一种手指肌力定量测定仪的研制

目的:研制一种新型手指肌力定量测定仪,实现单根手指肌力的定量测定。方法:该装置主要由肌力测量装置、光信号采集、后续处理系统组成。肌力测量装置包括受力臂、支座和底板;受力臂设置在支座远离底板的一端,形成悬臂结构,其端部设有肌力受力孔,其内设置有手指固定装置方便固定手指;光信号采集及处理系统包括与肌力测量装置相连的光纤光栅、光谱分析仪、数据分析系统。结果:该手指肌力定量测定仪可实现任意方向单根手指肌力的定量测定,经过临床试验可以测定正常及异常肌力。结论:该手指肌力定量测定仪安全精确,首次实现了智能化单根手指肌力的测定及评估。

一种感觉神经定量测定仪的研制

开发一种以一片89C51单片机、一个精密正弦波发生器和一个高压恒流输出电路为核心,可产生3种不同频率(2000Hz、250Hz和5Hz)的正弦波精密恒定电流输出的感觉神经定量测定仪。其刺激输出强度范围为0.01mA～10.00mA。该仪器能比较客观地判断神经感觉状况,为临床神经病变的诊断提供一种新方法。

一种基于S3 C2410的CFID控制系统设计

提出了一种嵌入式化学发光免疫定量测定仪(CFID)中央控制系统的设计方法.该控制系统以S3C2410嵌入式微处理器为硬件核心,移植了嵌入式Linux内核、TCP/IP协议栈,配合相应的硬件驱动和上层应用软件,实现了网关、嵌入式Web、人机界面及内部模块控制等功能,以及仪器的远程和本地化操作.该系统开发成本低,运行稳定,操作灵活,安全可靠.

Detection of thiopurine s-methyltransferase mutations by template directed determinator in incorporation with fluorescence polarization (TDI-FP)

Objective: To develop a new method for the detection of TPMT gene mutations and determine the frequencies of four TPMT alleles, TPMT *1, *3A , *3B and *3C in a healthy Chinese population. Methods: A TDI-FP assay system was set up in out lab. To evaluate this system, 220 healthy individuals were analyzed for the polymorphic sites at positions 460(G→A)and 719(A→G)of the TPMP gene using our new TDI–FP method. Results: Three TPMP*3C(G 460→G 719) heterozygotes were identified, TPMP *3A and TPMP *3B were not found. All mutations were confirmed by conventional DNA sequencing analysis. Conclusion: TDI-FP method has proven to be very efficient as a rapid and accurate approach for TPMP genotyping. TPMP *3C was the only polymorphism identified in this clinical samples we have registered.