A new descriptor,namely scores vector of zero dimension,one dimension,two dimension and three dimension(SZOTT),was derived from principle components analysis of a matrix of 1 369 structural variables including 0D,1D,2...A new descriptor,namely scores vector of zero dimension,one dimension,two dimension and three dimension(SZOTT),was derived from principle components analysis of a matrix of 1 369 structural variables including 0D,1D,2D and 3D information for 20 coded amino acids.SZOTT scales were then employed to express structures of 20 thromboplastin inhibitors and 34 bactericidal peptides.The correlation coefficients of both whole calibration(%R%2=%R%2cu)and of cross validation(%Q%2=%R%2cv)for the multiple-variable models by classical partial least squares(PLS)and orthogonal signal correction-partial least squares(OSC-PLS)of 20 thromboplastin inhibitors were 0.989 and 0.748,0.994 and 0.936,respectively.%R%2 and %Q%2 for the models by PLS and OSC-PLS of 34 bactericidal peptides were 0.619 and 0.406,0.910 and 0.503,respectively.Satisfactory results obtained showed that structural information related to biological activity in both data sets could be described by SZOTT which included plentiful information related to biological activity,and which was conveniently operated and easy interpreted.,also predictive capability of models were relative robust.There is a high prospect for SZOTT wide applications on quantitative sequence-activity modeling(QSAM)of peptides.展开更多
Video Super-Resolution （SR） reconstruction produces video sequences with High Resolution （HR） via the fusion of several Low-Resolution （LR） video frames. Traditional methods rely on the accurate estimation of su...Video Super-Resolution （SR） reconstruction produces video sequences with High Resolution （HR） via the fusion of several Low-Resolution （LR） video frames. Traditional methods rely on the accurate estimation of subpixel motion, which constrains their applicability to video sequences with relatively simple motions such as global translation. We propose an efficient iterative spatio-temporal adaptive SR reconstruction model based on Zemike Moment （ZM）, which is effective for spatial video sequences with arbitrary motion. The model uses region correlation judgment and self-adaptive threshold strategies to improve the effect and time efficiency of the ZM-based SR method. This leads to better mining of non-local self-similarity and local structural regularity, and is robust to noise and rotation. An efficient iterative curvature-based interpolation scheme is introduced to obtain the initial HR estimation of each LR video frame. Experimental results both on spatial and standard video sequences demonstrate that the proposed method outperforms existing methods in terms of both subjective visual and objective quantitative evaluations, and greatly improves the time efficiency.展开更多
文摘A new descriptor,namely scores vector of zero dimension,one dimension,two dimension and three dimension(SZOTT),was derived from principle components analysis of a matrix of 1 369 structural variables including 0D,1D,2D and 3D information for 20 coded amino acids.SZOTT scales were then employed to express structures of 20 thromboplastin inhibitors and 34 bactericidal peptides.The correlation coefficients of both whole calibration(%R%2=%R%2cu)and of cross validation(%Q%2=%R%2cv)for the multiple-variable models by classical partial least squares(PLS)and orthogonal signal correction-partial least squares(OSC-PLS)of 20 thromboplastin inhibitors were 0.989 and 0.748,0.994 and 0.936,respectively.%R%2 and %Q%2 for the models by PLS and OSC-PLS of 34 bactericidal peptides were 0.619 and 0.406,0.910 and 0.503,respectively.Satisfactory results obtained showed that structural information related to biological activity in both data sets could be described by SZOTT which included plentiful information related to biological activity,and which was conveniently operated and easy interpreted.,also predictive capability of models were relative robust.There is a high prospect for SZOTT wide applications on quantitative sequence-activity modeling(QSAM)of peptides.
基金the National Basic Research Program of China (973 Program) under Grant No.2012CB821200，the National Natural Science Foundation of China under Grants No.91024001,No.61070142，the Beijing Natural Science Foundation under Grant No.4111002
文摘Video Super-Resolution （SR） reconstruction produces video sequences with High Resolution （HR） via the fusion of several Low-Resolution （LR） video frames. Traditional methods rely on the accurate estimation of subpixel motion, which constrains their applicability to video sequences with relatively simple motions such as global translation. We propose an efficient iterative spatio-temporal adaptive SR reconstruction model based on Zemike Moment （ZM）, which is effective for spatial video sequences with arbitrary motion. The model uses region correlation judgment and self-adaptive threshold strategies to improve the effect and time efficiency of the ZM-based SR method. This leads to better mining of non-local self-similarity and local structural regularity, and is robust to noise and rotation. An efficient iterative curvature-based interpolation scheme is introduced to obtain the initial HR estimation of each LR video frame. Experimental results both on spatial and standard video sequences demonstrate that the proposed method outperforms existing methods in terms of both subjective visual and objective quantitative evaluations, and greatly improves the time efficiency.
