Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnorm...Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnormalities in about 70%. It appears to be a developmental anomaly, starting in the 4th embryonic week. In an experimental study, targeted knockdown of cardiac troponin T in the chick was performed at day 3, after the heart tube has formed. Morpholino treatment of gene TNNT2 at this stage led to the development of left ventricular diver- ticula （LVD） in the primitive left ventricular wall. Diagnosis of left ventricular aneurysms （LVA）/LVD can be made after exclusion of coro- nary artery disease, local or systemic inflammation or traumatic causes as well as cardiomyopathies. Clinically, most of LVA and LVD are asymptomatic or may cause systemic embolization, congestive heart failure, valvular regurgitation, ventricular wall rupture, ventricular tachycardia or sudden cardiac death. Diagnosis is established by imaging studies （echocardiography, magnetic resonance imaging or left ventricular angiography） visualizing the structural changes and accompanying abnormalities. Mode of treatment has to be individually tai- lored and depends on clinical presentation, accompanying abnormalities and possible complications, options include surgical resection （espe- cially in symptomatic patients）, anticoagulation after systemic embolization, radiofrequency ablation or implantation of an implantable car- dioverter defibrillator （ICD） in case of symptomatic ventricular tachycardias, and occasionally combined with class I- or III-antiarrhythmic drugs. Cardiac death occurs usually in childhood, is significantly more frequent in LVA patients and caused by congestive heart failure in most of the cases, whereas patients diagnosed with LVD died more frequently from rupture of the LVD.展开更多
Due to the high price and formation damage of the guargum fracturing fluid, many oilfields are more and more interested in surfactant based fracturing fluids. The rheological properties of erucicamide dimethyl amidopr...Due to the high price and formation damage of the guargum fracturing fluid, many oilfields are more and more interested in surfactant based fracturing fluids. The rheological properties of erucicamide dimethyl amidopropyl betaine （EDAB）-HC1 acid blended system and its suitability as fracturing fluid were investigated in this work. The effects of pH, concentration of EDAB, and temperature on the rheological properties of the blended system were studied. The results show that addition of EDAB improved the viscosity of the system from less than 10 mPa. s to about 400 mPa. s, which could retard the acid-rock reaction to about one half at 60℃ and one quarter at 90℃ comparing to straight HC1 acid, suggesting that there is sufficient time for the blended fluid to react with formation rock when it is used as fracturing fluid in an oil field. Core flow tests demonstrated that the EDAB-acid blended fluid could divert itself from high permeability formation core to low permeability one, thus ensuring proper acid placement in the target reservoirs.展开更多
To study the pressure distribution of the volute casing, front casing and back casing in a prototype centrifugal pump, the pressure experiments and numerical simulations are carried out at six working conditions in th...To study the pressure distribution of the volute casing, front casing and back casing in a prototype centrifugal pump, the pressure experiments and numerical simulations are carried out at six working conditions in this paper. The experimental results shows that the asymmetry of static pressure distribution on volute casing and front cavity is caused by the tongue of the volute and it may result in high radial and axial resultant force which can cause vibration and noise in the centrifugal pump. With the increasing of flow rote, the asymmetry of static pressure distribution and the magnitude of static pressure values reduce. The numerical results indicate that the pressure fluctuation near the tongue is strongest and it becomes slighter at point away from the tongue. With the increasing of flow rote, the local high=pressure region in impeller passage reduces and the flow becomes smoother accordingly, whereas the fluid speed becomes much higher which may cause further flow losses. The results predicted by numcrical simulation are in coincident with the experimental ones. It shows that the turbulence model for simulating the flow field in centrifugal pumps is feasible.展开更多
文摘Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnormalities in about 70%. It appears to be a developmental anomaly, starting in the 4th embryonic week. In an experimental study, targeted knockdown of cardiac troponin T in the chick was performed at day 3, after the heart tube has formed. Morpholino treatment of gene TNNT2 at this stage led to the development of left ventricular diver- ticula （LVD） in the primitive left ventricular wall. Diagnosis of left ventricular aneurysms （LVA）/LVD can be made after exclusion of coro- nary artery disease, local or systemic inflammation or traumatic causes as well as cardiomyopathies. Clinically, most of LVA and LVD are asymptomatic or may cause systemic embolization, congestive heart failure, valvular regurgitation, ventricular wall rupture, ventricular tachycardia or sudden cardiac death. Diagnosis is established by imaging studies （echocardiography, magnetic resonance imaging or left ventricular angiography） visualizing the structural changes and accompanying abnormalities. Mode of treatment has to be individually tai- lored and depends on clinical presentation, accompanying abnormalities and possible complications, options include surgical resection （espe- cially in symptomatic patients）, anticoagulation after systemic embolization, radiofrequency ablation or implantation of an implantable car- dioverter defibrillator （ICD） in case of symptomatic ventricular tachycardias, and occasionally combined with class I- or III-antiarrhythmic drugs. Cardiac death occurs usually in childhood, is significantly more frequent in LVA patients and caused by congestive heart failure in most of the cases, whereas patients diagnosed with LVD died more frequently from rupture of the LVD.
基金Supported by the Fundamental Research Funds for the Central Universities(2652013107)the Laboratory Open Funds of China University of Geosciences(Beijing)
文摘Due to the high price and formation damage of the guargum fracturing fluid, many oilfields are more and more interested in surfactant based fracturing fluids. The rheological properties of erucicamide dimethyl amidopropyl betaine （EDAB）-HC1 acid blended system and its suitability as fracturing fluid were investigated in this work. The effects of pH, concentration of EDAB, and temperature on the rheological properties of the blended system were studied. The results show that addition of EDAB improved the viscosity of the system from less than 10 mPa. s to about 400 mPa. s, which could retard the acid-rock reaction to about one half at 60℃ and one quarter at 90℃ comparing to straight HC1 acid, suggesting that there is sufficient time for the blended fluid to react with formation rock when it is used as fracturing fluid in an oil field. Core flow tests demonstrated that the EDAB-acid blended fluid could divert itself from high permeability formation core to low permeability one, thus ensuring proper acid placement in the target reservoirs.
基金supported by the Joint Project from National Natural Science Foundation of China and Liaoning Province(U1608258)
文摘To study the pressure distribution of the volute casing, front casing and back casing in a prototype centrifugal pump, the pressure experiments and numerical simulations are carried out at six working conditions in this paper. The experimental results shows that the asymmetry of static pressure distribution on volute casing and front cavity is caused by the tongue of the volute and it may result in high radial and axial resultant force which can cause vibration and noise in the centrifugal pump. With the increasing of flow rote, the asymmetry of static pressure distribution and the magnitude of static pressure values reduce. The numerical results indicate that the pressure fluctuation near the tongue is strongest and it becomes slighter at point away from the tongue. With the increasing of flow rote, the local high=pressure region in impeller passage reduces and the flow becomes smoother accordingly, whereas the fluid speed becomes much higher which may cause further flow losses. The results predicted by numcrical simulation are in coincident with the experimental ones. It shows that the turbulence model for simulating the flow field in centrifugal pumps is feasible.
