[Objective] The aim of this study was to elucidate the quantitative traits of plants mutagenized by ion beam. [Method] The particular variation phenotypes, a- gronomic traits, and protein and wet gluten contents of pr...[Objective] The aim of this study was to elucidate the quantitative traits of plants mutagenized by ion beam. [Method] The particular variation phenotypes, a- gronomic traits, and protein and wet gluten contents of progenies derived from the same ion beam induced mutant were investigated. [Result] Morphological polymor- phism existed in some individuals. Plant height, spike length and protein content were significantly influenced by ion beam, and effective tiller number and wet gluten content were moderately influenced. Multiple comparisons of all the indices within groups indicated genomic instability among these groups. Coefficient of variation im- plied the differences within group were very low. [Conclusion] Ion beam irradiation displayed characteristics of multi-directivity and non-directiveness. It aroused multiple variations in the same mutant. Instability among progeny indicates cells had different fate even in the same irradiated tissue. It may take several generations for mutants to stabilize particular phenotypes. The effects of ion beam irradiation may be the in- terrelated direct irradiation damage, indirect irradiation damage and late effect, such as bystander effect and adaptive response.展开更多
We compared DVHs （dose volume histograms） of two tangential irradiation techniques for whole breast RT （radiotherapy） CT （computed tomography） based 2D （two dimensional） technique with wedge filters and 3D CRT...We compared DVHs （dose volume histograms） of two tangential irradiation techniques for whole breast RT （radiotherapy） CT （computed tomography） based 2D （two dimensional） technique with wedge filters and 3D CRT （three dimensional conformal radiotherapy） with segmented fields. These two modalities are commonly used in external beam radiotherapy of breast cancer in Clinical Center Nis, Clinic of Oncology, Serbia. Therapy plans that employed two techniques were generated for eighteen patients. Dosimetric outcomes of each technique were investigated. The maximum dose of breast CTV was significantly reduced from 55.83 Gy for 2D to 54.1 Gy for 3D CRT. Also, the maximum dose of lung tissue decreased from 51.81 Gy for 2D to 49.61 Gy for 3D. The dose conformity and uniformity were much better with 3D CRT segmented field technique.展开更多
开发一个一个地向细胞预定位置投射离子的技术对评估环境低剂量暴露的危害性，研究基因不稳定性、细胞近旁效应以及辐照损伤微观机理等具有重要作用．技术的核心在于高品质徽束的获取以及粒子个数和定位照射的精确控制两个方面．CAS—L...开发一个一个地向细胞预定位置投射离子的技术对评估环境低剂量暴露的危害性，研究基因不稳定性、细胞近旁效应以及辐照损伤微观机理等具有重要作用．技术的核心在于高品质徽束的获取以及粒子个数和定位照射的精确控制两个方面．CAS—LIBB单离子徽束装置由一台5．5 MeV Van de Graft静电加速器产生离子，经两级磁偏转选择获得单能质子束流．束流通过1．0gm内径、980μm高的石英毛细管瞄准器准直，从3．5μm真空封膜引出．能量发散度(FWHM)<40keV，再穿过7μm反光铝箔、18μm闪烁体薄膜和3.5μm封装膜，FWHM<64．5keV．束流直径小于5μm，粒子数500-20000质子·s^-1可调．在细胞照射过程中，闪烁体探测器和250ns快速电子开关结合计算机控制模块，粒子计数精度>98％，定位精度≤±2μm．展开更多
基金Supported by National Natural Science Foundation of China (30800204)Basic and Frontier Technology Research Program of Henan Province (102300413206)~~
文摘[Objective] The aim of this study was to elucidate the quantitative traits of plants mutagenized by ion beam. [Method] The particular variation phenotypes, a- gronomic traits, and protein and wet gluten contents of progenies derived from the same ion beam induced mutant were investigated. [Result] Morphological polymor- phism existed in some individuals. Plant height, spike length and protein content were significantly influenced by ion beam, and effective tiller number and wet gluten content were moderately influenced. Multiple comparisons of all the indices within groups indicated genomic instability among these groups. Coefficient of variation im- plied the differences within group were very low. [Conclusion] Ion beam irradiation displayed characteristics of multi-directivity and non-directiveness. It aroused multiple variations in the same mutant. Instability among progeny indicates cells had different fate even in the same irradiated tissue. It may take several generations for mutants to stabilize particular phenotypes. The effects of ion beam irradiation may be the in- terrelated direct irradiation damage, indirect irradiation damage and late effect, such as bystander effect and adaptive response.
文摘We compared DVHs （dose volume histograms） of two tangential irradiation techniques for whole breast RT （radiotherapy） CT （computed tomography） based 2D （two dimensional） technique with wedge filters and 3D CRT （three dimensional conformal radiotherapy） with segmented fields. These two modalities are commonly used in external beam radiotherapy of breast cancer in Clinical Center Nis, Clinic of Oncology, Serbia. Therapy plans that employed two techniques were generated for eighteen patients. Dosimetric outcomes of each technique were investigated. The maximum dose of breast CTV was significantly reduced from 55.83 Gy for 2D to 54.1 Gy for 3D CRT. Also, the maximum dose of lung tissue decreased from 51.81 Gy for 2D to 49.61 Gy for 3D. The dose conformity and uniformity were much better with 3D CRT segmented field technique.
文摘开发一个一个地向细胞预定位置投射离子的技术对评估环境低剂量暴露的危害性，研究基因不稳定性、细胞近旁效应以及辐照损伤微观机理等具有重要作用．技术的核心在于高品质徽束的获取以及粒子个数和定位照射的精确控制两个方面．CAS—LIBB单离子徽束装置由一台5．5 MeV Van de Graft静电加速器产生离子，经两级磁偏转选择获得单能质子束流．束流通过1．0gm内径、980μm高的石英毛细管瞄准器准直，从3．5μm真空封膜引出．能量发散度(FWHM)<40keV，再穿过7μm反光铝箔、18μm闪烁体薄膜和3.5μm封装膜，FWHM<64．5keV．束流直径小于5μm，粒子数500-20000质子·s^-1可调．在细胞照射过程中，闪烁体探测器和250ns快速电子开关结合计算机控制模块，粒子计数精度>98％，定位精度≤±2μm．
