To test the accuracy of real-time three-dimensional echocardiography (RT3DE) imaging system for evaluating left ventricular mass (LVM) in phantom and excised canine heart. Methods Ten left ventricular (LV) wall phanto...To test the accuracy of real-time three-dimensional echocardiography (RT3DE) imaging system for evaluating left ventricular mass (LVM) in phantom and excised canine heart. Methods Ten left ventricular (LV) wall phantoms made of two rubber-bursas, ten excised canine hearts underwent RT3DE and two-dimensional echocardiography (2DE). In RT3DE "full volume" imaging, the myocardial volume was mea-sured using 2,4,8, and 16-plane method with the analysis software of RT3DE. Mass was then calculated by multiplying the resulting myocardial volume by specific density of myocardial tissue. In 2DE the masses were measured by area-length meth-od. The true LV wall phantom mass was measured by water displacement and the canine LVM was weighed by anatomy, which served as a reference standard. We compared RT3DE or 2DE with true mass. Results In LV wall phantoms, RT3DE correlated with true masses strongly (r = 0.813-0.994) and weakly correlated between 2DE and true masses (r = 0.628). In excised canine hearts, there is an excellent correlation between RT3DE and true masses (r = 0.764-0.991), while 2DE value showed a lesser correlation (r = 0.514). There are no difference between RT-3DE and true masses (P > 0.05) but different between 2DE and true masses (P < 0.05). In different planes, there was no difference between 8-plane and 16-plane (P > 0.05) but different between 8-plane and 2, 4-plane (P < 0.05). Conclusion RT3DE can accurately quantify LVM and provide a new tool to evaluate LV function. For LVM by RT3DE, 8-plane measurement method is the best choice for accuracy and convenience.展开更多
Objective To evaluate the feasibility and accuracy of measurement of myocardial perfusion defects with intravenous contrast-enhanced real-time three-dimensional echocardiography (CE-RT3DE). Methods RT3DE was performed...Objective To evaluate the feasibility and accuracy of measurement of myocardial perfusion defects with intravenous contrast-enhanced real-time three-dimensional echocardiography (CE-RT3DE). Methods RT3DE was performed in 21 open-chest mongrel dogs undergoing acute ligation of the left anterior descending artery (LAD, n=14) or distal branch of the left circumflex artery (LCX, n=7). A perfluorocarbon microbubble contrast agent was injected intravenously to assess the resulting myocardial perfusion defects with Philips Sonos-7500 ultrasound system. Evans blue dye was injected into the occluded coronary artery for subsequent anatomic identification of underperfused myocardium. In vitro anatomic measurement of myocardial mass after removal of the animal’s heart was regarded as the control. Blinded off-line calculation of left ventricular mass and perfusion defect mass from RT3DE images were performed using an interactive aided-manual tracing technique.Results Total left ventricular (LV) myocardial mass ranged from 38.9 to 78.5 (mean±SD: 60.0±10.1) g. The mass of perfusion defect ranged from 0 to 21.4 (mean±SD: 12.0±5.0) g or 0 to 27% of total LV mass (mean±SD: 19%±6%). The RT3DE estimation of total LV mass (mean±SD: 59.8±9.9 g) strongly correlated with the anatomic measurement (r=0.98; y=2.01+0.96x). The CE-RT3DE calculation of the mass of underperfused myocardium (mean±SD: 12.3±5.3 g) also strongly correlated with the anatomic measurement (r=0.96; y=-0.10+1.04x) and when expressed as percentage of total LV mass (r=0.95; y=-0.20+1.04x). Conclusions RT3DE with myocardial contrast opacification could accurately estimate underperfused myocardial mass in dogs of acute coronary occlusion and would play an important role in quantitative assessment of myocardial perfusion defects in patients with coronary artery disease.展开更多
