leads to abnormalities in IQ and specific fields. Overtreatment may advance cognitive development in 5-12-to 7-year-olds. Suboptimal initial treatment may lead to behavioral problems. We recommend that TSH concentrations be maintained within the normal range in patients with CH.
文摘由于传统淡水鱼池塘养殖存在废物过量堆积、水体污染严重等问题,以及中国对水产品需求的增加,工厂化循环水养殖、集装箱、圈养模式等高质量、高产量、集约化的新型淡水鱼养殖模式逐渐得到应用。针对新型淡水鱼养殖模式存在投饲劳动强度大、自动化程度低等问题,设计了一款气送式自动投饲系统,实现了定向、定时和定量投饲功能。设计了特定的四通装置和三通装置以保证饲料的定向输送;基于计算流体力学和离散单元法(Computational fluid dynamics-Discrete element method,CFD-DEM)耦合技术,初步确定了满足投饲要求的投饲速度并由此确定了风机型号;开发了以Arduino Mega 2560单片机为核心处理器的投饲控制系统,通过时钟模块实时获取当前时间信息,通过称量传感器实时获取料仓内物料质量信息,通过蓝牙传输预计投饲区域、投饲时间和投饲质量,从而实现定向定时定量投饲;最后试制样机并进行了性能试验,两种工况下投饲的实际投饲距离与仿真结果误差分别为5.74%和9.54%,定向、定时和定量投饲可以准确实现,控制系统响应时间小于1 s,定量投饲最大误差为5.37%。研究结果表明,自动投饲系统结构可靠、控制系统精度较高,满足自动投饲要求。