The class of bi-directional optimal velocity models can describe the bi-directional looking effect that usually exists in the reality and is even enhanced with the development of the connected vehicle technologies. It...The class of bi-directional optimal velocity models can describe the bi-directional looking effect that usually exists in the reality and is even enhanced with the development of the connected vehicle technologies. Its combined string stability condition can be obtained through the method of the ring-road based string stability analysis. However, the partial string stability about traffic fluctuation propagated backward or forward was neglected, which will be analyzed in detail in this work by the method of transfer function and its H∞ norm from the viewpoint of control theory. Then, through comparing the conditions of combined and partial string stabilities, their relationships can make traffic flow be divided into three distinguishable regions, displaying various combined and partial string stability performance. Finally, the numerical experiments verify the theoretical results and find that the final displaying string stability or instability performance results from the accumulated and offset effects of traffic fluctuations propagated from different directions.展开更多
To investigate the unsteady flow characteristics in centrifugal pump, the flow field in a low-specific-speed centri- fugal pump with complex impeller is numerically simulated under different conditions. The RNG r-e tu...To investigate the unsteady flow characteristics in centrifugal pump, the flow field in a low-specific-speed centri- fugal pump with complex impeller is numerically simulated under different conditions. The RNG r-e turbulence model and sliding mesh are adopted during the process of computation. The results show that the interaction be- tween impeller and volute results in the unstable flow of the fluid, which causes the uneven distribution of pres- sure fluctuations around the circumference of volute. Besides the main frequency and its multiple frequency of pressure fluctuations in the centrifugal pump, the frequency caused by the long blades of complex impeller also plays a dominant role in the low-frequency areas. Furthermore, there exists biggish fluctuation phenomenon near the tongue. The composition of static pressure fluctuations frequency on the volute wall and blade outlet is similar except that the fluctuation amplitude near the volute wall reduces. In general, the different flow rates mainly have influence on the amplitude of fluctuation frequency in the pump, while have little effect on the frequency compo- sition.展开更多
This paper considers the stabilization of the transmission problem of wave equations with variable coefficients. By introducing both boundary feedback control and distribute feedback control near the transmission boun...This paper considers the stabilization of the transmission problem of wave equations with variable coefficients. By introducing both boundary feedback control and distribute feedback control near the transmission boundary, the author establishes the uniform energy decay rate for the problem.展开更多
文摘To test the accuracy of real-time three-dimensional echocardiography (RT3DE) imaging system for evaluating left ventricular mass (LVM) in phantom and excised canine heart. Methods Ten left ventricular (LV) wall phantoms made of two rubber-bursas, ten excised canine hearts underwent RT3DE and two-dimensional echocardiography (2DE). In RT3DE "full volume" imaging, the myocardial volume was mea-sured using 2,4,8, and 16-plane method with the analysis software of RT3DE. Mass was then calculated by multiplying the resulting myocardial volume by specific density of myocardial tissue. In 2DE the masses were measured by area-length meth-od. The true LV wall phantom mass was measured by water displacement and the canine LVM was weighed by anatomy, which served as a reference standard. We compared RT3DE or 2DE with true mass. Results In LV wall phantoms, RT3DE correlated with true masses strongly (r = 0.813-0.994) and weakly correlated between 2DE and true masses (r = 0.628). In excised canine hearts, there is an excellent correlation between RT3DE and true masses (r = 0.764-0.991), while 2DE value showed a lesser correlation (r = 0.514). There are no difference between RT-3DE and true masses (P > 0.05) but different between 2DE and true masses (P < 0.05). In different planes, there was no difference between 8-plane and 16-plane (P > 0.05) but different between 8-plane and 2, 4-plane (P < 0.05). Conclusion RT3DE can accurately quantify LVM and provide a new tool to evaluate LV function. For LVM by RT3DE, 8-plane measurement method is the best choice for accuracy and convenience.
文摘Objective To evaluate the feasibility and accuracy of measurement of myocardial perfusion defects with intravenous contrast-enhanced real-time three-dimensional echocardiography (CE-RT3DE). Methods RT3DE was performed in 21 open-chest mongrel dogs undergoing acute ligation of the left anterior descending artery (LAD, n=14) or distal branch of the left circumflex artery (LCX, n=7). A perfluorocarbon microbubble contrast agent was injected intravenously to assess the resulting myocardial perfusion defects with Philips Sonos-7500 ultrasound system. Evans blue dye was injected into the occluded coronary artery for subsequent anatomic identification of underperfused myocardium. In vitro anatomic measurement of myocardial mass after removal of the animal’s heart was regarded as the control. Blinded off-line calculation of left ventricular mass and perfusion defect mass from RT3DE images were performed using an interactive aided-manual tracing technique.Results Total left ventricular (LV) myocardial mass ranged from 38.9 to 78.5 (mean±SD: 60.0±10.1) g. The mass of perfusion defect ranged from 0 to 21.4 (mean±SD: 12.0±5.0) g or 0 to 27% of total LV mass (mean±SD: 19%±6%). The RT3DE estimation of total LV mass (mean±SD: 59.8±9.9 g) strongly correlated with the anatomic measurement (r=0.98; y=2.01+0.96x). The CE-RT3DE calculation of the mass of underperfused myocardium (mean±SD: 12.3±5.3 g) also strongly correlated with the anatomic measurement (r=0.96; y=-0.10+1.04x) and when expressed as percentage of total LV mass (r=0.95; y=-0.20+1.04x). Conclusions RT3DE with myocardial contrast opacification could accurately estimate underperfused myocardial mass in dogs of acute coronary occlusion and would play an important role in quantitative assessment of myocardial perfusion defects in patients with coronary artery disease.
基金Projects(51108465,71371192)supported by the National Natural Science Foundation of ChinaProject(2014M552165)supported by China Postdoctoral Science FoundationProject(20113187851460)supported by Technology Project of the Ministry of Transport of China
文摘The class of bi-directional optimal velocity models can describe the bi-directional looking effect that usually exists in the reality and is even enhanced with the development of the connected vehicle technologies. Its combined string stability condition can be obtained through the method of the ring-road based string stability analysis. However, the partial string stability about traffic fluctuation propagated backward or forward was neglected, which will be analyzed in detail in this work by the method of transfer function and its H∞ norm from the viewpoint of control theory. Then, through comparing the conditions of combined and partial string stabilities, their relationships can make traffic flow be divided into three distinguishable regions, displaying various combined and partial string stability performance. Finally, the numerical experiments verify the theoretical results and find that the final displaying string stability or instability performance results from the accumulated and offset effects of traffic fluctuations propagated from different directions.
基金supported by the National Natural Science Foundation of China granted No.51276172
文摘To investigate the unsteady flow characteristics in centrifugal pump, the flow field in a low-specific-speed centri- fugal pump with complex impeller is numerically simulated under different conditions. The RNG r-e turbulence model and sliding mesh are adopted during the process of computation. The results show that the interaction be- tween impeller and volute results in the unstable flow of the fluid, which causes the uneven distribution of pres- sure fluctuations around the circumference of volute. Besides the main frequency and its multiple frequency of pressure fluctuations in the centrifugal pump, the frequency caused by the long blades of complex impeller also plays a dominant role in the low-frequency areas. Furthermore, there exists biggish fluctuation phenomenon near the tongue. The composition of static pressure fluctuations frequency on the volute wall and blade outlet is similar except that the fluctuation amplitude near the volute wall reduces. In general, the different flow rates mainly have influence on the amplitude of fluctuation frequency in the pump, while have little effect on the frequency compo- sition.
基金This research is supported by the National Natural Science Foundation of China under Grant Nos. 10571161 and 60774014.
文摘This paper considers the stabilization of the transmission problem of wave equations with variable coefficients. By introducing both boundary feedback control and distribute feedback control near the transmission boundary, the author establishes the uniform energy decay rate for the problem.